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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:32063
Term: propylparaben
Definition: The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.
Chemical ID: MESH:C006068
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDpropylparaben results in increased expression of PPARG mRNAPMID:22956630
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDpropylparaben binds to and results in increased activity of PPARG proteinPMID:24155963 PMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDPPARG protein promotes the reaction [propylparaben binds to and results in increased activity of PPARG protein]; propylparaben binds to and results in increased activity of PPARG proteinPMID:24155963 PMID:33049310
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