Bnip3 (BCL2 interacting protein 3) - Rat Genome Database

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Gene: Bnip3 (BCL2 interacting protein 3) Rattus norvegicus
Analyze
Symbol: Bnip3
Name: BCL2 interacting protein 3
RGD ID: 620800
Description: Enables identical protein binding activity. Involved in several processes, including autophagic cell death; cardiac muscle cell apoptotic process; and central nervous system development. Located in cytoplasm; dendrite; and nucleoplasm. Used to study congestive heart failure. Biomarker of several diseases, including cerebrovascular disease (multiple); chronic obstructive pulmonary disease; end stage renal disease; obesity; and retinal detachment. Orthologous to human BNIP3 (BCL2 interacting protein 3); PARTICIPATES IN hypoxia inducible factor pathway; intrinsic apoptotic pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 3, nuclear gene for mitochondrial product; BCL2/adenovirus E1B interacting protein 3; MGC93043
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bnip3-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81203,137,778 - 203,154,962 (-)NCBIGRCr8
mRatBN7.21193,708,164 - 193,725,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1193,708,167 - 193,725,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1202,078,679 - 202,095,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01209,213,763 - 209,230,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01201,887,245 - 201,904,303 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,248,098 - 211,265,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,248,098 - 211,265,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,174,697 - 218,191,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41198,683,009 - 198,700,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11198,833,000 - 198,850,067 (-)NCBI
Celera1191,399,941 - 191,417,104 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Bnip3RatChronic Intermittent Hypoxia  IEP 11561988 RGD 
Bnip3Ratchronic obstructive pulmonary disease treatmentIEP 11561985 RGD 
Bnip3Ratcongestive heart failure treatmentIMP 11561982 RGD 
Bnip3Ratductal carcinoma in situ  ISOBNIP3 (Homo sapiens)7483575 RGD 
Bnip3Ratend stage renal disease  IEP 11561926protein:increased expression:kidneyRGD 
Bnip3RatHemorrhage  IEP 11564331protein:increased expression:heart left ventricleRGD 
Bnip3RatHyperoxia  IEP 5128796mRNA:decreased expression:retinaRGD 
Bnip3RatKidney Reperfusion Injury  IEP 11561968mRNA and protein:increased expression:kidneyRGD 
Bnip3Ratmiddle cerebral artery infarction  IEP 9685412protein:increased expression:brainRGD 
Bnip3Ratmyocardial infarction  IEP 11557988mRNA:increased expression:plantarisRGD 
Bnip3RatMyocardial Reperfusion Injury treatmentIMP 11561983 RGD 
Bnip3RatMyocardial Reperfusion Injury  IEP 155260328protein:decreased expression:myocardium (human)RGD 
Bnip3Ratobesity  IEP 2292682 RGD 
Bnip3Ratperinatal necrotizing enterocolitis  ISOBNIP3 (Homo sapiens)11561971protein:increased expression:ileumRGD 
Bnip3Ratretinal detachment  IEP 11561987 RGD 
Bnip3RatSpinal Cord Injuries  IEP 11564330protein:increased expression:spinal cordRGD 
Bnip3RatSubarachnoid Hemorrhage treatmentIEP 11561986 RGD 
Bnip3Rattransient cerebral ischemia  IEP 2314028 RGD 
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Bnip3Ratdistal 10q deletion syndrome  ISOBNIP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal 10q deletion syndromeClinVarPMID:31690835
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Bnip3RatManganese Poisoning  ISOBNIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19442826
Bnip3Ratmultiple myeloma  ISOBNIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18172295
Bnip3RatProstatic Neoplasms  ISOBNIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18163427
Bnip3RatStomach Neoplasms  ISOBNIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16367923

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Bnip3Rat(+)-dexrazoxane increases expressionISOBnip3 (Mus musculus)6480464Dexrazoxane results in increased expression of BNIP3 mRNACTDPMID:26873546
Bnip3Rat(+)-epicatechin-3-O-gallate multiple interactionsISOBNIP3 (Homo sapiens)6480464[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein] and BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]CTDPMID:29061316
Bnip3Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of BNIP3 mRNACTDPMID:17971868
Bnip3Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BNIP3 mRNA]CTDPMID:31150632
Bnip3Rat(-)-alpha-phellandrene increases expressionISOBNIP3 (Homo sapiens)6480464alpha phellandrene results in increased expression of BNIP3 mRNACTDPMID:25075043
Bnip3Rat(-)-demecolcine decreases expressionISOBNIP3 (Homo sapiens)6480464Demecolcine results in decreased expression of BNIP3 mRNACTDPMID:23649840
Bnip3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOBNIP3 (Homo sapiens)6480464[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein] and BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]CTDPMID:29061316
Bnip3Rat(S)-nicotine multiple interactionsISOBnip3 (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Bnip3Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o more ...CTDPMID:22937105
Bnip3Rat1,2-dimethylhydrazine decreases expressionISOBnip3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of BNIP3 mRNACTDPMID:22206623
Bnip3Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOBnip3 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Bnip3Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOBnip3 (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Bnip3Rat17alpha-ethynylestradiol affects expressionISOBnip3 (Mus musculus)6480464Ethinyl Estradiol affects the expression of BNIP3 mRNACTDPMID:17555576
Bnip3Rat17alpha-ethynylestradiol decreases expressionISOBnip3 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of BNIP3 mRNACTDPMID:17942748
Bnip3Rat17alpha-ethynylestradiol multiple interactionsISOBnip3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BNIP3 mRNACTDPMID:17942748
Bnip3Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of BNIP3 mRNACTDPMID:32145629
Bnip3Rat17beta-estradiol decreases expressionISOBnip3 (Mus musculus)6480464Estradiol results in decreased expression of BNIP3 mRNACTDPMID:39298647
Bnip3Rat1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one multiple interactionsISOBnip3 (Mus musculus)64804641H-(1 more ...CTDPMID:11592958
Bnip3Rat1H-pyrazole decreases expressionISOBnip3 (Mus musculus)6480464pyrazole results in decreased expression of BNIP3 mRNACTDPMID:17945193
Bnip3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOBnip3 (Mus musculus)6480464[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BNIP3 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BNIP3 mRNACTDPMID:15251184 and PMID:17942748

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Biological Process
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Bnip3Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Bnip3Ratautophagic cell death  IMP 5128797 RGD 
Bnip3Ratbrown fat cell differentiation acts_upstream_of_or_withinISOBnip3 (Mus musculus)1624291 PMID:18492766RGDPMID:18492766
Bnip3Ratbrown fat cell differentiation acts_upstream_of_or_withinIEAUniProtKB:O55003 and ensembl:ENSMUSP000001017181600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratcardiac muscle cell apoptotic process  IMP 632019 RGD 
Bnip3Ratcellular response to cobalt ion involved_inISOBNIP3 (Homo sapiens)1624291 PMID:20436456RGDPMID:20436456
Bnip3Ratcellular response to cobalt ion involved_inIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratcellular response to hydrogen peroxide  IMP 5128797 RGD 
Bnip3Ratcellular response to hydrogen peroxide  IEP 155260328 RGD 
Bnip3Ratcellular response to hypoxia involved_inISOBNIP3 (Homo sapiens)1624291 PMID:20436456RGDPMID:20436456
Bnip3Ratcellular response to hypoxia involved_inIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratcellular response to hypoxia acts_upstream_of_or_withinISOBNIP3 (Homo sapiens)1624291UniProtKB:O60238 and PMID:19273585RGDPMID:19273585
Bnip3Ratcellular response to hypoxia  IEP 9685412 RGD 
Bnip3Ratcellular response to mechanical stimulus involved_inISOBNIP3 (Homo sapiens)1624291 PMID:19593445RGDPMID:19593445
Bnip3Ratcellular response to mechanical stimulus involved_inIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratcerebral cortex development  IEP 11561980 RGD 
Bnip3Ratdefense response to virus involved_inISSUniProtKB:Q129831600115GO_REF:0000024UniProtGO_REF:0000024
Bnip3Ratdefense response to virus involved_inIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratdefense response to virus involved_inISOBNIP3 (Homo sapiens)1624291 PMID:9973195RGDPMID:9973195
Bnip3Ratgranzyme-mediated programmed cell death signaling pathway involved_inISOBNIP3 (Homo sapiens)1624291 PMID:9396766RGDPMID:9396766
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Cellular Component
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Bnip3Ratcytoplasm located_inIDA 2314028PMID:14972662UniProt 
Bnip3Ratdendrite  IDA 2314028 RGD 
Bnip3Ratdendrite located_inIDA 2314028PMID:14972662UniProt 
Bnip3Ratendoplasmic reticulum is_active_inIBAPANTHER:PTN000795991 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Bnip3Ratendoplasmic reticulum membrane is_active_inISOBNIP3 (Homo sapiens)1624291 PMID:22505714RGDPMID:22505714
Bnip3Ratendoplasmic reticulum membrane is_active_inIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Bnip3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Bnip3Ratmembrane located_inIEAInterPro:IPR0105481600115GO_REF:0000002InterProGO_REF:0000002
Bnip3Ratmitochondrial envelope located_inIEAInterPro:IPR0105481600115GO_REF:0000002InterProGO_REF:0000002
Bnip3Ratmitochondrial membrane located_inISSUniProtKB:Q129831600115GO_REF:0000024UniProtGO_REF:0000024
Bnip3Ratmitochondrial membrane located_inIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratmitochondrial membrane located_inIEAUniProtKB:O55003 and ensembl:ENSMUSP000001017181600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratmitochondrial membrane located_inIEAUniProtKB-SubCell:SL-01711600115GO_REF:0000044UniProtGO_REF:0000044
Bnip3Ratmitochondrial membrane located_inISOBnip3 (Mus musculus)1624291 PMID:10891486RGDPMID:10891486
Bnip3Ratmitochondrial membrane located_inISOBNIP3 (Homo sapiens)1624291 PMID:10891486 and PMID:9396766RGDPMID:10891486 and PMID:9396766
Bnip3Ratmitochondrial outer membrane is_active_inISOBNIP3 (Homo sapiens)1624291 PMID:22505714RGDPMID:22505714
Bnip3Ratmitochondrial outer membrane is_active_inIBAPANTHER:PTN001032684 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Bnip3Ratmitochondrial outer membrane located_inISOBNIP3 (Homo sapiens)1624291 PMID:10891486 and PMID:22292033RGDPMID:10891486 and PMID:22292033
Bnip3Ratmitochondrial outer membrane located_inISSUniProtKB:Q129831600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Bnip3Ratendoplasmic reticulum-autophagosome adaptor activity enablesISOBNIP3 (Homo sapiens)1624291 PMID:22505714RGDPMID:22505714
Bnip3Ratendoplasmic reticulum-autophagosome adaptor activity enablesIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3RatGTPase binding enablesISOBNIP3 (Homo sapiens)1624291UniProtKB:O60313 and PMID:20436456RGDPMID:20436456
Bnip3RatGTPase binding enablesIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratidentical protein binding  IPIBnip3 (Rattus norvegicus)11561967homodimerizationRGD 
Bnip3Ratidentical protein binding enablesIEAUniProtKB:O55003 and ensembl:ENSMUSP000001017181600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratidentical protein binding enablesISOBnip3 (Mus musculus)1624291PR:O55003 PMID:22044588RGDPMID:22044588
Bnip3Ratidentical protein binding enablesIEAARBA:ARBA000279301600115GO_REF:0000117UniProtGO_REF:0000117
Bnip3Ratidentical protein binding enablesIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratidentical protein binding enablesISOBNIP3 (Homo sapiens)1624291UniProtKB:Q12983 more ...RGDPMID:10381623 more ...
Bnip3Ratmitochondrion autophagosome adaptor activity enablesISOBNIP3 (Homo sapiens)1624291 PMID:22505714RGDPMID:22505714
Bnip3Ratmitochondrion autophagosome adaptor activity enablesIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratprotein binding  IPIVdac1 (Rattus norvegicus)11561967 RGD 
Bnip3Ratprotein binding enablesISOBNIP3 (Homo sapiens)1624291UniProtKB:O00559 more ...RGDPMID:10381623 more ...
Bnip3Ratprotein homodimerization activity enablesISSUniProtKB:Q129831600115GO_REF:0000024UniProtGO_REF:0000024
Bnip3Ratprotein homodimerization activity enablesIEAUniProtKB:Q12983 and ensembl:ENSP000003576251600115GO_REF:0000107EnsemblGO_REF:0000107
Bnip3Ratprotein homodimerization activity enablesISOBNIP3 (Homo sapiens)1624291 PMID:10381623 and PMID:9396766RGDPMID:10381623 and PMID:9396766
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RGD Manual Annotations


  

Imported Annotations - PID (archival)

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Bnip3Rathypoxia inducible factor pathway   ISOBNIP3 (Homo sapiens)6484113 PIDPID:200202
Bnip3RatmTOR signaling pathway   ISOBNIP3 (Homo sapiens)6484113 PIDPID:200096

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#
Reference Title
Reference Citation
1. Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway. Byun YJ, etal., Neurosci Lett. 2009 Sep 18;461(2):131-5. Epub 2009 Jun 17.
2. Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure. Chaanine AH, etal., Circ Heart Fail. 2013 May;6(3):572-83. doi: 10.1161/CIRCHEARTFAILURE.112.000200. Epub 2013 Mar 18.
3. Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat. Cho B, etal., Mol Cells. 2012 Jun;33(6):605-10. doi: 10.1007/s10059-012-0051-0. Epub 2012 May 23.
4. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Dhingra R, etal., Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5537-44. doi: 10.1073/pnas.1414665111. Epub 2014 Dec 8.
5. MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3. Diao H, etal., Biosci Biotechnol Biochem. 2017 Sep;81(9):1712-1720. doi: 10.1080/09168451.2017.1343118. Epub 2017 Jun 29.
6. Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease. Dong Y, etal., BMC Complement Altern Med. 2015 Mar 10;15:51. doi: 10.1186/s12906-015-0559-x.
7. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. Fedorova LV, etal., BMC Nephrol. 2013 Oct 4;14:209. doi: 10.1186/1471-2369-14-209.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Hamacher-Brady A, etal., Cell Death Differ. 2007 Jan;14(1):146-57. Epub 2006 Apr 28.
11. Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Ishihara M, etal., Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F495-509. doi: 10.1152/ajprenal.00642.2012. Epub 2013 May 22.
12. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
13. Autophagy signaling in skeletal muscle of infarcted rats. Jannig PR, etal., PLoS One. 2014 Jan 10;9(1):e85820. doi: 10.1371/journal.pone.0085820. eCollection 2014.
14. Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury. Jian B, etal., Mol Med. 2011 May-Jun;17(5-6):542-9. doi: 10.2119/molmed.2010.00195. Epub 2010 Dec 22.
15. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Kubasiak LA, etal., Proc Natl Acad Sci U S A 2002 Oct 1;99(20):12825-30.
16. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
17. MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H(2)O(2))-induced apoptosis through targeting the mitochondria apoptotic pathway. Li R, etal., PLoS One. 2012;7(9):e44907. doi: 10.1371/journal.pone.0044907. Epub 2012 Sep 18.
18. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
19. More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. Lu MC, etal., Obesity (Silver Spring). 2007 Nov;15(11):2634-42.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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PMID:7954800   PMID:9396766   PMID:9973195   PMID:10381623   PMID:10891486   PMID:14651853   PMID:16189514   PMID:16291751   PMID:16344406   PMID:16464515   PMID:16954213   PMID:16987017  
PMID:17082476   PMID:17114649   PMID:17274962   PMID:18096822   PMID:18337831   PMID:18371312   PMID:18492766   PMID:18790835   PMID:19088195   PMID:19147804   PMID:19255257   PMID:19273585  
PMID:19593445   PMID:19737385   PMID:20025887   PMID:20436456   PMID:20668412   PMID:21122071   PMID:21415393   PMID:21437288   PMID:21575413   PMID:21890690   PMID:22044588   PMID:22292033  
PMID:22403878   PMID:23012479   PMID:23395931   PMID:23648705   PMID:23692407   PMID:23716698   PMID:25416956   PMID:25810259   PMID:26317696   PMID:26471219   PMID:27107012   PMID:27112557  
PMID:27472881   PMID:27886395   PMID:28838842   PMID:29538088   PMID:29566574   PMID:30173922   PMID:30851408   PMID:31320615   PMID:31321998   PMID:31657084   PMID:31707369   PMID:31993850  
PMID:35951252   PMID:36627546   PMID:37542244  



Bnip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81203,137,778 - 203,154,962 (-)NCBIGRCr8
mRatBN7.21193,708,164 - 193,725,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1193,708,167 - 193,725,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1202,078,679 - 202,095,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01209,213,763 - 209,230,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01201,887,245 - 201,904,303 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,248,098 - 211,265,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,248,098 - 211,265,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,174,697 - 218,191,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41198,683,009 - 198,700,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11198,833,000 - 198,850,067 (-)NCBI
Celera1191,399,941 - 191,417,104 (-)NCBICelera
Cytogenetic Map1q41NCBI
BNIP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810131,967,684 - 131,981,923 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10131,967,684 - 131,981,967 (-)EnsemblGRCh38hg38GRCh38
GRCh3710133,781,188 - 133,795,427 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610133,631,194 - 133,645,425 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410133,631,193 - 133,645,425NCBI
Celera10127,425,370 - 127,439,605 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10127,330,366 - 127,344,602 (-)NCBIHuRef
CHM1_110134,062,287 - 134,076,530 (-)NCBICHM1_1
T2T-CHM13v2.010132,907,935 - 132,922,186 (-)NCBIT2T-CHM13v2.0
Bnip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397138,492,565 - 138,511,235 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7138,492,565 - 138,511,248 (-)EnsemblGRCm39 Ensembl
GRCm387138,890,836 - 138,909,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7138,890,836 - 138,909,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv377146,082,519 - 146,101,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367138,729,179 - 138,747,849 (-)NCBIMGSCv36mm8
Celera7138,707,907 - 138,726,495 (-)NCBICelera
Cytogenetic Map7F4NCBI
cM Map782.95NCBI
Bnip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554779,621,812 - 9,638,099 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554779,621,812 - 9,630,406 (-)NCBIChiLan1.0ChiLan1.0
BNIP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28143,924,591 - 143,938,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110143,929,948 - 143,944,284 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010128,671,663 - 128,685,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110132,857,375 - 132,871,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10132,858,211 - 132,871,634 (-)Ensemblpanpan1.1panPan2
BNIP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12840,037,681 - 40,050,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2840,038,643 - 40,049,797 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2840,097,449 - 40,110,338 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02840,678,012 - 40,690,914 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2840,676,814 - 40,689,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12840,162,663 - 40,175,507 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02840,150,654 - 40,163,548 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02840,549,677 - 40,562,589 (-)NCBIUU_Cfam_GSD_1.0
Bnip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072137,077,703 - 7,111,927 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648618,448,494 - 18,455,927 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648618,449,371 - 18,460,435 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BNIP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14140,362,127 - 140,371,907 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114140,362,123 - 140,371,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214152,194,909 - 152,204,744 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BNIP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19124,570,958 - 124,586,002 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9124,568,695 - 124,585,980 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604886,009,563 - 86,024,560 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bnip3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473714,848,350 - 14,862,965 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473714,848,355 - 14,863,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Bnip3
95 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145rno-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23028672

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:241
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000023477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 90 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

1 to 10 of 90 rows
Bnip3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,763,896 - 48,764,118 (+)MAPPERmRatBN7.2
Rnor_6.0953,617,317 - 53,617,538NCBIRnor6.0
Rnor_5.0953,285,469 - 53,285,690UniSTSRnor5.0
Celera946,432,519 - 46,432,740UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map9q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 24 of 24 rows
RefSeq Transcripts NM_053420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF243515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY095482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO403082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC660101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENSRNOT00000023477   ⟹   ENSRNOP00000023477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1193,708,167 - 193,725,359 (-)Ensembl
Rnor_6.0 Ensembl1211,248,098 - 211,265,282 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080041   ⟹   ENSRNOP00000071075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1193,709,097 - 193,725,359 (-)Ensembl
Rnor_6.0 Ensembl1211,251,501 - 211,265,161 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094035   ⟹   ENSRNOP00000096119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1193,709,273 - 193,725,359 (-)Ensembl
RefSeq Acc Id: NM_053420   ⟹   NP_445872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81203,137,778 - 203,154,962 (-)NCBI
mRatBN7.21193,708,164 - 193,725,348 (-)NCBI
Rnor_6.01211,248,098 - 211,265,282 (-)NCBI
Rnor_5.01218,174,697 - 218,191,883 (-)NCBI
RGSC_v3.41198,683,009 - 198,700,075 (-)RGD
Celera1191,399,941 - 191,417,104 (-)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_445872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF98317 (Get FASTA)   NCBI Sequence Viewer  
  AAH70958 (Get FASTA)   NCBI Sequence Viewer  
  AAH81690 (Get FASTA)   NCBI Sequence Viewer  
  AAM23314 (Get FASTA)   NCBI Sequence Viewer  
  AGJ84332 (Get FASTA)   NCBI Sequence Viewer  
  EDM11831 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023477
  ENSRNOP00000023477.4
  ENSRNOP00000071075.1
  ENSRNOP00000096119.1
1 to 11 of 11 rows
RefSeq Acc Id: NP_445872   ⟸   NM_053420
- UniProtKB: Q9ET45 (UniProtKB/TrEMBL),   A6HX99 (UniProtKB/TrEMBL),   A6INV7 (UniProtKB/TrEMBL),   F7FHM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071075   ⟸   ENSRNOT00000080041
Ensembl Acc Id: ENSRNOP00000023477   ⟸   ENSRNOT00000023477
Ensembl Acc Id: ENSRNOP00000096119   ⟸   ENSRNOT00000094035

Name Modeler Protein Id AA Range Protein Structure
AF-Q9ET45-F1-model_v2 AlphaFold Q9ET45 1-187 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690506
Promoter ID:EPDNEW_R1025
Type:initiation region
Name:Bnip3_1
Description:BCL2 interacting protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01211,265,252 - 211,265,312EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57103 BioCyc
Ensembl Genes ENSRNOG00000017243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023477 ENTREZGENE
  ENSRNOT00000023477.7 UniProtKB/TrEMBL
  ENSRNOT00000080041.2 UniProtKB/TrEMBL
  ENSRNOT00000094035.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.1020 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105707 IMAGE-MGC_LOAD
  IMAGE:7190121 IMAGE-MGC_LOAD
InterPro BNIP3 UniProtKB/TrEMBL
KEGG Report rno:84480 UniProtKB/TrEMBL
MGC_CLONE MGC:91405 IMAGE-MGC_LOAD
  MGC:93043 IMAGE-MGC_LOAD
NCBI Gene 84480 ENTREZGENE
PANTHER BCL2/ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 3 UniProtKB/TrEMBL
  PTHR15186 UniProtKB/TrEMBL
Pfam BNIP3 UniProtKB/TrEMBL
PhenoGen Bnip3 PhenoGen
RatGTEx ENSRNOG00000017243 RatGTEx
UniProt A0A8I6AQ99_RAT UniProtKB/TrEMBL
  A6HX99 ENTREZGENE
  A6INV7 ENTREZGENE, UniProtKB/TrEMBL
  F7FHM5 ENTREZGENE, UniProtKB/TrEMBL
  M9VYP0_RAT UniProtKB/TrEMBL
  Q9ET45 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6HX99 UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 Bnip3  BCL2 interacting protein 3  Bnip3  BCL2/adenovirus E1B interacting protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Bnip3  BCL2/adenovirus E1B interacting protein 3  Bnip3  BCL2/adenovirus E1B 19 kDa-interacting protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Bnip3  BCL2/adenovirus E1B 19 kDa-interacting protein 3    BCL2/adenovirus E1B 19 kDa-interacting protein 3, nuclear gene for mitochondrial product  Name updated 1299863 APPROVED
2002-08-07 Bnip3  BCL2/adenovirus E1B 19 kDa-interacting protein 3, nuclear gene for mitochondrial product      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_mutations_overexpression overexpression results in membrane insertion and initiation of a cell death pathway with features similar to necrosis  
gene_product member of the BH3-only subfamily of Bcl-2 family proteins