NTRK1 (neurotrophic receptor tyrosine kinase 1) - Rat Genome Database

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Gene: NTRK1 (neurotrophic receptor tyrosine kinase 1) Pan paniscus
Analyze
Symbol: NTRK1
Name: neurotrophic receptor tyrosine kinase 1
RGD ID: 329345987
Description: ENCODES a protein that exhibits kinase binding (ortholog); nerve growth factor binding (ortholog); neurotrophin p75 receptor binding (ortholog); INVOLVED IN axon guidance (ortholog); B cell differentiation (ortholog); behavioral response to formalin induced pain (ortholog); ASSOCIATED WITH Alcohol-Related Disorders (ortholog); Alcoholic Intoxication (ortholog); Alzheimer's disease (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: high affinity nerve growth factor receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2192,962,864 - 92,984,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,697,515 - 92,718,687 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1136,007,476 - 136,047,355 (+)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View
Alcohol-Related Disorders  (ISO)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
COVID-19  (ISO)
diabetic neuropathy  (ISO)
endometriosis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial medullary thyroid carcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary sensory neuropathy  (ISO)
hereditary sensory neuropathy type 4  (ISO)
high grade glioma  (ISO)
Hirschsprung's disease  (ISO)
Hyperalgesia  (ISO)
immunodeficiency 42  (ISO)
intellectual disability  (ISO)
Lewy body dementia  (ISO)
Lung Injury  (ISO)
lymphoproliferative syndrome  (ISO)
MHC class II deficiency  (ISO)
myofascial pain syndrome  (ISO)
Neuralgia  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
parathyroid carcinoma  (ISO)
Parkinsonism  (ISO)
periodontitis  (ISO)
Primary Ovarian Failure  (ISO)
primary ovarian insufficiency  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
retinal detachment  (ISO)
Retrograde Degeneration  (ISO)
rhinitis  (ISO)
schizophrenia  (ISO)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
Spinal Cord Injuries  (ISO)
X-linked lymphoproliferative syndrome 1  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (ISO)
axonogenesis involved in innervation  (IEA)
B cell differentiation  (IEA,ISO)
behavioral response to formalin induced pain  (IEA,ISO)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell communication  (IEA)
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to nicotine  (ISO)
chromatin remodeling  (IEA)
circadian rhythm  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
innervation  (IEA,ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
learning or memory  (ISO)
macrophage colony-stimulating factor signaling pathway  (IEA)
mechanoreceptor differentiation  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cellular process  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
nerve growth factor signaling pathway  (IEA,ISO)
nervous system development  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron development  (ISO)
neuron projection development  (ISO)
neurotrophin TRK receptor signaling pathway  (IEA)
olfactory nerve development  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of programmed cell death  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Ras protein signal transduction  (IEA,ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
programmed cell death involved in cell development  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
response to activity  (ISO)
response to axon injury  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to hydrostatic pressure  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
Sertoli cell development  (ISO)
spermatogenesis  (ISO)
sympathetic nervous system development  (IEA)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NTRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2192,962,864 - 92,984,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,697,515 - 92,718,687 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1136,007,476 - 136,047,355 (+)Ensemblpanpan1.1panPan2
NTRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,815,750 - 156,881,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,815,636 - 156,881,850 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,785,542 - 156,851,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,052,166 - 155,118,266 (+)NCBINCBI36Build 36hg18NCBI36
Build 341153,643,743 - 153,664,715NCBI
Celera1129,856,788 - 129,922,861 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1128,143,945 - 128,209,968 (+)NCBIHuRef
CHM1_11158,181,737 - 158,247,825 (+)NCBICHM1_1
T2T-CHM13v2.01155,952,603 - 156,018,667 (+)NCBIT2T-CHM13v2.0
Ntrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,685,551 - 87,702,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,685,551 - 87,702,469 (-)EnsemblGRCm39 Ensembl
GRCm38387,778,244 - 87,795,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,778,244 - 87,795,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37387,582,166 - 87,599,084 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36387,864,171 - 87,881,089 (-)NCBIMGSCv36mm8
Celera387,816,061 - 87,832,981 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.62NCBI
Ntrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,534,844 - 175,551,664 (-)NCBIGRCr8
mRatBN7.22173,236,961 - 173,253,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,236,963 - 173,253,770 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,385,200 - 180,401,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,407,539 - 178,424,344 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,997,036 - 173,013,812 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,143,568 - 187,160,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,143,568 - 187,160,373 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,548,566 - 206,565,385 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,838,740 - 179,855,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,788,845 - 179,805,651 (-)NCBI
Celera2167,186,754 - 167,203,558 (-)NCBICelera
Cytogenetic Map2q34NCBI
Ntrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,929,704 - 2,947,579 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,929,704 - 2,947,579 (+)NCBIChiLan1.0ChiLan1.0
NTRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,140,931 - 41,159,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,140,879 - 41,159,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,627,981 - 40,646,334 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,003,176 - 41,021,761 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,003,175 - 41,037,050 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,785,455 - 40,803,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,838,471 - 40,856,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,121,978 - 41,140,332 (-)NCBIUU_Cfam_GSD_1.0
Ntrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,971,788 - 26,991,308 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365806,002,120 - 6,021,709 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365806,002,168 - 6,021,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,219,516 - 93,255,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,219,509 - 93,237,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,791,572 - 101,810,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1206,987,903 - 7,027,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl206,987,905 - 7,008,670 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,276,759 - 6,297,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,989,138 - 2,005,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,989,027 - 2,005,474 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000045677   ⟹   ENSPPAP00000022863
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1136,007,476 - 136,047,147 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000045682   ⟹   ENSPPAP00000022868
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1136,007,488 - 136,041,078 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000045683   ⟹   ENSPPAP00000022869
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1136,026,206 - 136,047,355 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000045686   ⟹   ENSPPAP00000022872
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1136,026,267 - 136,047,147 (+)Ensembl
RefSeq Acc Id: XM_055113050   ⟹   XP_054969025
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2192,962,864 - 92,984,198 (-)NCBI
NHGRI_mPanPan1192,697,515 - 92,718,687 (-)NCBI
RefSeq Acc Id: XM_055113052   ⟹   XP_054969027
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2192,962,864 - 92,984,198 (-)NCBI
NHGRI_mPanPan1192,697,515 - 92,718,687 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054969025 (Get FASTA)   NCBI Sequence Viewer  
  XP_054969027 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000022863.1
  ENSPPAP00000022868.1
  ENSPPAP00000022869.1
  ENSPPAP00000022872.1
Ensembl Acc Id: ENSPPAP00000022863   ⟸   ENSPPAT00000045677
Ensembl Acc Id: ENSPPAP00000022872   ⟸   ENSPPAT00000045686
Ensembl Acc Id: ENSPPAP00000022868   ⟸   ENSPPAT00000045682
Ensembl Acc Id: ENSPPAP00000022869   ⟸   ENSPPAT00000045683
RefSeq Acc Id: XP_054969027   ⟸   XM_055113052
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AZV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054969025   ⟸   XM_055113050
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B3Y6 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   LRRCT   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034577 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045677.1 UniProtKB/TrEMBL
  ENSPPAT00000045682.1 UniProtKB/TrEMBL
  ENSPPAT00000045683.1 UniProtKB/TrEMBL
  ENSPPAT00000045686.1 UniProtKB/TrEMBL
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
  Ribonuclease Inhibitor UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRR_TM_domain-containing UniProtKB/TrEMBL
  NTRK UniProtKB/TrEMBL
  NTRK1 UniProtKB/TrEMBL
  NTRK_LRRCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  TrkA_TMD UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
NCBI Gene NTRK1 ENTREZGENE
PANTHER ANTIGEN BSP, PUTATIVE-RELATED UniProtKB/TrEMBL
  HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR UniProtKB/TrEMBL
  PLATELET GLYCOPROTEIN IB ALPHA CHAIN UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRCT_2 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  TrkA_TMD UniProtKB/TrEMBL
PRINTS NTKRECEPTOR UniProtKB/TrEMBL
  NTKRECEPTOR1 UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART LRRCT UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
  L domain-like UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A0A2R9AZV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1B0_PANPA UniProtKB/TrEMBL
  A0A2R9B1B7_PANPA UniProtKB/TrEMBL
  A0A2R9B3Y6 ENTREZGENE, UniProtKB/TrEMBL