Sh3glb1 (SH3 domain -containing GRB2-like endophilin B1) - Rat Genome Database

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Gene: Sh3glb1 (SH3 domain -containing GRB2-like endophilin B1) Rattus norvegicus
Analyze
Symbol: Sh3glb1
Name: SH3 domain -containing GRB2-like endophilin B1
RGD ID: 1304859
Description: Predicted to enable fatty acid binding activity; lysophosphatidic acid acyltransferase activity; and protein homodimerization activity. Involved in positive regulation of neurotrophin TRK receptor signaling pathway; regulation of cell morphogenesis; and regulation of early endosome to late endosome transport. Located in early endosome; neuronal cell body; and synaptic vesicle. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1); PARTICIPATES IN mitochondria fission pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endophilin-B1; LOC292156; SH3 domain-containing GRB2-like protein B1; SH3-domain GRB2-like B1 (endophilin); SH3-domain GRB2-like endophilin B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22233,750,838 - 233,784,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2233,750,838 - 233,784,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2241,542,137 - 241,570,014 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02239,436,138 - 239,464,031 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02234,299,748 - 234,327,625 (-)NCBIRnor_WKY
Rnor_6.02250,709,812 - 250,744,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2250,709,439 - 250,744,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02269,236,633 - 269,271,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42242,874,678 - 242,903,467 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12242,861,417 - 242,890,207 (-)NCBI
Celera2225,746,540 - 225,774,430 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
atazanavir sulfate  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enniatin  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
nefazodone  (ISO)
oxybenzone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, etal., J Neurosci. 2008 Sep 3;28(36):9002-12. doi: 10.1523/JNEUROSCI.0767-08.2008.
10. Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production. Wang MQ, etal., J Biol. 2003;3(1):4. Epub 2003 Dec 4.
Additional References at PubMed
PMID:11161816   PMID:12456676   PMID:12477932   PMID:16227588   PMID:16606361   PMID:16763559   PMID:17437541   PMID:17891140   PMID:19074440   PMID:19805544   PMID:20562859   PMID:20643123  
PMID:21068542   PMID:23376485   PMID:23414517   PMID:24270810   PMID:24523556   PMID:25002582   PMID:25416956   PMID:25468996   PMID:26253702  


Genomics

Comparative Map Data
Sh3glb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22233,750,838 - 233,784,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2233,750,838 - 233,784,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2241,542,137 - 241,570,014 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02239,436,138 - 239,464,031 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02234,299,748 - 234,327,625 (-)NCBIRnor_WKY
Rnor_6.02250,709,812 - 250,744,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2250,709,439 - 250,744,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02269,236,633 - 269,271,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42242,874,678 - 242,903,467 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12242,861,417 - 242,890,207 (-)NCBI
Celera2225,746,540 - 225,774,430 (-)NCBICelera
Cytogenetic Map2q44NCBI
SH3GLB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38186,704,576 - 86,748,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl186,704,570 - 86,748,184 (+)EnsemblGRCh38hg38GRCh38
GRCh37187,170,259 - 87,213,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36186,942,845 - 86,986,455 (+)NCBINCBI36Build 36hg18NCBI36
Build 34186,882,524 - 86,921,290NCBI
Celera185,413,638 - 85,457,246 (+)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef185,280,855 - 85,324,463 (+)NCBIHuRef
CHM1_1187,285,087 - 87,328,713 (+)NCBICHM1_1
T2T-CHM13v2.0186,544,605 - 86,588,211 (+)NCBIT2T-CHM13v2.0
Sh3glb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393144,389,426 - 144,426,186 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3144,389,439 - 144,426,096 (-)EnsemblGRCm39 Ensembl
GRCm383144,683,665 - 144,720,408 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3144,683,678 - 144,720,335 (-)EnsemblGRCm38mm10GRCm38
MGSCv373144,351,808 - 144,383,287 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363144,626,230 - 144,657,709 (-)NCBIMGSCv36mm8
Celera3151,130,849 - 151,162,252 (-)NCBICelera
Cytogenetic Map3H2NCBI
Sh3glb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554237,393,186 - 7,423,903 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554237,393,186 - 7,414,199 (-)NCBIChiLan1.0ChiLan1.0
SH3GLB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11139,378,255 - 139,421,980 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01119,224,304 - 119,267,986 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1188,077,401 - 88,121,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl188,077,420 - 88,121,056 (+)Ensemblpanpan1.1panPan2
SH3GLB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1661,439,414 - 61,471,414 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl661,439,415 - 61,462,087 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha664,153,405 - 64,186,410 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0661,979,099 - 62,012,117 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl661,974,692 - 62,011,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1661,512,632 - 61,545,627 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0661,475,720 - 61,508,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0661,974,409 - 62,007,415 (-)NCBIUU_Cfam_GSD_1.0
Sh3glb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505897,341,464 - 97,372,308 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367322,067,204 - 2,097,631 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367322,066,848 - 2,097,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3GLB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4129,357,552 - 129,395,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14129,361,596 - 129,395,790 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24141,809,640 - 141,843,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GLB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12046,707,556 - 46,746,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2046,707,910 - 46,746,735 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603371,094,700 - 71,138,519 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3glb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474210,845,333 - 10,883,705 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh3glb1
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000017770
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
RH128900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22233,756,927 - 233,757,139 (+)MAPPERmRatBN7.2
Rnor_6.02250,715,902 - 250,716,113NCBIRnor6.0
Rnor_5.02269,242,723 - 269,242,934UniSTSRnor5.0
RGSC_v3.42242,874,712 - 242,874,923UniSTSRGSC3.4
Celera2225,746,574 - 225,746,785UniSTS
RH 3.4 Map7476.91UniSTS
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017770   ⟹   ENSRNOP00000017771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2233,756,896 - 233,784,784 (-)Ensembl
Rnor_6.0 Ensembl2250,715,868 - 250,744,196 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084337   ⟹   ENSRNOP00000074019
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2233,750,841 - 233,784,544 (-)Ensembl
Rnor_6.0 Ensembl2250,709,439 - 250,743,960 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098552   ⟹   ENSRNOP00000092051
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2233,756,896 - 233,784,784 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104475   ⟹   ENSRNOP00000093719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2233,756,896 - 233,784,784 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109147   ⟹   ENSRNOP00000078654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2233,750,838 - 233,784,536 (-)Ensembl
RefSeq Acc Id: NM_001011929   ⟹   NP_001011929
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,756,894 - 233,784,784 (-)NCBI
Rnor_6.02250,715,868 - 250,744,196 (-)NCBI
Rnor_5.02269,236,633 - 269,271,033 (-)NCBI
RGSC_v3.42242,874,678 - 242,903,467 (-)RGD
Celera2225,746,540 - 225,774,430 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233431   ⟹   XP_006233493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,752,845 - 233,784,815 (-)NCBI
Rnor_6.02250,711,819 - 250,744,215 (-)NCBI
Rnor_5.02269,236,633 - 269,271,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233433   ⟹   XP_006233495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,752,845 - 233,784,814 (-)NCBI
Rnor_6.02250,711,819 - 250,744,214 (-)NCBI
Rnor_5.02269,236,633 - 269,271,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233435   ⟹   XP_006233497
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,750,838 - 233,784,813 (-)NCBI
Rnor_6.02250,709,812 - 250,744,213 (-)NCBI
Rnor_5.02269,236,633 - 269,271,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590681   ⟹   XP_017446170
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,750,838 - 233,784,815 (-)NCBI
Rnor_6.02250,709,812 - 250,744,215 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590682   ⟹   XP_017446171
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,750,838 - 233,784,816 (-)NCBI
Rnor_6.02250,709,812 - 250,744,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101875   ⟹   XP_038957803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,752,845 - 233,784,817 (-)NCBI
RefSeq Acc Id: XM_039101876   ⟹   XP_038957804
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22233,750,838 - 233,784,813 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001011929   ⟸   NM_001011929
- UniProtKB: Q6AYE2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233497   ⟸   XM_006233435
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZL78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233493   ⟸   XM_006233431
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AKY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233495   ⟸   XM_006233433
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017446171   ⟸   XM_017590682
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017446170   ⟸   XM_017590681
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000074019   ⟸   ENSRNOT00000084337
RefSeq Acc Id: ENSRNOP00000017771   ⟸   ENSRNOT00000017770
RefSeq Acc Id: XP_038957804   ⟸   XM_039101876
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K714 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957803   ⟸   XM_039101875
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000078654   ⟸   ENSRNOT00000109147
RefSeq Acc Id: ENSRNOP00000092051   ⟸   ENSRNOT00000098552
RefSeq Acc Id: ENSRNOP00000093719   ⟸   ENSRNOT00000104475
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYE2-F1-model_v2 AlphaFold Q6AYE2 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691819
Promoter ID:EPDNEW_R2326
Type:initiation region
Name:Sh3glb1_2
Description:SH3 domain -containing GRB2-like endophilin B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2327  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02250,743,986 - 250,744,046EPDNEW
RGD ID:13691802
Promoter ID:EPDNEW_R2327
Type:initiation region
Name:Sh3glb1_1
Description:SH3 domain -containing GRB2-like endophilin B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2326  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02250,744,204 - 250,744,264EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304859 AgrOrtholog
BioCyc Gene G2FUF-50940 BioCyc
Ensembl Genes ENSRNOG00000012957 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017771 ENTREZGENE
  ENSRNOP00000017771.4 UniProtKB/Swiss-Prot
  ENSRNOP00000074019 ENTREZGENE
  ENSRNOP00000074019.2 UniProtKB/TrEMBL
  ENSRNOP00000078654 ENTREZGENE
  ENSRNOP00000078654.1 UniProtKB/TrEMBL
  ENSRNOP00000092051.1 UniProtKB/TrEMBL
  ENSRNOP00000093719 ENTREZGENE
  ENSRNOP00000093719.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017770 ENTREZGENE
  ENSRNOT00000017770.6 UniProtKB/Swiss-Prot
  ENSRNOT00000084337 ENTREZGENE
  ENSRNOT00000084337.2 UniProtKB/TrEMBL
  ENSRNOT00000098552.1 UniProtKB/TrEMBL
  ENSRNOT00000104475 ENTREZGENE
  ENSRNOT00000104475.1 UniProtKB/TrEMBL
  ENSRNOT00000109147 ENTREZGENE
  ENSRNOT00000109147.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123144 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3GLB1_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3GLB_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292156 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94050 IMAGE-MGC_LOAD
NCBI Gene 292156 ENTREZGENE
PANTHER PTHR14167:SF52 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh3glb1 PhenoGen
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K714 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL78 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADA0_RAT UniProtKB/TrEMBL
  A0A8I6AKY2 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYE2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Sh3glb1  SH3 domain -containing GRB2-like endophilin B1  Sh3glb1  SH3-domain GRB2-like endophilin B1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Sh3glb1  SH3-domain GRB2-like endophilin B1  Sh3glb1  SH3-domain GRB2-like B1 (endophilin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Sh3glb1  SH3-domain GRB2-like B1 (endophilin)  Sh3glb1_predicted  SH3-domain GRB2-like B1 (endophilin) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sh3glb1_predicted  SH3-domain GRB2-like B1 (endophilin) (predicted)      Symbol and Name status set to approved 70820 APPROVED