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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism


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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 IDA RGD PMID:16476568 RGD:2317620 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acaca acetyl-CoA carboxylase alpha involved_in IEA
ISO
GO_REF:0000107
(MGI:4840155|PMID:20952656)
Ensembl
RGD
PMID:20952656 GO_REF:0000107 MGI:4840155 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acacb acetyl-CoA carboxylase beta involved_in ISO (PMID:20952656) RGD PMID:20952656 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acly ATP citrate lyase IDA RGD PMID:18062843 RGD:2317315 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acot12 acyl-CoA thioesterase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2450440|PMID:12545200)
Ensembl
RGD
PMID:12545200 GO_REF:0000107 MGI:2450440 NCBI chr 2:20,857,056...20,901,656
Ensembl chr 2:20,857,202...20,901,659
JBrowse link
G Cs citrate synthase IDA RGD PMID:5820645, PMID:938457, PMID:818082 RGD:2306824, RGD:2306828, RGD:2306825 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Fasn fatty acid synthase IDA RGD PMID:18062843 RGD:2317315 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO
IBA
(PMID:23751782)
PMID:21873635
RGD PMID:23751782, PMID:21873635 RGD:13792537 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) RGD PMID:17371050 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acly ATP citrate lyase involved_in NAS
IEA
ISO
IBA
GO_REF:0000107
(PMID:1371749)
PMID:21873635
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:1371749, PMID:2295639, PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:631761, RGD:13792537 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in
acts_upstream_of_or_within
ISO (PMID:16788062)
(MGI:2151932|PMID:11150295)
RGD PMID:11150295 PMID:16788062 MGI:2151932 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 acts_upstream_of_or_within ISO (MGI:2151932|PMID:11150295) RGD PMID:11150295 MGI:2151932 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Dip2a disco-interacting protein 2 homolog A involved_in ISO (MGI:6478983|PMID:30672040) RGD PMID:30672040 MGI:6478983 NCBI chr20:13,044,056...13,127,971
Ensembl chr20:13,044,104...13,127,487
JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in IDA
IEA
ISO
IBA
GO_REF:0000041
(PMID:10417274), (PMID:10455107), (PMID:9869665)
PMID:21873635
UniProt
RGD
PMID:9869665 PMID:10417274 PMID:10455107, PMID:17316539, PMID:21873635 GO_REF:0000041, RGD:1600790, RGD:13792537 NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO (PMID:29754768) RGD PMID:29754768 NCBI chr 5:138,466,298...138,470,108
Ensembl chr 5:138,466,293...138,470,096
JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7487891, PMID:21873635 RGD:1599112, RGD:13792537 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Dld dihydrolipoamide dehydrogenase IDA RGD PMID:7487891 RGD:1599112 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in IDA
ISO
IBA
IEA
(PMID:19081061)
PMID:21873635
GO_REF:0000002
RGD
InterPro
PMID:19081061, PMID:7487891, PMID:21873635 GO_REF:0000002, RGD:1599112, RGD:13792537 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:88,344,440...88,347,335
Ensembl chr16:88,345,247...88,347,369
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7487891, PMID:21873635 RGD:1599112, RGD:13792537 NCBI chr 2:246,736,449...246,737,997
Ensembl chr 2:246,736,459...246,737,997
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
ISO
IEA
IBA
(PMID:19081061)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:19081061, PMID:7487891, PMID:21873635 GO_REF:0000107, RGD:1599112, RGD:13792537 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:92,910,300...92,933,725
Ensembl chr 3:92,909,725...92,969,050
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) RGD PMID:17371050 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Nudt7 nudix hydrolase 7 involved_in
acts_upstream_of_or_within
ISO (MGI:6450264|PMID:18799520)
(MGI:2137102|PMID:11415433)
RGD PMID:11415433 PMID:18799520 MGI:2137102 MGI:6450264 NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050
JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:197206, PMID:21873635 RGD:2316852, RGD:13792537 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mvk mevalonate kinase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:197206, PMID:21873635 GO_REF:0000041, RGD:2316852, RGD:13792537 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Pmvk phosphomevalonate kinase involved_in IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:197206, PMID:21873635 GO_REF:0000041, RGD:2316852, RGD:13792537 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase involved_in ISO
IBA
(PMID:10642506)
PMID:21873635
RGD PMID:10642506, PMID:21873635 RGD:13792537 NCBI chr10:64,951,986...64,964,865
Ensembl chr10:64,952,119...64,964,862
JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Aass aminoadipate-semialdehyde synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558) RGD PMID:22628558 MGI:5428352 NCBI chr 1:53,026,608...53,038,229
Ensembl chr 1:53,026,608...53,038,229
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within ISO MGI:5635078 (MGI:5428352|PMID:22628558), (MGI:5576400|PMID:24910426) RGD PMID:22628558 PMID:24910426 MGI:5428352 MGI:5576400 NCBI chr13:83,680,527...83,700,491
Ensembl chr13:83,681,322...83,700,213
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within ISO MGI:2182095|MGI:2386703 (MGI:3817854|PMID:18586888) RGD PMID:18586888 MGI:3817854 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5487511|PMID:22195962)
Ensembl
RGD
PMID:22195962 GO_REF:0000107 MGI:5487511 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5428826|PMID:22360721)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22360721 GO_REF:0000024 GO_REF:0000107 MGI:5428826 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3692363|PMID:16606348)
GO_REF:0000024
(PMID:21852536)
Ensembl
RGD
UniProt
PMID:16606348 PMID:21852536 GO_REF:0000024 GO_REF:0000107 MGI:3692363 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase IDA RGD PMID:7236232 RGD:2303721 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7236232, PMID:21873635 RGD:2303721, RGD:13792537 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    metabolic process 11878
      organic substance metabolic process 11408
        thioester metabolic process 89
          acyl-CoA metabolic process 89
            acetyl-CoA metabolic process 38
              L-lysine catabolic process to acetyl-CoA + 4
              L-threonine catabolic process to acetyl-CoA 0
              acetyl-CoA biosynthetic process + 20
              acetyl-CoA catabolic process + 2
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
              tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      cellular metabolic process 10831
        heterocycle metabolic process 5553
          nucleobase-containing compound metabolic process 5419
            nucleobase-containing small molecule metabolic process 578
              nucleoside phosphate metabolic process 511
                nucleotide metabolic process 503
                  ribonucleotide metabolic process 419
                    purine ribonucleotide metabolic process 401
                      acyl-CoA metabolic process 89
                        acetyl-CoA metabolic process 38
                          L-lysine catabolic process to acetyl-CoA + 4
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 20
                          acetyl-CoA catabolic process + 2
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root