RGD Reference Report - Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. - Rat Genome Database

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Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure.

Authors: Moore, D Blaine  Madorsky, Irina  Paiva, Michael  Barrow Heaton, Marieta 
Citation: Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
RGD ID: 401976555
Pubmed: PMID:15188277   (View Abstract at PubMed)
DOI: DOI:10.1002/neu.20010   (Journal Full-text)

The detrimental effects of ethanol exposure during nervous system development have been well established. The cellular mechanisms of ethanol neurotoxicity, however, have not been clearly defined. Recent studies suggest that neurotrophin signaling pathways may be involved in ethanol-mediated neuronal death. The present investigation, therefore, was designed to examine ethanol-induced alterations in neurotrophin receptor protein levels in the developing central nervous system (CNS) following chronic ethanol treatment administered during the early neonatal period. For this study, rats were exposed to ethanol via vapor inhalation from postnatal day 4 (P4) to P10. Brains were then dissected on P10 or P21, and Western blots used to quantify expression of neurotrophin receptors TrkA, TrkB, TrkC, and p75. This early postnatal ethanol treatment produced significant alterations in receptor levels in hippocampus, septum, cerebral cortex, and cerebellum. The alterations seen were variable, with decreases generally found in hippocampus and cerebellum, increases noted in septum, and changes in both directions occurring in cortex. These alterations were generally more prevalent in males than in females. While most of the receptor changes observed were transient, sustained or delayed alterations were occasionally seen in hippocampus, cortex, and cerebellum. These results suggest that developmental ethanol exposure modulates expression of these neurotrophin receptors throughout the CNS, alterations which could have wide-ranging effects on functional CNS development. The possible linkage between such changes and abnormalities encountered in the fetal alcohol syndrome are considered.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NGFRHumanAlcohol-Related Disorders  ISONgfr (Rattus norvegicus)protein:altered expression:brainRGD 
NTRK1HumanAlcohol-Related Disorders  ISONtrk1 (Rattus norvegicus)protein:decreased expression:brainRGD 
NTRK2HumanAlcohol-Related Disorders  ISONtrk2 (Rattus norvegicus)protein:altered expression:brainRGD 
NTRK3HumanAlcohol-Related Disorders  ISONtrk3 (Rattus norvegicus)protein:altered expression:brainRGD 
NgfrRatAlcohol-Related Disorders  IEP protein:altered expression:brainRGD 
NgfrMouseAlcohol-Related Disorders  ISONgfr (Rattus norvegicus)protein:altered expression:brainRGD 
Ntrk1RatAlcohol-Related Disorders  IEP protein:decreased expression:brainRGD 
Ntrk1MouseAlcohol-Related Disorders  ISONtrk1 (Rattus norvegicus)protein:decreased expression:brainRGD 
Ntrk2RatAlcohol-Related Disorders  IEP protein:altered expression:brainRGD 
Ntrk2MouseAlcohol-Related Disorders  ISONtrk2 (Rattus norvegicus)protein:altered expression:brainRGD 
Ntrk3RatAlcohol-Related Disorders  IEP protein:altered expression:brainRGD 
Ntrk3MouseAlcohol-Related Disorders  ISONtrk3 (Rattus norvegicus)protein:altered expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)
Ntrk1  (neurotrophic receptor tyrosine kinase 1)
Ntrk2  (neurotrophic receptor tyrosine kinase 2)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)

Genes (Mus musculus)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))
Ntrk1  (neurotrophic tyrosine kinase, receptor, type 1)
Ntrk2  (neurotrophic tyrosine kinase, receptor, type 2)
Ntrk3  (neurotrophic tyrosine kinase, receptor, type 3)

Genes (Homo sapiens)
NGFR  (nerve growth factor receptor)
NTRK1  (neurotrophic receptor tyrosine kinase 1)
NTRK2  (neurotrophic receptor tyrosine kinase 2)
NTRK3  (neurotrophic receptor tyrosine kinase 3)

Additional Information