RGD Reference Report - Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. - Rat Genome Database

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Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure.

Authors: Moore, D Blaine  Madorsky, Irina  Paiva, Michael  Barrow Heaton, Marieta 
Citation: Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
RGD ID: 401976554
Pubmed: PMID:15188276   (View Abstract at PubMed)
DOI: DOI:10.1002/neu.20009   (Journal Full-text)

Developmental ethanol exposure produces significant central nervous system (CNS) abnormalities. The cellular mechanisms of ethanol neurotoxicity, however, remain elusive. Recent data implicate altered neurotrophin signaling pathways in ethanol-mediated neuronal death. The present study investigated ethanol-induced alterations in neurotrophin receptor proteins in the rat CNS following chronic ethanol treatment during gestation, via liquid diet to pregnant dams. Brains were dissected on P1 and P10, and Western blots for the neurotrophin receptors TrkA, TrkB, TrkC, and p75 were quantified. Such ethanol treatment produced significant changes in neurotrophin receptor levels in the hippocampus, septum, cerebral cortex, and cerebellum. Receptor levels in hippocampus, septum, and cerebellum, tended to be decreased, while levels in cortex were consistently increased. Males were generally more affected than females. While most of these alterations were transient, sustained or delayed changes were present in P10 septum, cortex, and cerebellum. These results indicate that developmental ethanol exposure produces major changes in the normal physiological levels of the neurotrophin receptors throughout the CNS. These changes in the receptor complement during critical prenatal stages could relate to the anomalous development of the CNS seen in the fetal alcohol syndrome. This relationship is discussed, together with the potential biological effects of such dramatic changes in neurotrophin receptor expression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NGFRHumanAlcohol-Related Disorders  ISONgfr (Rattus norvegicus)protein:decreased expression:brainRGD 
NTRK1HumanAlcohol-Related Disorders  ISONtrk1 (Rattus norvegicus)protein:altered expression:brainRGD 
NTRK2HumanAlcohol-Related Disorders  ISONtrk2 (Rattus norvegicus)protein:altered expression:brainRGD 
NTRK3HumanAlcohol-Related Disorders  ISONtrk3 (Rattus norvegicus)protein:altered expression:brainRGD 
NgfrRatAlcohol-Related Disorders  IEP protein:decreased expression:brainRGD 
NgfrMouseAlcohol-Related Disorders  ISONgfr (Rattus norvegicus)protein:decreased expression:brainRGD 
Ntrk1RatAlcohol-Related Disorders  IEP protein:altered expression:brainRGD 
Ntrk1MouseAlcohol-Related Disorders  ISONtrk1 (Rattus norvegicus)protein:altered expression:brainRGD 
Ntrk2RatAlcohol-Related Disorders  IEP protein:altered expression:brainRGD 
Ntrk2MouseAlcohol-Related Disorders  ISONtrk2 (Rattus norvegicus)protein:altered expression:brainRGD 
Ntrk3RatAlcohol-Related Disorders  IEP protein:altered expression:brainRGD 
Ntrk3MouseAlcohol-Related Disorders  ISONtrk3 (Rattus norvegicus)protein:altered expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)
Ntrk1  (neurotrophic receptor tyrosine kinase 1)
Ntrk2  (neurotrophic receptor tyrosine kinase 2)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)

Genes (Mus musculus)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))
Ntrk1  (neurotrophic tyrosine kinase, receptor, type 1)
Ntrk2  (neurotrophic tyrosine kinase, receptor, type 2)
Ntrk3  (neurotrophic tyrosine kinase, receptor, type 3)

Genes (Homo sapiens)
NGFR  (nerve growth factor receptor)
NTRK1  (neurotrophic receptor tyrosine kinase 1)
NTRK2  (neurotrophic receptor tyrosine kinase 2)
NTRK3  (neurotrophic receptor tyrosine kinase 3)


Additional Information