Lig3 (DNA ligase 3) - Rat Genome Database

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Gene: Lig3 (DNA ligase 3) Rattus norvegicus
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Symbol: Lig3
Name: DNA ligase 3
RGD ID: 1309875
Description: Enables DNA ligase activity. Predicted to be involved in DNA metabolic process; mitochondrion organization; and negative regulation of mitochondrial DNA replication. Predicted to act upstream of or within double-strand break repair via nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm and synaptonemal complex. Predicted to be part of DNA ligase III-XRCC1 complex. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-hydroperoxycyclophosphamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA ligase (ATP) 3; ligase III, DNA, ATP-dependent; LOC303369
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp301
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,215,371 - 68,238,705 (+)NCBIGRCr8
mRatBN7.21067,717,808 - 67,741,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,717,812 - 67,798,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,337,877 - 72,361,210 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,843,252 - 71,866,586 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,305,075 - 67,328,397 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,134,734 - 70,158,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,134,729 - 70,158,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,765,441 - 69,788,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,000,287 - 71,021,398 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,013,909 - 71,035,020 (+)NCBI
Celera1066,662,184 - 66,683,295 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Lig3Ratmiddle cerebral artery infarction  IEP 2302580associated with transient cerebral ischemia and protein:increased expression:brainRGD 
Lig3Ratpancreatic cancer resistanceISOLIG3 (Homo sapiens)2317363DNA:SNP:intron:rs 2074522 (human)RGD 
Object Symbol
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Reference
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Original Reference(s)
Lig3RatCardiac Arrhythmias  ISOLIG3 (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiac arrhythmiaClinVar 
Lig3Ratgenetic disease  ISOLIG3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Lig3Ratmitochondrial DNA depletion syndrome 20  ISOLIG3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Lig3RatNeurodevelopmental Disorders  ISOLIG3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
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Original Reference(s)
Lig3Ratmitochondrial DNA depletion syndrome 20  ISOLIG3 (Homo sapiens)7240710 OMIM 

1 to 20 of 96 rows

  
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Original Reference(s)
Lig3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOLIG3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LIG3 mRNACTDPMID:22079256
Lig3Rat17alpha-ethynylestradiol multiple interactionsISOLig3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG3 mRNACTDPMID:17942748
Lig3Rat17beta-estradiol increases expressionISOLig3 (Mus musculus)6480464Estradiol results in increased expression of LIG3 mRNACTDPMID:39298647
Lig3Rat1H-pyrazole increases expressionISOLig3 (Mus musculus)6480464pyrazole results in increased expression of LIG3 mRNACTDPMID:17945193
Lig3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOLig3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG3 mRNACTDPMID:17942748
Lig3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLIG3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of LIG3 mRNACTDPMID:20106945 and PMID:21632981
Lig3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLig3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LIG3 mRNACTDPMID:21570461
Lig3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of LIG3 mRNACTDPMID:21215274 and PMID:33387578
Lig3Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of LIG3 mRNACTDPMID:21346803
Lig3Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOLIG3 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LIG3 mRNACTDPMID:28628672
Lig3Rat4-hydroperoxycyclophosphamide decreases expressionEXP 6480464perfosfamide results in decreased expression of LIG3 mRNACTDPMID:11754170
Lig3Rat4-hydroxyphenyl retinamide increases expressionISOLig3 (Mus musculus)6480464Fenretinide results in increased expression of LIG3 mRNACTDPMID:28973697
Lig3Ratacrylamide decreases expressionISOLIG3 (Homo sapiens)6480464Acrylamide results in decreased expression of LIG3 mRNACTDPMID:32763439
Lig3Rataflatoxin B1 increases expressionISOLig3 (Mus musculus)6480464Aflatoxin B1 results in increased expression of LIG3 mRNACTDPMID:19770486
Lig3Rataflatoxin B1 increases methylationISOLIG3 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of LIG3 intronCTDPMID:30157460
Lig3Rataristolochic acid A decreases expressionISOLIG3 (Homo sapiens)6480464aristolochic acid I results in decreased expression of LIG3 mRNACTDPMID:33212167
Lig3Ratarsane decreases expressionISOLIG3 (Homo sapiens)6480464Arsenic results in decreased expression of LIG3 mRNA and Arsenic results in decreased expression of LIG3 proteinCTDPMID:21332098
Lig3Ratarsane multiple interactionsISOLIG3 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LIG3 mRNA more ...CTDPMID:21332098 and PMID:39836092
Lig3Ratarsenic atom decreases expressionISOLIG3 (Homo sapiens)6480464Arsenic results in decreased expression of LIG3 mRNA and Arsenic results in decreased expression of LIG3 proteinCTDPMID:21332098
Lig3Ratarsenic atom multiple interactionsISOLIG3 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LIG3 mRNA more ...CTDPMID:21332098 and PMID:39836092

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Biological Process
1 to 20 of 28 rows

  
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Original Reference(s)
Lig3Ratbase-excision repair involved_inISOLIG3 (Homo sapiens)1624291 PMID:19589734RGDPMID:19589734
Lig3Ratbase-excision repair involved_inIEAUniProtKB:P49916 and ensembl:ENSP000003677871600115GO_REF:0000107EnsemblGO_REF:0000107
Lig3Ratbase-excision repair involved_inISOLIG3 (Homo sapiens) and UniProtKB:P49916-11624291 PMID:24674627RGDPMID:24674627
Lig3RatDNA biosynthetic process involved_inIEAInterPro:IPR0009771600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Lig3RatDNA recombination involved_inIEAUniProtKB-KW:KW-02331600115GO_REF:0000043UniProtGO_REF:0000043
Lig3RatDNA recombination involved_inIEAInterPro:IPR012308 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA repair involved_inIEAInterPro:IPR012308 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA repair involved_inIEAARBA:ARBA000290081600115GO_REF:0000117UniProtGO_REF:0000117
Lig3RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Lig3RatDNA replication involved_inIEAUniProtKB-KW:KW-02351600115GO_REF:0000043UniProtGO_REF:0000043
Lig3Ratdouble-strand break repair involved_inISOLIG3 (Homo sapiens)1624291 PMID:19589734RGDPMID:19589734
Lig3Ratdouble-strand break repair involved_inIEAUniProtKB:P49916 and ensembl:ENSP000003677871600115GO_REF:0000107EnsemblGO_REF:0000107
Lig3Ratdouble-strand break repair involved_inIBAMGI:109152 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lig3Ratdouble-strand break repair via alternative nonhomologous end joining involved_inISOLig3 (Mus musculus)1624291 PMID:21655080RGDPMID:21655080
Lig3Ratdouble-strand break repair via alternative nonhomologous end joining involved_inISOLIG3 (Homo sapiens) and UniProtKB:P49916-31624291UniProtKB:P13010 and PMID:24837021RGDPMID:24837021
Lig3Ratdouble-strand break repair via nonhomologous end joining acts_upstream_of_or_withinISOLig3 (Mus musculus)1624291 PMID:21655080RGDPMID:21655080
Lig3Ratlagging strand elongation involved_inIBAPANTHER:PTN000048696 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lig3Ratmitochondrial DNA repair involved_inISOLIG3 (Homo sapiens) and UniProtKB:P49916-11624291 PMID:21390132RGDPMID:21390132
Lig3Ratmitochondrial DNA repair involved_inIEAUniProtKB:P49916 and ensembl:ENSP000003677871600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 12 of 12 rows

  
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Original Reference(s)
Lig3Ratcondensed nuclear chromosome located_inISOLig3 (Mus musculus)1624291 PMID:9001252RGDPMID:9001252
Lig3RatDNA ligase III-XRCC1 complex part_ofISOLIG3 (Homo sapiens) and UniProtKB:P49916-31624291 PMID:8532526RGDPMID:8532526
Lig3Ratmitochondrion located_inISOLIG3 (Homo sapiens) and UniProtKB:P49916-11624291 PMID:10207110 and PMID:24837021RGDPMID:10207110 and PMID:24837021
Lig3Ratmitochondrion is_active_inISOLIG3 (Homo sapiens)1624291 PMID:24674627RGDPMID:24674627
Lig3Ratmitochondrion is_active_inIEAUniProtKB:P49916 and ensembl:ENSP000003677871600115GO_REF:0000107EnsemblGO_REF:0000107
Lig3Ratnucleoplasm located_inIEAUniProtKB:P49916 and ensembl:ENSP000003677871600115GO_REF:0000107EnsemblGO_REF:0000107
Lig3Ratnucleoplasm located_inISOLIG3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Lig3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Lig3Ratnucleus is_active_inIBAMGI:101789 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lig3Ratnucleus located_inISOLIG3 (Homo sapiens) and UniProtKB:P49916-31624291 PMID:10207110 and PMID:24837021RGDPMID:10207110 and PMID:24837021
Lig3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Lig3Ratsynaptonemal complex located_inISOLig3 (Mus musculus)1624291 PMID:9001252RGDPMID:9001252
1 to 12 of 12 rows

Molecular Function
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Original Reference(s)
Lig3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Lig3RatATP binding enablesIEAInterPro:IPR000977 and InterPro:IPR0123101600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA binding enablesIEAInterPro:IPR001510 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA ligase (ATP) activity enablesISOLIG3 (Homo sapiens) and UniProtKB:P49916-31624291 PMID:7565692RGDPMID:7565692
Lig3RatDNA ligase (ATP) activity enablesIEAEC:6.5.1.11600115GO_REF:0000003UniProtGO_REF:0000003
Lig3RatDNA ligase (ATP) activity enablesIBAFB:FBgn0262619 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lig3RatDNA ligase (ATP) activity enablesIEAInterPro:IPR000977 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA ligase (ATP) activity enablesISOLIG3 (Homo sapiens) and UniProtKB:P49916-11624291 PMID:10207110RGDPMID:10207110
Lig3RatDNA ligase activity  IDA 2302580 RGD 
Lig3RatDNA ligase activity enablesISOLIG3 (Homo sapiens)1624291 PMID:19589734 and PMID:9809069RGDPMID:19589734 and PMID:9809069
Lig3RatDNA ligase activity enablesIEAUniProtKB:P49916 and ensembl:ENSP000003677871600115GO_REF:0000107EnsemblGO_REF:0000107
Lig3RatDNA ligase activity enablesIEAInterPro:IPR0160591600115GO_REF:0000002InterProGO_REF:0000002
Lig3RatDNA ligase activity enablesISOLIG3 (Homo sapiens) and UniProtKB:P49916-11624291 PMID:24674627RGDPMID:24674627
Lig3Ratligase activity enablesIEAUniProtKB-KW:KW-04361600115GO_REF:0000043UniProtGO_REF:0000043
Lig3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Lig3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Lig3Ratprotein binding enablesISOLIG3 (Homo sapiens) and UniProtKB:P49916-31624291UniProtKB:P18887 and PMID:8532526RGDPMID:8532526
Lig3Ratprotein binding enablesISOLIG3 (Homo sapiens)1624291UniProtKB:P06746 more ...RGDPMID:15744309 more ...
Lig3Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
Lig3Ratzinc ion binding enablesIEAInterPro:IPR001510 and InterPro:IPR0369571600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  
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Original Reference(s)
Lig3Ratnucleotide excision repair pathway   ISOLIG3 (Homo sapiens)7246935 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Lig3Ratbase excision repair pathway  IEA 6907045 KEGGrno:03410

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
4. DNA repair gene polymorphisms and risk of pancreatic cancer. Li D, etal., Clin Cancer Res. 2009 Jan 15;15(2):740-6.
5. Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair. Li N, etal., DNA Repair (Amst). 2007 Sep 1;6(9):1297-306. Epub 2007 Apr 6.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
1 to 11 of 11 rows
PMID:7565692   PMID:8532526   PMID:9001252   PMID:9809069   PMID:10207110   PMID:12477932   PMID:16648486   PMID:19589734   PMID:21390131   PMID:21390132   PMID:21655080   PMID:21878356  
PMID:24674627   PMID:24837021   PMID:37315345  



Lig3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,215,371 - 68,238,705 (+)NCBIGRCr8
mRatBN7.21067,717,808 - 67,741,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,717,812 - 67,798,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,337,877 - 72,361,210 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,843,252 - 71,866,586 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,305,075 - 67,328,397 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,134,734 - 70,158,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,134,729 - 70,158,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,765,441 - 69,788,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,000,287 - 71,021,398 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,013,909 - 71,035,020 (+)NCBI
Celera1066,662,184 - 66,683,295 (+)NCBICelera
Cytogenetic Map10q26NCBI
LIG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,980,512 - 35,010,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,980,512 - 35,009,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371733,307,531 - 33,336,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,331,651 - 30,356,201 (+)NCBINCBI36Build 36hg18NCBI36
Build 341730,331,696 - 30,355,936NCBI
Celera1730,217,714 - 30,242,284 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,493,447 - 29,518,012 (+)NCBIHuRef
CHM1_11733,371,911 - 33,396,481 (+)NCBICHM1_1
T2T-CHM13v2.01735,928,368 - 35,957,659 (+)NCBIT2T-CHM13v2.0
Lig3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,671,977 - 82,695,100 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,671,934 - 82,695,100 (+)EnsemblGRCm39 Ensembl
GRCm381182,781,109 - 82,804,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,781,108 - 82,804,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,594,637 - 82,617,776 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,597,330 - 82,620,469 (+)NCBIMGSCv36mm8
Celera1192,400,612 - 92,423,646 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.23NCBI
Lig3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554819,696,054 - 9,715,637 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554819,696,050 - 9,716,154 (+)NCBIChiLan1.0ChiLan1.0
LIG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21929,456,509 - 29,487,762 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11731,342,056 - 31,367,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,776,483 - 21,805,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,073,487 - 22,097,754 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,074,046 - 22,095,220 (-)Ensemblpanpan1.1panPan2
LIG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,346,275 - 38,366,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,346,199 - 38,366,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,569,261 - 37,590,027 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,158,185 - 39,178,954 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,155,826 - 39,178,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,940,790 - 37,961,563 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,226,708 - 38,247,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,314,196 - 38,334,891 (-)NCBIUU_Cfam_GSD_1.0
Lig3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,328,228 - 37,350,583 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538206,839 - 226,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538206,179 - 228,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,153,397 - 40,183,622 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,153,105 - 40,205,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,714,491 - 41,773,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,487,953 - 28,511,945 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,490,434 - 28,511,130 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660751,476,469 - 1,500,221 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lig3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,872,357 - 2,893,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248752,871,944 - 2,907,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Lig3
43 total Variants

Predicted Target Of
Summary Value
Count of predictions:453
Count of miRNA genes:240
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000055982
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 89 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat

1 to 10 of 89 rows
D10Chm170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,720,219 - 67,720,443 (+)MAPPERmRatBN7.2
Rnor_6.01070,137,131 - 70,137,354NCBIRnor6.0
Rnor_5.01069,767,838 - 69,768,061UniSTSRnor5.0
RGSC_v3.41071,002,650 - 71,002,873UniSTSRGSC3.4
Celera1066,664,547 - 66,664,770UniSTS
Cytogenetic Map10q26UniSTS
BE109015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,728,917 - 67,729,074 (+)MAPPERmRatBN7.2
Rnor_6.01070,145,829 - 70,145,985NCBIRnor6.0
Rnor_5.01069,776,536 - 69,776,692UniSTSRnor5.0
RGSC_v3.41071,011,348 - 71,011,504UniSTSRGSC3.4
Celera1066,673,245 - 66,673,401UniSTS
Cytogenetic Map10q26UniSTS
RH134877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,716,622 - 67,716,808 (+)MAPPERmRatBN7.2
Rnor_6.01070,133,534 - 70,133,719NCBIRnor6.0
Rnor_5.01069,764,241 - 69,764,426UniSTSRnor5.0
RGSC_v3.41070,999,053 - 70,999,238UniSTSRGSC3.4
Celera1066,660,950 - 66,661,135UniSTS
Cytogenetic Map10q26UniSTS
RH141104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,739,005 - 67,739,212 (+)MAPPERmRatBN7.2
Rnor_6.01070,155,916 - 70,156,122NCBIRnor6.0
Rnor_5.01069,786,623 - 69,786,829UniSTSRnor5.0
RGSC_v3.41071,021,435 - 71,021,641UniSTSRGSC3.4
Celera1066,683,332 - 66,683,538UniSTS
Cytogenetic Map10q26UniSTS
MARC_3929-3930:996679185:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,733,525 - 67,734,591 (+)MAPPERmRatBN7.2
Rnor_6.01070,150,436 - 70,151,501NCBIRnor6.0
Rnor_5.01069,781,143 - 69,782,208UniSTSRnor5.0
RGSC_v3.41071,015,955 - 71,017,020UniSTSRGSC3.4
Celera1066,677,852 - 66,678,917UniSTS
Cytogenetic Map10q26UniSTS
Lig3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81068,224,677 - 68,225,542 (+)Marker Load Pipeline
mRatBN7.21067,727,114 - 67,727,979 (+)MAPPERmRatBN7.2
Rnor_6.01070,144,026 - 70,144,890NCBIRnor6.0
Rnor_5.01069,774,733 - 69,775,597UniSTSRnor5.0
RGSC_v3.41071,009,545 - 71,010,409UniSTSRGSC3.4
Celera1066,671,442 - 66,672,306UniSTS
Cytogenetic Map10q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001394035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000055982   ⟹   ENSRNOP00000052836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,717,857 - 67,738,968 (+)Ensembl
Rnor_6.0 Ensembl1070,134,768 - 70,155,881 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076703   ⟹   ENSRNOP00000068142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1070,153,427 - 70,154,512 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076739   ⟹   ENSRNOP00000068489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,717,812 - 67,741,142 (+)Ensembl
Rnor_6.0 Ensembl1070,134,729 - 70,158,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084076   ⟹   ENSRNOP00000069379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,717,812 - 67,798,414 (+)Ensembl
Rnor_6.0 Ensembl1070,136,855 - 70,156,772 (+)Ensembl
RefSeq Acc Id: NM_001394035   ⟹   NP_001380964
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,371 - 68,238,703 (+)NCBI
mRatBN7.21067,717,808 - 67,741,141 (+)NCBI
RefSeq Acc Id: NM_001394036   ⟹   NP_001380965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,371 - 68,238,703 (+)NCBI
mRatBN7.21067,717,808 - 67,741,141 (+)NCBI
RefSeq Acc Id: NR_172067
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,371 - 68,238,703 (+)NCBI
mRatBN7.21067,717,808 - 67,741,141 (+)NCBI
RefSeq Acc Id: XM_008768020   ⟹   XP_008766242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,595 - 68,238,705 (+)NCBI
mRatBN7.21067,719,943 - 67,741,141 (+)NCBI
Rnor_6.01070,134,922 - 70,158,051 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768021   ⟹   XP_008766243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,602 - 68,238,705 (+)NCBI
mRatBN7.21067,719,943 - 67,741,141 (+)NCBI
Rnor_6.01070,134,925 - 70,158,051 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086028   ⟹   XP_038941956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,217,248 - 68,238,705 (+)NCBI
mRatBN7.21067,719,677 - 67,741,141 (+)NCBI
RefSeq Acc Id: XM_039086029   ⟹   XP_038941957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,885 - 68,238,705 (+)NCBI
mRatBN7.21067,718,320 - 67,741,141 (+)NCBI
RefSeq Acc Id: XM_039086030   ⟹   XP_038941958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,886 - 68,238,705 (+)NCBI
mRatBN7.21067,718,537 - 67,741,141 (+)NCBI
RefSeq Acc Id: XM_039086031   ⟹   XP_038941959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,593 - 68,230,798 (+)NCBI
mRatBN7.21067,719,943 - 67,733,236 (+)NCBI
RefSeq Acc Id: XM_063269079   ⟹   XP_063125149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,604 - 68,238,705 (+)NCBI
RefSeq Acc Id: XM_063269080   ⟹   XP_063125150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,216,888 - 68,238,705 (+)NCBI
RefSeq Acc Id: XM_063269081   ⟹   XP_063125151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,601 - 68,235,180 (+)NCBI
RefSeq Acc Id: XM_063269082   ⟹   XP_063125152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,217,510 - 68,238,705 (+)NCBI
RefSeq Acc Id: XM_063269083   ⟹   XP_063125153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,215,600 - 68,235,180 (+)NCBI
1 to 5 of 17 rows
1 to 5 of 17 rows
RefSeq Acc Id: XP_008766243   ⟸   XM_008768021
- Peptide Label: isoform X4
- UniProtKB: A0A096MKE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766242   ⟸   XM_008768020
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JV76 (UniProtKB/TrEMBL),   A6HHE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052836   ⟸   ENSRNOT00000055982
Ensembl Acc Id: ENSRNOP00000069379   ⟸   ENSRNOT00000084076
Ensembl Acc Id: ENSRNOP00000068489   ⟸   ENSRNOT00000076739
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MKE9-F1-model_v2 AlphaFold A0A096MKE9 1-1002 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697515
Promoter ID:EPDNEW_R8039
Type:initiation region
Name:Lig3_1
Description:DNA ligase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,134,766 - 70,134,826EPDNEW


1 to 40 of 57 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23919 BioCyc
Ensembl Genes ENSRNOG00000021815 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055982 ENTREZGENE
  ENSRNOT00000055982.5 UniProtKB/TrEMBL
  ENSRNOT00000076739 ENTREZGENE
  ENSRNOT00000076739.3 UniProtKB/TrEMBL
  ENSRNOT00000084076 ENTREZGENE
  ENSRNOT00000084076.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3260.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.30.1490.70 UniProtKB/TrEMBL
  3.30.1740.10 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
  DNA ligase/mRNA capping enzyme UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135421 IMAGE-MGC_LOAD
InterPro ATP-dep_DNA_ligase UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  DNA_ligase UniProtKB/TrEMBL
  DNA_ligase_A_C UniProtKB/TrEMBL
  DNA_ligase_A_M UniProtKB/TrEMBL
  DNA_ligase_A_N UniProtKB/TrEMBL
  DNA_ligase_CS UniProtKB/TrEMBL
  DNA_ligase_N_sf UniProtKB/TrEMBL
  LIG3_BRCT UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Znf_PARP UniProtKB/TrEMBL
  Znf_PARP_sf UniProtKB/TrEMBL
MGC_CLONE MGC:95328 IMAGE-MGC_LOAD
NCBI Gene 303369 ENTREZGENE
PANTHER DNA LIGASE 1/3 FAMILY MEMBER UniProtKB/TrEMBL
  DNA LIGASE 3 UniProtKB/TrEMBL
Pfam DNA_ligase_A_C UniProtKB/TrEMBL
  DNA_ligase_A_M UniProtKB/TrEMBL
  DNA_ligase_A_N UniProtKB/TrEMBL
  LIG3_BRCT UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
PhenoGen Lig3 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
  DNA_LIGASE_A1 UniProtKB/TrEMBL
1 to 40 of 57 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Lig3  DNA ligase 3  Lig3  ligase III, DNA, ATP-dependent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lig3  ligase III, DNA, ATP-dependent  Lig3_predicted  ligase III, DNA, ATP-dependent (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lig3_predicted  ligase III, DNA, ATP-dependent (predicted)      Symbol and Name status set to approved 70820 APPROVED