RGD Reference Report - A genome scan for Loci associated with aerobic running capacity in rats. - Rat Genome Database

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A genome scan for Loci associated with aerobic running capacity in rats.

Authors: Ways, JA  Cicila, GT  Garrett, MR  Koch, LG 
Citation: Ways JA, etal., Genomics 2002 Jul;80(1):13-20.
RGD ID: 619535
Pubmed: PMID:12079278   (View Abstract at PubMed)

Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running and serve as contrasting genetic models for aerobic capacity. A genome scan was carried out on an F(2)(COPxDA) segregating population (n=224) to detect quantitative trait loci (QTLs) associated with aerobic running capacity. Linkage analysis revealed a significant QTL on chromosome 16 (lod score, 4.0). A suggestive linkage was found near the p-terminus of chromosome 3 (lod score, 2.2) with evidence of an interaction with another QTL on chromosome 16 (lod score, 2.9). All three QTLs showed a dominant mode of inheritance in which the presence of at least one DA allele was associated with a greater distance run. These results represent the first aerobic capacity QTLs identified in genetic models. (c)2002 Elsevier Science (USA).



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Objects Annotated

QTLs
Arunc1  (Aerobic running capacity QTL 1)
Arunc2  (Aerobic running capacity QTL 2)
Arunc3  (Aerobic running capacity QTL 3)

Strains
COP/OlaHsd  (NA)
DA/OlaHsd  (NA)


Additional Information