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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tph2
Name: tryptophan hydroxylase 2
Acc ID: CHEBI:59331
Term: mephedrone
Definition: An aromatic ketone that is propiophenone substituted at C-4 and at C-beta with methyl and methylamino groups respectively. It is a synthetic stimulant and entactogen drug of the amphetamine and cathinone classes.
Chemical ID: MESH:C548233
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tph2decreases expressionEXP 6480464CTDmephedrone results in decreased expression of TPH2 proteinPMID:25817894
Tph2decreases expressionISOTph2 (Mus musculus)6480464CTDmephedrone results in decreased expression of TPH2 proteinPMID:26747301
Tph2multiple interactionsISOTph2 (Mus musculus)6480464CTDEthanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein]PMID:26747301
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