Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chukincreases activityISOCHUK (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased activity of CHUK proteinPMID:15498850
Chukincreases activityISOChuk (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased activity of CHUK proteinPMID:16474181
Chukincreases expressionISOCHUK (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of CHUK proteinPMID:21035309
Chukincreases expressionISOChuk (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of CHUK proteinPMID:31351099
Chukincreases phosphorylationISOCHUK (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of CHUK proteinPMID:26220752
Chukmultiple interactionsISOCHUK (Homo sapiens)6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]; Estradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CHUK protein]; Fulvestrant promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CHUK protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein]; Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CHUK protein]PMID:15498850 PMID:21035309 PMID:23899529 PMID:26220752
Chukmultiple interactionsISOChuk (Mus musculus)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]; [Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein; Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CHUK protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]PMID:10820281 PMID:16474181 PMID:31351099
Go Back to source page   Continue to Ontology report