Nasp (nuclear autoantigenic sperm protein) - Rat Genome Database

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Gene: Nasp (nuclear autoantigenic sperm protein) Rattus norvegicus
Analyze
Symbol: Nasp
Name: nuclear autoantigenic sperm protein
RGD ID: 1359609
Description: Predicted to enable histone binding activity and histone chaperone activity. Involved in male gonad development and response to testosterone. Predicted to be located in chromatin; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human NASP (nuclear autoantigenic sperm protein); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93869; nuclear autoantigenic sperm protein (histone-binding)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,294,599 - 135,319,992 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5135,294,032 - 135,319,591 (-)EnsemblGRCr8
mRatBN7.25130,057,363 - 130,083,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,057,363 - 130,082,928 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5132,682,003 - 132,707,029 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,436,600 - 134,461,622 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,458,993 - 134,484,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,446,485 - 135,472,113 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,446,962 - 135,472,116 (-)Ensemblrn6Rnor6.0
Rnor_5.05139,242,666 - 139,268,285 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45136,884,705 - 136,910,192 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5128,585,369 - 128,610,666 (-)NCBICelera
RGSC_v3.15136,889,931 - 136,915,418 (-)NCBI
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
mercaptopurine  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
purine-6-thiol  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle. Alekseev OM, etal., J Biol Chem 2003 Mar 7;278(10):8846-52. Epub 2002 Dec 30.
2. Analysis of the expression of human tumor antigens in ovarian cancer tissues. Ali-Fehmi R, etal., Cancer Biomark. 2010;6(1):33-48. doi: 10.3233/CBM-2009-0117.
3. Histone chaperones in nucleosome assembly and human disease. Burgess RJ and Zhang Z, Nat Struct Mol Biol. 2013 Jan;20(1):14-22. doi: 10.1038/nsmb.2461.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP). Ma W, etal., J Biol Chem. 2012 Mar 23;287(13):10189-99. doi: 10.1074/jbc.M111.303636. Epub 2011 Dec 22.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. Stanton PG, etal., PLoS One. 2012;7(7):e41718. doi: 10.1371/journal.pone.0041718. Epub 2012 Jul 30.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure. Wang M, etal., Asian J Androl. 2009 Mar;11(2):183-92. doi: 10.1038/aja.2008.59. Epub 2009 Feb 16.
Additional References at PubMed
PMID:10893414   PMID:14718166   PMID:15489334   PMID:16728391   PMID:25615412   PMID:27618665  


Genomics

Comparative Map Data
Nasp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,294,599 - 135,319,992 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5135,294,032 - 135,319,591 (-)EnsemblGRCr8
mRatBN7.25130,057,363 - 130,083,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,057,363 - 130,082,928 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5132,682,003 - 132,707,029 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,436,600 - 134,461,622 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,458,993 - 134,484,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,446,485 - 135,472,113 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,446,962 - 135,472,116 (-)Ensemblrn6Rnor6.0
Rnor_5.05139,242,666 - 139,268,285 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45136,884,705 - 136,910,192 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5128,585,369 - 128,610,666 (-)NCBICelera
RGSC_v3.15136,889,931 - 136,915,418 (-)NCBI
Cytogenetic Map5q35NCBI
NASP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,584,041 - 45,618,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,583,581 - 45,618,905 (+)Ensemblhg38GRCh38
GRCh37146,049,713 - 46,084,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,822,304 - 45,857,154 (+)NCBIBuild 36Build 36hg18NCBI36
Celera144,333,703 - 44,368,554 (+)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,161,002 - 44,195,831 (+)NCBIHuRef
CHM1_1146,166,808 - 46,201,724 (+)NCBICHM1_1
T2T-CHM13v2.0145,456,407 - 45,491,244 (+)NCBIT2T-CHM13v2.0
Nasp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,458,249 - 116,488,894 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,458,249 - 116,485,138 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384116,601,052 - 116,628,676 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,601,052 - 116,627,941 (-)Ensemblmm10GRCm38
MGSCv374116,273,657 - 116,300,556 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364116,099,541 - 116,125,873 (-)NCBIMGSCv36mm8
Celera4115,334,710 - 115,361,311 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.24NCBI
Nasp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,667,050 - 12,697,769 (-)Ensembl
ChiLan1.0NW_00495546412,667,050 - 12,697,021 (-)NCBIChiLan1.0ChiLan1.0
NASP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,191,936 - 181,228,766 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,333,490 - 180,369,914 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,885,433 - 44,920,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,242,482 - 46,278,736 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,242,841 - 46,278,737 (+)EnsemblpanPan2panpan1.1
NASP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,742,008 - 14,782,186 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,742,012 - 14,808,592 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1514,863,100 - 14,903,386 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01514,896,457 - 14,937,013 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,896,489 - 14,963,353 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,693,885 - 14,734,077 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,763,569 - 14,803,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,833,512 - 14,873,792 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nasp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,885,180 - 60,918,554 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,710,229 - 26,743,254 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,710,364 - 26,743,336 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NASP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,770,055 - 165,805,383 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16165,773,964 - 165,804,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NASP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,180,440 - 87,215,418 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,180,453 - 87,215,939 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603329,752,276 - 29,789,237 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nasp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1140,241,508 - 40,267,082 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nasp
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000022170
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
AW531846  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85135,294,059 - 135,294,233 (+)Marker Load Pipeline
mRatBN7.25130,057,396 - 130,057,570 (+)MAPPERmRatBN7.2
Rnor_6.05135,446,515 - 135,446,688NCBIRnor6.0
Rnor_5.05139,242,696 - 139,242,869UniSTSRnor5.0
RGSC_v3.45136,884,166 - 136,884,339UniSTSRGSC3.4
Celera5128,584,830 - 128,585,003UniSTS
RH 3.4 Map5835.7UniSTS
Cytogenetic Map5q36UniSTS
RH139010  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X48,779,993 - 48,780,184 (+)Marker Load Pipeline
mRatBN7.2X44,863,041 - 44,863,232 (+)MAPPERmRatBN7.2
Rnor_6.0X48,238,610 - 48,238,800NCBIRnor6.0
Rnor_5.0X48,439,320 - 48,439,510UniSTSRnor5.0
RGSC_v3.4X66,949,853 - 66,950,043UniSTSRGSC3.4
CeleraX45,515,014 - 45,515,204UniSTS
Cytogenetic MapXq22UniSTS
Cytogenetic Map5q36UniSTS
RH136150  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85135,295,133 - 135,296,103 (+)Marker Load Pipeline
mRatBN7.25130,058,470 - 130,059,440 (+)MAPPERmRatBN7.2
Rnor_6.05135,447,589 - 135,448,558NCBIRnor6.0
Rnor_5.05139,243,770 - 139,244,739UniSTSRnor5.0
RGSC_v3.45136,885,240 - 136,886,209UniSTSRGSC3.4
Celera5128,585,904 - 128,586,874UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001436699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022170   ⟹   ENSRNOP00000022170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,294,603 - 135,319,591 (-)Ensembl
mRatBN7.2 Ensembl5130,057,940 - 130,082,928 (-)Ensembl
Rnor_6.0 Ensembl5135,446,962 - 135,472,116 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099538   ⟹   ENSRNOP00000078719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,294,032 - 135,312,202 (-)Ensembl
mRatBN7.2 Ensembl5130,057,369 - 130,075,539 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105479   ⟹   ENSRNOP00000079908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,294,603 - 135,319,591 (-)Ensembl
mRatBN7.2 Ensembl5130,057,363 - 130,082,518 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119622   ⟹   ENSRNOP00000091359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5135,294,603 - 135,319,591 (-)Ensembl
mRatBN7.2 Ensembl5130,057,363 - 130,082,518 (-)Ensembl
RefSeq Acc Id: NM_001005543   ⟹   NP_001005543
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,591 (-)NCBI
mRatBN7.25130,057,936 - 130,082,928 (-)NCBI
Rnor_6.05135,447,054 - 135,472,046 (-)NCBI
Rnor_5.05139,242,666 - 139,268,285 (-)NCBI
RGSC_v3.45136,884,705 - 136,910,192 (-)RGD
Celera5128,585,369 - 128,610,666 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238646   ⟹   XP_006238708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,992 (-)NCBI
mRatBN7.25130,057,363 - 130,083,003 (-)NCBI
Rnor_6.05135,446,485 - 135,472,113 (-)NCBI
Rnor_5.05139,242,666 - 139,268,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238647   ⟹   XP_006238709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,604 (-)NCBI
mRatBN7.25130,057,363 - 130,082,530 (-)NCBI
Rnor_6.05135,446,485 - 135,471,654 (-)NCBI
Rnor_5.05139,242,666 - 139,268,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763993   ⟹   XP_008762215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,626 (-)NCBI
mRatBN7.25130,057,363 - 130,082,893 (-)NCBI
Rnor_6.05135,446,485 - 135,472,018 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063287407   ⟹   XP_063143477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,617 (-)NCBI
RefSeq Acc Id: XM_063287408   ⟹   XP_063143478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,623 (-)NCBI
RefSeq Acc Id: XM_063287409   ⟹   XP_063143479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,294,599 - 135,319,563 (-)NCBI
RefSeq Acc Id: NP_001005543   ⟸   NM_001005543
- UniProtKB: Q66HD3 (UniProtKB/Swiss-Prot),   A6JZ86 (UniProtKB/TrEMBL),   A0A8I5ZLB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238708   ⟸   XM_006238646
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006238709   ⟸   XM_006238647
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008762215   ⟸   XM_008763993
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000022170   ⟸   ENSRNOT00000022170
Ensembl Acc Id: ENSRNOP00000079908   ⟸   ENSRNOT00000105479
Ensembl Acc Id: ENSRNOP00000091359   ⟸   ENSRNOT00000119622
Ensembl Acc Id: ENSRNOP00000078719   ⟸   ENSRNOT00000099538
RefSeq Acc Id: XP_063143478   ⟸   XM_063287408
- Peptide Label: isoform X1
- UniProtKB: Q66HD3 (UniProtKB/Swiss-Prot),   A6JZ86 (UniProtKB/TrEMBL),   A0A8I5ZLB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143477   ⟸   XM_063287407
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143479   ⟸   XM_063287409
- Peptide Label: isoform X1
- UniProtKB: Q66HD3 (UniProtKB/Swiss-Prot),   A6JZ86 (UniProtKB/TrEMBL),   A0A8I5ZLB9 (UniProtKB/TrEMBL)
Protein Domains
Tetratricopeptide SHNi-TPR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HD3-F1-model_v2 AlphaFold Q66HD3 1-776 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693936
Promoter ID:EPDNEW_R4461
Type:initiation region
Name:Nasp_1
Description:nuclear autoantigenic sperm protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,472,064 - 135,472,124EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359609 AgrOrtholog
BioCyc Gene G2FUF-40246 BioCyc
Ensembl Genes ENSRNOG00000016454 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022170 ENTREZGENE
  ENSRNOT00000022170.6 UniProtKB/Swiss-Prot
  ENSRNOT00000119622 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112076 IMAGE-MGC_LOAD
InterPro NASP-associated_protein UniProtKB/Swiss-Prot
  Tetratricopeptide_SHNi-TPR_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:298441 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93869 IMAGE-MGC_LOAD
NCBI Gene 298441 ENTREZGENE
PANTHER NUCLEAR AUTOANTIGENIC SPERM PROTEIN UniProtKB/Swiss-Prot
  NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED UniProtKB/Swiss-Prot
Pfam SHNi-TPR UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PhenoGen Nasp PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016454 RatGTEx
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZP00 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFA6 ENTREZGENE, UniProtKB/TrEMBL
  A6JZ85 ENTREZGENE, UniProtKB/TrEMBL
  A6JZ86 ENTREZGENE, UniProtKB/TrEMBL
  NASP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-17 Nasp  nuclear autoantigenic sperm protein  Nasp  nuclear autoantigenic sperm protein (histone-binding)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nasp  nuclear autoantigenic sperm protein (histone-binding)    nuclear autoantigenic sperm protein  Name updated 1299863 APPROVED
2005-07-29 Nasp  nuclear autoantigenic sperm protein      Symbol and Name status set to provisional 70820 PROVISIONAL