Faah (fatty acid amide hydrolase) - Rat Genome Database

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Gene: Faah (fatty acid amide hydrolase) Rattus norvegicus
Analyze
Symbol: Faah
Name: fatty acid amide hydrolase
RGD ID: 61808
Description: Enables several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; identical protein binding activity; and monoacylglycerol lipase activity. Involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Located in organelle membrane. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anandamide amidase; anandamide amidohydrolase 1; fatty acid ester hydrolase; fatty-acid amide hydrolase 1; oleamide hydrolase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: This locus corresponds to the rat Faah gene and shares synteny with Faah in mouse and human. Rat Faah was previously associated with GeneID: 29347, which may correspond to a duplication of this locus in the rat assembly. [19 Mar 2019]; Note: This locus was previously annotated as the rat Faah gene, which is now associated with GeneID: 100911581. GeneID: 100911581 shares synteny with Faah in mouse and human. This locus corresponds to a duplication of Faah in the rat assembly. [06 Jul 2022]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,716,545 - 134,735,396 (-)NCBIGRCr8
mRatBN7.25129,479,774 - 129,499,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,096,062 - 132,114,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,850,947 - 133,869,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,873,084 - 133,891,959 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,852,899 - 134,872,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,636,638 - 138,655,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,310,965 - 136,329,817 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,316,189 - 136,333,987 (+)NCBI
Celera5128,010,075 - 128,029,275 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FaahRatobesity  ISOFAAH (Homo sapiens)1625726 RGD 
FaahRatsubstance-related disorder  ISOFAAH (Homo sapiens)1300311DNA:missense mutation:cds:p.P129T (human)RGD 
FaahRatsubstance-related disorder  ISOFAAH (Homo sapiens)1625741 RGD 
Object Symbol
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Term
Qualifier
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Original Reference(s)
FaahRatdrug dependence  ISOFAAH (Homo sapiens)8554872ClinVar Annotator: match by term: Drug addiction and susceptibility toClinVarPMID:12060782 more ...
FaahRatsubstance-related disorder  ISOFAAH (Homo sapiens)8554872ClinVar Annotator: match by term: Polysubstance abuse and susceptibility toClinVarPMID:12060782 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
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Original Reference(s)
FaahRatHuntington's disease  ISOFAAH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20929960
FaahRatobesity  ISOFAAH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19103437 and PMID:20716455
FaahRatPregnancy Complications  ISOFAAH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16886060
FaahRatsubstance-related disorder  ISOFAAH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12060782 and PMID:19103437
FaahRatwithdrawal disorder  ISOFAAH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18705688 and PMID:19002671
Object Symbol
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Original Reference(s)
FaahRatsubstance-related disorder susceptibilityISOFAAH (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
FaahRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FAAH mRNA]CTDPMID:31150632
FaahRat(1->4)-beta-D-glucan multiple interactionsISOFaah (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FAAH mRNACTDPMID:36331819
FaahRat1,2-dimethylhydrazine increases expressionISOFaah (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of FAAH mRNACTDPMID:22206623
FaahRat17alpha-ethynylestradiol affects expressionISOFaah (Mus musculus)6480464Ethinyl Estradiol affects the expression of FAAH mRNACTDPMID:17555576
FaahRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of FAAH mRNACTDPMID:17108234
FaahRat17alpha-ethynylestradiol increases expressionISOFaah (Mus musculus)6480464Ethinyl Estradiol results in increased expression of FAAH mRNACTDPMID:17942748
FaahRat17alpha-ethynylestradiol multiple interactionsISOFaah (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAAH mRNACTDPMID:17942748
FaahRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of FAAH mRNACTDPMID:32145629
FaahRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFaah (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of FAAH mRNACTDPMID:21570461
FaahRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of FAAH mRNACTDPMID:22298810
FaahRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of FAAH mRNACTDPMID:21215274
FaahRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOFaah (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of FAAH mRNACTDPMID:18796159 and PMID:19770486
FaahRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFaah (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of FAAH mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAAH mRNACTDPMID:16214954 and PMID:17942748
FaahRat2,4-dinitrobenzenesulfonic acid increases response to substanceISOFaah (Mus musculus)6480464FAAH results in increased susceptibility to 2 and 4-dinitrobenzenesulfonic acidCTDPMID:15085199
FaahRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of FAAH mRNACTDPMID:21346803
FaahRat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of FAAH mRNACTDPMID:30723492
FaahRat4,4'-sulfonyldiphenol decreases expressionISOFaah (Mus musculus)6480464bisphenol S results in decreased expression of FAAH mRNACTDPMID:39298647
FaahRat4-hydroxyphenyl retinamide decreases expressionISOFaah (Mus musculus)6480464Fenretinide results in decreased expression of FAAH mRNACTDPMID:28973697
FaahRat4-hydroxyphenyl retinamide increases expressionISOFaah (Mus musculus)6480464Fenretinide results in increased expression of FAAH mRNACTDPMID:28973697
FaahRat4-phenylbutyric acid increases expressionISOFAAH (Homo sapiens)64804644-phenylbutyric acid results in increased expression of FAAH mRNACTDPMID:14583596

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Biological Process
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Cellular Component
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Object Symbol
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Original Reference(s)
FaahRatendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
FaahRatendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
FaahRatglutamatergic synapse is_active_inISOFaah (Mus musculus)1624291 PMID:30532004RGDPMID:30532004
FaahRatglutamatergic synapse is_active_inIEAUniProtKB:O08914 and ensembl:ENSMUSP000000415431600115GO_REF:0000107EnsemblGO_REF:0000107
FaahRatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
FaahRatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
FaahRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
FaahRatorganelle membrane located_inIDA 8554689PMID:9122178UniProt 
FaahRatpostsynapse is_active_inIDA 405650310PMID:15233753SynGO 
FaahRatpresynapse is_active_inIDA 405650310PMID:15233753SynGO 
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Molecular Function
1 to 20 of 23 rows

  
Object Symbol
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Term
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Evidence
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Reference
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Original Reference(s)
FaahRatamidase activity  IDA 1625736 RGD 
FaahRatamidase activity enablesIBAPANTHER:PTN000224177 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
FaahRatfatty acid amide hydrolase activity  IMP 1625723 RGD 
FaahRatfatty acid amide hydrolase activity enablesIEARHEA:26136 and RHEA:265061600115GO_REF:0000116RHEAGO_REF:0000116
FaahRatfatty acid amide hydrolase activity enablesIEAEC:3.5.1.991600115GO_REF:0000003UniProtGO_REF:0000003
FaahRatfatty acid amide hydrolase activity enablesIEAUniProtKB:O00519 and ensembl:ENSP000002431671600115GO_REF:0000107EnsemblGO_REF:0000107
FaahRatfatty acid amide hydrolase activity enablesIBAPANTHER:PTN000224177 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
FaahRatfatty acid amide hydrolase activity enablesISOFAAH (Homo sapiens)1624291 PMID:17015445 and PMID:9122178RGDPMID:17015445 and PMID:9122178
FaahRatfatty acid amide hydrolase activity enablesIDA 8554689PMID:9122178UniProt 
FaahRatfatty acid amide hydrolase activity enablesIDA 14397564PMID:17649977UniProt 
FaahRatfatty acid amide hydrolase activity  IDA 1625736 RGD 
FaahRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
FaahRathydrolase activity, acting on ester bonds  IDA 1625736 RGD 
FaahRatidentical protein binding  IMP 1625734homodimerizationRGD 
FaahRatidentical protein binding enablesIPIUniProtKB:P9761213432302PMID:18753625IntAct 
FaahRatidentical protein binding  IPIFaah (Rattus norvegicus)728491homodimerizationRGD 
FaahRatlipid binding  IDA 1625736 RGD 
FaahRatmonoacylglycerol lipase activity enablesIDA 14397564PMID:17649977UniProt 
FaahRatmonoacylglycerol lipase activity enablesIEAUniProtKB:O08914 and ensembl:ENSMUSP000000415431600115GO_REF:0000107EnsemblGO_REF:0000107
FaahRatmonoacylglycerol lipase activity enablesISOFaah (Mus musculus)1624291 PMID:20657592RGDPMID:20657592
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BioCyc Pathways


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Reference Title
Reference Citation
1. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Bracey MH, etal., Science 2002 Nov 29;298(5599):1793-6.
2. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Cravatt BF, etal., Nature 1996 Nov 7;384(6604):83-7.
3. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. Flanagan JM, etal., Hum Genet. 2006 Nov;120(4):581-8. Epub 2006 Sep 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Molecular characterization of human and mouse fatty acid amide hydrolases. Giang DK and Cravatt BF, Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Gulyas AI, etal., Eur J Neurosci. 2004 Jul;20(2):441-58. doi: 10.1111/j.1460-9568.2004.03428.x.
8. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Ho WS and Randall MD, Br J Pharmacol. 2007 Mar;150(5):641-51. Epub 2007 Jan 22.
9. Endocannabinoid Enhancement Protects Against Kainic Acid-Induced Seizures and Associated Brain Damage. Karanian DA, etal., J Pharmacol Exp Ther. 2007 Jun 1;.
10. Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. McKinney MK and Cravatt BF, J Biol Chem. 2003 Sep 26;278(39):37393-9. Epub 2003 May 6.
11. Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase. Mei G, etal., J Biol Chem. 2007 Feb 9;282(6):3829-36. Epub 2006 Dec 7.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Mileni M, etal., Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. doi: 10.1073/pnas.0806121105. Epub 2008 Aug 27.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Sipe JC, etal., Int J Obes (Lond). 2005 Jul;29(7):755-9.
20. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Sipe JC, etal., Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8394-9.
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PMID:9452020   PMID:12678501   PMID:14506913   PMID:15233754   PMID:15632090   PMID:16418162   PMID:16866346   PMID:17543306   PMID:17555521   PMID:19095868   PMID:19321773   PMID:20493882  
PMID:20657592   PMID:20665820   PMID:21241462   PMID:21867744   PMID:21930339   PMID:22606285   PMID:22776900   PMID:23455058   PMID:24788435   PMID:24861565   PMID:25041240   PMID:25456842  
PMID:25608877   PMID:26238495   PMID:28148494   PMID:28726298   PMID:29038048   PMID:29197803   PMID:29953903   PMID:30159798   PMID:30578649   PMID:32041998   PMID:32488870   PMID:32682844  
PMID:33359656   PMID:36154489   PMID:38368587  



Faah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,716,545 - 134,735,396 (-)NCBIGRCr8
mRatBN7.25129,479,774 - 129,499,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,096,062 - 132,114,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,850,947 - 133,869,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,873,084 - 133,891,959 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,852,899 - 134,872,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,636,638 - 138,655,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,310,965 - 136,329,817 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,316,189 - 136,333,987 (+)NCBI
Celera5128,010,075 - 128,029,275 (-)NCBICelera
Cytogenetic Map5q35NCBI
FAAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,394,317 - 46,413,845 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,394,317 - 46,413,848 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,859,989 - 46,879,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,632,575 - 46,652,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 34146,572,011 - 46,591,536NCBI
Celera145,147,299 - 45,166,880 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef144,975,524 - 44,995,057 (+)NCBIHuRef
CHM1_1146,976,965 - 46,996,516 (+)NCBICHM1_1
T2T-CHM13v2.0146,271,530 - 46,291,059 (+)NCBIT2T-CHM13v2.0
Faah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,853,866 - 115,876,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,824,342 - 115,875,123 (-)EnsemblGRCm39 Ensembl
GRCm384115,996,668 - 116,018,837 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,967,145 - 116,017,926 (-)EnsemblGRCm38mm10GRCm38
MGSCv374115,669,261 - 115,690,507 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,494,600 - 115,515,834 (-)NCBIMGSCv36mm8
Celera4114,735,873 - 114,757,118 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.08NCBI
Faah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,873,368 - 11,885,369 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,873,368 - 11,885,366 (-)NCBIChiLan1.0ChiLan1.0
FAAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,394,843 - 180,414,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,536,454 - 179,555,961 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,697,173 - 45,716,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,053,436 - 47,072,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,053,436 - 47,072,283 (+)Ensemblpanpan1.1panPan2
FAAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,023,111 - 14,040,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,023,299 - 14,040,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,143,619 - 14,160,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,173,706 - 14,190,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,171,285 - 14,190,759 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,974,934 - 13,991,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,043,437 - 14,060,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,112,894 - 14,129,901 (-)NCBIUU_Cfam_GSD_1.0
Faah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,594,374 - 61,616,279 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,419,078 - 27,441,039 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,419,211 - 27,441,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,060,285 - 165,079,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,060,279 - 165,079,340 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,539,044 - 152,558,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Faah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,287,985 - 2,313,172 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249062,288,251 - 2,313,172 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Faah
66 total Variants

Predicted Target Of
Summary Value
Count of predictions:492
Count of miRNA genes:234
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000015667, ENSRNOT00000015961
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 51 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat

1 to 10 of 51 rows
RH131970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,480,995 - 129,481,177 (+)MAPPERmRatBN7.2
Rnor_6.05134,854,071 - 134,854,252NCBIRnor6.0
Rnor_6.05134,331,376 - 134,331,557NCBIRnor6.0
Rnor_5.05138,637,810 - 138,637,991UniSTSRnor5.0
Rnor_5.05138,121,847 - 138,122,028UniSTSRnor5.0
RGSC_v3.45136,328,464 - 136,328,645UniSTSRGSC3.4
Celera5128,011,247 - 128,011,428UniSTS
RH 3.4 Map5836.5UniSTS
Cytogenetic Map5q36UniSTS
RH133581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,480,048 - 129,480,250 (+)MAPPERmRatBN7.2
Rnor_6.05134,853,124 - 134,853,325NCBIRnor6.0
Rnor_6.05134,330,429 - 134,330,630NCBIRnor6.0
Rnor_5.05138,636,863 - 138,637,064UniSTSRnor5.0
Rnor_5.05138,120,900 - 138,121,101UniSTSRnor5.0
RGSC_v3.45136,329,391 - 136,329,592UniSTSRGSC3.4
Celera5128,010,300 - 128,010,501UniSTS
RH 3.4 Map5837.7UniSTS
Cytogenetic Map5q36UniSTS
MARC_7381-7382:996687840:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,484,171 - 129,485,414 (+)MAPPERmRatBN7.2
Rnor_6.05134,857,247 - 134,858,489NCBIRnor6.0
Rnor_6.05134,334,552 - 134,335,794NCBIRnor6.0
Rnor_5.05138,125,023 - 138,126,265UniSTSRnor5.0
Rnor_5.05138,640,986 - 138,642,228UniSTSRnor5.0
RGSC_v3.45136,324,227 - 136,325,469UniSTSRGSC3.4
Celera5128,014,423 - 128,015,665UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 62 65 57 33 12 33 12 112 48 38 19 38 24



Ensembl Acc Id: ENSRNOT00000015667   ⟹   ENSRNOP00000015667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)Ensembl
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000015961   ⟹   ENSRNOP00000015961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)Ensembl
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)Ensembl
RefSeq Acc Id: NM_001369126   ⟹   NP_001356055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,716,545 - 134,735,396 (-)NCBI
mRatBN7.25129,479,824 - 129,498,677 (-)NCBI
Protein RefSeqs NP_001356055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91148 (Get FASTA)   NCBI Sequence Viewer  
  EDL90296 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015667
  ENSRNOP00000015667.6
GenBank Protein P97612 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000015667   ⟸   ENSRNOT00000015667
RefSeq Acc Id: NP_001356055   ⟸   NM_001369126
- UniProtKB: P97612 (UniProtKB/Swiss-Prot),   Q5BKA3 (UniProtKB/Swiss-Prot),   A6JZ57 (UniProtKB/TrEMBL),   A0A8L2Q8I2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000015961   ⟸   ENSRNOT00000015961
Amidase

Name Modeler Protein Id AA Range Protein Structure
AF-P97612-F1-model_v2 AlphaFold P97612 1-579 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40269 BioCyc
BioCyc Pathway PWY6666-1 [anandamide degradation] BioCyc
BioCyc Pathway Image PWY6666-1 BioCyc
Ensembl Genes ENSRNOG00000011019 Ensembl
  ENSRNOG00000045949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015667 ENTREZGENE
  ENSRNOT00000015667.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1300.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370226 IMAGE-MGC_LOAD
InterPro Amidase_CS UniProtKB/Swiss-Prot
  Amidase_dom UniProtKB/Swiss-Prot
  AS_sf UniProtKB/Swiss-Prot
  Endocannabinoid_amidase UniProtKB/Swiss-Prot
MGC_CLONE MGC:108682 IMAGE-MGC_LOAD
NCBI Gene 100911581 ENTREZGENE
PANTHER FATTY ACID AMIDE HYDROLASE UniProtKB/Swiss-Prot
  PTHR45847:SF3 UniProtKB/Swiss-Prot
Pfam Amidase UniProtKB/Swiss-Prot
PhenoGen Faah PhenoGen
PIRSF Amidase_fungi UniProtKB/Swiss-Prot
PROSITE AMIDASES UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011019 RatGTEx
  ENSRNOG00000045949 RatGTEx
Superfamily-SCOP SSF75304 UniProtKB/Swiss-Prot
TIGR TC236093
UniProt A0A8L2Q8I2 ENTREZGENE, UniProtKB/TrEMBL
  A6JZ57 ENTREZGENE, UniProtKB/TrEMBL
  FAAH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKA3 ENTREZGENE
UniProt Secondary Q5BKA3 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Faah  fatty acid amide hydrolase       Name updated 70584 APPROVED

Note Type Note Reference