RGD Reference Report - Nerve growth factor helps protect retina in experimental retinal detachment. - Rat Genome Database

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Nerve growth factor helps protect retina in experimental retinal detachment.

Authors: Sun, X  Xu, X  Wang, F  Zhang, X  Ho, PC  Liu, H  Qian, J  Yu, Z  Lu, H  Xu, W 
Citation: Sun X, etal., Ophthalmologica. 2008;222(1):58-61. Epub 2007 Dec 19.
RGD ID: 5684405
Pubmed: PMID:18097183   (View Abstract at PubMed)
DOI: DOI:10.1159/000109281   (Journal Full-text)

PURPOSE: To investigate the expression of nerve growth factor (NGF) and its receptor TrkA on the retina at different time points after retinal detachment (RD) and the protection effect of NGF in experimental RD. METHODS: Sprague-Dawley rats were used as an RD animal model by injection of 0.1% sodium hyaluronate under the neurosensory retina. The expression of endogenous NGF and its receptor TrkA in the rat retina was detected using immunohistochemistry. The NGF (5 mug/eye) or phosphate-buffered saline were injected separately into vitreous every 4 days after the RD. The rat eyes were then observed at various time points. Morphologic changes were investigated by light microscopy. Retinal gliosis was detected by glial fibrillary acidic protein labeling. RESULTS: The expression of endogenous NGF and TrkA was upregulated during RD procedure. Most of the NGF-treated retina had a well-organized structure. In NGF-treated RD eyes, the cells were still significantly more numerous than in phosphate-buffered-saline-treated retina. Glial fibrillary acidic protein labeling increased quickly after RD; the NGF-treated retina had less reactive gliosis than the control groups. CONCLUSIONS: Intravitreal injection of exogenous NGF can protect retinal cells from degeneration in experimental RD. It may exert its protective action by preventing the apoptosis of retinal cells after RD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
retinal detachment  ISONtrk1 (Rattus norvegicus)5684405; 5684405protein:increased expression:retinaRGD 
retinal detachment  IEP 5684405protein:increased expression:retinaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk1  (neurotrophic receptor tyrosine kinase 1)

Genes (Mus musculus)
Ntrk1  (neurotrophic tyrosine kinase, receptor, type 1)

Genes (Homo sapiens)
NTRK1  (neurotrophic receptor tyrosine kinase 1)


Additional Information