FAAH (fatty acid amide hydrolase) - Rat Genome Database

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Gene: FAAH (fatty acid amide hydrolase) Canis lupus familiaris
Analyze
Symbol: FAAH
Name: fatty acid amide hydrolase
RGD ID: 12148534
Description: ENCODES a protein that exhibits amidase activity (ortholog); fatty acid amide hydrolase activity (ortholog); hydrolase activity, acting on ester bonds (ortholog); INVOLVED IN fatty acid catabolic process (ortholog); fatty acid metabolic process (ortholog); monoacylglycerol catabolic process (ortholog); ASSOCIATED WITH drug dependence (ortholog); Huntington's disease (ortholog); obesity (ortholog); FOUND IN organelle membrane (ortholog); postsynapse (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fatty-acid amide hydrolase 1; LOC482510
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,023,111 - 14,040,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,023,299 - 14,040,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,143,619 - 14,160,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,173,706 - 14,190,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,171,285 - 14,190,759 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,974,934 - 13,991,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,043,437 - 14,060,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,112,894 - 14,129,901 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogobesity  ISORGD:7370529068941DNA:polymorphismRGDPMID:15809662|REF_RGD_ID:1625726
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogdrug dependence  ISORGD:7370528554872ClinVar Annotator: match by term: Drug addiction, susceptibility toClinVarPMID:12060782|PMID:15254019|PMID:16972078|PMID:23556448|PMID:25741868
FAAHDogsubstance-related disorder  ISORGD:7370528554872ClinVar Annotator: match by term: Polysubstance abuse, susceptibility toClinVarPMID:12060782|PMID:15254019|PMID:16972078|PMID:23556448|PMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogHuntington's disease  ISORGD:7370529068941CTD Direct Evidence: marker/mechanismCTDPMID:20929960
FAAHDogobesity  ISORGD:7370529068941CTD Direct Evidence: marker/mechanismCTDPMID:19103437|PMID:20716455
FAAHDogPregnancy Complications  ISORGD:7370529068941CTD Direct Evidence: marker/mechanismCTDPMID:16886060
FAAHDogwithdrawal disorder  ISORGD:7370529068941CTD Direct Evidence: marker/mechanismCTDPMID:18705688|PMID:19002671
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogsubstance-related disorder susceptibilityISORGD:7370527240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogfatty acid catabolic process  ISORGD:618089068941 RGDPMID:12734197|REF_RGD_ID:1625736
FAAHDogfatty acid catabolic process involved_inIBAPANTHER:PTN000224177|RGD:61808|UniProtKB:O00519150520179 GO_CentralGO_REF:0000033
FAAHDogfatty acid catabolic process involved_inIEAUniProtKB:O00519|ensembl:ENSP00000243167150520179 EnsemblGO_REF:0000107
FAAHDogfatty acid metabolic process  ISORGD:618089068941 RGDPMID:17545313|REF_RGD_ID:1625723
FAAHDogmonoacylglycerol catabolic process involved_inISORGD:618089068941PMID:17649977UniProtPMID:17649977|REF_RGD_ID:14397564
FAAHDogpositive regulation of vasoconstriction  ISORGD:618089068941 RGDPMID:17245358|REF_RGD_ID:1625725
FAAHDogregulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission involved_inIEAUniProtKB:O08914|ensembl:ENSMUSP00000041543150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogglutamatergic synapse is_active_inIEAUniProtKB:O08914|ensembl:ENSMUSP00000041543150520179 EnsemblGO_REF:0000107
FAAHDogmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
FAAHDogorganelle membrane located_inISORGD:618089068941PMID:9122178UniProtPMID:9122178|REF_RGD_ID:8554689
FAAHDogpostsynapse is_active_inISORGD:618089068941PMID:15233753SynGOPMID:15233753|REF_RGD_ID:405650310
FAAHDogpresynapse is_active_inISORGD:618089068941PMID:15233753SynGOPMID:15233753|REF_RGD_ID:405650310

Molecular Function
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FAAHDogamidase activity  ISORGD:618089068941 RGDPMID:12734197|REF_RGD_ID:1625736
FAAHDogamidase activity enablesIBAPANTHER:PTN000224177|RGD:61808|UniProtKB:Q90578150520179 GO_CentralGO_REF:0000033
FAAHDogfatty acid amide hydrolase activity  ISORGD:618089068941 RGDPMID:12734197|PMID:17545313|REF_RGD_ID:1625723|REF_RGD_ID:1625736
FAAHDogfatty acid amide hydrolase activity enablesIBAPANTHER:PTN000224177|RGD:61808|UniProtKB:O00519150520179 GO_CentralGO_REF:0000033
FAAHDogfatty acid amide hydrolase activity enablesIEAUniProtKB:O00519|ensembl:ENSP00000243167150520179 EnsemblGO_REF:0000107
FAAHDoghydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
FAAHDoghydrolase activity, acting on ester bonds  ISORGD:618089068941 RGDPMID:12734197|REF_RGD_ID:1625736
FAAHDogidentical protein binding  ISORGD:618089068941homodimerizationRGDPMID:12459591|PMID:17158103|REF_RGD_ID:1625734|REF_RGD_ID:728491
FAAHDogidentical protein binding enablesISOUniProtKB:P976129068941PMID:18753625IntActPMID:18753625|REF_RGD_ID:13432302
FAAHDoglipid binding  ISORGD:618089068941 RGDPMID:12734197|REF_RGD_ID:1625736
FAAHDogmonoacylglycerol lipase activity enablesIEAUniProtKB:O08914|ensembl:ENSMUSP00000041543150520179 EnsemblGO_REF:0000107
FAAHDogphospholipid binding  ISORGD:618089068941 RGDPMID:17158103|REF_RGD_ID:1625734
FAAHDogprotein binding enablesISOUniProtKB:A0A0G2K916,UniProtKB:B2GV38,UniProtKB:B5DFN4,UniProtKB:D3Z941,UniProtKB:D4AA63,UniProtKB:F1M853,UniProtKB:P11250,UniProtKB:P51593,UniProtKB:P61107,UniProtKB:P62718,UniProtKB:Q09167,UniProtKB:Q498M4,UniProtKB:Q5PPJ6,UniProtKB:Q5PPK9,UniProtKB:Q63569,UniProtKB:Q6AYJ79068941PMID:27191843UniProtPMID:27191843|REF_RGD_ID:11344934
FAAHDogprotein binding enablesISOUniProtKB:Q7Z3S99068941 PMID:25416956IntActPMID:25416956
1 to 14 of 14 rows

PMID:30032202  



FAAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,023,111 - 14,040,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,023,299 - 14,040,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,143,619 - 14,160,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,173,706 - 14,190,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,171,285 - 14,190,759 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,974,934 - 13,991,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,043,437 - 14,060,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,112,894 - 14,129,901 (-)NCBIUU_Cfam_GSD_1.0
FAAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,394,317 - 46,413,845 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,394,317 - 46,413,848 (+)EnsemblGRCh38hg38GRCh38
GRCh37146,859,989 - 46,879,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,632,575 - 46,652,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 34146,572,011 - 46,591,536NCBI
Celera145,147,299 - 45,166,880 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef144,975,524 - 44,995,057 (+)NCBIHuRef
CHM1_1146,976,965 - 46,996,516 (+)NCBICHM1_1
T2T-CHM13v2.0146,271,530 - 46,291,059 (+)NCBIT2T-CHM13v2.0
Faah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,853,866 - 115,876,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,824,342 - 115,875,123 (-)EnsemblGRCm39 Ensembl
GRCm384115,996,668 - 116,018,837 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,967,145 - 116,017,926 (-)EnsemblGRCm38mm10GRCm38
MGSCv374115,669,261 - 115,690,507 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,494,600 - 115,515,834 (-)NCBIMGSCv36mm8
Celera4114,735,873 - 114,757,118 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.08NCBI
Faah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,716,545 - 134,735,396 (-)NCBIGRCr8
mRatBN7.25129,479,774 - 129,499,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,096,062 - 132,114,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,850,947 - 133,869,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,873,084 - 133,891,959 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,852,899 - 134,872,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,636,638 - 138,655,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,310,965 - 136,329,817 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,316,189 - 136,333,987 (+)NCBI
Celera5128,010,075 - 128,029,275 (-)NCBICelera
Cytogenetic Map5q35NCBI
Faah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,873,368 - 11,885,369 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,873,368 - 11,885,366 (-)NCBIChiLan1.0ChiLan1.0
FAAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,394,843 - 180,414,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,536,454 - 179,555,961 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,697,173 - 45,716,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,053,436 - 47,072,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,053,436 - 47,072,283 (+)Ensemblpanpan1.1panPan2
Faah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,594,374 - 61,616,279 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,419,078 - 27,441,039 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,419,211 - 27,441,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,060,285 - 165,079,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,060,279 - 165,079,340 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,539,044 - 152,558,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Faah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,287,985 - 2,313,172 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249062,288,251 - 2,313,172 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in FAAH
212 total Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
15 14023478 14023479 G C snv Border Collie (BC272), Border Collie (BC597), Australian Cattle dog (AC065), Border Collie (BC0480), Border Collie (BC485), Border Collie (BC555) View more Information
15 14028994 14028995 G A snv Sloughi (SG008) View more Information
15 14029046 14029047 G A snv Australian Cattle dog (AC046) View more Information




adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10



Ensembl Acc Id: ENSCAFT00000006827   ⟹   ENSCAFP00000006320
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1514,023,299 - 14,040,212 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845034663   ⟹   ENSCAFP00845027150
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1514,171,285 - 14,190,759 (-)Ensembl
RefSeq Acc Id: XM_038495787   ⟹   XP_038351715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11513,974,934 - 13,991,885 (-)NCBI
RefSeq Acc Id: XM_038558161   ⟹   XP_038414089
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01514,112,894 - 14,129,901 (-)NCBI
RefSeq Acc Id: XM_038622034   ⟹   XP_038477962
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01514,043,437 - 14,060,387 (-)NCBI
RefSeq Acc Id: XM_038687783   ⟹   XP_038543711
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01514,173,706 - 14,190,680 (-)NCBI
RefSeq Acc Id: XM_539627   ⟹   XP_539627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11514,023,111 - 14,040,156 (-)NCBI
Dog10K_Boxer_Tasha1514,143,619 - 14,160,572 (-)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs XP_038351715 (Get FASTA)   NCBI Sequence Viewer  
  XP_038414089 (Get FASTA)   NCBI Sequence Viewer  
  XP_038477962 (Get FASTA)   NCBI Sequence Viewer  
  XP_038543711 (Get FASTA)   NCBI Sequence Viewer  
  XP_539627 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000006320.3
  ENSCAFP00030031183.1
  ENSCAFP00040025855.1
  ENSCAFP00845027150
  ENSCAFP00845027150.1
1 to 10 of 10 rows
RefSeq Acc Id: XP_539627   ⟸   XM_539627
- UniProtKB: A0A8C0RNU5 (UniProtKB/TrEMBL),   A0A8P0N732 (UniProtKB/TrEMBL),   A0A8C0KM66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000006320   ⟸   ENSCAFT00000006827
RefSeq Acc Id: XP_038351715   ⟸   XM_038495787
RefSeq Acc Id: XP_038477962   ⟸   XM_038622034
RefSeq Acc Id: XP_038543711   ⟸   XM_038687783
- UniProtKB: A0A8I3P542 (UniProtKB/TrEMBL),   A0A8C0KM66 (UniProtKB/TrEMBL)
Amidase

RGD ID:13685897
Promoter ID:EPDNEW_C3966
Type:initiation region
Name:FAAH_1
Description:fatty acid amide hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11514,040,124 - 14,040,184EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000004254 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019464 UniProtKB/TrEMBL
  ENSCAFG00040016159 UniProtKB/TrEMBL
  ENSCAFG00845019651 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006827.5 UniProtKB/TrEMBL
  ENSCAFT00030035752.1 UniProtKB/TrEMBL
  ENSCAFT00040029764.1 UniProtKB/TrEMBL
  ENSCAFT00845034663 ENTREZGENE
  ENSCAFT00845034663.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1300.10 UniProtKB/TrEMBL
InterPro Amidase_CS UniProtKB/TrEMBL
  Amidase_dom UniProtKB/TrEMBL
  AS_sf UniProtKB/TrEMBL
  Endocannabinoid_amidase UniProtKB/TrEMBL
KEGG Report cfa:482510 UniProtKB/TrEMBL
NCBI Gene LOC482510 ENTREZGENE
PANTHER FATTY ACID AMIDE HYDROLASE UniProtKB/TrEMBL
  PTHR45847:SF3 UniProtKB/TrEMBL
Pfam Amidase UniProtKB/TrEMBL
PROSITE AMIDASES UniProtKB/TrEMBL
Superfamily-SCOP SSF75304 UniProtKB/TrEMBL
UniProt A0A8C0KM66 ENTREZGENE
  A0A8C0RNU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P542 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N732 ENTREZGENE
UniProt Secondary A0A8P0N732 UniProtKB/TrEMBL
VGNC ID VGNC:56993 ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-07 FAAH  fatty acid amide hydrolase  LOC482510  fatty-acid amide hydrolase 1  Symbol and/or name change 5135510 APPROVED