LOC100739508 (glutathione S-transferase P-like)

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Gene: LOC100739508 (glutathione S-transferase P-like) Sus scrofa

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Symbol:

LOC100739508

Name:

glutathione S-transferase P-like

RGD ID:

14068854

Description:

ENCODES a protein that exhibits dinitrosyl-iron complex binding (ortholog); fatty acid binding (ortholog); glutathione peroxidase activity (ortholog); INVOLVED IN glutathione derivative biosynthetic process (ortholog); glutathione metabolic process (ortholog); hepoxilin biosynthetic process (ortholog); PARTICIPATES IN paracetamol pharmacokinetics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); TRAF2-GSTP1 complex (ortholog); INTERACTS WITH 1-chloro-2,4-dinitrobenzene; glutathione; monobromobimane

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	5,005,498 - 5,009,247 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,634,793 - 3,637,656 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

acute kidney failure (ISO)

acute lymphoblastic leukemia (ISO)

acute myeloid leukemia (ISO)

Aicardi-Goutieres Syndrome 3 (ISO)

Airway Obstruction (ISO)

allergic disease (ISO)

Alzheimer's disease (ISO)

amphetamine abuse (ISO)

amyotrophic lateral sclerosis (ISO)

asthma (ISO)

atopic dermatitis (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

bone marrow disease (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

bronchiolo-alveolar adenocarcinoma (ISO)

bronchopulmonary dysplasia (ISO)

bronchus carcinoma (ISO)

carcinoma (ISO)

carotid artery disease (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chemotherapy-Induced Febrile Neutropenia (ISO)

cholangiocarcinoma (ISO)

Chromosome Aberrations (ISO)

chronic myeloid leukemia (ISO)

chronic obstructive pulmonary disease (ISO)

clear cell renal cell carcinoma (ISO)

colorectal adenoma (ISO)

Colorectal Neoplasms (ISO)

congenital heart disease (ISO)

conjunctivochalasis (ISO)

contact dermatitis (ISO)

Cough (ISO)

diffuse large B-cell lymphoma (ISO)

Disease Progression (ISO)

drug allergy (ISO)

Drug-Induced Leukopenia (ISO)

Drug-induced Neutropenia (ISO)

esophagus squamous cell carcinoma (ISO)

essential tremor (ISO)

Experimental Liver Neoplasms (ISO)

Gallbladder Neoplasms (ISO)

Graves' disease (ISO)

hematopoietic system disease (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

Hodgkin's lymphoma (ISO)

hypertension (ISO)

intellectual disability (ISO)

Kidney Calculi (ISO)

kidney disease (ISO)

Kuhnt-Junius degeneration (ISO)

Laryngeal Neoplasms (ISO)

late onset Parkinson's disease (ISO)

liver disease (ISO)

lung disease (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

lymphoid leukemia (ISO)

malignant astrocytoma (ISO)

melanoma (ISO)

meningitis (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

mitochondrial metabolism disease (ISO)

movement disease (ISO)

multiple myeloma (ISO)

multiple sclerosis (ISO)

myelodysplastic syndrome (ISO)

myeloid leukemia (ISO)

Myocardial Ischemia (ISO)

Necrosis (ISO)

oral squamous cell carcinoma (ISO)

osteoporosis (ISO)

osteosarcoma (ISO)

ovarian cancer (ISO)

pancreatic cancer (ISO)

pancreatic ductal carcinoma (ISO)

Parkinson's disease (ISO)

Perennial Allergic Rhinitis (ISO)

peripheral nervous system disease (ISO)

peritonitis (ISO)

Plasmodium falciparum malaria (ISO)

pre-eclampsia (ISO)

pre-malignant neoplasm (ISO)

prostate cancer (ISO)

prostate carcinoma in situ (ISO)

Prostatic Neoplasms (ISO)

Pseudomonas Infections (ISO)

psoriasis (ISO)

pulmonary emphysema (ISO)

pulmonary fibrosis (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

renal cell carcinoma (ISO)

Respiratory Sounds (ISO)

respiratory system disease (ISO)

sarcoma (ISO)

senile cataract (ISO)

squamous cell carcinoma (ISO)

Stomach Neoplasms (ISO)

substance-induced psychosis (ISO)

testicular cancer (ISO)

toxic encephalopathy (ISO)

type 2 diabetes mellitus (ISO)

Ureteral Calculi (ISO)

urinary bladder cancer (ISO)

vestibular disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-chloro-2,4-dinitrobenzene (EXP)

glutathione (EXP)

monobromobimane (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glutathione derivative biosynthetic process (ISO)

glutathione metabolic process (ISO)

hepoxilin biosynthetic process (ISO)

linoleic acid metabolic process (ISO)

negative regulation of biosynthetic process (ISO)

negative regulation of ERK1 and ERK2 cascade (ISO)

negative regulation of extrinsic apoptotic signaling pathway (ISO)

negative regulation of interleukin-1 beta production (ISO)

negative regulation of JUN kinase activity (ISO)

negative regulation of MAP kinase activity (ISO)

negative regulation of monocyte chemotactic protein-1 production (ISO)

negative regulation of protein kinase activity (ISO)

negative regulation of tumor necrosis factor production (ISO)

obsolete negative regulation of nitric-oxide synthase biosynthetic process (ISO)

prostaglandin metabolic process (ISO)

xenobiotic metabolic process (ISO)

Cellular Component

cytosol (IBA,ISO)

mitochondrion (ISO)

TRAF2-GSTP1 complex (ISO)

Molecular Function

dinitrosyl-iron complex binding (ISO)

fatty acid binding (ISO)

glutathione peroxidase activity (ISO)

glutathione transferase activity (IEA)

protein binding (ISO)

S-nitrosoglutathione binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

paracetamol pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC100739508
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	5,005,498 - 5,009,247 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,634,793 - 3,637,656 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSTP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	67,583,812 - 67,586,653 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	67,583,742 - 67,586,656 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	67,351,283 - 67,354,124 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	67,107,862 - 67,110,699 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	67,107,861 - 67,110,699	NCBI
Celera	11	64,685,527 - 64,688,585 (+)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	63,680,236 - 63,683,230 (+)	NCBI		HuRef
CHM1_1	11	67,234,118 - 67,237,177 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	67,578,501 - 67,581,343 (+)	NCBI		T2T-CHM13v2.0

Variants

Variants in LOC100739508
82 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005660621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01082166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005660621 ⟹ XP_005660678

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	5,005,498 - 5,009,247 (-)	NCBI

Sequence:

show sequence

ATGCGGCGTGTTCGGATGCGGCTAGGGACTAGGGACTGGGTGTTGCTAAGTCTGGATGCCTCCG
GTAAAGCCGCCGGCCTGCAGGCGGGGTGCATCCCCGCAGCGAGCAGGTGCGCCCCTCCGGCTCT
GCCTCCCAATCAGCCGCACCAGAAAGGCTGCGTGACTTGGCACATTCCCAGGGTGGAGCGCCGG
GGGTGGAGCAGGACGGTAAATATAAGGCCTCCGGGTCCTCCCCACTTCCTGCCACACTTGCCCG
CCGCCGCCGCCATGCCGTCTTACACCATCGTCTACTTCCCGGCCCGAGGACGCTGTGAGGCCAT
GCGCATGCTGCTGGCTGACCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCAAGGAGACCTGG
CTCCAGGGCCCACTCAAGGCCACCTGCCTGTATGGGCAGCTCCCCAAGTTCCAGGACGGAGACC
TCACCCTGTACCAGTCCAATGCCATCCTGCGCCACCTGGGCCGCTCCTTGGGGCTCTATGGCAA
AGACCTGCAGGAGGCGGCGCTGCTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCAGGCTG
TGCGGCCACCTCATCCGCCACAACTATGAAGAGGACAAGGCCCGGTATGTGGAGGAGCTGCCGG
GGCACCTGAGGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGCGGCCAGGCCTTCATCGTGGG
CAGCCAGATCTCCTTTGCCGACTACAACCTGCTGGACCTTCTGCTGAGCCACCAGGTCCTGGTC
CCCAGCTGCCTGGACGCCTTCCCCCTGCTCTCGGCCTATGTGGCCCGCCTCAGCGCCCGGCCCA
AGCTCAAGGCCTTCCTGGCCTCCCCCGAGCACGTGAACCGCCCCATCTTTGGAAGCCGCAAGAT
ATGAACCCCCTCAGCCTCTCCCCCCCCCCCGCCCCCAGTGAGGGGTGCCCTTGGGACCAATAAA
CACCGTGAGAGGAGAGCCACACTGTGGTCATGGGGGACCCTCTGCCCCTTCCCAAGCTGCCTCT
GGGAGGATAAGGGCTGGGCCAGGCCCTGGAAAAGCTTTAGGCTCCCAGTGCTGCCAGGAGTCAA
AGAGGCATTCTAAGTCCAAAGAGGAAGATGAGATTCCAAACCTCAGATCTCCATCCTGGAGGAC
TTCCTGCAGGAGGCGGGCTTGCATGCTTATGGCAGCCTGGGAACCATCTCCATCCAGGAGGAGG
GCAGCCCCGAACAGGGCAGATCGTCCCTGCCATGGTCCATGTGACGAGTTCTGTCGTCTGGCAC
AAGCAGGGTGGCTGCTCCCTGCACACGCAGCTGCTGGGCACATACTTCGCTTGGGAGTGACACA
CACACTTAGGTGACTCACATGCAGGTCAGTGGTGCCTGTTCTCGTGCGTGCGGCAGGTGTCCAG
CAGGGCCCAGGTGTGTGACTGCAATAGACCAGGGAGCTCTAGGTACGTCGTGCTGCTTGGGGAC
CTGAAGGGGGTCAGGGGTTTCCTCCAGCTCCAAGGAGCCTCTGTCAGCCCCGGGTGAGAGCACC
CTGGCTCCTGCACAGTCCCAGCCCGTCTCCCTCCTGAAAGGCTGTGACCGCCTCCTGCCTGGCA
CCCTCAGCCTGCCCCGCCCCTCCTGTTGGCTCGTTGGGCAAAGTGGAGTCGAACAATGCCAGAA
CTCTGGGCACTCCCGGTGCAAAGCTCTCAGGGGCTCCTTGCTGCCCTGCAGGCAATGTCCACAG
CCTGGTGAGCCTGCCAGGCCCTCCTTGATGTGACTTTTCCCGTGGAATCCAGAATGTTCCCCAC
CCGCCTGCCTGGTTCACCCTTAGAGCTGCTCTCGGCTCTCCAGAGAGGGCAGCTCTGCCTCACA
GCC

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Protein Sequences


Protein RefSeqs	XP_005660678	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000013714
	ENSSSCP00000013714.4
	ENSSSCP00000045999.3
	ENSSSCP00070008511.1

RefSeq Acc Id:

XP_005660678 ⟸ XM_005660621

- UniProtKB:

A0A4X1T0S7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRRVRMRLGTRDWVLLSLDASGKAAGLQAGCIPAASRCAPPALPPNQPHQKGCVTWHIPRVERR
GWSRTVNIRPPGPPHFLPHLPAAAAMPSYTIVYFPARGRCEAMRMLLADQGQSWKEEVVTKETW
LQGPLKATCLYGQLPKFQDGDLTLYQSNAILRHLGRSLGLYGKDLQEAALLDMVNDGVEDLRRL
CGHLIRHNYEEDKARYVEELPGHLRPFETLLSQNQGGQAFIVGSQISFADYNLLDLLLSHQVLV
PSCLDAFPLLSAYVARLSARPKLKAFLASPEHVNRPIFGSRKI

hide sequence

Protein Domains

GST C-terminal GST N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000060071	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070005457	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000014100	ENTREZGENE
	ENSSSCT00000014100.5	UniProtKB/TrEMBL
	ENSSSCT00000062862.3	UniProtKB/TrEMBL
	ENSSSCT00070010369.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Glutathione_S-Trfase_N	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	GST_pi	UniProtKB/TrEMBL
	GST_superfamily	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	LOC100739508	ENTREZGENE
PANTHER	GLUTATHIONE S-TRANSFERASE	UniProtKB/TrEMBL
	GST CLASS-PI	UniProtKB/TrEMBL
Pfam	GST_C_3	UniProtKB/TrEMBL
	GST_N	UniProtKB/TrEMBL
PRINTS	GSTRNSFRASEP	UniProtKB/TrEMBL
PROSITE	GST_CTER	UniProtKB/TrEMBL
	GST_NTER	UniProtKB/TrEMBL
Superfamily-SCOP	GST C-terminal domain-like	UniProtKB/TrEMBL
	Thioredoxin-like	UniProtKB/TrEMBL
UniProt	A0A287AQ27_PIG	UniProtKB/TrEMBL
	A0A4X1T0S7	ENTREZGENE, UniProtKB/TrEMBL
	F1RVN0_PIG	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB