Chuk (component of inhibitor of nuclear factor kappa B kinase complex) - Rat Genome Database

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Gene: Chuk (component of inhibitor of nuclear factor kappa B kinase complex) Rattus norvegicus
Analyze
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
RGD ID: 1306661
Description: Predicted to enable several functions, including protein dimerization activity; scaffold protein binding activity; and transferrin receptor binding activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including response to acetate; response to cholecystokinin; and response to hydroperoxide. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH (+)-Tetrandrine; 1-naphthyl isothiocyanate; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conserved helix-loop-helix ubiquitous kinase; Ikbka; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; LOC309361
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,908,748 - 252,944,273 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,908,749 - 252,944,273 (-)EnsemblGRCr8
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)Ensemblrn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1238,777,027 - 238,812,551 (-)NCBICelera
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-Erythraline  (ISO)
(+)-Tetrandrine  (EXP)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-phenylprop-2-enal  (EXP)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-ribose  (ISO)
allyl methyl disulfide  (ISO)
alpinumisoflavone  (ISO)
Anemoside B4  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony(0)  (ISO)
apigenin  (EXP)
Arctiin  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auranofin  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
Berbamine  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celastrol  (EXP)
celecoxib  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Crenigacestat  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-ribofuranose  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP,ISO)
dimethylarsinic acid  (EXP)
diquat  (EXP)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
equol  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
filipin III  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
Gingerenone A  (ISO)
ginsenoside Re  (ISO)
glutathione  (ISO)
graphene oxide  (ISO)
helenalin  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (ISO)
Inotodiol  (ISO)
ionomycin  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-1,4-dithiothreitol  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP)
linderalactone  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercaptoethanol  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
mevalonic acid  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N-dimethylformamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
Neferine  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
phenobarbital  (ISO)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
protosappanin A  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
resiquimod  (ISO)
resveratrol  (ISO)
rocaglamide  (ISO)
rotenone  (ISO)
rutin  (ISO)
SB 203580  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SNX-2112  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
testosterone  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
thiopental  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wedelolactone  (EXP)
Xanthorrhizol  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Increased IKKa expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors. Alameda JP, etal., PLoS One. 2011;6(7):e21984. doi: 10.1371/journal.pone.0021984. Epub 2011 Jul 6.
2. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
3. Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. Bruno ME, etal., Arch Biochem Biophys. 2002 Oct 15;406(2):153-64.
4. Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation. Canicio J, etal., J Biol Chem. 2001 Jun 8;276(23):20228-33. Epub 2001 Mar 28.
5. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Chung S, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L192-203. Epub 2010 May 14.
6. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
7. NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. Fontan E, etal., FEBS J. 2007 May;274(10):2540-51. Epub 2007 Apr 10.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
11. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Ho RC, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C794-801. Epub 2005 May 11.
12. Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide. Lee JY, etal., Free Radic Res. 2005 Apr;39(4):399-409.
13. CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. Lim JH, etal., Cell Microbiol. 2008 Nov;10(11):2247-56. Epub 2008 Jul 16.
14. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Luo JL, etal., Nature. 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Park KA, etal., Carcinogenesis. 2007 Jan;28(1):71-80. doi: 10.1093/carcin/bgl094. Epub 2006 Jun 14.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. Rattan R, etal., Free Radic Biol Med. 2003 Nov 1;35(9):1037-50.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Apigenin blocks IKKa activation and suppresses prostate cancer progression. Shukla S, etal., Oncotarget. 2015 Oct 13;6(31):31216-32. doi: 10.18632/oncotarget.5157.
25. Suppression of NF-¿B and NF-¿B-Regulated Gene Expression by Apigenin through I¿Ba and IKK Pathway in TRAMP Mice. Shukla S, etal., PLoS One. 2015 Sep 17;10(9):e0138710. doi: 10.1371/journal.pone.0138710. eCollection 2015.
26. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
27. Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules. Tando Y, etal., Digestion. 2002;66(4):237-45. doi: 10.1159/000068364.
28. The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. Van Gammeren D, etal., FASEB J. 2009 Feb;23(2):362-70. doi: 10.1096/fj.08-114249. Epub 2008 Sep 30.
29. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
30. Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase. Wu L, etal., J Hypertens. 2006 Jan;24(1):123-30.
Additional References at PubMed
PMID:9520446   PMID:11536016   PMID:11747812   PMID:12477932   PMID:14743216   PMID:14960276   PMID:15485831   PMID:15684432   PMID:16079150   PMID:19386987   PMID:20434986   PMID:20442316  
PMID:20614026   PMID:22982470   PMID:23016877   PMID:23091055   PMID:23487264   PMID:23776175   PMID:24784232   PMID:24928390   PMID:26514923   PMID:30341167   PMID:30988283   PMID:32746986  


Genomics

Comparative Map Data
Chuk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,908,748 - 252,944,273 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,908,749 - 252,944,273 (-)EnsemblGRCr8
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)Ensemblrn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1238,777,027 - 238,812,551 (-)NCBICelera
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Cytogenetic Map1q54NCBI
CHUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,186,319 - 100,229,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,188,300 - 100,229,596 (-)Ensemblhg38GRCh38
GRCh3710101,948,057 - 101,989,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,811 - 102,274,037 (-)NCBICHM1_1
T2T-CHM13v2.010101,070,561 - 101,113,853 (-)NCBIT2T-CHM13v2.0
Chuk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)Ensemblmm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBIMGSCv36mm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
Chuk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,067,203 - 6,102,001 (-)Ensembl
ChiLan1.0NW_0049555076,066,026 - 6,102,066 (-)NCBIChiLan1.0ChiLan1.0
CHUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,077,682 - 112,118,610 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,083,001 - 112,123,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,794,228 - 96,835,449 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,276,290 - 100,317,082 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,280,490 - 100,316,918 (-)EnsemblpanPan2panpan1.1
CHUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,964,670 - 13,001,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,965,479 - 13,001,512 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2813,147,837 - 13,184,707 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02813,433,260 - 13,470,158 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,433,260 - 13,470,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,980,085 - 13,016,958 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,017,918 - 13,055,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,152,231 - 13,189,348 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chuk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,995,060 - 34,039,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493663633,673 - 79,194 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493663633,933 - 78,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chuk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,022,419 - 12,052,131 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473712,022,081 - 12,052,128 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Chuk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1243,604,916 - 43,639,986 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chuk
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:269
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000030782
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH133833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,959,637 - 242,959,854 (+)MAPPERmRatBN7.2
Rnor_6.01263,848,928 - 263,849,144NCBIRnor6.0
Rnor_5.01271,293,920 - 271,294,136UniSTSRnor5.0
RGSC_v3.41249,158,055 - 249,158,271UniSTSRGSC3.4
Celera1238,777,125 - 238,777,341UniSTS
RH 3.4 Map11617.52UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030782   ⟹   ENSRNOP00000034134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,908,749 - 252,944,273 (-)Ensembl
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096055   ⟹   ENSRNOP00000095574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,908,749 - 252,943,683 (-)Ensembl
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117849   ⟹   ENSRNOP00000080169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,912,662 - 252,944,273 (-)Ensembl
mRatBN7.2 Ensembl1242,964,114 - 242,994,755 (-)Ensembl
RefSeq Acc Id: NM_001107588   ⟹   NP_001101058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,908,749 - 252,944,273 (-)NCBI
mRatBN7.21242,959,540 - 242,995,065 (-)NCBI
Rnor_6.01263,848,830 - 263,884,354 (-)NCBI
Rnor_5.01271,293,821 - 271,329,346 (-)NCBI
RGSC_v3.41249,122,845 - 249,158,369 (+)RGD
Celera1238,777,027 - 238,812,551 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264605   ⟹   XP_063120675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,911,477 - 252,944,271 (-)NCBI
RefSeq Acc Id: XM_063264608   ⟹   XP_063120678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,908,748 - 252,944,020 (-)NCBI
RefSeq Acc Id: NP_001101058   ⟸   NM_001107588
- UniProtKB: A6JHE8 (UniProtKB/TrEMBL),   A0A8I6ANR6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034134   ⟸   ENSRNOT00000030782
Ensembl Acc Id: ENSRNOP00000095574   ⟸   ENSRNOT00000096055
Ensembl Acc Id: ENSRNOP00000080169   ⟸   ENSRNOT00000117849
RefSeq Acc Id: XP_063120678   ⟸   XM_063264608
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ANR6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120675   ⟸   XM_063264605
- Peptide Label: isoform X1
- UniProtKB: B5DF32 (UniProtKB/TrEMBL),   A0A8I6ANR6 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V926-F1-model_v2 AlphaFold G3V926 1-745 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690934
Promoter ID:EPDNEW_R1459
Type:initiation region
Name:Chuk_1
Description:conserved helix-loop-helix ubiquitous kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,884,331 - 263,884,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306661 AgrOrtholog
BioCyc Gene G2FUF-55612 BioCyc
Ensembl Genes ENSRNOG00000022485 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030782 ENTREZGENE
  ENSRNOT00000030782.6 UniProtKB/TrEMBL
  ENSRNOT00000096055 ENTREZGENE
  ENSRNOT00000096055.2 UniProtKB/TrEMBL
  ENSRNOT00000117849 ENTREZGENE
  ENSRNOT00000117849.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/TrEMBL
  6.10.250.2110 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/TrEMBL
  IKK UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:309361 UniProtKB/TrEMBL
NCBI Gene 309361 ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Chuk PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022485 RatGTEx
SMART IKKbetaNEMObind UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZSH4_RAT UniProtKB/TrEMBL
  A0A8I6ANR6 ENTREZGENE, UniProtKB/TrEMBL
  A6JHE8 ENTREZGENE, UniProtKB/TrEMBL
  B5DF32 ENTREZGENE, UniProtKB/TrEMBL
  G3V926_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Chuk  component of inhibitor of nuclear factor kappa B kinase complex  Chuk  conserved helix-loop-helix ubiquitous kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Chuk  conserved helix-loop-helix ubiquitous kinase   Chuk_predicted  conserved helix-loop-helix ubiquitous kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Chuk_predicted  conserved helix-loop-helix ubiquitous kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED