Many caspase substrates have been indentified; they include proteins involved in cell cycle and DNA repair, regulatory and structural proteins. For many however, the functional consequence of cleavage is not well known. Likely, depending on which apoptotic pathway is elicited and where, particular subsets of substrates are processed. For more information, check PMIDs 15725726, 12655297, 17273173. Several target genes are listed with aliases in parentheses, full names and links to gene report pages:

Dffa (Dff45) – DNA fragmentation factor subunit alpha
Ndufs1 – NADH ubiquinone oxidoreductase core subunit S1
Gsn – gelsolin
Krt18 (K18) – keratin 18
Krt19 (K19) – keratin 19
Vim – vimentin
Ctnnb1 (beta-catenin, catenin beta, Catnb) – catenin beta 1
Jup (Pkgb, gamma-catenin) – junction plakoglobin
Prkdc (DNA-PK) – protein kinase, DNA activated, catalytic polypeptide
Rad51 (RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)) – RAD51 recombinase
Atm (Ata, Ate, Tel1) – ATM serine/threonine kinase
Cdc27 – cell division cycle 27
Wee1 – WEE1 G2 checkpoint kinase
Cdkn1a (p21Cip1) – cyclin-dependent kinase inhibitor 1A
Cdkn1b (p27Kip1) – cyclin-dependent kinase inhibitor 1B
Pak2 (gamma-PAK, p21-activated kinase 2) – p21 (RAC1) activated kinase 2
Rock1 (p160Rock) – Rho-associated coiled-coil containing protein kinase 1
Rb1 (Rb, retinoblastoma 1) – RB transcriptional corepressor 1