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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mexiletine pharmacodynamics pathway
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Accession:PW:0002339 term browser browse the term
Definition:The pathway of mexiletine-target interaction and of the biochemical or physiological responses to drug. The drug is a non-selective voltage-gated sodium channel blocker antiarrhythmic agent. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00329

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mexiletine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00329 NCBI chrNW_004955414:32,216,243...32,289,028
Ensembl chrNW_004955414:32,216,196...32,289,053 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO SMPDB SMP:00329 NCBI chrNW_004955413:17,385,966...17,510,220
Ensembl chrNW_004955413:17,382,564...17,510,132 		JBrowse link
G Adrb1 adrenoceptor beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955431:19,025,663...19,027,026 JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO SMPDB SMP:00329 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00329 NCBI chrNW_004955435:19,537,224...19,563,631
Ensembl chrNW_004955435:19,536,634...19,564,580 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00329 NCBI chrNW_004955468:11,898,786...11,924,341
Ensembl chrNW_004955468:11,898,915...11,922,400 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00329 NCBI chrNW_004955555:869,508...892,510
Ensembl chrNW_004955555:869,325...893,542 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955462:8,072,519...8,095,311
Ensembl chrNW_004955462:8,073,679...8,094,880 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00329 NCBI chrNW_004955467:9,261,775...9,268,743
Ensembl chrNW_004955467:9,261,775...9,268,743 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00329 NCBI chrNW_004955508:3,848,745...3,875,992
Ensembl chrNW_004955508:3,859,399...3,875,276 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00329 NCBI chrNW_004955572:1,507,290...1,524,359
Ensembl chrNW_004955572:1,507,290...1,524,422 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO SMPDB SMP:00329 NCBI chrNW_004955482:7,233,336...7,295,754
Ensembl chrNW_004955482:7,233,336...7,295,754 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO SMPDB SMP:00329 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO SMPDB SMP:00329 NCBI chrNW_004955451:11,136,885...11,194,321
Ensembl chrNW_004955451:11,137,214...11,194,036 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO SMPDB SMP:00329 NCBI chrNW_004955442:16,047,965...16,108,862
Ensembl chrNW_004955442:16,045,895...16,108,862 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00329 NCBI chrNW_004955532:2,163,529...2,283,509
Ensembl chrNW_004955532:2,163,529...2,283,508 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955451:14,041,848...14,059,740
Ensembl chrNW_004955451:14,038,668...14,059,848 		JBrowse link
G Calm1 calmodulin 1 ISO SMPDB SMP:00329 NCBI chrNW_004955438:12,842,437...12,854,028
Ensembl chrNW_004955438:12,842,437...12,854,028 		JBrowse link
G Chrm2 cholinergic receptor muscarinic 2 ISO SMPDB SMP:00329 NCBI chrNW_004955494:5,845,581...5,975,614
Ensembl chrNW_004955494:5,847,156...5,848,556 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO SMPDB SMP:00329 NCBI chrNW_004955420:13,068,289...13,273,805
Ensembl chrNW_004955420:13,068,289...13,273,805 		JBrowse link
G Fxyd2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00329 NCBI chrNW_004955412:19,039,635...19,046,172
Ensembl chrNW_004955412:19,039,635...19,046,159 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO SMPDB SMP:00329 NCBI chrNW_004955450:4,139,852...4,181,377
Ensembl chrNW_004955450:4,139,852...4,181,377 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 ISO SMPDB SMP:00329 NCBI chrNW_004955413:2,835,730...2,838,761
Ensembl chrNW_004955413:2,836,146...2,837,966 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 ISO SMPDB SMP:00329 NCBI chrNW_004955435:15,227,386...15,431,136
Ensembl chrNW_004955435:15,227,615...15,431,190 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO SMPDB SMP:00329 NCBI chrNW_004955407:33,807,581...33,814,356
Ensembl chrNW_004955407:33,807,581...33,814,356 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO SMPDB SMP:00329 NCBI chrNW_004955407:33,734,969...33,736,609
Ensembl chrNW_004955407:33,735,148...33,735,513 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO SMPDB SMP:00329 NCBI chrNW_004955491:5,391,444...5,422,241
Ensembl chrNW_004955491:5,391,384...5,422,241 		JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00329 NCBI chrNW_004955485:8,468,117...8,472,220
Ensembl chrNW_004955485:8,467,207...8,470,950 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO SMPDB SMP:00329 NCBI chrNW_004955414:32,209,426...32,212,424
Ensembl chrNW_004955414:32,210,545...32,211,717 		JBrowse link
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 ISO SMPDB SMP:00329 NCBI chrNW_004955478:2,734,795...2,745,217
Ensembl chrNW_004955478:2,734,795...2,745,217 		JBrowse link
G Kcnj3 potassium inwardly rectifying channel subfamily J member 3 ISO SMPDB SMP:00329 NCBI chrNW_004955440:19,716,081...19,836,957
Ensembl chrNW_004955440:19,716,081...19,833,437 		JBrowse link
G Kcnj4 potassium inwardly rectifying channel subfamily J member 4 ISO SMPDB SMP:00329 NCBI chrNW_004955413:24,605,887...24,634,524
Ensembl chrNW_004955413:24,605,887...24,634,524 		JBrowse link
G Kcnj5 potassium inwardly rectifying channel subfamily J member 5 ISO SMPDB SMP:00329 NCBI chrNW_004955412:29,850,097...29,874,213
Ensembl chrNW_004955412:29,850,097...29,874,213 		JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 ISO SMPDB SMP:00329 NCBI chrNW_004955413:17,364,447...17,371,255
Ensembl chrNW_004955413:17,364,213...17,371,255 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO SMPDB SMP:00329 NCBI chrNW_004955492:5,805,170...5,846,402
Ensembl chrNW_004955492:5,805,170...5,846,402 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO SMPDB SMP:00329 NCBI chrNW_004955422:14,212,563...14,544,556
Ensembl chrNW_004955422:14,212,553...14,544,556 		JBrowse link
G Mylk myosin light chain kinase ISO SMPDB SMP:00329 NCBI chrNW_004955427:22,760,432...23,008,432
Ensembl chrNW_004955427:22,762,221...22,970,508 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955415:18,210,608...18,915,099
Ensembl chrNW_004955415:18,210,662...18,915,158 		JBrowse link
G Pln phospholamban ISO SMPDB SMP:00329 NCBI chrNW_004955436:1,439,098...1,447,070
Ensembl chrNW_004955436:1,439,098...1,447,070 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO SMPDB SMP:00329 NCBI chrNW_004955415:32,794,172...32,807,944
Ensembl chrNW_004955415:32,793,718...32,812,930 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO SMPDB SMP:00329 NCBI chrNW_004955478:4,241,283...4,262,119
Ensembl chrNW_004955478:4,241,283...4,263,087 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO SMPDB SMP:00329 NCBI chrNW_004955492:2,647,597...3,275,512
Ensembl chrNW_004955492:2,648,956...3,076,509 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO SMPDB SMP:00329 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO SMPDB SMP:00329 NCBI chrNW_004955441:7,653,107...8,037,784
Ensembl chrNW_004955441:7,656,031...7,957,640 		JBrowse link
G Snta1 syntrophin alpha 1 ISO SMPDB SMP:00329 NCBI chrNW_004955422:27,844,699...27,872,104
Ensembl chrNW_004955422:27,844,853...27,871,547 		JBrowse link
G Sntb1 syntrophin beta 1 ISO SMPDB SMP:00329 NCBI chrNW_004955417:25,906,013...26,128,134
Ensembl chrNW_004955417:25,904,654...26,128,134 		JBrowse link
G Sntb2 syntrophin beta 2 ISO SMPDB SMP:00329 NCBI chrNW_004955484:7,391,076...7,489,357 JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004955430:2,438,644...2,441,596
Ensembl chrNW_004955430:2,434,874...2,441,596 		JBrowse link
G Tnnc2 troponin C2, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955445:11,466,579...11,469,123
Ensembl chrNW_004955445:11,466,579...11,469,123 		JBrowse link
G Tnni1 troponin I1, slow skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955406:37,535,397...37,554,868
Ensembl chrNW_004955406:37,534,453...37,554,868 		JBrowse link
G Tnni2 troponin I2, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955422:13,649,827...13,652,342
Ensembl chrNW_004955422:13,650,515...13,652,247 		JBrowse link
G Tnni3 troponin I3, cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004955567:1,037,325...1,042,102
Ensembl chrNW_004955567:1,037,462...1,042,039 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955567:1,039,625...1,050,581
Ensembl chrNW_004955567:1,043,026...1,055,039 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO SMPDB SMP:00329 NCBI chrNW_004955406:37,491,462...37,507,360
Ensembl chrNW_004955406:37,487,154...37,507,639 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type ISO SMPDB SMP:00329 NCBI chrNW_004955422:13,702,015...13,718,915
Ensembl chrNW_004955422:13,702,015...13,718,915 		JBrowse link
G Tpm1 tropomyosin 1 ISO SMPDB SMP:00329 NCBI chrNW_004955450:12,197,241...12,223,372
Ensembl chrNW_004955450:12,194,755...12,224,011 		JBrowse link
G Tpm2 tropomyosin 2 ISO SMPDB SMP:00329 NCBI chrNW_004955472:611,079...617,823
Ensembl chrNW_004955472:611,028...617,821 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    drug pathway 348
      cardiovascular system drug pathway 162
        antiarrhythmic drug pathway 90
          mexiletine drug pathway 57
            mexiletine pharmacodynamics pathway 57
paths to the root