Lig3 (DNA ligase 3) - Rat Genome Database

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Gene: Lig3 (DNA ligase 3) Ictidomys tridecemlineatus
Analyze
Symbol: Lig3
Name: DNA ligase 3
RGD ID: 12722924
Description: ENCODES a protein that exhibits DNA ligase activity (ortholog); INVOLVED IN DNA ligation (ortholog); double-strand break repair via alternative nonhomologous end joining (ortholog); double-strand break repair via nonhomologous end joining (ortholog); PARTICIPATES IN nucleotide excision repair pathway; ASSOCIATED WITH Cardiac Arrhythmias (ortholog); genetic disease (ortholog); middle cerebral artery infarction (ortholog); FOUND IN condensed nuclear chromosome (ortholog); mitochondrion (ortholog); synaptonemal complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA ligase 3, transcript variant X1; DNA ligase 3, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,328,228 - 37,350,583 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538206,839 - 226,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538206,179 - 228,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lig3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,328,228 - 37,350,583 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538206,839 - 226,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538206,179 - 228,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,980,512 - 35,010,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,980,512 - 35,009,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371733,307,531 - 33,336,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,331,651 - 30,356,201 (+)NCBINCBI36Build 36hg18NCBI36
Build 341730,331,696 - 30,355,936NCBI
Celera1730,217,714 - 30,242,284 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,493,447 - 29,518,012 (+)NCBIHuRef
CHM1_11733,371,911 - 33,396,481 (+)NCBICHM1_1
T2T-CHM13v2.01735,928,368 - 35,957,659 (+)NCBIT2T-CHM13v2.0
Lig3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,671,977 - 82,695,100 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,671,934 - 82,695,100 (+)EnsemblGRCm39 Ensembl
GRCm381182,781,109 - 82,804,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,781,108 - 82,804,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,594,637 - 82,617,776 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,597,330 - 82,620,469 (+)NCBIMGSCv36mm8
Celera1192,400,612 - 92,423,646 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.23NCBI
Lig3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,215,371 - 68,238,705 (+)NCBIGRCr8
mRatBN7.21067,717,808 - 67,741,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,717,812 - 67,798,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,337,877 - 72,361,210 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,843,252 - 71,866,586 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,305,075 - 67,328,397 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,134,734 - 70,158,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,134,729 - 70,158,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,765,441 - 69,788,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,000,287 - 71,021,398 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,013,909 - 71,035,020 (+)NCBI
Celera1066,662,184 - 66,683,295 (+)NCBICelera
Cytogenetic Map10q26NCBI
Lig3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554819,696,054 - 9,715,637 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554819,696,050 - 9,716,154 (+)NCBIChiLan1.0ChiLan1.0
LIG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21929,456,509 - 29,487,762 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11731,342,056 - 31,367,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,776,483 - 21,805,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,073,487 - 22,097,754 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,074,046 - 22,095,220 (-)Ensemblpanpan1.1panPan2
LIG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,346,275 - 38,366,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,346,199 - 38,366,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,569,261 - 37,590,027 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,158,185 - 39,178,954 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,155,826 - 39,178,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,940,790 - 37,961,563 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,226,708 - 38,247,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,314,196 - 38,334,891 (-)NCBIUU_Cfam_GSD_1.0
LIG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,153,397 - 40,183,622 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,153,105 - 40,205,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,714,491 - 41,773,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,487,953 - 28,511,945 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,490,434 - 28,511,130 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660751,476,469 - 1,500,221 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lig3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,872,357 - 2,893,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248752,871,944 - 2,907,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000006090   ⟹   ENSSTOP00000005449
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936538206,839 - 226,441 (-)Ensembl
RefSeq Acc Id: XM_005327765   ⟹   XP_005327822
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560237,328,228 - 37,350,583 (-)NCBI
SpeTri2.0NW_004936538206,179 - 228,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013359798   ⟹   XP_013215252
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560237,329,859 - 37,350,583 (-)NCBI
SpeTri2.0NW_004936538207,227 - 228,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040269132   ⟹   XP_040125066
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560237,330,755 - 37,350,583 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005327822 (Get FASTA)   NCBI Sequence Viewer  
  XP_013215252 (Get FASTA)   NCBI Sequence Viewer  
  XP_040125066 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005449.3
GenBank Protein KAG3269498 (Get FASTA)   NCBI Sequence Viewer  
  KAG3269499 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005327822   ⟸   XM_005327765
- Peptide Label: isoform X1
- UniProtKB: I3M790 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013215252   ⟸   XM_013359798
- Peptide Label: isoform X2
- UniProtKB: I3M790 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040125066   ⟸   XM_040269132
- Peptide Label: isoform X3
- UniProtKB: I3M790 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000005449   ⟸   ENSSTOT00000006090

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006065 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006090.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3260.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.30.1490.70 UniProtKB/TrEMBL
  3.30.1740.10 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
  DNA ligase/mRNA capping enzyme UniProtKB/TrEMBL
InterPro ATP-dep_DNA_ligase UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  DNA_ligase_ATP-dep UniProtKB/TrEMBL
  DNA_ligase_ATP-dep_C UniProtKB/TrEMBL
  DNA_ligase_ATP-dep_cent UniProtKB/TrEMBL
  DNA_ligase_ATP-dep_CS UniProtKB/TrEMBL
  DNA_ligase_ATP-dep_N UniProtKB/TrEMBL
  DNA_ligase_N_sf UniProtKB/TrEMBL
  LIG3_BRCT UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Znf_PARP UniProtKB/TrEMBL
  Znf_PARP_sf UniProtKB/TrEMBL
NCBI Gene Lig3 ENTREZGENE
PANTHER DNA LIGASE 1/3 FAMILY MEMBER UniProtKB/TrEMBL
  DNA LIGASE 3 UniProtKB/TrEMBL
Pfam DNA_ligase_A_C UniProtKB/TrEMBL
  DNA_ligase_A_M UniProtKB/TrEMBL
  DNA_ligase_A_N UniProtKB/TrEMBL
  LIG3_BRCT UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
PROSITE BRCT UniProtKB/TrEMBL
  DNA_LIGASE_A1 UniProtKB/TrEMBL
  DNA_LIGASE_A2 UniProtKB/TrEMBL
  DNA_LIGASE_A3 UniProtKB/TrEMBL
  PARP_ZN_FINGER_1 UniProtKB/TrEMBL
  PARP_ZN_FINGER_2 UniProtKB/TrEMBL
SMART BRCT UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
Superfamily-SCOP DNA ligase/mRNA capping enzyme, catalytic domain UniProtKB/TrEMBL
  Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF117018 UniProtKB/TrEMBL
  SSF50249 UniProtKB/TrEMBL
  SSF52113 UniProtKB/TrEMBL
UniProt I3M790 ENTREZGENE, UniProtKB/TrEMBL