| 1310457 | Traf2 | Tnf receptor-associated factor 2 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding; protein kinase binding; protein-containing complex binding; INVOLVED IN negative regulation of glial cell apoptotic process; obsolete positive regulation of NF-kappaB transcription factor activity; tumor necrosis factor-mediated signaling pathway; PARTICIPATES IN tumor necrosis factor mediated signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; ASSOCIATED WITH Transplant Rejection; developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cell cortex; protein-containing complex; CD40 receptor complex (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 1H-pyrazole | 3 | 28740098 | 28764752 | Rat | 341 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1321367 | TRAF2 | TNF receptor associated factor 2 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric comp lex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008] | 9 | 136881958 | 136926607 | Human | 392 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321368 | Traf2 | TNF receptor-associated factor 2 | Enables CD40 receptor binding activity; signaling adaptor activity; and ubiquitin protein ligase activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several p rocesses, including canonical NF-kappaB signal transduction; cellular response to nitric oxide; and regulation of intracellular signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; liver; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 25407994 | 25436952 | Mouse | 418 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8827655 | Traf2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits CD40 receptor binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN CD27 signaling pathway (ortholog); CD40 signaling pathway (ortholog); cellular response to nitric oxide (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN CD40 receptor complex (ortholog); cell cortex (ortholog); cytoplasm (ortholog) | NW_004955513 | 4964692 | 4984359 | Chinchilla | 173 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11792884 | TRAF2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to nitric oxide (ortholog); negative regulation of glial cell apoptotic process (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN cell cortex (ortholog); protein-containing complex (ortholog) | 9 | 107938935 | 107984797 | Bonobo | 198 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12305240 | TRAF2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to nitric oxide (ortholog); negative regulation of glial cell apoptotic process (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN cell cortex (ortholog); protein-containing complex (ortholog) | 9 | 48688071 | 48713936 | Dog | 199 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12570749 | Traf2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to nitric oxide (ortholog); negative regulation of glial cell apoptotic process (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN cell cortex (ortholog); protein-containing complex (ortholog) | NW_004936669 | 1004891 | 1034913 | Squirrel | 197 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14109094 | TRAF2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to nitric oxide (ortholog); negative regulation of glial cell apoptotic process (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN cell cortex (ortholog); protein-containing complex (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; fumonisin B1 | | | | Pig | 202 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18349269 | TRAF2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to nitric oxide (ortholog); negative regulation of glial cell apoptotic process (ortholog); obsolete positive regulation of NF-kappaB transcription factor activity (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN cell cortex (ortholog); protein-containing complex (ortholog) | | | | Green Monkey | 196 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935922 | Traf2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits CD40 receptor binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN CD27 signaling pathway (ortholog); CD40 signaling pathway (ortholog); cellular response to nitric oxide (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Transplant Rejection (ortholog); FOUND IN CD40 receptor complex (ortholog); cell cortex (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 184 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258805 | traf2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625915486 | Traf2 | TNF receptor associated factor 2 | ENCODES a protein that exhibits CD40 receptor binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN CD27 signaling pathway (ortholog); CD40 signaling pathway (ortholog); cellular response to nitric oxide (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Transplant Rejection (ortholog); FOUND IN CD40 receptor complex (ortholog); cell cortex (ortholog); cytoplasm (ortholog) | | | | Black Rat | 172 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251925 | traf2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248264 | traf2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 734196 | TANK | TRAF family member associated NFKB activator | The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2 span>, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] | 2 | 161136963 | 161236230 | Human | 142 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1346178 | TNIK | TRAF2 and NCK interacting kinase | Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017] | 3 | 171058414 | 171460408 | Human | 201 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1558507 | Tnik | TRAF2 and NCK interacting kinase | Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental diso rder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 28317362 | 28724734 | Mouse | 209 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561817 | Tnik | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cytoskeleton organization (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN tumor necrosis factor m ediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse; postsynaptic density, intracellular component; presynapse; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 113112937 | 113511341 | Rat | 189 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8731686 | Tnik | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cytoskeleton organization (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN tumor necrosis factor m ediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); cytoskeleton (ortholog) | NW_004955420 | 1166340 | 1542712 | Chinchilla | 43 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11885128 | TNIK | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ort holog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog) | 3 | 168067839 | 168466290 | Bonobo | 55 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12283260 | TNIK | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ort holog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog) | 34 | 35426716 | 35727308 | Dog | 57 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12670239 | Tnik | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ort holog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog) | NW_004936593 | 1166995 | 1546253 | Squirrel | 53 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13899318 | TNIK | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ort holog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog) | | | | Pig | 57 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18632890 | TNIK | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ort holog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog) | | | | Green Monkey | 54 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18907685 | Tnik | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (ort holog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog) | | | | Naked Mole-Rat | 53 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625858000 | Tnik | TRAF2 and NCK interacting kinase | ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cytoskeleton organization (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN tumor necrosis factor m ediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); cytoskeleton (ortholog) | | | | Black Rat | 43 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 40910295 | LOC119875689 | traf2 and NCK-interacting protein kinase-like | | | | | Dog | | name | gene, protein-coding, MODEL [RefSeq] |
| 1359151 | Tifa | TRAF-interacting protein with forkhead-associated domain | INVOLVED IN cytoplasmic pattern recognition receptor signaling pathway (ortholog); innate immune response (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethan e; bisphenol A | 2 | 218927724 | 218942111 | Rat | 119 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1556897 | Tifa | TRAF-interacting protein with forkhead-associated domain | Involved in positive regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; gut; liver; and trigeminal ganglion. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 127582524 | 127592043 | Mouse | 125 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1606192 | TIFA | TRAF interacting protein with forkhead associated domain | This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecul ar interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018] | 4 | 112274537 | 112285904 | Human | 126 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1350695 | TRADD | TNFRSF1A associated via death domain | The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibito r-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] | 16 | 67154185 | 67159909 | Human | 225 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351243 | TRAF1 | TNF receptor associated factor 1 | The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heter odimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] | 9 | 120902393 | 120929171 | Human | 197 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1601884 | TRAIP | TRAF interacting protein | This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with ... (more) an style='font-weight:700;'>TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008] | 3 | 49828601 | 49856564 | Human | 250 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1347209 | BIRC2 | baculoviral IAP repeat containing 2 | The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhi bits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] | 11 | 102347214 | 102378670 | Human | 420 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732624 | BIRC3 | baculoviral IAP repeat containing 3 | This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] | 11 | 102317484 | 102339403 | Human | 542 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1353701 | CD27 | CD27 molecule | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces si gnals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] | 12 | 6443892 | 6451713 | Human | 164 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1308743 | Ern2 | endoplasmic reticulum to nucleus signaling 2 | ENCODES a protein that exhibits ATP binding (ortholog); endonuclease activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN apoptotic chromosome condensation (ortholog); intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ortholog); negative regulation of D NA-templated transcription (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum quality control compartment (ortholog); IRE1-TRAF2-ASK1 complex (ortholog); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium atom | 1 | 186153115 | 186174521 | Rat | 113 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318694 | Ern2 | endoplasmic reticulum to nucleus signalling 2 | Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and unfolded protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JUN kinase activity; and regulation of D NA-templated transcription. Located in endoplasmic reticulum quality control compartment. Part of IRE1-TRAF2-ASK1 complex. Is expressed in central nervous system and retina. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 121769116 | 121785454 | Mouse | 117 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8758286 | Ern2 | endoplasmic reticulum to nucleus signaling 2 | ENCODES a protein that exhibits ATP binding (ortholog); endonuclease activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN apoptotic chromosome condensation (ortholog); intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ortholog); negative regulation of D NA-templated transcription (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum quality control compartment (ortholog); IRE1-TRAF2-ASK1 complex (ortholog) | NW_004955493 | 2217187 | 2233920 | Chinchilla | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 625843158 | Ern2 | endoplasmic reticulum to nucleus signaling 2 | ENCODES a protein that exhibits ATP binding (ortholog); endonuclease activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN apoptotic chromosome condensation (ortholog); intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ortholog); negative regulation of D NA-templated transcription (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum quality control compartment (ortholog); IRE1-TRAF2-ASK1 complex (ortholog) | | | | Black Rat | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 2308220 | Gstp-ps | glutathione S-transferase, pi, pseudogene | Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cytokine production; and negative regu lation of signal transduction. Predicted to be located in cytosol and mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. [provided by Alliance of Genome Resources, Apr 2025] | 1 | 191758036 | 191762461 | Mouse | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 12322688 | GSTP1 | glutathione S-transferase pi 1 | ENCODES a protein that exhibits dinitrosyl-iron complex binding (ortholog); fatty acid binding (ortholog); glutathione peroxidase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to cell-matrix adhesion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN protein-containing complex (ortholog); TRAF2-GSTP1 complex (ortholog) | 18 | 49905161 | 49908182 | Dog | 240 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18421980 | GSTP1 | glutathione S-transferase pi 1 | ENCODES a protein that exhibits dinitrosyl-iron complex binding (ortholog); fatty acid binding (ortholog); glutathione peroxidase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to cell-matrix adhesion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN mitochondrion (ortholog); protein-containing complex (ortholog); TRAF2-GSTP1 complex (ortholog) | | | | Green Monkey | 232 | description | gene, protein-coding, MODEL [RefSeq] |
| 1316892 | Gstp3 | glutathione S-transferase pi 3 | Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cytokine production; and negative regu lation of signal transduction. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Is expressed in liver lobe. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 4107470 | 4109587 | Mouse | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 14068854 | LOC100739508 | glutathione S-transferase P-like | ENCODES a protein that exhibits dinitrosyl-iron complex binding (ortholog); fatty acid binding (ortholog); glutathione peroxidase activity (ortholog); INVOLVED IN glutathione derivative biosynthetic process (ortholog); hepoxilin biosynthetic process (ortholog); linoleic acid metabolic process (ortho log); PARTICIPATES IN paracetamol pharmacokinetics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN mitochondrion (ortholog); TRAF2-GSTP1 complex (ortholog); INTERACTS WITH 1-chloro-2,4-dinitrobenzene; glutathione; monobromobimane | | | | Pig | 181 | description | gene, protein-coding, MODEL [RefSeq] |
| 1322717 | LRR1 | leucine rich repeat protein 1 | The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated fa ctor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] | 14 | 49598940 | 49614672 | Human | 76 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1321416 | MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an N F-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] | 17 | 45263119 | 45317020 | Human | 221 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315044 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of JNK cascade; and positive regulation of myoblast differentiation. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intrinsic apoptotic signaling pathway in response to oxidative stress; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 19809847 | 20018496 | Mouse | 442 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317839 | MAP4K2 | mitogen-activated protein kinase kinase kinase kinase 2 | The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activa ted by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] | 11 | 64784918 | 64803214 | Human | 116 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1603527 | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3 | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in resp onse to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] | X | 30827442 | 30889254 | Human | 107 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737374 | TNFRSF4 | TNF receptor superfamily member 4 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the exp ression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] | 1 | 1211340 | 1214153 | Human | 119 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737226 | TNFRSF8 | TNF receptor superfamily member 8 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activ ation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 1 | 12063303 | 12144207 | Human | 124 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1353417 | XIAP | X-linked inhibitor of apoptosis | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associa ted factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] | X | 123859708 | 123913972 | Human | 692 | description | gene, protein-coding, REVIEWED [RefSeq] |
