Adora1 (adenosine A1 receptor) - Rat Genome Database

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Gene: Adora1 (adenosine A1 receptor) Rattus norvegicus
Analyze
Symbol: Adora1
Name: adenosine A1 receptor
RGD ID: 2048
Description: Enables several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of lipid catabolic process; and regulation of secretion. Located in several cellular components, including axon; basolateral plasma membrane; and presynaptic active zone. Is active in calyx of Held; postsynaptic membrane; and presynaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor); INTERACTS WITH (+)-pilocarpine; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenosine receptor A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Adora1em3Mcwi   Adora1em4Mcwi  
Genetic Models: SS-Adora1em4Mcwi SS-Adora1em3Mcwi
Candidate Gene For: Bp328
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,210,922 - 48,247,826 (-)NCBIGRCr8
mRatBN7.21345,658,872 - 45,695,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,658,872 - 45,695,801 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,270,569 - 48,302,744 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,558,626 - 49,590,806 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,823,488 - 46,855,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Adora1Ratasthma  ISOADORA1 (Homo sapiens)5129097protein:increased expression:bronchusRGD 
Adora1Ratasthma  ISOAdora1 (Mus musculus)4145444 RGD 
Adora1Ratasthma  ISOADORA1 (Homo sapiens)4890386DNA:SNPs: :1405C>T (human)RGD 
Adora1RatBrain Hypoxia-Ischemia  IEP 152995398protein:decreased expression:brain:RGD 
Adora1Ratcerebral infarction  IDA 1625229 RGD 
Adora1RatDiabetic Nephropathies  IMP 2313803associated with Diabetes Mellitus and ExperimentalRGD 
Adora1RatExperimental Diabetes Mellitus treatmentIDA 1625365associated with hypertensionRGD 
Adora1RatExperimental Diabetes Mellitus  ISOAdora1 (Mus musculus)2313804 RGD 
Adora1RatExperimental Diabetes Mellitus  IEP 2313805protein:decreased expression:hippocampusRGD 
Adora1RatExperimental Diabetes Mellitus  IDA 2313808 RGD 
Adora1RatHyperalgesia  IDA 5129094associated with Spinal Cord InjuriesRGD 
Adora1Rathypertension treatmentIDA 1625365associated with diabetes mellitus and experimentalRGD 
Adora1Rathypertension  IMP 1625366 RGD 
Adora1Rathypertension no_associationISOADORA1 (Homo sapiens)1625367 RGD 
Adora1RatInflammation  IDA 5129103 RGD 
Adora1RatInsulin Resistance  ISOADORA1 (Homo sapiens)2313807associated with ObesityRGD 
Adora1RatInsulin Resistance treatmentIDA 1625243 RGD 
Adora1Ratlung disease  IDA 5129095associated with Reperfusion InjuryRGD 
Adora1Ratlung disease  ISOAdora1 (Mus musculus)5129093Acute Lung InjuryRGD 
Adora1Ratobesity  ISOADORA1 (Homo sapiens)1625369 RGD 
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Adora1Ratfamilial adult myoclonic epilepsy 5  ISOADORA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:28492532
Adora1Ratgastrointestinal stromal tumor  ISOADORA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Adora1RatHypokalemic Periodic Paralysis, Type 1  ISOADORA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypokalemic periodic paralysis and type 1ClinVarPMID:28492532
Adora1Ratparathyroid carcinoma  ISOADORA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
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Adora1RatBradycardia  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18313046
Adora1RatCatalepsy  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9407998
Adora1Ratdrug allergy  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19019667
Adora1RatDrug-Related Side Effects and Adverse Reactions  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15641640
Adora1RatGenetic Predisposition to Disease  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19019667
Adora1RatHypotension  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15641640 and PMID:18313046
Adora1Ratischemia  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18950269
Adora1Ratmiddle cerebral artery infarction  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23437309
Adora1Ratmyocardial infarction  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:12160945
Adora1RatNerve Degeneration  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23437309
Adora1RatPrenatal Exposure Delayed Effects  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19092996
Adora1RatSubarachnoid Hemorrhage  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18950269
Adora1Rattransient cerebral ischemia  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23437309
Adora1RatVentricular Dysfunction  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15641640
Adora1Ratwithdrawal disorder  ISOADORA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16226742
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Adora1Ratpanic disorder  ISOADORA1 (Homo sapiens)1331525 GAD 

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Adora1Rat(+)-pilocarpine multiple interactionsEXP 6480464[2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to PilocarpineCTDPMID:11311893
Adora1Rat(1->4)-beta-D-glucan multiple interactionsISOAdora1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ADORA1 mRNACTDPMID:36331819
Adora1Rat(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin multiple interactionsEXP 6480464[1 more ...CTDPMID:8987795
Adora1Rat1,2-dichloroethane decreases expressionISOAdora1 (Mus musculus)6480464ethylene dichloride results in decreased expression of ADORA1 mRNACTDPMID:28189721 and PMID:28960355
Adora1Rat1,2-dimethylhydrazine multiple interactionsISOAdora1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ADORA1 mRNACTDPMID:22206623
Adora1Rat1,4-dithiothreitol multiple interactionsEXP 6480464[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein] more ...CTDPMID:10413299
Adora1Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile multiple interactionsISOAdora1 (Mus musculus)6480464[Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA and [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNACTDPMID:29107002
Adora1Rat1-naphthyl isothiocyanate increases response to substanceISOAdora1 (Mus musculus)6480464ADORA1 protein results in increased susceptibility to 1-NaphthylisothiocyanateCTDPMID:22956627
Adora1Rat17beta-estradiol multiple interactionsISOADORA1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of ADORA1 mRNA more ...CTDPMID:19698761 more ...
Adora1Rat17beta-estradiol increases expressionISOAdora1 (Mus musculus)6480464Estradiol results in increased expression of ADORA1 mRNACTDPMID:39298647
Adora1Rat17beta-estradiol increases expressionISOADORA1 (Homo sapiens)6480464Estradiol results in increased expression of ADORA1 mRNACTDPMID:23019147 more ...
Adora1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ADORA1 proteinCTDPMID:18950269
Adora1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOAdora1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Adora1Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOAdora1 (Mus musculus)64804642 more ...CTDPMID:30294300
Adora1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAdora1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ADORA1 mRNACTDPMID:19933214
Adora1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAdora1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Adora1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOAdora1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of ADORA1 mRNACTDPMID:18172886 more ...
Adora1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOAdora1 (Mus musculus)6480464tetrabromobisphenol A results in increased expression of ADORA1 mRNACTDPMID:25172293
Adora1Rat3,4-methylenedioxymethamphetamine increases expressionISOAdora1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ADORA1 mRNACTDPMID:20188158
Adora1Rat4,4'-sulfonyldiphenol increases expressionISOAdora1 (Mus musculus)6480464bisphenol S results in increased expression of ADORA1 mRNACTDPMID:39298647

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Biological Process
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Original Reference(s)
Adora1Ratadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  IMP 1625235 RGD 
Adora1Ratcognition  IMP 2317919 RGD 
Adora1Ratdetection of temperature stimulus involved in sensory perception of pain  IMP 5129094 RGD 
Adora1Ratexcitatory postsynaptic potential  IMP 2317911 RGD 
Adora1Ratexcitatory postsynaptic potential acts_upstream_of_or_withinIEAUniProtKB:Q60612 and ensembl:ENSMUSP000000836561600115GO_REF:0000107EnsemblGO_REF:0000107
Adora1Ratexcitatory postsynaptic potential acts_upstream_of_or_withinISOAdora1 (Mus musculus)1624291 PMID:17428973RGDPMID:17428973
Adora1Ratfatty acid homeostasis  IDA 1625243 RGD 
Adora1RatG protein-coupled adenosine receptor signaling pathway involved_inIEAInterPro:IPR0016341600115GO_REF:0000002InterProGO_REF:0000002
Adora1RatG protein-coupled purinergic nucleotide receptor signaling pathway involved_inIDA 8553380PMID:11390975BHF-UCL 
Adora1RatG protein-coupled receptor signaling pathway  IDA 1625267 RGD 
Adora1RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0010681600115GO_REF:0000002InterProGO_REF:0000002
Adora1RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Adora1RatG protein-coupled receptor signaling pathway involved_inIBAFB:FBgn0039747 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adora1Ratleukocyte migration acts_upstream_ofISOAdora1 (Mus musculus)1624291MGI:87916 PMID:15630442RGDPMID:15630442
Adora1Ratleukocyte migration acts_upstream_ofIEAUniProtKB:Q60612 and ensembl:ENSMUSP000000836561600115GO_REF:0000107EnsemblGO_REF:0000107
Adora1Ratlipid catabolic process  IMP 2317920 RGD 
Adora1Ratlong-term synaptic depression acts_upstream_ofISOAdora1 (Mus musculus)1624291MGI:95808 PMID:24259587RGDPMID:24259587
Adora1Ratlong-term synaptic depression acts_upstream_ofIEAUniProtKB:Q60612 and ensembl:ENSMUSP000000836561600115GO_REF:0000107EnsemblGO_REF:0000107
Adora1Ratmucus secretion acts_upstream_ofISOAdora1 (Mus musculus)1624291MGI:87916 PMID:15630442RGDPMID:15630442
Adora1Ratmucus secretion acts_upstream_ofIEAUniProtKB:Q60612 and ensembl:ENSMUSP000000836561600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Adora1Ratasymmetric synapse  IDA 1625231 RGD 
Adora1Rataxolemma  IDA 1625231 RGD 
Adora1Ratbasolateral plasma membrane  IDA 1625258in hepatocytesRGD 
Adora1Ratcalyx of Held is_active_inIDA 13702434PMID:12963795SynGO 
Adora1Ratcalyx of Held is_active_inEXP 13702434PMID:12963795SynGO 
Adora1Ratcell body located_inIDA 8554816PMID:12417330BHF-UCL 
Adora1Ratcilium located_inISOADORA1 (Homo sapiens) and UniProtKB:P30542-11624291 RGDGO_REF:0000052
Adora1Ratcilium located_inIEAUniProtKB:P30542 and ensembl:ENSP000003384351600115GO_REF:0000107EnsemblGO_REF:0000107
Adora1Ratdendrite  IDA 1625217 RGD 
Adora1Ratdendrite is_active_inIBAMGI:99401 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adora1Ratdendrite located_inIDA 8554816PMID:12417330BHF-UCL 
Adora1Ratdendritic spine located_inISOAdora1 (Mus musculus)1624291 PMID:24259587RGDPMID:24259587
Adora1Ratdendritic spine located_inIEAUniProtKB:Q60612 and ensembl:ENSMUSP000000836561600115GO_REF:0000107EnsemblGO_REF:0000107
Adora1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Adora1Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Adora1Ratneuronal cell body  IDA 1625242 RGD 
Adora1Ratplasma membrane is_active_inIBAMGI:104847 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adora1Ratplasma membrane located_inIEAUniProtKB:P30542 and ensembl:ENSP000003384351600115GO_REF:0000107EnsemblGO_REF:0000107
Adora1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Adora1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Adora1RatG protein-coupled adenosine receptor activity  IDA 631744 RGD 
Adora1RatG protein-coupled adenosine receptor activity enablesIDA 8553380PMID:11390975BHF-UCL 
Adora1RatG protein-coupled adenosine receptor activity enablesIEAInterPro:IPR0016341600115GO_REF:0000002InterProGO_REF:0000002
Adora1RatG protein-coupled adenosine receptor activity enablesIBAMGI:104847 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adora1RatG protein-coupled adenosine receptor activity  TAS 625619 RGD 
Adora1RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Adora1RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Adora1RatG protein-coupled receptor binding enablesIPIUniProtKB:P496518554816PMID:12417330BHF-UCL 
Adora1RatG protein-coupled receptor binding enablesIPIUniProtKB:P496518553380PMID:11390975BHF-UCL 
Adora1RatG protein-coupled receptor binding enablesIPIUniProtKB:P412328553380PMID:11390975BHF-UCL 
Adora1RatG-protein beta/gamma-subunit complex binding  IDA 1625267 RGD 
Adora1Ratheat shock protein binding  IPIHspa8 (Rattus norvegicus)10059330 RGD 
Adora1Ratheterotrimeric G-protein binding  IDA 1625267 RGD 
Adora1Ratprotein binding  IPIKcnj11 (Rattus norvegicus) and Cav3 (Rattus norvegicus)7297041 RGD 
Adora1Ratprotein binding enablesISOAdora1 (Mus musculus)1624291PR:P23818 PMID:24259587RGDPMID:24259587
Adora1Ratprotein binding enablesISOADORA1 (Homo sapiens)1624291UniProtKB:P07550 more ...RGDPMID:16481441 more ...
Adora1Ratprotein binding enablesIPIUniProtKB:P412328553380PMID:11390975BHF-UCL 
Adora1Ratprotein heterodimerization activity enablesIPIUniProtKB:P496518553380PMID:11390975BHF-UCL 
Adora1Ratprotein-containing complex binding  IPIAdora2a (Rattus norvegicus)1625231heterodimerizationRGD 
Adora1Ratpurine nucleoside binding  IPIadenosine1625291 RGD 
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Reference Title
Reference Citation
1. Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats. Ajamieh HH, etal., Clin Sci (Lond). 2008 Jul;115(2):69-77.
2. Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. Akaiwa K, etal., Brain Res. 2006 Nov 29;1122(1):47-55. Epub 2006 Oct 24.
3. Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Almeida T, etal., Neuroscience. 2003;122(1):111-21.
4. Revista española de cardiología Alvarado-Tapias E, etal., Rev Esp Cardiol. 2010 Apr;63(4):478-82.
5. Effects of the adenosine A1 receptor inhibitor FK 838 on proximal tubular fluid output in rats. Bak M and Thomsen K, Nephrol Dial Transplant. 2004 May;19(5):1077-82. Epub 2004 Feb 19.
6. Protective effect of adenosine in diabetic neuropathic pain is mediated through adenosine A1-receptors. Balasubramanyan S and Sharma SS, Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):233-42.
7. Differences in the expression of the adenosine A1 receptor in adipose tissue of obese black and white women. Barakat H, etal., J Clin Endocrinol Metab. 2006 May;91(5):1882-6. Epub 2006 Feb 28.
8. Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia. Barros RC, etal., Respir Physiol Neurobiol. 2006 Sep 28;153(2):115-25. Epub 2005 Dec 13.
9. Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices. Batti L and O'Connor JJ, J Neuroimmunol. 2010 Jan 25;218(1-2):21-7. Epub 2009 Nov 25.
10. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
11. Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects. Brown RA, etal., Eur Respir J. 2008 Feb;31(2):311-9. Epub 2007 Oct 24.
12. Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. Cheng JT, etal., Auton Neurosci. 2000 Oct 2;83(3):127-33.
13. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. Ciruela F, etal., J Neurosci. 2006 Feb 15;26(7):2080-7.
14. Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance. Dong Q, etal., Diabetes Obes Metab. 2001 Oct;3(5):360-6.
15. Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Duarte JM, etal., Neurochem Int. 2006 Jan;48(2):144-50. Epub 2005 Oct 26.
16. ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors. Duflot S, etal., Mol Cell Biol. 2004 Apr;24(7):2710-9.
17. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Fenton RA, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H718-25. Epub 2009 Jun 12.
18. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
19. The role of the basal forebrain adenosine receptors in sleep homeostasis. Gass N, etal., Neuroreport. 2009 Jul 15;20(11):1013-8.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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PMID:1658635   PMID:11952152   PMID:12106679   PMID:12381818   PMID:12697266   PMID:12789654   PMID:12821393   PMID:12974671   PMID:15057516   PMID:15241185   PMID:15255939   PMID:15283758  
PMID:15308482   PMID:15681707   PMID:15719142   PMID:16055264   PMID:16683708   PMID:16696848   PMID:16707501   PMID:17254024   PMID:17372967   PMID:17428973   PMID:17497078   PMID:17512911  
PMID:17516542   PMID:17548208   PMID:17622285   PMID:17664389   PMID:17965278   PMID:17982009   PMID:18007182   PMID:18052983   PMID:18054436   PMID:18163981   PMID:18313046   PMID:18322364  
PMID:18360306   PMID:18397365   PMID:18480183   PMID:18584206   PMID:18849358   PMID:18940592   PMID:18947392   PMID:19110076   PMID:19139607   PMID:19146833   PMID:19212009   PMID:19344634  
PMID:19427366   PMID:19477241   PMID:19619617   PMID:19781535   PMID:19782066   PMID:19822132   PMID:19908252   PMID:19995597   PMID:20054814   PMID:20109537   PMID:20237259   PMID:20500549  
PMID:20730620   PMID:21061016   PMID:21186374   PMID:21335481   PMID:21764782   PMID:21878793   PMID:21983553   PMID:21993001   PMID:22064330   PMID:22126400   PMID:22150479   PMID:22233927  
PMID:22323824   PMID:22389722   PMID:22449383   PMID:23106524   PMID:23221044   PMID:23598433   PMID:23613526   PMID:23783558   PMID:23810661   PMID:24014158   PMID:24259587   PMID:24309216  
PMID:24352876   PMID:24513151   PMID:24845382   PMID:25232008   PMID:25251152   PMID:25401477   PMID:25661317   PMID:25667928   PMID:25907806   PMID:26010290   PMID:26658041   PMID:26709861  
PMID:26728617   PMID:27005940   PMID:27060487   PMID:27134041   PMID:27301321   PMID:27301342   PMID:27792010   PMID:28446460   PMID:28882563   PMID:29149028   PMID:29380238   PMID:29514102  
PMID:31346513   PMID:31868057   PMID:31909494   PMID:33174009   PMID:33391483   PMID:34830353   PMID:35653908   PMID:37330931   PMID:37714421  
1 to 10 of 10 rows



Adora1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,210,922 - 48,247,826 (-)NCBIGRCr8
mRatBN7.21345,658,872 - 45,695,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,658,872 - 45,695,801 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,270,569 - 48,302,744 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,558,626 - 49,590,806 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,823,488 - 46,855,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
ADORA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,127,726 - 203,167,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,090,654 - 203,167,405 (+)EnsemblGRCh38hg38GRCh38
GRCh371203,096,854 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,363,459 - 201,403,156 (+)NCBINCBI36Build 36hg18NCBI36
Build 341199,791,438 - 199,868,189NCBI
Celera1176,226,082 - 176,265,774 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,262,408 - 174,301,662 (+)NCBIHuRef
CHM1_11204,519,171 - 204,558,852 (+)NCBICHM1_1
T2T-CHM13v2.01202,390,478 - 202,430,156 (+)NCBIT2T-CHM13v2.0
Adora1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,126,953 - 134,163,195 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,126,963 - 134,163,169 (-)EnsemblGRCm39 Ensembl
GRCm381134,199,215 - 134,235,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,199,223 - 134,235,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371136,095,799 - 136,132,008 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,015,633 - 136,051,842 (-)NCBIMGSCv36mm8
Celera1136,811,737 - 136,847,932 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.15NCBI
Adora1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,149,689 - 39,187,688 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,148,811 - 39,183,577 (+)NCBIChiLan1.0ChiLan1.0
ADORA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,210,718 - 46,250,302 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,178,264 - 46,216,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,728,751 - 178,769,066 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,023,466 - 183,063,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,023,466 - 183,063,760 (+)Ensemblpanpan1.1panPan2
ADORA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1744,819 - 74,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl744,820 - 73,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7100,548 - 128,787 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0755,302 - 84,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl755,305 - 83,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,539 - 71,770 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07153,116 - 181,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07175,551 - 203,789 (-)NCBIUU_Cfam_GSD_1.0
Adora1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,195,448 - 72,227,851 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,429,817 - 1,462,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,430,128 - 1,508,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,835,921 - 113,872,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,835,279 - 113,875,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,293,656 - 125,331,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,180,898 - 26,221,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,182,446 - 26,220,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,957,323 - 26,997,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,674,927 - 7,705,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,674,164 - 7,705,736 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Adora1
165 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir150rno-miR-150-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:139
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000004602
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134463918245700190Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat

1 to 10 of 34 rows
D13Hmgc03  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,689,077 - 45,689,314 (+)MAPPERmRatBN7.2
Rnor_6.01351,070,083 - 51,070,319NCBIRnor6.0
Rnor_5.01356,125,418 - 56,125,654UniSTSRnor5.0
RGSC_v3.41347,187,081 - 47,187,317UniSTSRGSC3.4
Celera1346,017,042 - 46,017,266UniSTS
Cytogenetic Map13q13UniSTS
BB176431  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81348,213,949 - 48,214,049 (+)Marker Load Pipeline
mRatBN7.21345,661,914 - 45,662,013 (+)MAPPERmRatBN7.2
Rnor_6.01351,042,925 - 51,043,023NCBIRnor6.0
Rnor_5.01356,098,605 - 56,098,703UniSTSRnor5.0
RGSC_v3.41347,159,719 - 47,159,817UniSTSRGSC3.4
Celera1345,989,983 - 45,990,081UniSTS
Cytogenetic Map13q13UniSTS
UniSTS:141040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,662,660 - 45,662,839 (+)MAPPERmRatBN7.2
Rnor_6.01351,043,671 - 51,043,849NCBIRnor6.0
Rnor_5.01356,099,351 - 56,099,529UniSTSRnor5.0
RGSC_v3.41347,160,465 - 47,160,643UniSTSRGSC3.4
Celera1345,990,729 - 45,990,907UniSTS
Cytogenetic Map13q13UniSTS


This gene Adora1 is modified in the following models/strains:
SS-Adora1em4Mcwi     SS-Adora1em3Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 87 86 55 25 55 6 214 97 93 45 60 31


1 to 20 of 20 rows
RefSeq Transcripts NM_001429640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB001089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M69045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000004602   ⟹   ENSRNOP00000004602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,658,872 - 45,695,801 (-)Ensembl
Rnor_6.0 Ensembl1351,042,248 - 51,076,165 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078993   ⟹   ENSRNOP00000073958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1351,043,334 - 51,076,852 (-)Ensembl
RefSeq Acc Id: NM_017155   ⟹   NP_058851
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,214,523 - 48,246,831 (-)NCBI
mRatBN7.21345,662,488 - 45,694,801 (-)NCBI
Rnor_6.01351,043,498 - 51,075,806 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
RGSC_v3.41347,160,292 - 47,192,804 (-)RGD
Celera1345,990,556 - 46,022,753 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249859   ⟹   XP_006249921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,804 (-)NCBI
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.01351,042,111 - 51,076,906 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090617   ⟹   XP_038946545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,293 (-)NCBI
mRatBN7.21345,658,872 - 45,695,595 (-)NCBI
RefSeq Acc Id: XM_039090618   ⟹   XP_038946546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,804 (-)NCBI
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
RefSeq Acc Id: XM_039090619   ⟹   XP_038946547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,293 (-)NCBI
mRatBN7.21345,658,872 - 45,695,596 (-)NCBI
RefSeq Acc Id: XM_039090620   ⟹   XP_038946548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,826 (-)NCBI
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
RefSeq Acc Id: XM_063272203   ⟹   XP_063128273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,294 (-)NCBI
RefSeq Acc Id: NP_058851   ⟸   NM_017155
- UniProtKB: P25099 (UniProtKB/Swiss-Prot),   A6ICB1 (UniProtKB/TrEMBL),   O08766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249921   ⟸   XM_006249859
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000004602   ⟸   ENSRNOT00000004602
Ensembl Acc Id: ENSRNOP00000073958   ⟸   ENSRNOT00000078993
RefSeq Acc Id: XP_038946548   ⟸   XM_039090620
- Peptide Label: isoform X2
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-P25099-F1-model_v2 AlphaFold P25099 1-326 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698833
Promoter ID:EPDNEW_R9352
Type:multiple initiation site
Name:Adora1_1
Description:adenosine A1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01351,076,239 - 51,076,299EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18247 BioCyc
Ensembl Genes ENSRNOG00000003442 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000084234 ENTREZGENE
Ensembl Transcript ENSRNOT00000004602.3 UniProtKB/Swiss-Prot
  ENSRNOT00000172800 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Adeno_A1_rcpt UniProtKB/Swiss-Prot
  Adenosn_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29290 UniProtKB/Swiss-Prot
NCBI Gene 29290 ENTREZGENE
PANTHER ADENOSINE RECEPTOR A1 UniProtKB/Swiss-Prot
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADORA1 RGD
PhenoGen Adora1 PhenoGen
PRINTS ADENOSINEA1R UniProtKB/Swiss-Prot
  ADENOSINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003442 RatGTEx
  ENSRNOG00000084234 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC203917
UniProt A6ICB1 ENTREZGENE, UniProtKB/TrEMBL
  AA1R_RAT UniProtKB/Swiss-Prot
  O08766 ENTREZGENE, UniProtKB/TrEMBL
  P25099 ENTREZGENE
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Adora1  adenosine A1 receptor    adenosine A1 receptor   Name updated 625702 APPROVED
2002-06-10 Adora1  adenosine A1 receptor       Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_drugs 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) increases urine flow and sodium excretion 628573
gene_expression expressed in the cerebellum 631744
gene_expression expressed in many regions of the brain including cortex, cerebellum, hippocampus, and thalamus 69743
gene_expression distributed along nephron and in outer medullary desceding vasa recta; localized to specific nephron segments, including glomeruli, thick ascending limb and papillary collecting duct 628573
gene_expression expressed in renal cortex and medulla 628573
gene_expression protein and mRNA expressed at high levels in the preglomerular microvessels (PGMVs) of kidney 628573
gene_function inhibits adenylyl cyclase activity 69743
gene_function antidiuretic and antinatriuretic adenosine receptor 628573
gene_process involved in the regulation of arterial pressure and heart rate 631806
gene_process plays a role in adaptation in the kidney to promote sodium excretion 628562
gene_process administration of agonists cause vasoconstriction of the preglomerular microvessels (PGMVs) and potentiation of angiotensin II-induced changes in renal vascular resistance, reduction of the glomerular filtration rate and inhibition renin release 628573
gene_process may mediate antinatriuretic effects of adenosine 628573
gene_product member of the G-protein coupled receptor family 631744
gene_protein encodes a protein sequence of 326 amino acids 631744
gene_protein 38 kDa 628351
gene_protein 39 kDa 628573
gene_regulation a high salt diet (4% NaCl for 3 weeks) decreases mRNA expression 628573
gene_transcript mRNA transcripts of 5.6 and 3.1 kb are detected 69743