Tnnt1 (troponin T1, slow skeletal type) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tnnt1 (troponin T1, slow skeletal type) Chinchilla lanigera
Analyze
Symbol: Tnnt1
Name: troponin T1, slow skeletal type
RGD ID: 9067309
Description: ENCODES a protein that exhibits tropomyosin binding (ortholog); troponin T binding (ortholog); INVOLVED IN negative regulation of muscle contraction (ortholog); skeletal muscle contraction (ortholog); slow-twitch skeletal muscle fiber contraction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH cardiomyopathy (ortholog); dilated cardiomyopathy (ortholog); dilated cardiomyopathy 2A (ortholog); FOUND IN troponin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: troponin T type 1 (skeletal, slow); troponin T, slow skeletal muscle
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
TNNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,132,698 - 55,149,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,132,698 - 55,149,206 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,644,066 - 55,660,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,336,009 - 60,352,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,336,008 - 60,352,386NCBI
Celera1952,683,099 - 52,701,800 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,967,104 - 51,981,532 (-)NCBIHuRef
CHM1_11955,637,767 - 55,654,167 (-)NCBICHM1_1
T2T-CHM13v2.01958,226,372 - 58,243,170 (-)NCBIT2T-CHM13v2.0
Tnnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,507,568 - 4,518,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,507,569 - 4,519,381 (-)EnsemblGRCm39 Ensembl
GRCm3874,504,569 - 4,515,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,504,570 - 4,516,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,456,265 - 4,467,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,107,750 - 4,119,062 (-)NCBIMGSCv36mm8
Celera74,249,175 - 4,260,487 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.6NCBI
Tnnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
TNNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,268,613 - 61,282,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,997,739 - 63,012,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,173,523 - 52,190,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,868,241 - 60,885,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,868,330 - 60,882,005 (-)Ensemblpanpan1.1panPan2
TNNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,479,617 - 102,490,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,366,801 - 102,491,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,536,670 - 102,547,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,133,191 - 103,144,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,973,590 - 103,144,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,770,115 - 102,781,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,481,708 - 102,492,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,245,737 - 103,256,895 (+)NCBIUU_Cfam_GSD_1.0
Tnnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886425,331 - 434,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,347,582 - 59,365,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,351,445 - 59,365,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,300,086 - 54,314,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,726,049 - 47,743,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,726,002 - 47,743,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045282,217 - 298,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,094,903 - 2,100,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,093,852 - 2,100,647 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000000944   ⟹   ENSCLAP00000000907
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000000945   ⟹   ENSCLAP00000000908
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,044,283 - 1,050,487 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000000946   ⟹   ENSCLAP00000000909
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,045,147 - 1,050,487 (+)Ensembl
RefSeq Acc Id: XM_005413353   ⟹   XP_005413410
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,043,320 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005413354   ⟹   XP_005413411
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,043,338 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509279   ⟹   XP_013364733
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,043,320 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509280   ⟹   XP_013364734
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005413410   ⟸   XM_005413353
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UJD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005413411   ⟸   XM_005413354
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UJD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364734   ⟸   XM_013509280
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UJD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013364733   ⟸   XM_013509279
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UH84 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000000908   ⟸   ENSCLAT00000000945
Ensembl Acc Id: ENSCLAP00000000909   ⟸   ENSCLAT00000000946
Ensembl Acc Id: ENSCLAP00000000907   ⟸   ENSCLAT00000000944


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000944 ENTREZGENE
  ENSCLAT00000000944.1 UniProtKB/TrEMBL
  ENSCLAT00000000945 ENTREZGENE
  ENSCLAT00000000945.1 UniProtKB/TrEMBL
  ENSCLAT00000000946.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/TrEMBL
InterPro TNNT UniProtKB/TrEMBL
  Troponin UniProtKB/TrEMBL
  Troponin_sf UniProtKB/TrEMBL
NCBI Gene Tnnt1 ENTREZGENE
PANTHER PTHR11521 UniProtKB/TrEMBL
  TROPONIN T, SLOW SKELETAL MUSCLE UniProtKB/TrEMBL
Pfam Troponin UniProtKB/TrEMBL
Superfamily-SCOP SSF90250 UniProtKB/TrEMBL
UniProt A0A8C2UH84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UJD8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YID5_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tnnt1  troponin T1, slow skeletal type    troponin T type 1 (skeletal, slow)  Symbol and/or name change 5135510 APPROVED