Acat1 (acetyl-Coenzyme A acetyltransferase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Acat1 (acetyl-Coenzyme A acetyltransferase 1) Mus musculus
Analyze
Symbol: Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
RGD ID: 10060
MGI Page MGI
Description: Enables acetyl-CoA C-acetyltransferase activity. Predicted to be involved in carboxylic acid catabolic process; ketone body catabolic process; and purine nucleoside bisphosphate metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including brain; future brain; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330585C21Rik; Ac; Acat; acetoacetyl-CoA thiolase; acetyl-CoA acetyltransferase, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,491,822 - 53,521,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,491,822 - 53,521,682 (-)EnsemblGRCm39 Ensembl
GRCm38953,580,522 - 53,610,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,580,522 - 53,610,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,388,627 - 53,418,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,342,917 - 53,372,745 (-)NCBIMGSCv36mm8
Celera950,840,318 - 50,870,157 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7-ketocholesterol  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
acetamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chenodeoxycholic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
DDT  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
farnesol  (ISO)
fenofibrate  (ISO)
finasteride  (ISO)
folic acid  (EXP)
furan  (ISO)
GDP-beta-S  (ISO)
gentamycin  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
melatonin  (EXP,ISO)
methapyrilene  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nitroglycerin  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (EXP)
phosphatidylcholine  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
sarpogrelate  (ISO)
serotonin  (ISO)
sodium arsenite  (EXP,ISO)
soybean oil  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
2-aminoadipic 2-oxoadipic aciduria pathway  (ISO)
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway  (ISO)
3-hydroxyacyl-CoA dehydrogenase deficiency pathway  (ISO)
3-hydroxyisobutyric aciduria pathway  (ISO)
3-methylcrotonyl CoA carboxylase 1 deficiency pathway  (ISO)
3-methylglutaconic aciduria type 1 pathway  (ISO)
3-methylglutaconic aciduria type 3 pathway  (ISO)
butanoate metabolic pathway  (IEA,ISO)
carnitine palmitoyltransferase I deficiency pathway  (ISO)
ethylmalonic encephalopathy pathway   (ISO)
fatty acid beta degradation pathway  (ISO)
fatty acid metabolic pathway  (ISO)
glutaric aciduria type I pathway  (ISO)
glyoxylate and dicarboxylate metabolic pathway  (IEA)
hyperlysinemia pathway  (ISO)
isobutyryl-CoA dehydrogenase deficiency pathway  (ISO)
isovaleric acidemia pathway   (ISO)
ketone bodies metabolic pathway  (IEA,ISO)
Leigh disease pathway  (ISO)
lysine degradation pathway  (IEA,ISO)
malonic aciduria pathway  (ISO)
maple syrup urine disease pathway  (ISO)
medium chain acyl-CoA dehydrogenase deficiency pathway  (ISO)
methylmalonate semialdehyde dehydrogenase deficiency pathway  (ISO)
methylmalonic acidemia pathway  (ISO)
methylmalonic aciduria, cobalamin-related pathway  (ISO)
primary hyperoxaluria type 2 pathway  (ISO)
propanoate metabolic pathway  (IEA,ISO)
propionic acidemia pathway  (ISO)
pyruvate decarboxylase deficiency pathway  (ISO)
pyruvate dehydrogenase E1 deficiency pathway  (ISO)
pyruvate kinase deficiency of red cells pathway   (ISO)
pyruvate metabolic pathway  (IEA,ISO)
saccharopinuria pathway  (ISO)
short-chain acyl-CoA dehydrogenase deficiency pathway  (ISO)
succinyl-CoA:3-oxoacid transferase deficiency pathway  (ISO)
terpenoid biosynthetic pathway  (IEA)
trifunctional protein deficiency pathway  (ISO)
tryptophan metabolic pathway  (IEA)
valine, leucine and isoleucine degradation pathway  (IEA,ISO)
very long-chain acyl-CoA dehydrogenase deficiency pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
2. Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Forcheron F, etal., Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1711-7. Epub 2005 Jun 16.
3. Prenatal diagnosis in a family with mitochondrial acetoacetyl-coenzyme A thiolase deficiency with the use of the polymerase chain reaction followed by the heteroduplex detection method. Fukao T, etal., Prenat Diagn. 1995 Apr;15(4):363-7.
4. Sterol Regulatory Element-Binding Proteins, Liver X Receptor, ABCA1 Transporter, CD36, Scavenger Receptors A1 and B1 in Nephrotic Kidney. Kim HJ and Vaziri ND, Am J Nephrol. 2009 Jan 16;29(6):607-614.
5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
9. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
10. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1351831   PMID:3013550   PMID:7510589   PMID:7592824   PMID:7606725   PMID:8268678   PMID:8661102   PMID:8672141   PMID:8786135   PMID:9268631   PMID:9616220   PMID:10349636  
PMID:10765558   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11160132   PMID:11217851   PMID:12114517   PMID:12477932   PMID:12865426   PMID:12975367   PMID:14610273   PMID:14681479  
PMID:15489334   PMID:15845358   PMID:15851589   PMID:16141072   PMID:16141073   PMID:16916647   PMID:16935859   PMID:16969126   PMID:17103052   PMID:17916774   PMID:18245064   PMID:18307411  
PMID:18614015   PMID:19625658   PMID:20133765   PMID:20843517   PMID:21873635   PMID:22474282   PMID:23456478   PMID:23846496   PMID:23988655   PMID:24486017   PMID:24657401   PMID:25522268  
PMID:25602705   PMID:25737280   PMID:25930235   PMID:26025364   PMID:26108225   PMID:26801614   PMID:27160897   PMID:27678191   PMID:28378742   PMID:29097366   PMID:29533741   PMID:29549095  
PMID:30196744   PMID:30282838   PMID:30457570   PMID:30562941   PMID:30713523   PMID:31727739   PMID:32397995   PMID:32646003   PMID:35507892   PMID:36293380   PMID:36417873   PMID:37839992  
PMID:37879607  


Genomics

Comparative Map Data
Acat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,491,822 - 53,521,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,491,822 - 53,521,682 (-)EnsemblGRCm39 Ensembl
GRCm38953,580,522 - 53,610,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,580,522 - 53,610,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,388,627 - 53,418,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,342,917 - 53,372,745 (-)NCBIMGSCv36mm8
Celera950,840,318 - 50,870,157 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
ACAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811108,116,705 - 108,147,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11108,116,695 - 108,147,603 (+)EnsemblGRCh38hg38GRCh38
GRCh3711107,987,432 - 108,018,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,497,468 - 107,523,485 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411107,497,467 - 107,523,485NCBI
Celera11105,147,145 - 105,173,805 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11103,917,783 - 103,944,520 (+)NCBIHuRef
CHM1_111107,875,420 - 107,902,046 (+)NCBICHM1_1
T2T-CHM13v2.011108,124,245 - 108,155,151 (+)NCBIT2T-CHM13v2.0
Acat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,876,003 - 62,905,080 (-)NCBIGRCr8
mRatBN7.2853,979,813 - 54,008,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,979,813 - 54,008,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,505,211 - 59,534,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,784,239 - 57,813,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,648,477 - 55,677,476 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
Acat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,349,593 - 10,369,806 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,350,088 - 10,369,806 (+)NCBIChiLan1.0ChiLan1.0
ACAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29108,866,381 - 108,892,867 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111109,959,287 - 109,985,798 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011103,008,564 - 103,034,697 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111106,483,563 - 106,509,793 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,483,563 - 106,509,787 (+)Ensemblpanpan1.1panPan2
ACAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,361,301 - 24,379,807 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,361,301 - 24,379,812 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,286,784 - 24,306,232 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,389,926 - 24,409,658 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,389,926 - 24,409,643 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,437,216 - 24,456,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,338,692 - 24,358,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,396,960 - 24,416,675 (-)NCBIUU_Cfam_GSD_1.0
Acat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494790,910,486 - 90,941,886 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551591,695 - 626,056 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936551594,647 - 626,016 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,525,261 - 36,545,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,525,266 - 36,545,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,601,654 - 40,622,145 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,552,760 - 99,580,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,552,838 - 99,579,914 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,378,291 - 26,404,565 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247842,833,344 - 2,879,043 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acat1
1083 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:850
Count of miRNA genes:506
Interacting mature miRNAs:594
Transcripts:ENSMUST00000034547, ENSMUST00000167130, ENSMUST00000169317
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
13515057Adip20b_madiposity 20b (mouse)94870090853791702Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse

Markers in Region
UniSTS:236128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38953,609,337 - 53,609,448UniSTSGRCm38
MGSCv37953,417,442 - 53,417,553UniSTSGRCm37
Celera950,869,138 - 50,869,249UniSTS
Cytogenetic Map9C-DUniSTS
Acat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS
Acat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9C-DUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034547   ⟹   ENSMUSP00000034547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,491,822 - 53,521,682 (-)Ensembl
GRCm38.p6 Ensembl953,580,522 - 53,610,382 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167130
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,509,195 - 53,521,630 (-)Ensembl
GRCm38.p6 Ensembl953,597,895 - 53,610,330 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169317
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl953,493,787 - 53,495,057 (-)Ensembl
GRCm38.p6 Ensembl953,582,487 - 53,583,757 (-)Ensembl
RefSeq Acc Id: NM_144784   ⟹   NP_659033
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39953,491,822 - 53,521,650 (-)NCBI
GRCm38953,580,522 - 53,610,350 (-)ENTREZGENE
MGSCv37953,388,627 - 53,418,455 (-)RGD
Celera950,840,318 - 50,870,157 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_659033   ⟸   NM_144784
- Peptide Label: precursor
- UniProtKB: Q3TE92 (UniProtKB/Swiss-Prot),   Q8QZT1 (UniProtKB/Swiss-Prot),   Q3TQP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034547   ⟸   ENSMUST00000034547
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8QZT1-F1-model_v2 AlphaFold Q8QZT1 1-424 view protein structure

Promoters
RGD ID:6848903
Promoter ID:MM_TRO:10000
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:MTR001362.9.1101.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36953,400,036 - 53,400,536 (-)MPROMDB
RGD ID:6844062
Promoter ID:MM_KWN:57368
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_144784
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36953,418,154 - 53,418,654 (-)MPROMDB
RGD ID:8669616
Promoter ID:EPDNEW_M12839
Type:initiation region
Name:Acat1_1
Description:Mus musculus acetyl-Coenzyme A acetyltransferase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38953,610,352 - 53,610,412EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87870 AgrOrtholog
Ensembl Genes ENSMUSG00000032047 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034547 ENTREZGENE
  ENSMUST00000034547.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110446 UniProtKB/Swiss-Prot
MGD MGI:87870 ENTREZGENE
NCBI Gene 110446 ENTREZGENE
PANTHER ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acat1 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3TE92 ENTREZGENE
  Q3TQP7 ENTREZGENE, UniProtKB/TrEMBL
  Q8QZT1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TE92 UniProtKB/Swiss-Prot