Zfp976 (zinc finger protein 976) - Rat Genome Database

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Gene: Zfp976 (zinc finger protein 976) Mus musculus
Analyze
No known orthologs.
Symbol: Zfp976
Name: zinc finger protein 976
RGD ID: 1623019
MGI Page MGI
Description: Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein-macromolecule adaptor activity. Acts upstream of or within cellular response to heat. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF14 (zinc finger protein 14); ZNF234 (zinc finger protein 234); and ZNF254 (zinc finger protein 254).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9830147E19Rik; C330019L16Rik; hypothetical protein LOC208111; RIKEN cDNA 9830147E19 gene; zinc finger protein-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39742,258,938 - 42,293,684 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl742,258,950 - 42,292,012 (-)EnsemblGRCm39 Ensembl
GRCm38742,609,514 - 42,644,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl742,609,526 - 42,642,588 (-)EnsemblGRCm38mm10GRCm38
MGSCv37749,864,896 - 49,897,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36742,382,679 - 42,415,741 (-)NCBIMGSCv36mm8
Celera737,017,824 - 37,050,908 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12520002   PMID:14610273   PMID:15618518   PMID:15747579   PMID:16141072   PMID:16141073   PMID:17967808  
PMID:18287559   PMID:18755693   PMID:18799693   PMID:21267068   PMID:21873635  


Genomics

Variants

.
Variants in Zfp976
1220 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:175
Interacting mature miRNAs:187
Transcripts:ENSMUST00000098503, ENSMUST00000107994
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000098503   ⟹   ENSMUSP00000096105
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl742,261,928 - 42,291,971 (-)Ensembl
GRCm38.p6 Ensembl742,612,504 - 42,642,547 (-)Ensembl
RefSeq Acc Id: ENSMUST00000107994
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl742,258,950 - 42,292,012 (-)Ensembl
GRCm38.p6 Ensembl742,609,526 - 42,642,588 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187616   ⟹   ENSMUSP00000141023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl742,261,928 - 42,265,783 (-)Ensembl
GRCm38.p6 Ensembl742,612,504 - 42,616,359 (-)Ensembl
RefSeq Acc Id: NM_001242388   ⟹   NP_001229317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39742,258,950 - 42,292,028 (-)NCBI
GRCm38742,609,526 - 42,642,604 (-)NCBI
Celera737,017,808 - 37,050,908 (+)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017322075   ⟹   XP_017177564
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39742,258,938 - 42,293,684 (-)NCBI
GRCm38742,609,514 - 42,644,267 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001229317 (Get FASTA)   NCBI Sequence Viewer  
  XP_017177564 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE37010 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000096105
  ENSMUSP00000096105.3
  ENSMUSP00000141023.2
Reference Protein Sequences
RefSeq Acc Id: NP_001229317   ⟸   NM_001242388
- UniProtKB: E9Q981 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177564   ⟸   XM_017322075
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000141023   ⟸   ENSMUST00000187616
RefSeq Acc Id: ENSMUSP00000096105   ⟸   ENSMUST00000098503
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q981-F1-model_v2 AlphaFold E9Q981 1-636 view protein structure

Promoters
RGD ID:8663739
Promoter ID:EPDNEW_M9901
Type:single initiation site
Name:Zfp976_1
Description:Mus musculus zinc finger protein 976 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38742,642,593 - 42,642,653EPDNEW
RGD ID:6840754
Promoter ID:MM_KWN:50155
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   ES_Cell,   Liver,   MEF_B6
Transcripts:NM_001034857
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36749,897,771 - 49,898,271 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3036263 AgrOrtholog
Ensembl Genes ENSMUSG00000074158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098503 ENTREZGENE
  ENSMUST00000098503.9 UniProtKB/TrEMBL
  ENSMUST00000187616.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  ZNF781 UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:208111 UniProtKB/TrEMBL
MGD MGI:3036263 ENTREZGENE
NCBI Gene 208111 ENTREZGENE
PANTHER PTHR14947 UniProtKB/TrEMBL
  RIKEN CDNA D130040H23 GENE UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 564 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp976 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A087WSF4_MOUSE UniProtKB/TrEMBL
  E9Q981 ENTREZGENE, UniProtKB/TrEMBL
  Q3TRL8_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-28 Zfp976  zinc finger protein 976  9830147E19Rik  RIKEN cDNA 9830147E19 gene  Symbol and/or name change 5135510 APPROVED
2011-07-27 9830147E19Rik  RIKEN cDNA 9830147E19 gene  C330019L16Rik  RIKEN cDNA C330019L16 gene  Symbol and/or name change 5135510 APPROVED