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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tph2
Name: tryptophan hydroxylase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tph2increases expressionEXP 6480464CTDEstradiol results in increased expression of TPH2 mRNAPMID:21382399
Tph2multiple interactionsEXP 6480464CTD[Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA; Estradiol inhibits the reaction [Estrogens deficiency results in increased expression of TPH2 mRNA]; Estradiol inhibits the reaction [Estrogens deficiency results in increased expression of TPH2 protein]PMID:21382399 PMID:30565903
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