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ONTOLOGY REPORT - ANNOTATIONS


Term:pyruvate decarboxylation to acetyl-CoA
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Accession:GO:0006086 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
Synonyms:exact_synonym: acetyl-CoA anabolism from pyruvate;   acetyl-CoA biosynthetic process from pyruvate;   acetyl-CoA formation from pyruvate;   acetyl-CoA synthesis from pyruvate;   oxidative decarboxylation of pyruvate;   pyruvate dehydrogenase pathway
 narrow_synonym: pyruvate decarboxylation
 xref: MetaCyc:PYRUVDEHYD-PWY;   Reactome:R-HSA-9861559 "PDH complex synthesizes acetyl-CoA from PYR"



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pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
ISO
IBA
MGI:2386703 (PMID:17314311), (PMID:27621431)
GO_REF:0000033
(PMID:24534072)
RGD
GO_Central
PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000033, RGD:1599112 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479
JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
ISO
MGI:2386703 (PMID:17314311), (PMID:27621431)
(PMID:24534072)
RGD PMID:17314311 PMID:24534072 PMID:27621431 PMID:7487891 RGD:1599112 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within
involved_in
ISO (PMID:22628558) RGD PMID:22628558 NCBI chr 1:54,985,305...54,996,979
Ensembl chr 1:52,437,741...52,449,400
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within
ISO (PMID:22628558)
MGI:5635078 (PMID:22628558), (PMID:24910426)
RGD PMID:22628558 PMID:24910426 NCBI chr13:80,261,143...80,280,668
Ensembl chr13:77,728,250...77,747,664
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in
acts_upstream_of_or_within
IDA
IEA
ISO
IBA
GO_REF:0000117
MGI:2182095|MGI:2386703 (PMID:18586888)
GO_REF:0000033
GO_REF:0000114
(PMID:19081061), (PMID:24534072)
UniProt
RGD
GO_Central
ComplexPortal
PMID:18586888 PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:1599112 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:89,213,172...89,216,067
Ensembl chr16:82,511,511...82,514,372
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:7487891 GO_REF:0000033, RGD:1599112 NCBI chr 2:232,545,550...232,547,098 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
IBA
ISO
IEA
GO_REF:0000033
GO_REF:0000114
GO_REF:0000002
(PMID:19081061), (PMID:24534072)
GO_REF:0000107
GO_Central
ComplexPortal
InterPro
RGD
Ensembl
PMID:19081061 PMID:24534072 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1599112 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:16,750,980...16,758,500
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in ISO (PMID:24534072)
MGI:2386703 (PMID:17314311), (PMID:27621431)
RGD PMID:17314311 PMID:24534072 PMID:27621431 NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:89,371,497...89,431,773
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
negative regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:26942675) RGD PMID:26942675 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdk branched chain ketoacid dehydrogenase kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:182,515,327...182,536,633
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:22195962)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:22195962 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISS
IEA
ISO
IBA
GO_REF:0000024
GO_REF:0000107
(PMID:22360721)
GO_REF:0000033
UniProt
Ensembl
RGD
GO_Central
PMID:22360721 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:62,480,535...62,547,371
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
ISS
IEA
IBA
(PMID:21852536)
GO_REF:0000024
GO_REF:0000107
(PMID:16606348)
GO_REF:0000033
RGD
UniProt
Ensembl
GO_Central
PMID:16606348 PMID:21852536 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in ISO (PMID:38547260) RGD PMID:38547260 NCBI chr 4:73,170,125...73,557,683
Ensembl chr 4:72,170,134...72,557,694
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      metabolic process 12181
        purine-containing compound metabolic process 620
          acyl-CoA metabolic process 97
            acetyl-CoA metabolic process 42
              acetyl-CoA biosynthetic process 23
                pyruvate decarboxylation to acetyl-CoA 16
                  negative regulation of acetyl-CoA biosynthetic process from pyruvate 1
                  regulation of acetyl-CoA biosynthetic process from pyruvate + 7
Path 2
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      metabolic process 12181
        primary metabolic process 10757
          nucleobase-containing compound metabolic process 5951
            nucleobase-containing small molecule metabolic process 732
              nucleoside phosphate metabolic process 697
                acyl-CoA metabolic process 97
                  acyl-CoA biosynthetic process 38
                    acetyl-CoA biosynthetic process 23
                      pyruvate decarboxylation to acetyl-CoA 16
                        negative regulation of acetyl-CoA biosynthetic process from pyruvate 1
                        regulation of acetyl-CoA biosynthetic process from pyruvate + 7
paths to the root