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Anti-NGF treatment reduces bone resorption in periodontitis.

Authors: Gaspersic, R  Kovacic, U  Glisovic, S  Cor, A  Skaleric, U 
Citation: Gaspersic R, etal., J Dent Res. 2010 May;89(5):515-20. Epub 2010 Mar 3.
Pubmed: (View Article at PubMed) PMID:20200421
DOI: Full-text: DOI:10.1177/0022034510363108

Periodontitis is characterized by periodontal tissue destruction, including the alveolar bone. One of its critical components is the release of pro-inflammatory neuropeptides from sensory nerve endings innervating the periodontium. Since nerve growth factor (NGF) has been reported to up-regulate neuropeptides in sensory neurons, we hypothesized that it would be increased in ligature-induced periodontitis in rats, and that systemic NGF neutralization would reduce the periodontitis-associated alveolar bone resorption. Real-time PCR analysis disclosed a statistically significant time-dependent up-regulation of NGF mRNA in gingiva during 2 weeks of periodontitis. Interestingly, NGF up-regulation was also detected in the contralateral gingiva. In addition, immunohistochemistry of trigeminal ganglion neurons innervating the gingivomucosa demonstrated increased expression of TrkA receptor for NGF. Systemic anti-NGF treatment during periodontitis significantly reduced interleukin-1beta expression in gingiva and bilateral alveolar bone resorption. This suggests that NGF promotes periodontal inflammation and implicates a possible use of anti-NGF treatment in periodontitis.


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RGD Object Information
RGD ID: 5684768
Created: 2011-12-30
Species: All species
Last Modified: 2011-12-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.