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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Reelin signaling pathway
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Accession:PW:0000388 term browser browse the term
Definition:The reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in schizophrenic brains but the link between the reelin pathway and the disease remains to be established.
Synonyms:related_synonym: reelin-mediated signaling pathway
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Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 EXP PID PID:200062 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 EXP PID PID:200062 NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070 		JBrowse link
G CBL Cbl proto-oncogene EXP PID PID:200062 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926 		JBrowse link
G CDK5 cyclin dependent kinase 5 EXP PID PID:200062 NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 EXP PID PID:200062 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein EXP PID PID:200062 NCBI chr22:20,917,407...20,953,747
Ensembl chr22:20,917,407...20,953,747 		JBrowse link
G DAB1 DAB adaptor protein 1 TAS
EXP		 PID
RGD		 PMID:12764038 PID:200062, RGD:1358468 NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO
EXP		 PID
RGD		 PMID:12778121 PID:200062, RGD:2324970 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO RGD PMID:18237558 RGD:2325284 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO
EXP		 PID
RGD		 PMID:18237558 PID:200062, RGD:2325284 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO
EXP		 PID
RGD		 PMID:18237558 PID:200062, RGD:2325284 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta EXP PID PID:200062 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G ITGA3 integrin subunit alpha 3 ISO
EXP		 PID
RGD		 PMID:15583703 PID:200062, RGD:2325851 NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO
EXP		 PID
RGD		 PMID:15583703 PID:200062, RGD:2325851 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G LRP8 LDL receptor related protein 8 TAS
EXP		 PID
RGD		 PMID:19846452 PID:200062, RGD:2324974 NCBI chr 1:53,242,364...53,328,070
Ensembl chr 1:53,242,364...53,328,469 		JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 EXP PID PID:200062 NCBI chr 4:3,503,612...3,532,422
Ensembl chr 4:3,503,612...3,532,446 		JBrowse link
G MAP1B microtubule associated protein 1B EXP PID PID:200062 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 EXP PID PID:200062 NCBI chr19:7,903,877...7,914,478
Ensembl chr19:7,903,843...7,914,478 		JBrowse link
G MAP3K11 mitogen-activated protein kinase kinase kinase 11 EXP PID PID:200062 NCBI chr11:65,597,757...65,614,221
Ensembl chr11:65,597,756...65,615,382 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 EXP PID PID:200062 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPT microtubule associated protein tau EXP PID PID:200062 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G NCK2 NCK adaptor protein 2 EXP PID PID:200062 NCBI chr 2:105,744,453...105,894,272
Ensembl chr 2:105,744,912...105,894,274 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO
EXP		 PID
RGD		 PMID:17330141 PID:200062, RGD:4107040 NCBI chr17:2,593,183...2,685,615
Ensembl chr17:2,593,183...2,685,615 		JBrowse link
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr11:117,144,287...117,178,173
Ensembl chr11:117,144,284...117,176,894 		JBrowse link
G PAFAH1B3 platelet activating factor acetylhydrolase 1b catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr19:42,297,033...42,302,800
Ensembl chr19:42,297,033...42,303,546 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha EXP PID PID:200062 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO
EXP		 PID
RGD		 PMID:17167084 PID:200062, RGD:4108507 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family EXP PID PID:200062 NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 EXP PID PID:200062 NCBI chr 9:131,576,775...131,740,076
Ensembl chr 9:131,576,770...131,740,076 		JBrowse link
G RELN reelin TAS
EXP		 PID
RGD		 PMID:12893944 PID:200062, RGD:1358346 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase TAS RGD PMID:18237558 RGD:2325284 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G VLDLR very low density lipoprotein receptor TAS
EXP		 PID
RGD		 PMID:12893944 PID:200062, RGD:1358346 NCBI chr 9:2,621,787...2,660,056
Ensembl chr 9:2,621,182...2,660,056 		JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAB1 DAB adaptor protein 1 TAS RGD PMID:12764038 RGD:1358468 NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452 		JBrowse link
G ITGA3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G LRP8 LDL receptor related protein 8 TAS RGD PMID:19846452 RGD:2324974 NCBI chr 1:53,242,364...53,328,070
Ensembl chr 1:53,242,364...53,328,469 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr17:2,593,183...2,685,615
Ensembl chr17:2,593,183...2,685,615 		JBrowse link
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr11:117,144,287...117,178,173
Ensembl chr11:117,144,284...117,176,894 		JBrowse link
G PAFAH1B3 platelet activating factor acetylhydrolase 1b catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr19:42,297,033...42,302,800
Ensembl chr19:42,297,033...42,303,546 		JBrowse link
G RELN reelin ISS RGD PMID:12764038 RGD:1358468 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase TAS RGD PMID:18237558 RGD:2325284 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G VLDLR very low density lipoprotein receptor TAS RGD PMID:12764038 RGD:1358468 NCBI chr 9:2,621,787...2,660,056
Ensembl chr 9:2,621,182...2,660,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5956
    signaling pathway 2492
      signaling pathway pertinent to the brain and nervous system 467
        Reelin signaling pathway 32
          altered Reelin signaling pathway 11
Path 2
Term Annotations click to browse term
  pathway 5956
    signaling pathway 2492
      glycoconjugated protein signaling pathway 415
        glycoprotein signaling pathway 299
          Reelin signaling pathway 32
            altered Reelin signaling pathway 11
paths to the root