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ONTOLOGY REPORT - ANNOTATIONS

Term:acetyl-CoA biosynthetic process from pyruvate
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Accession:GO:0006086 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
Synonyms:exact_synonym: acetyl-CoA anabolism from pyruvate;   acetyl-CoA formation from pyruvate;   acetyl-CoA synthesis from pyruvate;   pyruvate dehydrogenase pathway
 xref: MetaCyc:PYRUVDEHYD-PWY;   Reactome:R-HSA-372342.1;   Reactome:R-HSA-71397.1


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acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
ISO
IBA
IEA		 MGI:2386703 (PMID:17314311), (PMID:27621431)
GO_REF:0000033
GO_REF:0000002
(PMID:24534072)		 RGD
GO_Central
InterPro		 PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000002 GO_REF:0000033, RGD:1599112 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
ISO		 MGI:2386703 (PMID:17314311), (PMID:27621431)
(PMID:24534072)		 RGD PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 RGD:1599112 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:22628558) RGD PMID:22628558 NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:22628558)
MGI:5635078 (PMID:22628558), (PMID:24910426)		 RGD PMID:22628558 PMID:24910426 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA		 GO_REF:0000002
(PMID:19081061), (PMID:24534072)
GO_REF:0000114
GO_REF:0000033
MGI:2182095|MGI:2386703 (PMID:18586888)		 InterPro
RGD
ComplexPortal
GO_Central		 PMID:18586888 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114, RGD:1599112 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:82,511,483...82,514,378
Ensembl chr16:82,511,511...82,514,372 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:7487891 GO_REF:0000033, RGD:1599112 NCBI chr 2:229,872,300...229,873,848 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
IBA
ISO
IEA		 GO_REF:0000033
GO_REF:0000114
GO_REF:0000002
(PMID:19081061), (PMID:24534072)
GO_REF:0000107		 GO_Central
ComplexPortal
InterPro
RGD
Ensembl		 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1599112 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in ISO (PMID:24534072) RGD PMID:24534072 NCBI chr 3:89,372,248...89,431,779
Ensembl chr 3:89,371,497...89,431,773 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5487511|PMID:22195962)		 Ensembl
RGD		 PMID:22195962 GO_REF:0000107 MGI:5487511 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISO
ISS
IEA		 (MGI:5428826|PMID:22360721)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22360721 GO_REF:0000024 GO_REF:0000107 MGI:5428826 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:58,486,554...58,553,557 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
ISS
IEA		 (PMID:21852536)
GO_REF:0000024
(MGI:3692363|PMID:16606348)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:16606348 PMID:21852536 GO_REF:0000024 GO_REF:0000107 MGI:3692363 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11448
      amide metabolic process 435
        acyl-CoA metabolic process 94
          acetyl-CoA metabolic process 39
            acetyl-CoA biosynthetic process 20
              acetyl-CoA biosynthetic process from pyruvate 13
                regulation of acetyl-CoA biosynthetic process from pyruvate 4
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11448
      organic substance metabolic process 10963
        organic cyclic compound metabolic process 6032
          nucleobase-containing compound metabolic process 5530
            nucleobase-containing small molecule metabolic process 688
              nucleoside phosphate metabolic process 616
                nucleotide metabolic process 606
                  purine nucleotide metabolic process 549
                    purine ribonucleotide metabolic process 467
                      acyl-CoA metabolic process 94
                        acetyl-CoA metabolic process 39
                          acetyl-CoA biosynthetic process 20
                            acetyl-CoA biosynthetic process from pyruvate 13
                              regulation of acetyl-CoA biosynthetic process from pyruvate 4
paths to the root