Tnnt1 (troponin T1, slow skeletal type) - Rat Genome Database

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Gene: Tnnt1 (troponin T1, slow skeletal type) Chinchilla lanigera
Analyze
Symbol: Tnnt1
Name: troponin T1, slow skeletal type
RGD ID: 9067309
Description: ENCODES a protein that exhibits tropomyosin binding (ortholog); troponin T binding (ortholog); INVOLVED IN negative regulation of muscle contraction (ortholog); skeletal muscle contraction (ortholog); slow-twitch skeletal muscle fiber contraction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH cardiomyopathy (ortholog); dilated cardiomyopathy (ortholog); dilated cardiomyopathy 2A (ortholog); FOUND IN troponin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: troponin T type 1 (skeletal, slow); troponin T, slow skeletal muscle
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 18 of 18 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnnt1Chinchillacardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: CardiomyopathiesClinVarPMID:24033266 more ...
Tnnt1Chinchilladilated cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated Cardiomyopathy and RecessiveClinVarPMID:18414213 more ...
Tnnt1Chinchilladilated cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated Cardiomyopathy and RecessiveClinVarPMID:18414213 more ...
Tnnt1Chinchilladilated cardiomyopathy 2A  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated cardiomyopathy 2AClinVarPMID:24033266 more ...
Tnnt1Chinchillafamilial hypertrophic cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary familial hypertrophic cardiomyopathyClinVarPMID:24033266 more ...
Tnnt1Chinchillafamilial restrictive cardiomyopathy 1  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiomyopathy more ...ClinVarPMID:24033266 more ...
Tnnt1Chinchillagenetic disease  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10952871 more ...
Tnnt1Chinchillahypertrophic cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:18414213 more ...
Tnnt1Chinchillahypertrophic cardiomyopathy 7  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathy 7ClinVarPMID:24033266 more ...
Tnnt1Chinchillamyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: MyopathyClinVar 
Tnnt1Chinchillanemaline myopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline Myopathy and RecessiveClinVarPMID:24033266 more ...
Tnnt1Chinchillanemaline myopathy 5A  ISOTNNT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10952871 more ...
Tnnt1Chinchillanemaline myopathy 5A  ISOTNNT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10952871 more ...
Tnnt1Chinchillanemaline myopathy 5B  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathy 5B more ...ClinVarPMID:25741868 more ...
Tnnt1Chinchillanemaline myopathy 5C  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathy 5C and autosomal dominantClinVarPMID:14315666 more ...
Tnnt1Chinchillaprimary ciliary dyskinesia  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:22387996 more ...
Tnnt1Chinchillarestrictive cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial restrictive cardiomyopathyClinVarPMID:18414213 more ...
Tnnt1ChinchillaWolff-Parkinson-White syndrome  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White SyndromeClinVarPMID:18414213 more ...
1 to 18 of 18 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnnt1Chinchillanemaline myopathy 5A  ISOTNNT1 (Homo sapiens)7240710 OMIM 
Tnnt1Chinchillanemaline myopathy 5B  ISOTNNT1 (Homo sapiens)7240710 OMIM 
Tnnt1Chinchillanemaline myopathy 5C  ISOTNNT1 (Homo sapiens)7240710 OMIM 


Biological Process

  

Cellular Component

  

Molecular Function

  

Imported Annotations - SMPDB

1 to 20 of 38 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnnt1Chinchillaacebutolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00296
Tnnt1Chinchillaadrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00296
Tnnt1Chinchillaamiodarone pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00665
Tnnt1Chinchillaamlodipine pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00376
Tnnt1Chinchillaatenolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00298
Tnnt1Chinchillabetaxolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00299
Tnnt1Chinchillabisoprolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00300
Tnnt1Chinchillabupranolol drug pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00670
Tnnt1Chinchillabupranolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00670
Tnnt1Chinchillacarvedilol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00367
Tnnt1Chinchilladiltiazem pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00359
Tnnt1Chinchilladisopyramide pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00325
Tnnt1Chinchilladobutamine pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00662
Tnnt1Chinchillaesmolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00301
Tnnt1Chinchillaflecainde pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00331
Tnnt1Chinchillafosphenytoin pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00326
Tnnt1Chinchillaibutilide pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00332
Tnnt1Chinchillaisoprenaline pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00663
Tnnt1Chinchillaisradipine pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00378
Tnnt1Chinchillalevobunolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)9068941 SMPDBSMP:00666
1 to 20 of 38 rows

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Tnnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
TNNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,132,698 - 55,149,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,132,698 - 55,149,206 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,644,066 - 55,660,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,336,009 - 60,352,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,336,008 - 60,352,386NCBI
Celera1952,683,099 - 52,701,800 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,967,104 - 51,981,532 (-)NCBIHuRef
CHM1_11955,637,767 - 55,654,167 (-)NCBICHM1_1
T2T-CHM13v2.01958,226,372 - 58,243,170 (-)NCBIT2T-CHM13v2.0
Tnnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,507,568 - 4,518,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,507,569 - 4,519,381 (-)EnsemblGRCm39 Ensembl
GRCm3874,504,569 - 4,515,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,504,570 - 4,516,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,456,265 - 4,467,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,107,750 - 4,119,062 (-)NCBIMGSCv36mm8
Celera74,249,175 - 4,260,487 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.6NCBI
Tnnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
TNNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,268,613 - 61,282,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,997,739 - 63,012,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,173,523 - 52,190,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,868,241 - 60,885,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,868,330 - 60,882,005 (-)Ensemblpanpan1.1panPan2
TNNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,479,617 - 102,490,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,366,801 - 102,491,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,536,670 - 102,547,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,133,191 - 103,144,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,973,590 - 103,144,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,770,115 - 102,781,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,481,708 - 102,492,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,245,737 - 103,256,895 (+)NCBIUU_Cfam_GSD_1.0
Tnnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886425,331 - 434,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,347,582 - 59,365,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,351,445 - 59,365,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,300,086 - 54,314,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,726,049 - 47,743,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,726,002 - 47,743,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045282,217 - 298,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,094,903 - 2,100,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,093,852 - 2,100,647 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000000944   ⟹   ENSCLAP00000000907
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000000945   ⟹   ENSCLAP00000000908
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,044,283 - 1,050,487 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000000946   ⟹   ENSCLAP00000000909
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,045,147 - 1,050,487 (+)Ensembl
RefSeq Acc Id: XM_005413353   ⟹   XP_005413410
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,043,320 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005413354   ⟹   XP_005413411
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,043,338 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509279   ⟹   XP_013364733
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,043,320 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509280   ⟹   XP_013364734
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs XP_005413410 (Get FASTA)   NCBI Sequence Viewer  
  XP_005413411 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364733 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364734 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000000907
  ENSCLAP00000000907.1
  ENSCLAP00000000908
  ENSCLAP00000000908.1
  ENSCLAP00000000909.1
1 to 9 of 9 rows
RefSeq Acc Id: XP_005413410   ⟸   XM_005413353
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UJD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005413411   ⟸   XM_005413354
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UJD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364734   ⟸   XM_013509280
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UJD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364733   ⟸   XM_013509279
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UH84 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000000908   ⟸   ENSCLAT00000000945



1 to 18 of 18 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000000706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000944 ENTREZGENE
  ENSCLAT00000000944.1 UniProtKB/TrEMBL
  ENSCLAT00000000945 ENTREZGENE
  ENSCLAT00000000945.1 UniProtKB/TrEMBL
  ENSCLAT00000000946.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/TrEMBL
InterPro TNNT UniProtKB/TrEMBL
  Troponin UniProtKB/TrEMBL
  Troponin_sf UniProtKB/TrEMBL
NCBI Gene Tnnt1 ENTREZGENE
PANTHER PTHR11521 UniProtKB/TrEMBL
  TROPONIN T, SLOW SKELETAL MUSCLE UniProtKB/TrEMBL
Pfam Troponin UniProtKB/TrEMBL
Superfamily-SCOP SSF90250 UniProtKB/TrEMBL
UniProt A0A8C2UH84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UJD8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YID5_CHILA UniProtKB/TrEMBL
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tnnt1  troponin T1, slow skeletal type    troponin T type 1 (skeletal, slow)  Symbol and/or name change 5135510 APPROVED