Ern2 (endoplasmic reticulum to nucleus signaling 2) - Rat Genome Database

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Gene: Ern2 (endoplasmic reticulum to nucleus signaling 2) Chinchilla lanigera
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Symbol: Ern2
Name: endoplasmic reticulum to nucleus signaling 2
RGD ID: 8758286
Description: ENCODES a protein that exhibits ATP binding (ortholog); endonuclease activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN apoptotic chromosome condensation (ortholog); intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ortholog); negative regulation of DNA-templated transcription (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum quality control compartment (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase/endoribonuclease IRE2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,217,384 - 2,233,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,217,187 - 2,233,920 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ern2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,217,384 - 2,233,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,217,187 - 2,233,920 (-)NCBIChiLan1.0ChiLan1.0
ERN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,690,310 - 23,713,222 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,690,310 - 23,713,226 (-)EnsemblGRCh38hg38GRCh38
GRCh371623,701,631 - 23,724,543 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,609,126 - 23,632,322 (-)NCBINCBI36Build 36hg18NCBI36
Build 341623,609,197 - 23,632,322NCBI
Celera1622,479,794 - 22,502,990 (-)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,791,249 - 21,814,449 (-)NCBIHuRef
CHM1_11624,713,344 - 24,736,565 (-)NCBICHM1_1
T2T-CHM13v2.01623,966,114 - 23,989,027 (-)NCBIT2T-CHM13v2.0
Ern2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,769,116 - 121,785,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,769,116 - 121,785,430 (-)EnsemblGRCm39 Ensembl
GRCm387122,169,893 - 122,186,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,169,893 - 122,186,207 (-)EnsemblGRCm38mm10GRCm38
MGSCv377129,313,407 - 129,329,730 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,961,086 - 121,977,323 (-)NCBIMGSCv36mm8
Celera7122,060,223 - 122,076,525 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.53NCBI
Ern2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,153,115 - 186,174,521 (-)NCBIGRCr8
mRatBN7.21176,726,454 - 176,743,289 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,726,454 - 176,743,289 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,054,450 - 185,071,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,240,406 - 192,257,191 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,924,466 - 184,941,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,126,023 - 192,142,865 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,126,023 - 192,142,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,188,292 - 199,205,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,012,795 - 181,029,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,152,704 - 181,169,643 (-)NCBI
Celera1174,434,976 - 174,451,775 (-)NCBICelera
Cytogenetic Map1q36NCBI
ERN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21825,101,112 - 25,124,396 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,620,572 - 29,643,848 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01614,397,697 - 14,420,618 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11623,940,716 - 23,963,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,940,716 - 23,963,894 (-)Ensemblpanpan1.1panPan2
ERN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,150,275 - 22,165,382 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,150,307 - 22,165,614 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,717,029 - 23,732,220 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0622,293,767 - 22,309,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,293,876 - 22,308,989 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,097,649 - 22,112,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0621,999,693 - 22,014,916 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,395,153 - 22,410,360 (+)NCBIUU_Cfam_GSD_1.0
Ern2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,234,586 - 120,252,648 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,332,601 - 8,350,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,332,507 - 8,350,176 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,510,558 - 22,537,868 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,510,067 - 22,537,872 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ERN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,408,517 - 21,446,764 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,404,770 - 21,431,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660688,350,609 - 8,388,406 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ern2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,823,146 - 8,840,280 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,823,114 - 8,840,073 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000020813   ⟹   ENSCLAP00000020615
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554932,217,384 - 2,233,920 (-)Ensembl
RefSeq Acc Id: XM_013504864   ⟹   XP_013360318
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554932,217,187 - 2,233,920 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013360318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000020615
  ENSCLAP00000020615.1
RefSeq Acc Id: XP_013360318   ⟸   XM_013504864
- UniProtKB: A0A8C2W136 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000020615   ⟸   ENSCLAT00000020813
Protein Domains
KEN   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014120 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000020813 ENTREZGENE
  ENSCLAT00000020813.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.180 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IRE1/2-like UniProtKB/TrEMBL
  KEN_dom UniProtKB/TrEMBL
  KEN_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PQQ_beta_propeller_repeat UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Ern2 ENTREZGENE
PANTHER PTHR13954 UniProtKB/TrEMBL
  PTHR13954:SF15 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Ribonuc_2-5A UniProtKB/TrEMBL
PROSITE KEN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART PQQ UniProtKB/TrEMBL
  PUG UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2W136 ENTREZGENE, UniProtKB/TrEMBL