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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:FasL mediated signaling pathway
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Accession:PW:0000681 term browser browse the term
Definition:Fas ligand binding to its receptor triggers a conformational change that allows the receptor to assemble a signaling complex known as DISC, followed by recruitment of pro-caspase-8 and activation of caspase-3 and -7. It is believed that Fas-mediated signaling to elicit apoptosis follows two routes.
Synonyms:related_synonym: Fas signaling pathway;   FasL/ CD95L signaling
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FasL mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO PID PID:200080 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G BID BH3 interacting domain death agonist ISO PID
RGD		 PMID:18090083 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 NCBI chr27:45,344,304...45,355,735
Ensembl chr27:45,337,145...45,384,059 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 ISO PID PID:200080 NCBI chr 5:29,294,080...29,314,837
Ensembl chr 5:29,294,692...29,312,771 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 ISO PID PID:200080 NCBI chr 5:29,324,893...29,343,322
Ensembl chr 5:29,325,331...29,337,240 		JBrowse link
G BTK Bruton tyrosine kinase ISO PID PID:200080 NCBI chr  X:75,270,952...75,302,663
Ensembl chr  X:75,270,979...75,302,562 		JBrowse link
G CASP10 caspase 10 ISO PID PID:200080 NCBI chr37:10,315,867...10,350,585 JBrowse link
G CASP3 caspase 3 ISO PID
RGD		 PMID:19239902 PID:200080 RGD:4143196 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CASP7 caspase 7 ISO RGD PMID:19239902 RGD:4143196 NCBI chr28:24,599,866...24,630,018
Ensembl chr28:24,599,493...24,628,668 		JBrowse link
G CASP8 caspase 8 ISO PID
RGD		 PMID:18090083 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO PID
RGD		 PMID:19107989 PMID:19239902 PID:200080 RGD:4143196 RGD:8662854 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200080 NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512 		JBrowse link
G CLTC clathrin heavy chain ISO PID PID:200080 NCBI chr 9:34,116,344...34,183,023
Ensembl chr 9:34,116,634...34,182,719 		JBrowse link
G EZR ezrin ISO PID PID:200080 NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036 		JBrowse link
G FADD Fas associated via death domain ISO PID
RGD		 PMID:19239902 PID:200080 RGD:4143196 NCBI chr18:48,087,447...48,094,497 JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 ISO PID PID:200080 NCBI chr27:4,802,711...4,831,230
Ensembl chr27:4,798,235...4,827,917 		JBrowse link
G FAS Fas cell surface death receptor ISO RGD
PID		 PMID:18090083 PMID:19107989 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 RGD:8662854 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FASLG Fas ligand ISO RGD
PID		 PMID:18090083 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200080 NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200080 NCBI chr  X:122,232,052...122,253,499
Ensembl chr  X:122,235,878...122,250,562 		JBrowse link
G LOC100856339 phosphatidylinositol 3-kinase regulatory subunit gamma ISO PID PID:200080 NCBI chr15:14,222,059...14,357,200
Ensembl chr15:14,235,824...14,353,832 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO PID PID:200080 NCBI chr 9:15,840,714...15,962,400
Ensembl chr 9:15,840,983...15,952,026 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 ISO PID PID:200080 NCBI chr20:52,594,450...52,604,236
Ensembl chr20:52,594,536...52,602,150 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200080 NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209 		JBrowse link
G MAPK10 mitogen-activated protein kinase 10 ISO PID PID:200080 NCBI chr32:9,584,437...9,889,118
Ensembl chr32:9,575,492...9,884,325 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 ISO PID PID:200080 NCBI chr10:16,977,133...16,984,764 JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO PID PID:200080 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO PID PID:200080 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO PID PID:200080 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200080 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200080 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO PID PID:200080 NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO PID PID:200080 NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200080 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200080 NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558 		JBrowse link
G RFC1 replication factor C subunit 1 ISO PID PID:200080 NCBI chr 3:73,062,292...73,136,576
Ensembl chr 3:73,062,329...73,135,096 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 ISO PID PID:200080 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 ISO PID PID:200080 NCBI chr21:29,714,418...29,719,035
Ensembl chr21:29,714,557...29,719,033 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200080 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
G SYK spleen associated tyrosine kinase ISO PID PID:200080 NCBI chr 1:95,903,501...95,955,577
Ensembl chr 1:95,903,566...95,955,583 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      cytokine and chemokine mediated signaling pathway 335
        cytokine mediated signaling pathway 334
          tumor necrosis factor superfamily mediated signaling pathway 88
            FasL mediated signaling pathway 39
              altered FasL mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4052
    regulatory pathway 2511
      cell death pathway 185
        programmed cell death pathway 185
          apoptotic cell death pathway 114
            extrinsic apoptotic pathway 88
              FasL mediated signaling pathway 39
                altered FasL mediated signaling pathway 0
paths to the root