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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism



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acetyl-CoA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 IDA RGD PMID:16476568 RGD:2317620 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acaca acetyl-CoA carboxylase alpha involved_in ISO (MGI:4840155|PMID:20952656) RGD PMID:20952656 MGI:4840155 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta involved_in ISO (PMID:20952656) RGD PMID:20952656 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acly ATP citrate lyase IDA RGD PMID:18062843 RGD:2317315 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acot12 acyl-CoA thioesterase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2450440|PMID:12545200)
Ensembl
RGD
PMID:12545200 GO_REF:0000107 MGI:2450440 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Cs citrate synthase IDA RGD PMID:5820645 PMID:938457 PMID:818082 RGD:2306824, RGD:2306828, RGD:2306825 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Fasn fatty acid synthase IDA RGD PMID:18062843 RGD:2317315 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO
IBA
(PMID:23751782)
PMID:21873635
RGD PMID:23751782 PMID:21873635 RGD:13792537 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) RGD PMID:17371050 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Acly ATP citrate lyase involved_in NAS
IEA
ISO
IBA
GO_REF:0000107
(PMID:1371749)
PMID:21873635
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:1371749 PMID:2295639 PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:631761, RGD:13792537 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:16788062)
PMID:21873635
(MGI:2151932|PMID:11150295)
RGD PMID:11150295 PMID:16788062 PMID:21873635 MGI:2151932, RGD:13792537 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:2151932|PMID:11150295)
PMID:21873635
RGD PMID:11150295 PMID:21873635 MGI:2151932, RGD:13792537 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Dip2a disco-interacting protein 2 homolog A involved_in ISO (MGI:6478983|PMID:30672040) RGD PMID:30672040 MGI:6478983 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in IDA
IEA
ISO
IBA
GO_REF:0000041
(PMID:10417274), (PMID:10455107), (PMID:9869665)
PMID:21873635
UniProt
RGD
PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 PMID:21873635 GO_REF:0000041, RGD:1600790, RGD:13792537 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO (PMID:29754768) RGD PMID:29754768 NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933
JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
IBA
ISO
PMID:21873635
(PMID:24534072)
RGD PMID:24534072 PMID:7487891 PMID:21873635 RGD:1599112, RGD:13792537 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
ISO
(PMID:24534072) RGD PMID:24534072 PMID:7487891 RGD:1599112 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
IEA
MGI:2182095|MGI:2386703 (MGI:3817854|PMID:18586888)
(PMID:19081061), (PMID:24534072)
PMID:21873635
GO_REF:0000002
RGD
InterPro
PMID:18586888 PMID:19081061 PMID:24534072 PMID:7487891 PMID:21873635 GO_REF:0000002 MGI:3817854, RGD:1599112, RGD:13792537 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:82,511,483...82,514,378
Ensembl chr16:82,511,511...82,514,372
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7487891 PMID:21873635 RGD:1599112, RGD:13792537 NCBI chr 2:229,872,300...229,873,848 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
ISO
IEA
IBA
(PMID:19081061), (PMID:24534072)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:19081061 PMID:24534072 PMID:7487891 PMID:21873635 GO_REF:0000107, RGD:1599112, RGD:13792537 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in ISO (PMID:24534072) RGD PMID:24534072 NCBI chr 3:89,372,472...89,396,759
Ensembl chr 3:89,371,497...89,431,773
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:17371050) RGD PMID:17371050 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Nudt7 nudix hydrolase 7 acts_upstream_of_or_within
involved_in
ISO (MGI:2137102|PMID:11415433)
(MGI:6157214|PMID:29378847), (MGI:6450264|PMID:18799520)
RGD PMID:11415433 PMID:18799520 PMID:29378847 MGI:2137102 MGI:6157214 MGI:6450264 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
JBrowse link
G Nudt8 nudix hydrolase 8 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:201,293,660...201,295,233
Ensembl chr 1:201,292,619...201,295,224
JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:197206 PMID:21873635 RGD:2316852, RGD:13792537 NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Mvk mevalonate kinase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt
RGD
PMID:197206 PMID:21873635 GO_REF:0000041, RGD:2316852, RGD:13792537 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Pmvk phosphomevalonate kinase involved_in IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt
RGD
PMID:197206 PMID:21873635 GO_REF:0000041, RGD:2316852, RGD:13792537 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase involved_in ISO
IBA
(PMID:10642506)
PMID:21873635
RGD PMID:10642506 PMID:21873635 RGD:13792537 NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370
JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Aass aminoadipate-semialdehyde synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within ISO (MGI:5428352|PMID:22628558) RGD PMID:22628558 MGI:5428352 NCBI chr 1:52,437,745...52,449,369
Ensembl chr 1:52,437,741...52,449,400
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within ISO MGI:5635078 (MGI:5428352|PMID:22628558), (MGI:5576400|PMID:24910426) RGD PMID:22628558 PMID:24910426 MGI:5428352 MGI:5576400 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within ISO MGI:2182095|MGI:2386703 (MGI:3817854|PMID:18586888) RGD PMID:18586888 MGI:3817854 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5487511|PMID:22195962)
Ensembl
RGD
PMID:22195962 GO_REF:0000107 MGI:5487511 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISO
ISS
(MGI:5428826|PMID:22360721)
GO_REF:0000024
RGD
UniProt
PMID:22360721 GO_REF:0000024 MGI:5428826 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
ISS
(PMID:21852536)
(MGI:3692363|PMID:16606348)
GO_REF:0000024
RGD
UniProt
PMID:16606348 PMID:21852536 GO_REF:0000024 MGI:3692363 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase IDA RGD PMID:7236232 RGD:2303721 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7236232 PMID:21873635 RGD:2303721, RGD:13792537 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    metabolic process 11591
      organic substance metabolic process 11152
        thioester metabolic process 93
          acyl-CoA metabolic process 93
            acetyl-CoA metabolic process 39
              L-lysine catabolic process to acetyl-CoA + 4
              L-threonine catabolic process to acetyl-CoA 0
              acetyl-CoA biosynthetic process + 20
              acetyl-CoA catabolic process + 3
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
              tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 18877
    cellular process 17586
      cellular metabolic process 9831
        heterocycle metabolic process 5576
          nucleobase-containing compound metabolic process 5422
            nucleobase-containing small molecule metabolic process 640
              nucleoside phosphate metabolic process 574
                nucleotide metabolic process 568
                  ribonucleotide metabolic process 452
                    purine ribonucleotide metabolic process 432
                      acyl-CoA metabolic process 93
                        acetyl-CoA metabolic process 39
                          L-lysine catabolic process to acetyl-CoA + 4
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 20
                          acetyl-CoA catabolic process + 3
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root