TNIK (TRAF2 and NCK interacting kinase) - Rat Genome Database

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Gene: TNIK (TRAF2 and NCK interacting kinase) Chlorocebus sabaeus
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Symbol: TNIK
Name: TRAF2 and NCK interacting kinase
RGD ID: 18632890
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); protein serine/threonine kinase activity (inferred); INVOLVED IN positive regulation of dendrite morphogenesis (ortholog); positive regulation of protein phosphorylation (ortholog); protein autophosphorylation (ortholog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); autosomal recessive intellectual developmental disorder 54 (ortholog); colorectal cancer (ortholog); FOUND IN glutamatergic synapse (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic density, intracellular component (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TRAF2 and NCK-interacting protein kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11518,011,137 - 18,403,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1518,011,170 - 18,399,981 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
TNIK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11518,011,137 - 18,403,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1518,011,170 - 18,399,981 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TNIK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383171,058,414 - 171,460,408 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3171,058,414 - 171,460,408 (-)EnsemblGRCh38hg38GRCh38
GRCh373170,776,203 - 171,178,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363172,264,364 - 172,660,546 (-)NCBINCBI36Build 36hg18NCBI36
Celera3169,180,163 - 169,578,027 (-)NCBICelera
Cytogenetic Map3q26.2-q26.31NCBI
HuRef3168,150,160 - 168,548,398 (-)NCBIHuRef
CHM1_13170,743,498 - 171,141,357 (-)NCBICHM1_1
T2T-CHM13v2.03173,842,724 - 174,244,711 (-)NCBIT2T-CHM13v2.0
Tnik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39328,317,362 - 28,724,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl328,317,363 - 28,730,007 (+)EnsemblGRCm39 Ensembl
GRCm38328,261,901 - 28,670,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl328,263,214 - 28,675,858 (+)EnsemblGRCm38mm10GRCm38
MGSCv37328,162,136 - 28,569,507 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36328,454,287 - 28,866,927 (+)NCBIMGSCv36mm8
Celera328,220,689 - 28,624,613 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map311.92NCBI
Tnik
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82113,112,937 - 113,511,341 (+)NCBIGRCr8
mRatBN7.22111,184,352 - 111,587,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2117,837,147 - 118,231,343 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,949,687 - 116,343,888 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02110,663,456 - 111,057,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,984,599 - 114,391,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,984,646 - 114,384,894 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02133,688,695 - 134,091,198 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42115,599,466 - 116,003,005 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2106,374,076 - 106,767,167 (+)NCBICelera
Cytogenetic Map2q24NCBI
Tnik
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554201,166,340 - 1,542,326 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554201,166,340 - 1,542,712 (-)NCBIChiLan1.0ChiLan1.0
TNIK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,942,615 - 169,341,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,947,339 - 169,345,832 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03168,067,839 - 168,466,290 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13176,250,090 - 176,651,195 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3176,255,547 - 176,650,795 (-)Ensemblpanpan1.1panPan2
TNIK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13435,426,716 - 35,727,308 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3435,427,217 - 35,807,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3444,437,640 - 44,820,028 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03435,509,666 - 35,891,390 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3435,509,416 - 35,891,334 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13435,448,700 - 35,832,182 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03435,418,689 - 35,795,208 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,680,818 - 36,057,283 (-)NCBIUU_Cfam_GSD_1.0
Tnik
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602102,075,693 - 102,459,787 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365931,167,395 - 1,540,399 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365931,166,995 - 1,546,253 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNIK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13109,643,895 - 110,052,236 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113109,642,848 - 110,052,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213118,585,748 - 118,697,232 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tnik
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473049,090,222 - 49,497,646 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473049,087,876 - 49,497,981 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000010842   ⟹   ENSCSAP00000008929
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1518,011,170 - 18,399,981 (+)Ensembl
RefSeq Acc Id: XM_007972103   ⟹   XP_007970294
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11518,011,137 - 18,403,676 (+)NCBI
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972104   ⟹   XP_007970295
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11518,011,138 - 18,403,676 (+)NCBI
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972105   ⟹   XP_007970296
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11518,011,137 - 18,403,676 (+)NCBI
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972106   ⟹   XP_007970297
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11518,011,138 - 18,403,676 (+)NCBI
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037988564   ⟹   XP_037844492
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606326,919,268 - 27,167,491 (+)NCBI
RefSeq Acc Id: XM_037988565   ⟹   XP_037844493
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606326,981,040 - 27,173,807 (+)NCBI
RefSeq Acc Id: XP_007970294   ⟸   XM_007972103
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RJZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007970296   ⟸   XM_007972105
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007970295   ⟸   XM_007972104
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007970297   ⟸   XM_007972106
- Peptide Label: isoform X4
Ensembl Acc Id: ENSCSAP00000008929   ⟸   ENSCSAT00000010842
RefSeq Acc Id: XP_037844492   ⟸   XM_037988564
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037844493   ⟸   XM_037988565
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010842.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CNH_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STE20_Ser-Thr_kinase UniProtKB/TrEMBL
KEGG Report csab:103221254 UniProtKB/TrEMBL
NCBI Gene TNIK ENTREZGENE
PANTHER CNH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MISSHAPEN LIKE KINASE 1 UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RJZ0 ENTREZGENE, UniProtKB/TrEMBL