BIRC2 (baculoviral IAP repeat containing 2) - Rat Genome Database

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Gene: BIRC2 (baculoviral IAP repeat containing 2) Canis lupus familiaris
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Symbol: BIRC2
Name: baculoviral IAP repeat containing 2
RGD ID: 12205988
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); transferase activity (ortholog); INVOLVED IN cellular response to tumor necrosis factor (ortholog); negative regulation of necroptotic process (ortholog); negative regulation of ripoptosome assembly involved in necroptotic process (ortholog); PARTICIPATES IN FasL mediated signaling pathway; nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); asphyxiating thoracic dystrophy (ortholog); ataxia telangiectasia (ortholog); FOUND IN protein-containing complex (ortholog); XY body (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: baculoviral IAP repeat-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,294,080 - 29,314,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,294,692 - 29,312,771 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,243,776 - 29,261,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,346,845 - 29,367,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,346,852 - 29,367,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,381,208 - 29,409,025 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,261,674 - 29,279,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,436,391 - 29,454,076 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BIRC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,294,080 - 29,314,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,294,692 - 29,312,771 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,243,776 - 29,261,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,346,845 - 29,367,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,346,852 - 29,367,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,381,208 - 29,409,025 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,261,674 - 29,279,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,436,391 - 29,454,076 (-)NCBIUU_Cfam_GSD_1.0
BIRC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,347,214 - 102,378,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,347,211 - 102,378,670 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,217,945 - 102,249,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,723,176 - 101,754,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,723,175 - 101,754,610NCBI
Celera1199,379,519 - 99,410,957 (+)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBIHuRef
CHM1_111102,100,910 - 102,132,418 (+)NCBICHM1_1
T2T-CHM13v2.011102,345,302 - 102,380,795 (+)NCBIT2T-CHM13v2.0
Birc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,818,227 - 7,837,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,818,228 - 7,837,065 (-)EnsemblGRCm39 Ensembl
GRCm3897,818,226 - 7,837,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,818,227 - 7,837,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,818,226 - 7,835,255 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,818,748 - 7,835,776 (-)NCBIMGSCv36mm8
Celera95,209,938 - 5,226,969 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Birc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,253,697 - 13,273,672 (-)NCBIGRCr8
mRatBN7.284,968,856 - 4,989,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,968,842 - 4,988,732 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,928,655 - 8,946,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,226,434 - 7,244,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,228,536 - 5,246,376 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,014,014 - 6,036,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,013,207 - 6,034,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,015,753 - 6,035,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,649,559 - 4,667,733 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,649,558 - 4,668,104 (-)NCBI
Celera86,528,673 - 6,546,071 (-)NCBICelera
Cytogenetic Map8q11NCBI
Birc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,659,478 - 5,685,114 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,658,322 - 5,685,628 (+)NCBIChiLan1.0ChiLan1.0
BIRC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,148,062 - 103,177,617 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,239,302 - 104,265,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,298,736 - 97,324,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,793,036 - 100,818,455 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,793,036 - 100,822,421 (+)Ensemblpanpan1.1panPan2
Birc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,000,642 - 86,020,605 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365515,515,904 - 5,535,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100622859
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,041,663 - 33,062,854 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,041,592 - 33,062,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,990,660 - 37,010,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BIRC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,721,449 - 93,746,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,117,251 - 32,142,556 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624878476,460 - 514,637 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BIRC2
392 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 18 2 6 2 6 6 12 8 10 6
Low 4 4 4
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000023996   ⟹   ENSCAFP00000022277
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl529,294,692 - 29,312,771 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001819   ⟹   ENSCAFP00845001433
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl529,346,852 - 29,367,441 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001848   ⟹   ENSCAFP00845001457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl529,346,858 - 29,367,327 (-)Ensembl
RefSeq Acc Id: NM_001048023   ⟹   NP_001041488
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1529,294,692 - 29,312,323 (-)NCBI
Dog10K_Boxer_Tasha529,243,776 - 29,261,396 (-)NCBI
ROS_Cfam_1.0529,347,457 - 29,365,098 (-)NCBI
UMICH_Zoey_3.1529,381,208 - 29,409,025 (-)NCBI
UNSW_CanFamBas_1.0529,261,674 - 29,279,330 (-)NCBI
UU_Cfam_GSD_1.0529,436,391 - 29,454,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038664105   ⟹   XP_038520033
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0529,346,845 - 29,367,441 (-)NCBI
RefSeq Acc Id: XM_038664106   ⟹   XP_038520034
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0529,346,845 - 29,367,441 (-)NCBI
RefSeq Acc Id: NP_001041488   ⟸   NM_001048023
- UniProtKB: Q38JA8 (UniProtKB/TrEMBL),   A0A8P0PGJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022277   ⟸   ENSCAFT00000023996
RefSeq Acc Id: XP_038520034   ⟸   XM_038664106
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038520033   ⟸   XM_038664105
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NP53 (UniProtKB/TrEMBL),   A0A8C0K7D9 (UniProtKB/TrEMBL),   A0A8I3MDM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001457   ⟸   ENSCAFT00845001848
RefSeq Acc Id: ENSCAFP00845001433   ⟸   ENSCAFT00845001819
Protein Domains
CARD   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023029 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014500 UniProtKB/TrEMBL
  ENSCAFG00040021002 UniProtKB/TrEMBL
  ENSCAFG00845001046 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023996.5 UniProtKB/TrEMBL
  ENSCAFT00000098172.1 UniProtKB/TrEMBL
  ENSCAFT00030026923.1 UniProtKB/TrEMBL
  ENSCAFT00040039106.1 UniProtKB/TrEMBL
  ENSCAFT00040039225.1 UniProtKB/TrEMBL
  ENSCAFT00040039254.1 UniProtKB/TrEMBL
  ENSCAFT00845001819 ENTREZGENE
  ENSCAFT00845001819.1 UniProtKB/TrEMBL
  ENSCAFT00845001848.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  BIRC2/BIRC3_UBA UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
KEGG Report cfa:479464 UniProtKB/TrEMBL
NCBI Gene BIRC2 ENTREZGENE
PANTHER DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2 UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART BIR UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
UniProt A0A8C0K7D9 ENTREZGENE
  A0A8C0NP53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MDM0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PGJ4 ENTREZGENE, UniProtKB/TrEMBL
  Q38JA8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38460 ENTREZGENE