RGD Reference Report - A genome scan for Loci associated with aerobic running capacity in rats. - Rat Genome Database

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A genome scan for Loci associated with aerobic running capacity in rats.

Authors: Ways, JA  Cicila, GT  Garrett, MR  Koch, LG 
Citation: Ways JA, etal., Genomics 2002 Jul;80(1):13-20.
RGD ID: 619535
Pubmed: (View Article at PubMed) PMID:12079278

Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running and serve as contrasting genetic models for aerobic capacity. A genome scan was carried out on an F(2)(COPxDA) segregating population (n=224) to detect quantitative trait loci (QTLs) associated with aerobic running capacity. Linkage analysis revealed a significant QTL on chromosome 16 (lod score, 4.0). A suggestive linkage was found near the p-terminus of chromosome 3 (lod score, 2.2) with evidence of an interaction with another QTL on chromosome 16 (lod score, 2.9). All three QTLs showed a dominant mode of inheritance in which the presence of at least one DA allele was associated with a greater distance run. These results represent the first aerobic capacity QTLs identified in genetic models. (c)2002 Elsevier Science (USA).



Phenotype Annotations    

Mammalian Phenotype

Objects Annotated

QTLs
Arunc1  (Aerobic running capacity QTL 1)
Arunc2  (Aerobic running capacity QTL 2)
Arunc3  (Aerobic running capacity QTL 3)

Objects referenced in this article
Strain COP/OlaHsd null Rattus norvegicus
Strain DA/OlaHsd null Rattus norvegicus

Additional Information