Tnnt1 (troponin T1, slow skeletal type) - Rat Genome Database

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Gene: Tnnt1 (troponin T1, slow skeletal type) Ictidomys tridecemlineatus
Analyze
Symbol: Tnnt1
Name: troponin T1, slow skeletal type
RGD ID: 12506640
Description: ENCODES a protein that exhibits troponin T binding (ortholog); INVOLVED IN slow-twitch skeletal muscle fiber contraction (ortholog); transition between fast and slow fiber (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH cardiomyopathy (ortholog); dilated cardiomyopathy (ortholog); dilated cardiomyopathy 2A (ortholog); FOUND IN troponin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: troponin T, slow skeletal muscle
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886425,331 - 434,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
troponin complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886425,331 - 434,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,132,698 - 55,149,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,132,698 - 55,149,206 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,644,066 - 55,660,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,336,009 - 60,352,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,336,008 - 60,352,386NCBI
Celera1952,683,099 - 52,701,800 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,967,104 - 51,981,532 (-)NCBIHuRef
CHM1_11955,637,767 - 55,654,167 (-)NCBICHM1_1
T2T-CHM13v2.01958,226,372 - 58,243,170 (-)NCBIT2T-CHM13v2.0
Tnnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,507,568 - 4,518,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,507,569 - 4,519,381 (-)EnsemblGRCm39 Ensembl
GRCm3874,504,569 - 4,515,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,504,570 - 4,516,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,456,265 - 4,467,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,107,750 - 4,119,062 (-)NCBIMGSCv36mm8
Celera74,249,175 - 4,260,487 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.6NCBI
Tnnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
Tnnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
TNNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,268,613 - 61,282,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,997,739 - 63,012,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,173,523 - 52,190,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,868,241 - 60,885,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,868,330 - 60,882,005 (-)Ensemblpanpan1.1panPan2
TNNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,479,617 - 102,490,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,366,801 - 102,491,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,536,670 - 102,547,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,133,191 - 103,144,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,973,590 - 103,144,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,770,115 - 102,781,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,481,708 - 102,492,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,245,737 - 103,256,895 (+)NCBIUU_Cfam_GSD_1.0
TNNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,347,582 - 59,365,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,351,445 - 59,365,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,300,086 - 54,314,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,726,049 - 47,743,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,726,002 - 47,743,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045282,217 - 298,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,094,903 - 2,100,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,093,852 - 2,100,647 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSSTOT00000026169   ⟹   ENSSTOP00000014844
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)Ensembl
RefSeq Acc Id: XM_040279825   ⟹   XP_040135759
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040135759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000014844.2
RefSeq Acc Id: XP_040135759   ⟸   XM_040279825
Ensembl Acc Id: ENSSTOP00000014844   ⟸   ENSSTOT00000026169


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025995 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000026169.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/TrEMBL
InterPro TNNT UniProtKB/TrEMBL
  Troponin UniProtKB/TrEMBL
  Troponin_sf UniProtKB/TrEMBL
NCBI Gene Tnnt1 ENTREZGENE
PANTHER PTHR11521 UniProtKB/TrEMBL
  TROPONIN T, SLOW SKELETAL MUSCLE UniProtKB/TrEMBL
Pfam Troponin UniProtKB/TrEMBL
Superfamily-SCOP SSF90250 UniProtKB/TrEMBL
UniProt I3MRU9_ICTTR UniProtKB/TrEMBL