Eif4h (eukaryotic translation initiation factor 4H) - Rat Genome Database

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Gene: Eif4h (eukaryotic translation initiation factor 4H) Rattus norvegicus
Analyze
Symbol: Eif4h
Name: eukaryotic translation initiation factor 4H
RGD ID: 1359222
Description: Predicted to enable RNA binding activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within developmental growth and sexual reproduction. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H); PARTICIPATES IN translation initiation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eIF-4H; MGC94887; Wbscr1; williams-Beuren syndrome chromosomal region 1 protein homolog; Williams-Beuren syndrome chromosome region 1 homolog; Williams-Beuren syndrome chromosome region 1 homolog (human)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,719,527 - 27,736,350 (+)NCBIGRCr8
mRatBN7.21222,083,155 - 22,099,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,082,835 - 22,099,876 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,226,405 - 23,243,089 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,837,491 - 23,854,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,903,979 - 22,920,627 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,093,119 - 25,109,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,093,149 - 25,109,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,093,323 - 27,110,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,148,332 - 23,164,980 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,008,888 - 23,025,536 (+)NCBI
Celera1223,847,161 - 23,863,817 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (ISO)
aloxistatin  (ISO)
amiodarone  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (EXP)
corosolic acid  (ISO)
CU-O LINKAGE  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glucose  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
leupeptin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
omeprazole  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
quizartinib  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, etal., Mamm Genome 2000 Oct;11(10):890-8.
3. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. Osborne LR, etal., Genomics. 1996 Sep 1;36(2):328-36.
4. mRNA helicases: the tacticians of translational control. Parsyan A, etal., Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45. doi: 10.1038/nrm3083.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. Richter-Cook NJ, etal., J Biol Chem 1998 Mar 27;273(13):7579-87.
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:19946888   PMID:22234171   PMID:22658674   PMID:22681889   PMID:25468996  


Genomics

Comparative Map Data
Eif4h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,719,527 - 27,736,350 (+)NCBIGRCr8
mRatBN7.21222,083,155 - 22,099,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,082,835 - 22,099,876 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,226,405 - 23,243,089 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,837,491 - 23,854,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,903,979 - 22,920,627 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,093,119 - 25,109,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,093,149 - 25,109,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,093,323 - 27,110,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,148,332 - 23,164,980 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,008,888 - 23,025,536 (+)NCBI
Celera1223,847,161 - 23,863,817 (+)NCBICelera
Cytogenetic Map12q12NCBI
EIF4H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,174,356 - 74,197,096 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,174,231 - 74,197,122 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,588,686 - 73,611,426 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,226,642 - 73,249,365 (+)NCBINCBI36Build 36hg18NCBI36
Build 34773,033,356 - 73,056,080NCBI
Celera769,068,153 - 69,090,994 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,470,180 - 69,492,897 (+)NCBIHuRef
CHM1_1773,733,792 - 73,756,510 (+)NCBICHM1_1
T2T-CHM13v2.0775,376,368 - 75,399,096 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,921,778 - 72,944,501 (+)NCBI
Eif4h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,648,726 - 134,668,263 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,648,575 - 134,668,344 (-)EnsemblGRCm39 Ensembl
GRCm385134,619,872 - 134,639,409 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,619,721 - 134,639,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,095,746 - 135,115,198 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,904,503 - 134,923,955 (-)NCBIMGSCv36mm8
Celera5131,627,926 - 131,647,368 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.71NCBI
Eif4h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,699,012 - 13,725,393 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,699,012 - 13,710,065 (-)NCBIChiLan1.0ChiLan1.0
EIF4H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,700,764 - 90,725,147 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17138,965,396 - 138,989,418 (-)NCBINHGRI_mPanPan1
PanPan1.1781,339,091 - 81,348,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,336,947 - 81,348,585 (+)Ensemblpanpan1.1panPan2
EIF4H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,180,189 - 6,202,835 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,181,827 - 6,207,116 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,878,270 - 7,905,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.065,994,613 - 6,021,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl65,994,619 - 6,021,897 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.165,985,558 - 6,012,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,933,300 - 5,960,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,096,813 - 6,123,967 (-)NCBIUU_Cfam_GSD_1.0
EIF4H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,320,797 - 11,348,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,321,486 - 11,348,473 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,003,785 - 11,031,697 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,878,250 - 8,903,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,879,946 - 8,903,828 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,674,083 - 7,700,226 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif4h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,779,024 - 13,801,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,779,387 - 13,801,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif4h
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:151
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000050059
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
RH128254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,099,484 - 22,099,712 (+)MAPPERmRatBN7.2
Rnor_6.01225,109,414 - 25,109,641NCBIRnor6.0
Rnor_5.01227,109,811 - 27,110,038UniSTSRnor5.0
RGSC_v3.41223,164,589 - 23,164,816UniSTSRGSC3.4
Celera1223,863,426 - 23,863,653UniSTS
RH 3.4 Map12349.1UniSTS
Cytogenetic Map12q12UniSTS
D5Ertd355e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,099,620 - 22,099,868 (+)MAPPERmRatBN7.2
Rnor_6.01225,109,550 - 25,109,797NCBIRnor6.0
Rnor_5.01227,109,947 - 27,110,194UniSTSRnor5.0
RGSC_v3.41223,164,725 - 23,164,972UniSTSRGSC3.4
Celera1223,863,562 - 23,863,809UniSTS
Cytogenetic Map12q12UniSTS
AU046599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,081,808 - 22,081,993 (+)MAPPERmRatBN7.2
Rnor_6.01225,091,743 - 25,091,927NCBIRnor6.0
Rnor_5.01227,092,140 - 27,092,324UniSTSRnor5.0
RGSC_v3.41223,146,918 - 23,147,102UniSTSRGSC3.4
Celera1223,845,755 - 23,845,939UniSTS
Cytogenetic Map12q12UniSTS
Wbscr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,097,517 - 22,098,178 (+)MAPPERmRatBN7.2
Rnor_6.01225,107,449 - 25,108,107NCBIRnor6.0
Rnor_5.01227,107,846 - 27,108,504UniSTSRnor5.0
RGSC_v3.41223,162,624 - 23,163,282UniSTSRGSC3.4
Celera1223,861,461 - 23,862,119UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000050059   ⟹   ENSRNOP00000043254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,092,189 - 22,099,876 (+)Ensembl
Rnor_6.0 Ensembl1225,093,149 - 25,109,799 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081084   ⟹   ENSRNOP00000075555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,082,835 - 22,099,876 (+)Ensembl
Rnor_6.0 Ensembl1225,093,524 - 25,108,174 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113874   ⟹   ENSRNOP00000084867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,082,835 - 22,099,867 (+)Ensembl
RefSeq Acc Id: NM_001006957   ⟹   NP_001006958
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,719,692 - 27,736,350 (+)NCBI
mRatBN7.21222,083,215 - 22,099,876 (+)NCBI
Rnor_6.01225,093,149 - 25,109,805 (+)NCBI
Rnor_5.01227,093,323 - 27,110,202 (+)NCBI
RGSC_v3.41223,148,332 - 23,164,980 (+)RGD
Celera1223,847,161 - 23,863,817 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249134   ⟹   XP_006249196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,719,527 - 27,736,350 (+)NCBI
mRatBN7.21222,083,155 - 22,099,870 (+)NCBI
Rnor_6.01225,093,119 - 25,108,336 (+)NCBI
Rnor_5.01227,093,323 - 27,110,202 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001006958 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249196 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83818 (Get FASTA)   NCBI Sequence Viewer  
  EDM13418 (Get FASTA)   NCBI Sequence Viewer  
  EDM13419 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043254.4
  ENSRNOP00000075555.2
  ENSRNOP00000084867.1
GenBank Protein Q5XI72 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006958   ⟸   NM_001006957
- UniProtKB: Q5XI72 (UniProtKB/Swiss-Prot),   A0A8L2QL20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249196   ⟸   XM_006249134
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QL20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075555   ⟸   ENSRNOT00000081084
Ensembl Acc Id: ENSRNOP00000043254   ⟸   ENSRNOT00000050059
Ensembl Acc Id: ENSRNOP00000084867   ⟸   ENSRNOT00000113874
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI72-F1-model_v2 AlphaFold Q5XI72 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698568
Promoter ID:EPDNEW_R9093
Type:initiation region
Name:Eif4h_1
Description:eukaryotic translation initiation factor 4H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01225,093,158 - 25,093,218EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359222 AgrOrtholog
BioCyc Gene G2FUF-19581 BioCyc
Ensembl Genes ENSRNOG00000001454 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050059.5 UniProtKB/TrEMBL
  ENSRNOT00000081084.2 UniProtKB/TrEMBL
  ENSRNOT00000113874.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110979 IMAGE-MGC_LOAD
InterPro eIF4H_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288599 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94887 IMAGE-MGC_LOAD
NCBI Gene 288599 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 4H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif4h PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001454 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAW7_RAT UniProtKB/TrEMBL
  A0A8I5ZYY8_RAT UniProtKB/TrEMBL
  A0A8L2QL20 ENTREZGENE, UniProtKB/TrEMBL
  IF4H_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Eif4h  eukaryotic translation initiation factor 4H  Wbscr1  Williams-Beuren syndrome chromosome region 1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Wbscr1  Williams-Beuren syndrome chromosome region 1 homolog (human)    eukaryotic translation initiation factor 4H  Name updated 1299863 APPROVED
2005-07-29 Wbscr1  eukaryotic translation initiation factor 4H      Symbol and Name status set to provisional 70820 PROVISIONAL