Dlg1 (discs large MAGUK scaffold protein 1) - Rat Genome Database

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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Chinchilla lanigera
Analyze
Symbol: Dlg1
Name: discs large MAGUK scaffold protein 1
RGD ID: 8770468
Description: ENCODES a protein that exhibits ionotropic glutamate receptor binding (ortholog); kinesin binding (ortholog); L27 domain binding (ortholog); INVOLVED IN actin filament organization (ortholog); activation of protein kinase activity (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH autistic disorder (ortholog); cervix uteri carcinoma in situ (ortholog); cleft palate (ortholog); FOUND IN basal plasma membrane (ortholog); basement membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: discs, large homolog 1 (Drosophila); disks large homolog 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
activation of protein kinase activity  (ISO)
amyloid precursor protein metabolic process  (ISO)
astral microtubule organization  (ISO)
bicellular tight junction assembly  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell adhesion  (ISO)
cell-cell adhesion  (ISO)
cellular protein-containing complex localization  (ISO)
cortical actin cytoskeleton organization  (ISO)
cortical microtubule organization  (ISO)
embryonic skeletal system morphogenesis  (ISO)
endothelial cell proliferation  (ISO)
establishment of centrosome localization  (ISO)
hard palate development  (ISO)
immunological synapse formation  (ISO)
lens development in camera-type eye  (ISO)
membrane raft organization  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
peristalsis  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
protein localization  (ISO)
protein localization to plasma membrane  (ISO)
regulation of cell shape  (ISO)
regulation of membrane potential  (ISO)
regulation of myelination  (ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
regulation of potassium ion export across plasma membrane  (ISO)
regulation of potassium ion import  (ISO)
regulation of protein localization  (ISO)
regulation of protein localization to synapse  (ISO)
regulation of ventricular cardiac muscle cell action potential  (ISO)
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  (ISO)
reproductive structure development  (ISO)
smooth muscle tissue development  (ISO)
T cell activation  (ISO)
tissue morphogenesis  (ISO)
ureteric bud development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
E-cadherin signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References


Genomics

Comparative Map Data
Dlg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBIChiLan1.0ChiLan1.0
DLG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3197,042,560 - 197,299,330 (-)EnsemblGRCh38hg38GRCh38
GRCh383197,042,560 - 197,299,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,769,431 - 197,026,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,253,828 - 198,509,844 (-)NCBINCBI36hg18NCBI36
Build 343198,259,732 - 198,513,757NCBI
Celera3195,354,807 - 195,610,760 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3194,068,872 - 194,324,699 (-)NCBIHuRef
CHM1_13196,740,135 - 196,996,969 (-)NCBICHM1_1
Dlg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,482,261 - 31,692,174 (+)NCBIGRCm39mm39
GRCm39 Ensembl1631,482,261 - 31,693,947 (+)Ensembl
GRCm381631,663,443 - 31,873,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,663,443 - 31,875,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv371631,664,125 - 31,873,432 (+)NCBIGRCm37mm9NCBIm37
MGSCv361631,583,786 - 31,793,093 (+)NCBImm8
Celera1632,162,337 - 32,367,214 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Dlg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,911,883 - 69,103,230 (-)NCBI
Rnor_6.0 Ensembl1172,163,749 - 72,378,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01172,164,566 - 72,378,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01175,389,409 - 75,454,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01175,239,783 - 75,349,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,735,283 - 70,930,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,792,871 - 70,987,963 (-)NCBI
Celera1168,335,260 - 68,524,109 (-)NCBICelera
Cytogenetic Map11q22NCBI
DLG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13204,319,410 - 204,586,232 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,323,724 - 204,584,987 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03194,386,263 - 194,648,015 (-)NCBIMhudiblu_PPA_v0panPan3
DLG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13330,016,323 - 30,253,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3330,016,600 - 30,253,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3330,039,726 - 30,276,522 (-)NCBI
ROS_Cfam_1.03330,264,744 - 30,502,044 (-)NCBI
UMICH_Zoey_3.13330,059,072 - 30,295,858 (-)NCBI
UNSW_CanFamBas_1.03330,096,091 - 30,333,239 (-)NCBI
UU_Cfam_GSD_1.03330,717,286 - 30,954,124 (-)NCBI
Dlg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602143,094,725 - 143,350,067 (-)NCBI
SpeTri2.0NW_004936833551,989 - 843,064 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,820,870 - 133,086,843 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113132,819,931 - 133,084,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,336,324 - 142,629,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLG1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,937,900 - 90,214,976 (+)NCBI
ChlSab1.1 Ensembl1590,055,964 - 90,215,652 (+)Ensembl
Vero_WHO_p1.0NW_02366604163,711,831 - 63,988,641 (+)NCBI
Dlg1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473062,001,547 - 62,223,098 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005383157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005383158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005383159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005383163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005383165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005383166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005383167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013513450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013513452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013513453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01020914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01020915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01020916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01020917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01020918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01020919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCB01057993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000021133   ⟹   ENSCLAP00000020932
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021134   ⟹   ENSCLAP00000020933
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021135   ⟹   ENSCLAP00000020934
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542013,068,289 - 13,273,805 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021136   ⟹   ENSCLAP00000020935
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542013,069,248 - 13,273,234 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021137   ⟹   ENSCLAP00000020936
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542013,069,248 - 13,188,661 (-)Ensembl
RefSeq Acc Id: XM_005383157   ⟹   XP_005383214
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383158   ⟹   XP_005383215
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383159   ⟹   XP_005383216
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383163   ⟹   XP_005383220
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383165   ⟹   XP_005383222
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383166   ⟹   XP_005383223
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383167   ⟹   XP_005383224
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513450   ⟹   XP_013368904
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513452   ⟹   XP_013368906
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,273,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513453   ⟹   XP_013368907
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542013,068,289 - 13,187,944 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005383222   ⟸   XM_005383165
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005383216   ⟸   XM_005383159
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005383223   ⟸   XM_005383166
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_005383220   ⟸   XM_005383163
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005383215   ⟸   XM_005383158
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005383214   ⟸   XM_005383157
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005383224   ⟸   XM_005383167
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_013368906   ⟸   XM_013513452
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_013368904   ⟸   XM_013513450
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013368907   ⟸   XM_013513453
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: ENSCLAP00000020936   ⟸   ENSCLAT00000021137
RefSeq Acc Id: ENSCLAP00000020933   ⟸   ENSCLAT00000021134
RefSeq Acc Id: ENSCLAP00000020932   ⟸   ENSCLAT00000021133
RefSeq Acc Id: ENSCLAP00000020935   ⟸   ENSCLAT00000021136
RefSeq Acc Id: ENSCLAP00000020934   ⟸   ENSCLAT00000021135


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014341 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000020932 ENTREZGENE
  ENSCLAP00000020933 ENTREZGENE
  ENSCLAP00000020934 ENTREZGENE
  ENSCLAP00000020936 ENTREZGENE
Ensembl Transcript ENSCLAT00000021133 ENTREZGENE
  ENSCLAT00000021134 ENTREZGENE
  ENSCLAT00000021135 ENTREZGENE
  ENSCLAT00000021137 ENTREZGENE
NCBI Gene Dlg1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Dlg1  discs large MAGUK scaffold protein 1    discs, large homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED