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Strain Registration

Strain: COP/OlaHsd

Symbol: COP/OlaHsd
Strain: COP
Substrain: OlaHsd
RGD ID: 10011
Citation ID: RRID:RGD_10011
Ontology ID: RS:0000186
Also Known As: MDC-03-77
Type: inbred
Available Source: Harlan
Description: These are derived from the original colony which was developed by Dr. W.F. Dunning.
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Sex-specific Genetic Loci for Femoral Neck Bone Mass and Strength Identified in Inbred COP and DA Rats. Alam I, etal., J Bone Miner Res. 2008 Feb 18;.
2. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. Barbato JC, etal., J Appl Physiol 1998 Aug;85(2):530-6.
3. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
4. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
5. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
6. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
7. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
8. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
9. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
10. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
11. Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Koch LG, etal., Physiol Genomics 1999 Aug 31;1(2):63-9.
12. Linkage screen for BMD phenotypes in male and female COP and DA rat strains. Koller DL, etal., J Bone Miner Res. 2008 Sep;23(9):1382-8.
13. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
14. Mapping of Mcs30, a New Mammary Carcinoma Susceptibility Quantitative Trait Locus (QTL30) on Rat Chromosome 12: Identification of Fry as a Candidate Mcs Gene. Ren X, etal., PLoS One. 2013 Sep 2;8(9):e70930. doi: 10.1371/journal.pone.0070930.
15. RGD Strain RSO annotation pipeline RGD Automated Pipelines
16. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
17. Genetic identification of multiple loci that control breast cancer susceptibility in the rat Shepel LA, etal., Genetics 1998 May;149(1):289-99
18. Susceptibility to estrogen-induced mammary cancer segregates as an incompletely dominant phenotype in reciprocal crosses between the ACI and Copenhagen rat strains. Shull JD, etal., Endocrinology 2001 Dec;142(12):5124-30.
19. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
20. Genetic loci affecting bone structure and strength in inbred COP and DA rats. Sun Q, etal., Bone. 2008 Mar;42(3):547-53. Epub 2007 Nov 28.
21. A genome scan for Loci associated with aerobic running capacity in rats. Ways JA, etal., Genomics 2002 Jul;80(1):13-20.

Region

Strain QTL Data
Symbol Name Trait
Arunc1 Aerobic running capacity QTL 1 exercise endurance trait   (VT:0002332)    
Arunc2 Aerobic running capacity QTL 2 exercise endurance trait   (VT:0002332)    
Arunc3 Aerobic running capacity QTL 3 exercise endurance trait   (VT:0002332)    
Bmd19 Bone mineral density QTL 19 femur mineral mass   (VT:0010011)    
Bmd20 Bone mineral density QTL 20 femur mineral mass   (VT:0010011)    
Bmd21 Bone mineral density QTL 21 femur mineral mass   (VT:0010011)    
Bmd22 Bone mineral density QTL 22 femur mineral mass   (VT:0010011)    
Bmd23 Bone mineral density QTL 23 femur mineral mass   (VT:0010011)    
Bmd24 Bone mineral density QTL 24 femur mineral mass   (VT:0010011)    
Bmd25 Bone mineral density QTL 25 femur mineral mass   (VT:0010011)    
Bmd26 Bone mineral density QTL 26 femur mineral mass   (VT:0010011)    
Bmd27 Bone mineral density QTL 27 femur mineral mass   (VT:0010011)    
Bmd28 Bone mineral density QTL 28 femur mineral mass   (VT:0010011)    
Bmd29 Bone mineral density QTL 29 femur size trait   (VT:1000369)    
Bmd30 Bone mineral density QTL 30 femur mineral mass   (VT:0010011)    
Bmd31 Bone mineral density QTL 31 femur size trait   (VT:1000369)    
Bmd32 Bone mineral density QTL 32 femur strength trait   (VT:0010010)    
Bmd33 Bone mineral density QTL 33 femur strength trait   (VT:0010010)    
Bmd34 Bone mineral density QTL 34 femur strength trait   (VT:0010010)    
Bmd35 Bone mineral density QTL 35 femur strength trait   (VT:0010010)    
Bmd36 Bone mineral density QTL 36 femur strength trait   (VT:0010010)    
Bmd37 Bone mineral density QTL 37 femur strength trait   (VT:0010010)    
Bmd38 Bone mineral density QTL 38 femur size trait   (VT:1000369)    
Bmd39 Bone mineral density QTL 39 femur strength trait   (VT:0010010)    
Bmd40 Bone mineral density QTL 40 femur mineral mass   (VT:0010011)    
Bmd41 Bone mineral density QTL 41 femur mineral mass   (VT:0010011)    
Bmd42 Bone mineral density QTL 42 lumbar vertebra mineral mass   (VT:0010511)    
Bmd43 Bone mineral density QTL 43 femur mineral mass   (VT:0010011)    
Bmd44 Bone mineral density QTL 44 lumbar vertebra mineral mass   (VT:0010511)    
Bmd45 Bone mineral density QTL 45 lumbar vertebra mineral mass   (VT:0010511)    
Bmd46 Bone mineral density QTL 46 femur mineral mass   (VT:0010011)    
Bmd47 Bone mineral density QTL 47 femur mineral mass   (VT:0010011)    
Bmd48 Bone mineral density QTL 48 femur mineral mass   (VT:0010011)    
Bmd49 Bone mineral density QTL 49 lumbar vertebra mineral mass   (VT:0010511)    
Bmd50 Bone mineral density QTL 50 femur mineral mass   (VT:0010011)    
Bmd51 Bone mineral density QTL 51 femur mineral mass   (VT:0010011)    
Bmd52 Bone mineral density QTL 52 femur mineral mass   (VT:0010011)    
Bmd53 Bone mineral density QTL 53 lumbar vertebra mineral mass   (VT:0010511)    
Bmd54 Bone mineral density QTL 54 femur mineral mass   (VT:0010011)    
Bmd55 Bone mineral density QTL 55 femur mineral mass   (VT:0010011)    
Bmd56 Bone mineral density QTL 56 femur mineral mass   (VT:0010011)    
Bmd57 Bone mineral density QTL 57 femur mineral mass   (VT:0010011)    
Bmd58 Bone mineral density QTL 58 lumbar vertebra mineral mass   (VT:0010511)    
Bmd59 Bone mineral density QTL 59 lumbar vertebra mineral mass   (VT:0010511)    
Bmd60 Bone mineral density QTL 60 femur mineral mass   (VT:0010011)    
Bmd61 Bone mineral density QTL 61 femur mineral mass   (VT:0010011)    
Bmd62 Bone mineral density QTL 62 lumbar vertebra mineral mass   (VT:0010511)    
Bmd63 Bone mineral density QTL 63 femur mineral mass   (VT:0010011)    
Bmd64 Bone mineral density QTL 64 lumbar vertebra mineral mass   (VT:0010511)    
Bmd65 Bone mineral density QTL 65 femur mineral mass   (VT:0010011)    
Bmd66 Bone mineral density QTL 66 lumbar vertebra mineral mass   (VT:0010511)    
Bmd67 Bone mineral density QTL 67 femur mineral mass   (VT:0010011)    
Bmd68 Bone mineral density QTL 68 femur mineral mass   (VT:0010011)    
Bmd88 Bone mineral density QTL 88 femur mineral mass   (VT:0010011)    
Bmd89 Bone mineral density QTL 89 femur strength trait   (VT:0010010)    
Bmd90 Bone mineral density QTL 90 femur size trait   (VT:1000369)    
Bmd91 Bone mineral density QTL 91 femur size trait   (VT:1000369)    
Bss22 Bone structure and strength QTL 22 femur morphology trait   (VT:0000559)    
Bss23 Bone structure and strength QTL 23 femur morphology trait   (VT:0000559)    
Bss24 Bone structure and strength QTL 24 femur morphology trait   (VT:0000559)    
Bss25 Bone structure and strength QTL 25 femur morphology trait   (VT:0000559)    
Bss26 Bone structure and strength QTL 26 femur morphology trait   (VT:0000559)    
Bss27 Bone structure and strength QTL 27 femur morphology trait   (VT:0000559)    
Bss28 Bone structure and strength QTL 28 femur morphology trait   (VT:0000559)    
Bss29 Bone structure and strength QTL 29 femur morphology trait   (VT:0000559)    
Bss30 Bone structure and strength QTL 30 femur strength trait   (VT:0010010)    
Bss31 Bone structure and strength QTL 31 femur strength trait   (VT:0010010)    
Bss32 Bone structure and strength QTL 32 femur strength trait   (VT:0010010)    
Bss33 Bone structure and strength QTL 33 femur strength trait   (VT:0010010)    
Bss34 Bone structure and strength QTL 34 femur strength trait   (VT:0010010)    
Bss35 Bone structure and strength QTL 35 femur strength trait   (VT:0010010)    
Bss36 Bone structure and strength QTL 36 femur strength trait   (VT:0010010)    
Bss37 Bone structure and strength QTL 37 femur strength trait   (VT:0010010)    
Bss38 Bone structure and strength QTL 38 femur strength trait   (VT:0010010)    
Bss39 Bone structure and strength QTL 39 femur strength trait   (VT:0010010)    
Bss40 Bone structure and strength QTL 40 femur strength trait   (VT:0010010)    
Bss41 Bone structure and strength QTL 41 lumbar vertebra size trait   (VT:0010518)    
Bss42 Bone structure and strength QTL 42 lumbar vertebra size trait   (VT:0010518)    
Bss43 Bone structure and strength QTL 43 lumbar vertebra size trait   (VT:0010518)    
Bss44 Bone structure and strength QTL 44 lumbar vertebra morphology trait   (VT:0010494)    
Bss45 Bone structure and strength QTL 45 lumbar vertebra morphology trait   (VT:0010494)    
Bss46 Bone structure and strength QTL 46 lumbar vertebra morphology trait   (VT:0010494)    
Bss47 Bone structure and strength QTL 47 lumbar vertebra size trait   (VT:0010518)    
Bss48 Bone structure and strength QTL 48 lumbar vertebra size trait   (VT:0010518)    
Bss49 Bone structure and strength QTL 49 lumbar vertebra size trait   (VT:0010518)    
Bss50 Bone structure and strength QTL 50 lumbar vertebra size trait   (VT:0010518)    
Mcs30 Mammary carcinoma susceptibility QTL 30 mammary gland integrity trait   (VT:0010552)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Have lower running capacity as compared to the DA/OlaHsd rats. 619535
strain_characteristics Have lower running capacity as compared to the DA/OlaHsd rats. 731241
strain_other These are the lowest performers out of 11 strains tested for the aerobic endurance performance that comprises of maximum running capacity on a treadmill and isolated cardiac performance. 1358977
strain_other On the basis of work, these females are the lowest performers. 1358977
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114
strain_phys_biochem Have a lower heart weight to body weight ratio as compared to the DA/OlaHsd strain. 731241
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. This strain was used for genotyping candidate single nucleotide polymorphisms (reference Guryev et al., Single Nucleotide Polymorphisms associated with rat expressed sequences., submitted). SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737878