Tph2 (tryptophan hydroxylase 2) - Rat Genome Database

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Gene: Tph2 (tryptophan hydroxylase 2) Rattus norvegicus
Analyze
Symbol: Tph2
Name: tryptophan hydroxylase 2
RGD ID: 631332
Description: Predicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including cellular response to lithium ion; response to activity; and response to estrogen. Located in axon and neuronal cell body. Used to study acute stress disorder; anxiety disorder; hypertension; and sleep apnea. Biomarker of several diseases, including alcohol use disorder; panic disorder; post-traumatic stress disorder; premature ejaculation; and premenstrual tension. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; anxiety disorder (multiple); autistic disorder; and drug dependence (multiple). Orthologous to human TPH2 (tryptophan hydroxylase 2); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3-bis(4-hydroxyphenyl)propionitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuronal tryptophan hydroxylase; Ntph; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Tph2em2Mcwi ; Tph2em3Mcwi
Genetic Models: DA-Tph2em2Mcwi ; DA-Tph2em3Mcwi ; DA-Tph2em3Mcwi+/+ ; DA-Tph2em2Mcwi-/- ; DA-Tph2em3Mcwi-/- ; DA-Tph2em2Mcwi+/- ; DA-Tph2em3Mcwi+/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,571,909 - 52,676,305 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl752,571,911 - 52,675,639 (-)EnsemblGRCr8
mRatBN7.2750,685,694 - 50,789,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl750,685,694 - 50,789,424 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx752,592,588 - 52,696,312 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,795,694 - 54,899,410 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,573,629 - 54,677,371 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,042,279 - 58,149,220 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,042,281 - 58,149,061 (-)Ensemblrn6Rnor6.0
Rnor_5.0758,053,268 - 58,157,949 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4754,321,033 - 54,430,706 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera747,478,282 - 47,582,240 (-)NCBICelera
RGSC_v3.1754,341,665 - 54,451,339 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
neuron projection  (IBA,IEA,ISO)
neuronal cell body  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat. Adori C, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):377-91. doi: 10.1007/s00213-010-2041-2. Epub 2010 Oct 30.
2. Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei. Bach H, etal., Alcohol Clin Exp Res. 2014 Jul;38(7):1894-901. doi: 10.1111/acer.12414. Epub 2014 Jun 18.
3. Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy. Bragatti JA, etal., Epilepsy Behav. 2014 Mar;32:59-63. doi: 10.1016/j.yebeh.2014.01.007. Epub 2014 Feb 1.
4. TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner. Brivio P, etal., Front Mol Neurosci. 2018 Oct 30;11:389. doi: 10.3389/fnmol.2018.00389. eCollection 2018.
5. Precision therapeutic opioid dosing implications from genetic biomarkers and craving score. Chang HW, etal., Medicine (Baltimore). 2020 May 29;99(22):e20429. doi: 10.1097/MD.0000000000020429.
6. The effects of glucocorticoids on depressive and anxiety-like behaviors, mineralocorticoid receptor-dependent cell proliferation regulates anxiety-like behaviors. Chen J, etal., Behav Brain Res. 2019 Apr 19;362:288-298. doi: 10.1016/j.bbr.2019.01.026. Epub 2019 Jan 14.
7. Rifaximin ameliorates depression-like behaviour in chronic unpredictable mild stress rats by regulating intestinal microbiota and hippocampal tryptophan metabolism. Cheng S, etal., J Affect Disord. 2023 May 15;329:30-41. doi: 10.1016/j.jad.2023.02.086. Epub 2023 Feb 24.
8. The combination of ethanol with mephedrone increases the signs of neurotoxicity and impairs neurogenesis and learning in adolescent CD-1 mice. Ciudad-Roberts A, etal., Toxicol Appl Pharmacol. 2016 Feb 15;293:10-20. doi: 10.1016/j.taap.2015.12.019. Epub 2015 Dec 30.
9. Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). Coon H, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):42-6.
10. H3K9 Acetylation of Tph2 Involved in Depression-like Behavior in Male, but not Female, Juvenile Offspring Rat Induced by Prenatal Stress. Dang S, etal., Neuroscience. 2018 Jun 15;381:138-148. doi: 10.1016/j.neuroscience.2018.03.043. Epub 2018 Apr 4.
11. Increased central cholinergic drive contributes to the apneas of serotonin-deficient rat pups during active sleep. Davis MR, etal., J Appl Physiol (1985). 2019 May 1;126(5):1175-1183. doi: 10.1152/japplphysiol.00909.2018. Epub 2019 Feb 14.
12. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. De Luca V, etal., Psychopharmacology (Berl). 2005 Dec;183(3):378-82. Epub 2005 Oct 21.
13. Elevated tph2 mRNA expression in a rat model of chronic anxiety. Donner NC, etal., Depress Anxiety. 2012 Apr;29(4):307-19. doi: 10.1002/da.21925.
14. Clinical and genetic risk factors for suicide under the influence of alcohol in a Polish sample. Fudalej S, etal., Alcohol Alcohol. 2009 Sep-Oct;44(5):437-42. doi: 10.1093/alcalc/agp045.
15. Tryptophan hydroxylase 2 gene and alcohol use among college students. Gacek P, etal., Addict Biol. 2008 Sep;13(3-4):440-8. doi: 10.1111/j.1369-1600.2008.00118.x.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Lentiviral vector-driven inhibition of 5-HT synthesis in B3 bulbo-spinal serotonergic projections - Consequences on nociception, inflammatory and neuropathic pain in rats. Gautier A, etal., Exp Neurol. 2017 Feb;288:11-24. doi: 10.1016/j.expneurol.2016.10.016. Epub 2016 Oct 29.
18. Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. Havranek MM, etal., Neuropsychopharmacology. 2015 Dec;40(13):2929-37. doi: 10.1038/npp.2015.146. Epub 2015 May 27.
19. Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Hiroi R, etal., Biol Psychiatry. 2006 Aug 1;60(3):288-95. Epub 2006 Feb 3.
20. Overexpression or knockdown of rat tryptophan hyroxylase-2 has opposing effects on anxiety behavior in an estrogen-dependent manner. Hiroi R, etal., Neuroscience. 2011 Mar 10;176:120-31. doi: 10.1016/j.neuroscience.2010.12.019. Epub 2010 Dec 20.
21. Endogenous Deficiency of Brain-Derived Neurotrophic Factor Induces the Downregulation of Tryptophan Hydroxylase-2 Expression in Raphe Nuclei of Rapid Ejaculator Rats. Huang Y, etal., J Sex Med. 2021 Sep;18(9):1491-1499. doi: 10.1016/j.jsxm.2021.07.009. Epub 2021 Aug 9.
22. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. Izikki M, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.
23. Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin. Kawa L, etal., J Neurotrauma. 2015 Aug 15;32(16):1190-9. doi: 10.1089/neu.2014.3669. Epub 2015 Apr 1.
24. Respiratory dysfunction in two rodent models of chronic epilepsy and acute seizures and its link with the brainstem serotonin system. Kouchi H, etal., Sci Rep. 2022 Jun 17;12(1):10248. doi: 10.1038/s41598-022-14153-6.
25. Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety. Laas K, etal., J Affect Disord. 2017 Jun;215:230-236. doi: 10.1016/j.jad.2017.03.045. Epub 2017 Mar 19.
26. Glycyrrhizin treatment ameliorates post-traumatic stress disorder-like behaviours and restores circadian oscillation of intracranial serotonin. Lai S, etal., Clin Exp Pharmacol Physiol. 2020 Jan;47(1):95-101. doi: 10.1111/1440-1681.13173. Epub 2019 Oct 7.
27. Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization. Lenicov FR, etal., J Neurochem. 2007 Dec;103(5):2047-57. Epub 2007 Sep 14.
28. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Liang J, etal., Neuroreport. 2004 Jun 28;15(9):1497-500.
29. Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. Lunden JW and Kirby LG, Neuroscience. 2013 Dec 19;254:160-72. doi: 10.1016/j.neuroscience.2013.08.071. Epub 2013 Sep 20.
30. Sex- and age-based differences in the effect of central serotonin on arterial blood pressure regulation. Magnusson JL, etal., J Appl Physiol (1985). 2020 Dec 1;129(6):1310-1323. doi: 10.1152/japplphysiol.00414.2020. Epub 2020 Sep 10.
31. Photoperiod regulates the daily profiles of tryptophan hydroxylase-2 gene expression the raphe nuclei of rats. Malek ZS and Labban LM, Int J Neurosci. 2021 Dec;131(12):1155-1161. doi: 10.1080/00207454.2020.1782903. Epub 2020 Jun 25.
32. Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. Malek ZS, etal., Endocrinology. 2007 Nov;148(11):5165-72. Epub 2007 Jun 26.
33. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Maron E, etal., Neurosci Lett. 2007 Jan 16;411(3):180-4. Epub 2006 Nov 22.
34. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. McNamara RK, etal., J Psychiatr Res. 2009 Mar;43(6):656-63. Epub 2008 Nov 4.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Alcohol dependence and polymorphisms of serotonin-related genes: association studies. Mokrović G, etal., Coll Antropol. 2008 Jan;32 Suppl 1:127-31.
37. Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Moon HY, etal., Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13094-9. doi: 10.1073/pnas.1205535109. Epub 2012 Jul 23.
38. Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex. Mouradian GC, etal., Physiol Rep. 2021 Jul;9(13):e14946. doi: 10.14814/phy2.14946.
39. TPH2 and TPH1: association of variants and interactions with heroin addiction. Nielsen DA, etal., Behav Genet. 2008 Mar;38(2):133-50. doi: 10.1007/s10519-007-9187-7. Epub 2008 Jan 8.
40. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Nielsen DA, etal., Genes Brain Behav. 2012 Nov;11(8):1001-8. doi: 10.1111/j.1601-183X.2012.00839.x. Epub 2012 Sep 27.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT1A receptor sensitivity. Peeters DGA, etal., Neuropharmacology. 2019 Jul 15;153:134-141. doi: 10.1016/j.neuropharm.2019.05.004. Epub 2019 May 9.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms. Plemenitaš A, etal., Neurosci Lett. 2015 Sep 14;604:86-90. doi: 10.1016/j.neulet.2015.07.037. Epub 2015 Jul 29.
45. On the interaction between BDNF and serotonin systems: The effects of long-term ethanol consumption in mice. Popova NK, etal., Alcohol. 2020 Sep;87:1-15. doi: 10.1016/j.alcohol.2020.04.002. Epub 2020 Apr 21.
46. Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia. Prakash N, etal., J Neurosci. 2020 Jan 15;40(3):569-584. doi: 10.1523/JNEUROSCI.1802-19.2019. Epub 2019 Dec 2.
47. Family-based association study of TPH1 and TPH2 polymorphisms in autism. Ramoz N, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):861-7.
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Comprehensive gene review and curation RGD comprehensive gene curation
52. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Scheuch K, etal., Brain Res. 2010 Jan 11;1307:14-21. Epub 2009 Oct 17.
53. TPH2 gene variants and anxiety during alcohol detoxification outcome. Serretti A, etal., Psychiatry Res. 2009 May 15;167(1-2):106-14. doi: 10.1016/j.psychres.2007.12.006. Epub 2009 Apr 9.
54. Serotonergic changes produced by repeated exposure to forced swimming: correlation with behavior. Shishkina GT, etal., Ann N Y Acad Sci. 2008 Dec;1148:148-53.
55. Genetic, Psychological, and Personal Network Factors Associated With Changes in Binge Drinking Over 2 Years Among Mexican Heritage Adolescents in the USA. Song S, etal., Ann Behav Med. 2019 Feb 1;53(2):126-137. doi: 10.1093/abm/kay019.
56. A serotonin-deficient rat model of neurogenic hypertension: influence of sex and sympathetic vascular tone. Spinieli RL, etal., J Neurophysiol. 2022 Nov 1;128(5):1199-1206. doi: 10.1152/jn.00358.2022. Epub 2022 Sep 28.
57. Identification and characterization of rostral ventromedial medulla neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis. Talluri B, etal., J Comp Neurol. 2022 Jun;530(8):1129-1147. doi: 10.1002/cne.25260. Epub 2021 Nov 8.
58. Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise. Vetreno RP, etal., Brain Behav Immun. 2017 Feb;60:333-345. doi: 10.1016/j.bbi.2016.09.018. Epub 2016 Sep 16.
59. Prenatal Hypoxia-Induced Adverse Reaction to Mild Stress is Associated with Depressive-Like Changes in the Glucocorticoid System of Rats. Vetrovoy O, etal., Neurochem Res. 2023 May;48(5):1455-1467. doi: 10.1007/s11064-022-03837-0. Epub 2022 Dec 10.
60. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Walther DJ, etal., Science 2003 Jan 3;299(5603):76.
61. Effects of Paeonia lactiflora Extract on Estrogen Receptor β, TPH2, and SERT in Rats with PMS Anxiety. Wang J, etal., Biomed Res Int. 2020 Mar 7;2020:4690504. doi: 10.1155/2020/4690504. eCollection 2020.
62. Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population. Wang RY, etal., PLoS One. 2018 Jul 30;13(7):e0201408. doi: 10.1371/journal.pone.0201408. eCollection 2018.
63. Zuojin pill improves chronic unpredictable stress-induced depression-like behavior and gastrointestinal dysfunction in mice via the theTPH2/5-HT pathway. Wang Y, etal., Phytomedicine. 2023 Nov;120:155067. doi: 10.1016/j.phymed.2023.155067. Epub 2023 Sep 3.
64. Active sleep unmasks apnea and delayed arousal in infant rat pups lacking central serotonin. Young JO, etal., J Appl Physiol (1985). 2017 Oct 1;123(4):825-834. doi: 10.1152/japplphysiol.00439.2017. Epub 2017 Aug 3.
65. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Zhang XJ, etal., Mol Brain. 2023 Feb 7;16(1):21. doi: 10.1186/s13041-023-00998-z.
66. The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress. Zhao X, etal., Neuroscience. 2013 Aug 29;246:82-93. doi: 10.1016/j.neuroscience.2013.04.046. Epub 2013 Apr 30.
67. The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor. Zhu T, etal., Andrology. 2022 Mar;10(3):595-603. doi: 10.1111/andr.13135. Epub 2021 Dec 17.
68. SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. Zill P, etal., Neuropsychopharmacology. 2007 Aug;32(8):1687-94. doi: 10.1038/sj.npp.1301318. Epub 2007 Jan 24.
69. TPH2 polymorphisms and alcohol-related suicide. Zupanc T, etal., Neurosci Lett. 2011 Feb 18;490(1):78-81. doi: 10.1016/j.neulet.2010.12.030. Epub 2010 Dec 21.
Additional References at PubMed
PMID:12911638   PMID:16115212   PMID:16917826   PMID:17950541   PMID:18197473   PMID:19559077   PMID:19588223   PMID:19647049   PMID:19906978   PMID:20127812   PMID:21272616   PMID:21924839  
PMID:31415826   PMID:31505169   PMID:36868221   PMID:37848703   PMID:38732220  


Genomics

Comparative Map Data
Tph2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,571,909 - 52,676,305 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl752,571,911 - 52,675,639 (-)EnsemblGRCr8
mRatBN7.2750,685,694 - 50,789,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl750,685,694 - 50,789,424 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx752,592,588 - 52,696,312 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0754,795,694 - 54,899,410 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,573,629 - 54,677,371 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,042,279 - 58,149,220 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,042,281 - 58,149,061 (-)Ensemblrn6Rnor6.0
Rnor_5.0758,053,268 - 58,157,949 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4754,321,033 - 54,430,706 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera747,478,282 - 47,582,240 (-)NCBICelera
RGSC_v3.1754,341,665 - 54,451,339 (-)NCBI
Cytogenetic Map7q22NCBI
TPH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,938,845 - 72,032,440 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,938,845 - 72,186,618 (+)Ensemblhg38GRCh38
GRCh371272,332,625 - 72,426,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,618,893 - 70,712,488 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341270,618,892 - 70,712,488NCBI
Celera1271,995,911 - 72,089,543 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1269,382,235 - 69,474,238 (+)NCBIHuRef
CHM1_11272,299,779 - 72,391,813 (+)NCBICHM1_1
T2T-CHM13v2.01271,916,323 - 72,008,338 (+)NCBIT2T-CHM13v2.0
Tph2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910114,914,546 - 115,020,927 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10114,914,546 - 115,020,927 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810115,078,641 - 115,185,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,078,641 - 115,185,022 (-)Ensemblmm10GRCm38
MGSCv3710114,515,697 - 114,622,078 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610114,482,751 - 114,589,132 (-)NCBIMGSCv36mm8
Celera10117,006,698 - 117,113,837 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Tph2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,886,206 - 11,982,550 (+)Ensembl
ChiLan1.0NW_00495540511,877,474 - 11,981,035 (+)NCBIChiLan1.0ChiLan1.0
TPH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21079,966,411 - 80,062,791 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11279,962,807 - 80,059,170 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01269,460,883 - 69,557,329 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11272,318,908 - 72,412,557 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1272,318,908 - 72,412,557 (+)EnsemblpanPan2panpan1.1
TPH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,442,611 - 13,526,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1013,442,611 - 13,527,243 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1013,381,425 - 13,464,836 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01013,578,664 - 13,662,404 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,578,143 - 13,663,110 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,440,095 - 13,523,686 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,688,920 - 13,772,483 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,812,858 - 13,896,308 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tph2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494544,662,510 - 44,753,680 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936568974,767 - 1,065,804 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936568974,575 - 1,065,800 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,918,370 - 36,017,509 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1535,917,159 - 36,016,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2538,620,459 - 38,716,640 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,568,744 - 67,664,911 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037177,991,214 - 178,084,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tph2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475025,702,630 - 25,801,618 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475025,702,597 - 25,801,938 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tph2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11193,235,628 - 193,336,387 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tph2
588 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:199
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000005157
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH132298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,685,695 - 50,685,852 (+)MAPPERmRatBN7.2
Rnor_6.0758,042,283 - 58,042,439NCBIRnor6.0
Rnor_5.0758,053,272 - 58,053,428UniSTSRnor5.0
RGSC_v3.4754,321,035 - 54,321,191UniSTSRGSC3.4
Celera747,478,284 - 47,478,440UniSTS
RH 3.4 Map7442.0UniSTS
Cytogenetic Map7q22UniSTS
BI279052  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2750,686,685 - 50,686,866 (+)MAPPERmRatBN7.2
Rnor_6.0758,043,273 - 58,043,453NCBIRnor6.0
Rnor_5.0758,054,262 - 58,054,442UniSTSRnor5.0
RGSC_v3.4754,322,025 - 54,322,205UniSTSRGSC3.4
Celera747,479,274 - 47,479,454UniSTS
RH 3.4 Map7442.6UniSTS
Cytogenetic Map7q22UniSTS


Genetic Models
This gene Tph2 is modified in the following models/strains:
DA-Tph2em2Mcwi     DA-Tph2em3Mcwi     DA-Tph2em3Mcwi+/+     DA-Tph2em2Mcwi-/-     DA-Tph2em3Mcwi-/-     DA-Tph2em2Mcwi+/-     DA-Tph2em3Mcwi+/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 1 6 117 30 15 6 14 6 2 96 35 1 101 42 72 9 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000005157   ⟹   ENSRNOP00000005157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl752,571,911 - 52,675,639 (-)Ensembl
mRatBN7.2 Ensembl750,685,694 - 50,789,424 (-)Ensembl
Rnor_6.0 Ensembl758,042,281 - 58,149,061 (-)Ensembl
RefSeq Acc Id: NM_173839   ⟹   NP_776211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8752,571,911 - 52,675,639 (-)NCBI
mRatBN7.2750,685,694 - 50,789,424 (-)NCBI
Rnor_6.0758,042,281 - 58,149,061 (-)NCBI
Rnor_5.0758,053,268 - 58,157,949 (-)NCBI
RGSC_v3.4754,321,033 - 54,430,706 (-)RGD
Celera747,478,282 - 47,582,240 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263689   ⟹   XP_063119759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8752,571,909 - 52,676,305 (-)NCBI
Protein Sequences
Protein RefSeqs NP_776211 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM28947 (Get FASTA)   NCBI Sequence Viewer  
  EDM16695 (Get FASTA)   NCBI Sequence Viewer  
  EDM16696 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005157
GenBank Protein Q8CGU9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_776211   ⟸   NM_173839
- UniProtKB: Q8CGU9 (UniProtKB/Swiss-Prot),   A6IGK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005157   ⟸   ENSRNOT00000005157
RefSeq Acc Id: XP_063119759   ⟸   XM_063263689
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1S6 (UniProtKB/TrEMBL)
Protein Domains
ACT   Biopterin-dependent aromatic amino acid hydroxylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGU9-F1-model_v2 AlphaFold Q8CGU9 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631332 AgrOrtholog
BioCyc Gene G2FUF-34069 BioCyc
BioCyc Pathway PWY-6030 [serotonin and melatonin biosynthesis] BioCyc
BioCyc Pathway Image PWY-6030 BioCyc
Ensembl Genes ENSRNOG00000003880 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005157 ENTREZGENE
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot
  ACT_dom UniProtKB/Swiss-Prot
  ArAA_hydroxylase UniProtKB/Swiss-Prot
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot
  Trp_5_mOase UniProtKB/Swiss-Prot
  TrpOH_cat UniProtKB/Swiss-Prot
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot
KEGG Report rno:317675 UniProtKB/Swiss-Prot
NCBI Gene 317675 ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot
  TRYPTOPHAN 5-HYDROXYLASE 2 UniProtKB/Swiss-Prot
Pfam ACT UniProtKB/Swiss-Prot
  Biopterin_H UniProtKB/Swiss-Prot
PharmGKB TPH2 RGD
PhenoGen Tph2 PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot
PROSITE ACT UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003880 RatGTEx
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot
  SSF56534 UniProtKB/Swiss-Prot
UniProt A0A8L2Q1S6 ENTREZGENE, UniProtKB/TrEMBL
  A6IGK2 ENTREZGENE, UniProtKB/TrEMBL
  A6IGK3_RAT UniProtKB/TrEMBL
  Q8CGU9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Tph2  tryptophan hydroxylase 2  Ntph  neuronal tryptophan hydroxylase  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 633509