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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propylparaben
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Accession:CHEBI:32063 term browser browse the term
Definition:The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.
Synonyms:exact_synonym: propyl 4-hydroxybenzoate
 related_synonym: 4-Hydroxybenzoic acid propyl ester;   Formula=C10H12O3;   InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3;   InChIKey=QELSKZZBTMNZEB-UHFFFAOYSA-N;   Propyl p-hydroxybenzoate;   Propyl parahydroxybenzoate;   SMILES=CCCOC(=O)c1ccc(O)cc1;   n-Propyl 4-hydroxybenzoate;   n-Propyl p-hydroxybenzoate;   n-propyl paraben;   p-Hydroxybenzoic acid propyl ester;   p-Hydroxybenzoic propyl ester;   p-Hydroxypropyl benzoate;   p-Oxybenzoesaeurepropylester;   propyl paraben
 xref: CAS:94-13-3;   Drug_Central:2307;   HMDB:HMDB0032574;   KEGG:D01422
 xref_mesh: MESH:C006068
 xref: PMID:21492176;   PMID:21549034;   PMID:21608130;   PMID:21645663;   PMID:21705745;   PMID:21886901;   PMID:22165009;   PMID:22177019;   PMID:22220814;   PMID:22237600;   PMID:22249112;   PMID:22305363;   PMID:22337803;   Reaxys:1103245;   Wikipedia:Propylparaben


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propylparaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO propylparaben results in increased expression of ADIPOQ mRNA CTD PMID:22956630 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO propylparaben results in increased expression of APAF1 mRNA CTD PMID:24481588 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 propylparaben binds to AR protein
propylparaben inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]		 CTD PMID:14565775 PMID:20371976 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO propylparaben results in increased expression of AREG mRNA CTD PMID:31939680 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO propylparaben results in increased expression of ATF4 mRNA CTD PMID:36277366 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atm ATM serine/threonine kinase affects expression ISO propylparaben affects the expression of ATM mRNA CTD PMID:24481588 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase increases expression ISO propylparaben results in increased expression of ATR mRNA CTD PMID:24481588 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
decreases expression		 ISO propylparaben results in increased expression of BAD mRNA
propylparaben results in decreased expression of BAD mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO propylparaben results in increased expression of BAK1 mRNA CTD PMID:24481588 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO propylparaben results in increased expression of BAX mRNA CTD PMID:24481588 PMID:31306770 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO propylparaben results in increased expression of BBC3 mRNA CTD PMID:24481588 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression		 ISO propylparaben results in increased expression of BCL2 mRNA
propylparaben results in decreased expression of BCL2 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO propylparaben results in increased expression of BCL2L1 mRNA; propylparaben results in increased expression of BCL2L1 protein CTD PMID:24481588 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO propylparaben results in increased expression of BCL2L11 mRNA CTD PMID:24481588 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO propylparaben results in increased expression of BCL2L2 mRNA CTD PMID:24481588 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO propylparaben results in increased expression of BID mRNA CTD PMID:24481588 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO propylparaben results in increased expression of BIK mRNA CTD PMID:24481588 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO propylparaben results in increased expression of BIRC5 mRNA CTD PMID:24481588 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO propylparaben results in increased expression of BIRC6 mRNA CTD PMID:24481588 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK increases expression ISO propylparaben results in increased expression of BOK mRNA CTD PMID:24481588 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp1 caspase 1 increases expression ISO propylparaben results in increased expression of CASP1 mRNA CTD PMID:24481588 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 increases expression ISO propylparaben results in increased expression of CASP2 mRNA CTD PMID:24481588 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression ISO propylparaben results in increased expression of CASP3 mRNA CTD PMID:24481588 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression ISO propylparaben results in increased expression of CASP4 mRNA CTD PMID:24481588 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 increases expression ISO propylparaben results in increased expression of CASP6 mRNA CTD PMID:24481588 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases expression ISO propylparaben results in increased expression of CASP7 mRNA CTD PMID:24481588 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases expression ISO propylparaben results in increased expression of CASP8 mRNA; propylparaben results in increased expression of CASP8 protein CTD PMID:24481588 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO propylparaben results in increased expression of CASP8AP2 mRNA CTD PMID:24481588 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275 		JBrowse link
G Casp9 caspase 9 increases expression ISO propylparaben results in increased expression of CASP9 mRNA; propylparaben results in increased expression of CASP9 protein CTD PMID:24481588 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO propylparaben results in increased expression of CCNA1 mRNA CTD PMID:24481588 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression		 ISO propylparaben results in increased expression of CCNA2 mRNA
propylparaben results in decreased expression of CCNA2 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO propylparaben results in decreased expression of CCNB1 mRNA CTD PMID:24481588 PMID:33358972 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO propylparaben results in increased expression of CCND1 mRNA CTD PMID:24481588 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression		 ISO propylparaben results in increased expression of CCNE1 mRNA
propylparaben results in decreased expression of CCNE1 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO propylparaben results in increased expression of CDC25A mRNA CTD PMID:24481588 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression
decreases expression		 ISO propylparaben results in increased expression of CDK2 mRNA
propylparaben results in decreased expression of CDK2 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO propylparaben results in increased expression of CDK4 mRNA CTD PMID:24481588 PMID:31306770 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO propylparaben results in decreased expression of CDK6 mRNA CTD PMID:24481588 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression		 ISO propylparaben results in decreased expression of CDKN1A mRNA; propylparaben results in decreased expression of CDKN1A protein
propylparaben results in increased expression of CDKN1A mRNA		 CTD PMID:24481588 PMID:31306770 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO propylparaben results in increased expression of CEBPA mRNA CTD PMID:22956630 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects expression
increases expression		 ISO propylparaben affects the expression of CYP19A1 mRNA; propylparaben affects the expression of CYP19A1 protein
propylparaben results in increased expression of CYP19A1 protein
propylparaben results in increased expression of CYP19A1 mRNA; propylparaben results in increased expression of CYP19A1 protein		 CTD PMID:23744433 PMID:34365652 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP
ISO		 propylparaben results in decreased activity of CYP1A1 protein CTD PMID:27432241 PMID:34181028 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP propylparaben results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP propylparaben results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP propylparaben results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP propylparaben results in decreased activity of CYP2E1 protein CTD PMID:27432241 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP propylparaben results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO propylparaben results in increased expression of DDIT3 mRNA CTD PMID:36277366 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO propylparaben results in increased expression of DIABLO mRNA CTD PMID:24481588 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO propylparaben results in increased expression of E2F1 mRNA CTD PMID:24481588 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 affects expression ISO propylparaben affects the expression of E2F3 mRNA CTD PMID:24481588 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity
increases expression		 EXP
ISO		 propylparaben binds to ESR1 protein
Fulvestrant inhibits the reaction [propylparaben results in increased activity of ESR1 protein]; propylparaben binds to and results in increased activity of ESR1 protein
propylparaben results in increased expression of ESR1 mRNA; propylparaben results in increased expression of ESR1 protein		 CTD PMID:11193391 PMID:19063592 PMID:20132880 PMID:22562034 PMID:23567241 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions
increases expression		 EXP
ISO		 propylparaben binds to ESR2 protein
propylparaben binds to and results in increased activity of ESR2 protein
propylparaben results in increased expression of ESR2 mRNA; propylparaben results in increased expression of ESR2 protein		 CTD PMID:11193391 PMID:20132880 PMID:23567241 PMID:25128701 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO propylparaben results in decreased activity of FAAH protein CTD PMID:27659731 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO propylparaben results in increased expression of FABP4 mRNA CTD PMID:22956630 PMID:24155963 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO propylparaben results in increased expression of FADD mRNA CTD PMID:24481588 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fasn fatty acid synthase increases expression ISO propylparaben results in increased expression of FASN mRNA CTD PMID:22956630 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Flg filaggrin multiple interactions ISO FLG gene mutant form affects the abundance of and affects the susceptibility to propylparaben CTD PMID:28525834 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [Parabens results in increased abundance of propylparaben] which results in decreased secretion of FSHB protein CTD PMID:32122340 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression ISO propylparaben results in increased expression of GPER1 mRNA; propylparaben results in increased expression of GPER1 protein CTD PMID:26253279 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO propylparaben results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form]		 CTD PMID:31939680 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hoxa10 homeobox A10 decreases expression ISO propylparaben results in decreased expression of HOXA10 protein CTD PMID:34101200 NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO propylparaben results in increased expression of HSPA5 mRNA CTD PMID:36277366 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Lep leptin decreases expression
increases expression		 ISO propylparaben results in decreased expression of LEP mRNA
propylparaben results in increased expression of LEP mRNA		 CTD PMID:22956630 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation ISO propylparaben affects the phosphorylation of MAPK1 protein CTD PMID:26253279 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO propylparaben affects the phosphorylation of MAPK3 protein CTD PMID:26253279 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO propylparaben results in increased expression of MCL1 mRNA CTD PMID:24481588 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO propylparaben results in decreased expression of MMP9 protein CTD PMID:34101200 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 ISO NRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]; propylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA] CTD PMID:26502914 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions		 EXP
ISO		 propylparaben results in increased expression of NR1I2 mRNA
propylparaben binds to and results in increased activity of NR1I2 protein		 CTD PMID:31472229 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO propylparaben results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO [butylparaben co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with propylparaben] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein
propylparaben results in increased activity of NR3C1 protein		 CTD PMID:25448277 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO NRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]; propylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA] CTD PMID:26502914 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Pgr progesterone receptor increases expression
decreases expression		 ISO propylparaben results in increased expression of PGR mRNA
propylparaben results in decreased expression of PGR mRNA		 CTD PMID:25128701 PMID:31939680 PMID:34101200 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP propylparaben affects the expression of PPARA mRNA CTD PMID:31472229 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO propylparaben results in increased expression of PPARG mRNA
propylparaben binds to and results in increased activity of PPARG protein
PPARG protein promotes the reaction [propylparaben binds to and results in increased activity of PPARG protein]; propylparaben binds to and results in increased activity of PPARG protein		 CTD PMID:22956630 PMID:24155963 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO propylparaben results in increased expression of RIPK1 mRNA CTD PMID:24481588 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 increases expression ISO propylparaben results in increased expression of RIPK2 mRNA CTD PMID:24481588 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G S100g S100 calcium binding protein G increases expression EXP propylparaben results in increased expression of S100G protein CTD PMID:19654335 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO propylparaben binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slc17a9 solute carrier family 17 member 9 increases methylation ISO propylparaben results in increased methylation of SLC17A9 gene CTD PMID:34523531 NCBI chr 3:167,839,246...167,857,462
Ensembl chr 3:167,839,385...167,855,985 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO propylparaben results in increased expression of STAR mRNA; propylparaben results in increased expression of STAR protein CTD PMID:31306770 PMID:34365652 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [propylparaben results in increased expression of TFF1 mRNA] CTD PMID:16797915 PMID:22562034 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO propylparaben binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO propylparaben binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO propylparaben results in increased expression of TNF mRNA CTD PMID:24481588 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO propylparaben results in increased expression of TNFRSF10A mRNA CTD PMID:24481588 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO propylparaben results in increased expression of TNFRSF1A mRNA CTD PMID:24481588 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO propylparaben results in increased expression of TNFRSF25 mRNA CTD PMID:24481588 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO propylparaben results in increased expression of TNFSF10 mRNA CTD PMID:24481588 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO propylparaben results in increased expression of TP53 mRNA; propylparaben results in increased expression of TP53 protein CTD PMID:24481588 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO propylparaben results in increased expression of TP53BP1 protein CTD PMID:31939680 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO propylparaben results in increased expression of TRADD mRNA CTD PMID:24481588 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO propylparaben results in increased expression of XBP1 mRNA; propylparaben results in increased expression of XBP1 mRNA alternative form CTD PMID:36277366 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          propylparaben 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      aromatic carboxylic acid 12598
                                        benzoic acids 12575
                                          benzoic acid 5327
                                            hydroxybenzoic acid 4794
                                              monohydroxybenzoic acid 2611
                                                4-hydroxybenzoic acid 1241
                                                  4-hydroxybenzoate ester 1238
                                                    paraben 1238
                                                      propylparaben 96
paths to the root