Abcc8 (ATP binding cassette subfamily C member 8) - Rat Genome Database

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Gene: Abcc8 (ATP binding cassette subfamily C member 8) Chinchilla lanigera
Analyze
Symbol: Abcc8
Name: ATP binding cassette subfamily C member 8
RGD ID: 8921689
Description: ENCODES a protein that exhibits ADP binding (ortholog); ATP binding (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); INVOLVED IN action potential (ortholog); cellular response to nutrient levels (ortholog); female pregnancy (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atrial heart septal defect (ortholog); brain edema (ortholog); Brain Injuries (ortholog); FOUND IN inward rectifying potassium channel (ortholog); plasma membrane (ortholog); presynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,216,196 - 32,289,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
atrial heart septal defect  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
cardiac arrest  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Hyperinsulinism  (ISO)
congestive heart failure  (ISO)
cryptorchidism  (ISO)
diabetes mellitus  (ISO)
Dwarfism  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
familial hyperinsulinemic hypoglycemia 1  (ISO)
familial hyperinsulinemic hypoglycemia 2  (ISO)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
hyperinsulinemic hypoglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
intellectual disability  (ISO)
leucine-sensitive hypoglycemia of infancy  (ISO)
Macrocephaly  (ISO)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 13  (ISO)
middle cerebral artery infarction  (ISO)
Muscle Hypotonia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
neonatal diabetes  (ISO)
Neonatal Hypoglycemia, Simulating Foetopathia Diabetica  (ISO)
Neuraminidase Deficiency  (ISO)
newborn respiratory distress syndrome  (ISO)
Parkinsonism  (ISO)
permanent neonatal diabetes mellitus  (ISO)
Permanent Neonatal Diabetes Mellitus 3  (ISO)
polyhydramnios  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Retrognathia  (ISO)
sciatic neuropathy  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
transient neonatal diabetes mellitus  (ISO)
Transient Neonatal Diabetes Mellitus, 2  (ISO)
Transient Neonatal Diabetes Mellitus, 3  (ISO)
Traumatic Subarachnoid Hemorrhage  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diabetes mellitus pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin secretion pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway   (ISO)
type 2 diabetes mellitus pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Abcc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,216,196 - 32,289,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBIChiLan1.0ChiLan1.0
ABCC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,392,498 - 17,476,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,392,498 - 17,476,894 (-)EnsemblGRCh38hg38GRCh38
GRCh371117,414,045 - 17,498,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,371,008 - 17,455,025 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,371,008 - 17,455,025NCBI
Celera1117,544,259 - 17,628,301 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,098,250 - 17,182,251 (-)NCBIHuRef
CHM1_11117,414,230 - 17,498,274 (-)NCBICHM1_1
T2T-CHM13v2.01117,490,094 - 17,574,439 (-)NCBIT2T-CHM13v2.0
Abcc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,753,952 - 45,829,441 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,753,947 - 45,829,457 (-)EnsemblGRCm39 Ensembl
GRCm38746,104,523 - 46,180,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,104,523 - 46,180,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,359,893 - 53,435,403 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,972,565 - 46,048,075 (-)NCBIMGSCv36mm8
Celera741,577,813 - 41,653,419 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
Abcc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,734,992 - 105,816,272 (-)NCBIGRCr8
mRatBN7.2196,598,568 - 96,679,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,598,647 - 96,679,510 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,984,796 - 102,065,631 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,456,780 - 110,537,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,747,149 - 103,827,975 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,110,708 - 102,191,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,110,708 - 102,191,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,194,473 - 103,275,508 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,622,574 - 96,703,723 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,700,590 - 96,781,880 (-)NCBI
Celera190,849,685 - 90,928,224 (-)NCBICelera
Cytogenetic Map1q22NCBI
ABCC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,726,501 - 19,810,466 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,686,950 - 19,770,932 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,447,564 - 17,531,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,133,063 - 17,216,870 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,133,063 - 17,216,870 (-)Ensemblpanpan1.1panPan2
ABCC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,963,001 - 40,037,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,962,947 - 40,036,981 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,461,452 - 39,537,172 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,066,585 - 41,142,504 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,066,585 - 41,142,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,079,280 - 40,154,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,286,724 - 40,362,392 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,625,433 - 40,701,220 (-)NCBIUU_Cfam_GSD_1.0
Abcc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,574,794 - 45,648,893 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,608,757 - 1,682,975 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,608,782 - 1,682,873 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,666,909 - 41,754,620 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,666,974 - 41,754,624 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,725,495 - 44,812,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,494,861 - 47,578,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,494,959 - 47,578,882 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038144,915,676 - 145,009,083 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,018,721 - 9,092,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,018,616 - 9,092,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025400   ⟹   ENSCLAP00000025154
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541432,216,196 - 32,289,053 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000025401   ⟹   ENSCLAP00000025155
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541432,216,347 - 32,288,949 (-)Ensembl
RefSeq Acc Id: XM_005380385   ⟹   XP_005380442
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005380386   ⟹   XP_005380443
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013512092   ⟹   XP_013367546
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013512093   ⟹   XP_013367547
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005380443   ⟸   XM_005380386
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W9D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005380442   ⟸   XM_005380385
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W7F0 (UniProtKB/TrEMBL),   A0A8C2W9D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013367547   ⟸   XM_013512093
- Peptide Label: isoform X4
- UniProtKB: A0A8C2W9D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013367546   ⟸   XM_013512092
- Peptide Label: isoform X3
- UniProtKB: A0A8C2W9D8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000025154   ⟸   ENSCLAT00000025400
Ensembl Acc Id: ENSCLAP00000025155   ⟸   ENSCLAT00000025401
Protein Domains
ABC transmembrane type-1   ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017273 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025400 ENTREZGENE
  ENSCLAT00000025400.1 UniProtKB/TrEMBL
  ENSCLAT00000025401 ENTREZGENE
  ENSCLAT00000025401.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like_ATP-bd UniProtKB/TrEMBL
  ABC_transporter-like_CS UniProtKB/TrEMBL
  ABC_transporter_C UniProtKB/TrEMBL
  ABCC8 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Sulphorea_rcpt UniProtKB/TrEMBL
NCBI Gene Abcc8 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PRINTS SULFNYLUR1 UniProtKB/TrEMBL
  SULFNYLUREAR UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A8C2W7F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W9D8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Abcc8  ATP binding cassette subfamily C member 8    ATP-binding cassette, sub-family C (CFTR/MRP), member 8  Symbol and/or name change 5135510 APPROVED