ADPRH (ADP-ribosylarginine hydrolase) - Rat Genome Database

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Gene: ADPRH (ADP-ribosylarginine hydrolase) Homo sapiens
Analyze
Symbol: ADPRH
Name: ADP-ribosylarginine hydrolase
RGD ID: 732427
HGNC Page HGNC:269
Description: Enables ADP-ribosylarginine hydrolase activity; magnesium ion binding activity; and potassium ion binding activity. Involved in protein modification process. Predicted to be located in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: [Protein ADP-ribosylarginine] hydrolase; ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylhydrolase ARH1; ARH1; hARH1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,579,492 - 119,589,945 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,579,268 - 119,589,945 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,298,339 - 119,308,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,781,213 - 120,791,482 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,781,212 - 120,791,481NCBI
Celera3117,707,084 - 117,717,352 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,674,244 - 116,684,477 (+)NCBIHuRef
CHM1_13119,262,027 - 119,272,296 (+)NCBICHM1_1
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ADP-ribosylarginine hydrolase regulates cell proliferation and tumorigenesis. Kato J, etal., Cancer Res. 2011 Aug 1;71(15):5327-35. doi: 10.1158/0008-5472.CAN-10-0733. Epub 2011 Jun 22.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:8349667   PMID:9193669   PMID:12070318   PMID:12477932   PMID:15489334   PMID:15546898   PMID:17207965   PMID:19407395   PMID:21044950   PMID:21873635   PMID:23602568   PMID:25416956  
PMID:28514442   PMID:30472116   PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
ADPRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,579,492 - 119,589,945 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,579,268 - 119,589,945 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,298,339 - 119,308,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,781,213 - 120,791,482 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,781,212 - 120,791,481NCBI
Celera3117,707,084 - 117,717,352 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,674,244 - 116,684,477 (+)NCBIHuRef
CHM1_13119,262,027 - 119,272,296 (+)NCBICHM1_1
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBIT2T-CHM13v2.0
Adprh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,265,761 - 38,273,051 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,264,392 - 38,273,065 (-)EnsemblGRCm39 Ensembl
GRCm381638,445,399 - 38,452,689 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,444,030 - 38,452,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv371638,445,479 - 38,452,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,364,632 - 38,371,922 (-)NCBIMGSCv36mm8
Celera1638,855,860 - 38,863,141 (-)NCBICelera
Cytogenetic Map16B3- B4NCBI
cM Map1626.86NCBI
Adprh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,805,347 - 75,811,686 (+)NCBIGRCr8
mRatBN7.21162,299,831 - 62,306,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,299,793 - 62,306,931 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,112,358 - 71,118,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,774,605 - 63,780,944 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,825,271 - 62,831,602 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,861,772 - 64,868,112 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,861,768 - 64,868,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,241,824 - 67,248,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,079,175 - 64,085,514 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,136,763 - 64,143,100 (+)NCBI
Celera1161,801,429 - 61,807,769 (+)NCBICelera
Cytogenetic Map11q21NCBI
Adprh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,271,561 - 19,280,288 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,271,734 - 19,280,189 (+)NCBIChiLan1.0ChiLan1.0
ADPRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,557,027 - 117,567,644 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,561,804 - 117,572,422 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,702,236 - 116,713,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,614,819 - 123,625,353 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,614,819 - 123,625,353 (+)Ensemblpanpan1.1panPan2
ADPRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,218,633 - 23,226,844 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,218,101 - 23,224,667 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,248,543 - 23,257,013 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,456,653 - 23,464,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,456,638 - 23,463,631 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,259,063 - 23,267,535 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,294,668 - 23,303,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03323,864,155 - 23,872,630 (+)NCBIUU_Cfam_GSD_1.0
Adprh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602131,013,681 - 131,022,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,499,256 - 6,508,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,499,316 - 6,508,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADPRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,673,101 - 140,681,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,638,526 - 140,681,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213150,002,965 - 150,023,022 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADPRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,230,280 - 61,239,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,229,647 - 61,239,472 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,073,025 - 105,083,915 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adprh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,613,773 - 28,620,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,611,995 - 28,620,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADPRH
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1		 pathogenic
GRCh38/hg38 3q13.32-21.2(chr3:119117166-125920734)x1 copy number loss See cases [RCV000051546] Chr3:119117166..125920734 [GRCh38]
Chr3:118836013..125639577 [GRCh37]
Chr3:120318703..127122267 [NCBI36]
Chr3:3q13.32-21.2		 pathogenic
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q13.32-13.33(chr3:117844958-120797026)x4 copy number gain See cases [RCV000135591] Chr3:117844958..120797026 [GRCh38]
Chr3:117563805..120515873 [GRCh37]
Chr3:119046495..121998563 [NCBI36]
Chr3:3q13.32-13.33		 uncertain significance
GRCh38/hg38 3q13.31-21.1(chr3:115019074-122513398)x1 copy number loss See cases [RCV000135961] Chr3:115019074..122513398 [GRCh38]
Chr3:114737921..122232245 [GRCh37]
Chr3:116220611..123714935 [NCBI36]
Chr3:3q13.31-21.1		 pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q13.31-21.2(chr3:114122562-124532374)x1 copy number loss See cases [RCV000142009] Chr3:114122562..124532374 [GRCh38]
Chr3:113841409..124251221 [GRCh37]
Chr3:115324099..125733911 [NCBI36]
Chr3:3q13.31-21.2		 pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q13.32-13.33(chr3:117844958-120826621)x4 copy number gain See cases [RCV000142877] Chr3:117844958..120826621 [GRCh38]
Chr3:117563805..120545468 [GRCh37]
Chr3:119046495..122028158 [NCBI36]
Chr3:3q13.32-13.33		 uncertain significance
GRCh38/hg38 3q13.2-13.33(chr3:112520553-120031022)x1 copy number loss See cases [RCV000142725] Chr3:112520553..120031022 [GRCh38]
Chr3:112239400..119749869 [GRCh37]
Chr3:113722090..121232559 [NCBI36]
Chr3:3q13.2-13.33		 pathogenic
GRCh38/hg38 3q13.32-21.3(chr3:118673898-126540730)x1 copy number loss See cases [RCV000143695] Chr3:118673898..126540730 [GRCh38]
Chr3:118392745..126259573 [GRCh37]
Chr3:119875435..127742263 [NCBI36]
Chr3:3q13.32-21.3		 pathogenic
GRCh37/hg19 3q13.33(chr3:119188677-119500810)x3 copy number gain See cases [RCV000240551] Chr3:119188677..119500810 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh37/hg19 3q13.33(chr3:119188677-119500751)x3 copy number gain See cases [RCV000445965] Chr3:119188677..119500751 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3q13.31-21.1(chr3:115518341-122129283)x1 copy number loss not provided [RCV000682298] Chr3:115518341..122129283 [GRCh37]
Chr3:3q13.31-21.1		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3q13.31-26.31(chr3:116620308-172042292)x3 copy number gain not provided [RCV002472621] Chr3:116620308..172042292 [GRCh37]
Chr3:3q13.31-26.31		 pathogenic
GRCh37/hg19 3q13.31-13.33(chr3:116109191-120328013)x1 copy number loss not provided [RCV002473909] Chr3:116109191..120328013 [GRCh37]
Chr3:3q13.31-13.33		 uncertain significance
NM_001125.4(ADPRH):c.22A>T (p.Met8Leu) single nucleotide variant Inborn genetic diseases [RCV002751794] Chr3:119582191 [GRCh38]
Chr3:119301038 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.242A>G (p.Tyr81Cys) single nucleotide variant Inborn genetic diseases [RCV002970328] Chr3:119582411 [GRCh38]
Chr3:119301258 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.790T>C (p.Ser264Pro) single nucleotide variant Inborn genetic diseases [RCV002901690] Chr3:119587594 [GRCh38]
Chr3:119306441 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.418C>T (p.Leu140Phe) single nucleotide variant Inborn genetic diseases [RCV002860068] Chr3:119586404 [GRCh38]
Chr3:119305251 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.706A>G (p.Ile236Val) single nucleotide variant Inborn genetic diseases [RCV002759829] Chr3:119587510 [GRCh38]
Chr3:119306357 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.239A>G (p.Tyr80Cys) single nucleotide variant Inborn genetic diseases [RCV002708906] Chr3:119582408 [GRCh38]
Chr3:119301255 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.479G>A (p.Arg160Gln) single nucleotide variant Inborn genetic diseases [RCV002645142] Chr3:119586465 [GRCh38]
Chr3:119305312 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.831T>G (p.Ile277Met) single nucleotide variant Inborn genetic diseases [RCV003184842] Chr3:119587635 [GRCh38]
Chr3:119306482 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.490C>G (p.His164Asp) single nucleotide variant Inborn genetic diseases [RCV003218807] Chr3:119586476 [GRCh38]
Chr3:119305323 [GRCh37]
Chr3:3q13.33		 uncertain significance
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
NM_001125.4(ADPRH):c.415G>C (p.Gly139Arg) single nucleotide variant Inborn genetic diseases [RCV003358705] Chr3:119586401 [GRCh38]
Chr3:119305248 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.191C>T (p.Ala64Val) single nucleotide variant Inborn genetic diseases [RCV003352230] Chr3:119582360 [GRCh38]
Chr3:119301207 [GRCh37]
Chr3:3q13.33		 uncertain significance
NM_001125.4(ADPRH):c.844G>A (p.Val282Ile) single nucleotide variant Inborn genetic diseases [RCV003362137] Chr3:119587648 [GRCh38]
Chr3:119306495 [GRCh37]
Chr3:3q13.33		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2488
Count of miRNA genes:860
Interacting mature miRNAs:1003
Transcripts:ENST00000357003, ENST00000465513, ENST00000471850, ENST00000478399, ENST00000478927, ENST00000481816, ENST00000485496
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH12819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,308,529 - 119,308,661UniSTSGRCh37
Build 363120,791,219 - 120,791,351RGDNCBI36
Celera3117,717,089 - 117,717,221RGD
Cytogenetic Map3q13.31-q13.33UniSTS
HuRef3116,684,214 - 116,684,346UniSTS
GeneMap99-GB4 RH Map3418.72UniSTS
NCBI RH Map3929.8UniSTS
ADPRH_8162  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,306,342 - 119,306,928UniSTSGRCh37
Build 363120,789,032 - 120,789,618RGDNCBI36
Celera3117,714,902 - 117,715,488RGD
HuRef3116,682,027 - 116,682,613UniSTS
STS-L13291  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373119,306,619 - 119,306,757UniSTSGRCh37
Build 363120,789,309 - 120,789,447RGDNCBI36
Celera3117,715,179 - 117,715,317RGD
Cytogenetic Map3q13.31-q13.33UniSTS
HuRef3116,682,304 - 116,682,442UniSTS
TNG Radiation Hybrid Map368084.0UniSTS
GeneMap99-GB4 RH Map3420.75UniSTS
NCBI RH Map3929.8UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 463 706 359 15 841 4 1281 417 291 93 224 873 13 887 654 1
Low 1927 2261 1310 560 1027 410 3062 1748 3263 315 1209 667 158 1 317 2133 2 1
Below cutoff 30 23 52 47 52 50 9 19 156 8 12 48 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001391992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC073352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000357003   ⟹   ENSP00000349496
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,579,492 - 119,589,945 (+)Ensembl
RefSeq Acc Id: ENST00000465513   ⟹   ENSP00000417430
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,582,065 - 119,588,064 (+)Ensembl
RefSeq Acc Id: ENST00000471850
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,579,464 - 119,588,213 (+)Ensembl
RefSeq Acc Id: ENST00000478399   ⟹   ENSP00000420200
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,579,268 - 119,589,945 (+)Ensembl
RefSeq Acc Id: ENST00000478927   ⟹   ENSP00000417528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,579,590 - 119,588,007 (+)Ensembl
RefSeq Acc Id: ENST00000481816   ⟹   ENSP00000419703
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,579,433 - 119,586,363 (+)Ensembl
RefSeq Acc Id: ENST00000485496
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3119,579,528 - 119,586,539 (+)Ensembl
RefSeq Acc Id: NM_001125   ⟹   NP_001116
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,492 - 119,589,945 (+)NCBI
GRCh373119,298,280 - 119,308,792 (+)NCBI
Build 363120,781,213 - 120,791,482 (+)NCBI Archive
Celera3117,707,084 - 117,717,352 (+)RGD
HuRef3116,674,244 - 116,684,477 (+)ENTREZGENE
CHM1_13119,261,784 - 119,272,296 (+)NCBI
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291949   ⟹   NP_001278878
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,492 - 119,589,945 (+)NCBI
CHM1_13119,261,784 - 119,272,296 (+)NCBI
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291950   ⟹   NP_001278879
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,492 - 119,589,945 (+)NCBI
CHM1_13119,261,784 - 119,272,296 (+)NCBI
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371092   ⟹   NP_001358021
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,492 - 119,589,945 (+)NCBI
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001391992   ⟹   NP_001378921
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,492 - 119,589,945 (+)NCBI
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047447476   ⟹   XP_047303432
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,492 - 119,589,945 (+)NCBI
RefSeq Acc Id: XM_054345307   ⟹   XP_054201282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.03122,299,217 - 122,309,670 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001116   ⟸   NM_001125
- Peptide Label: isoform 1
- UniProtKB: B2R8H1 (UniProtKB/Swiss-Prot),   D3DN83 (UniProtKB/Swiss-Prot),   P54922 (UniProtKB/Swiss-Prot),   A8K6X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278878   ⟸   NM_001291949
- Peptide Label: isoform 1
- UniProtKB: B2R8H1 (UniProtKB/Swiss-Prot),   D3DN83 (UniProtKB/Swiss-Prot),   P54922 (UniProtKB/Swiss-Prot),   A8K6X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278879   ⟸   NM_001291950
- Peptide Label: isoform 2
- UniProtKB: P54922 (UniProtKB/Swiss-Prot),   B4E341 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001358021   ⟸   NM_001371092
- Peptide Label: isoform 1
- UniProtKB: P54922 (UniProtKB/Swiss-Prot),   B2R8H1 (UniProtKB/Swiss-Prot),   D3DN83 (UniProtKB/Swiss-Prot),   A8K6X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000420200   ⟸   ENST00000478399
RefSeq Acc Id: ENSP00000417528   ⟸   ENST00000478927
RefSeq Acc Id: ENSP00000417430   ⟸   ENST00000465513
RefSeq Acc Id: ENSP00000419703   ⟸   ENST00000481816
RefSeq Acc Id: ENSP00000349496   ⟸   ENST00000357003
RefSeq Acc Id: NP_001378921   ⟸   NM_001391992
- Peptide Label: isoform 1
- UniProtKB: P54922 (UniProtKB/Swiss-Prot),   B2R8H1 (UniProtKB/Swiss-Prot),   D3DN83 (UniProtKB/Swiss-Prot),   A8K6X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047303432   ⟸   XM_047447476
- Peptide Label: isoform X1
- UniProtKB: P54922 (UniProtKB/Swiss-Prot),   B2R8H1 (UniProtKB/Swiss-Prot),   D3DN83 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054201282   ⟸   XM_054345307
- Peptide Label: isoform X1
- UniProtKB: P54922 (UniProtKB/Swiss-Prot),   B2R8H1 (UniProtKB/Swiss-Prot),   D3DN83 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54922-F1-model_v2 AlphaFold P54922 1-357 view protein structure

Promoters
RGD ID:6865350
Promoter ID:EPDNEW_H5840
Type:initiation region
Name:ADPRH_1
Description:ADP-ribosylarginine hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383119,579,760 - 119,579,820EPDNEW
RGD ID:6800580
Promoter ID:HG_KWN:45920
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:NM_001125,   UC010HQV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363120,781,026 - 120,781,526 (+)MPROMDB
RGD ID:6800582
Promoter ID:HG_KWN:45921
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC003ECT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363120,783,191 - 120,783,877 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:269 AgrOrtholog
COSMIC ADPRH COSMIC
Ensembl Genes ENSG00000144843 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000357003 ENTREZGENE
  ENST00000357003.8 UniProtKB/Swiss-Prot
  ENST00000465513.1 UniProtKB/Swiss-Prot
  ENST00000478399 ENTREZGENE
  ENST00000478399.5 UniProtKB/Swiss-Prot
  ENST00000478927 ENTREZGENE
  ENST00000478927.5 UniProtKB/Swiss-Prot
  ENST00000481816.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.4080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144843 GTEx
HGNC ID HGNC:269 ENTREZGENE
Human Proteome Map ADPRH Human Proteome Map
InterPro ADP-ribosylarg_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosyl_crysJ1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosyl_crysJ1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:141 UniProtKB/Swiss-Prot
NCBI Gene 141 ENTREZGENE
OMIM 603081 OMIM
PANTHER [PROTEIN ADP-RIBOSYLARGININE] HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADP-RIBOSYLGLYCOHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADP_ribosyl_GH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24590 PharmGKB
PIRSF ADP_ribslarg_hdr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K6X2 ENTREZGENE, UniProtKB/TrEMBL
  ADPRH_HUMAN UniProtKB/Swiss-Prot
  B2R8H1 ENTREZGENE
  B4E341 ENTREZGENE, UniProtKB/TrEMBL
  C9JZW7_HUMAN UniProtKB/TrEMBL
  D3DN83 ENTREZGENE
  P54922 ENTREZGENE
UniProt Secondary B2R8H1 UniProtKB/Swiss-Prot
  D3DN83 UniProtKB/Swiss-Prot