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ONTOLOGY REPORT - ANNOTATIONS

Term:acetyl-CoA biosynthetic process
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Accession:GO:0006085 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
Synonyms:exact_synonym: acetyl-CoA anabolism;   acetyl-CoA biosynthesis;   acetyl-CoA formation;   acetyl-CoA synthesis
 xref: MetaCyc:Acetyl-CoA-Biosynthesis


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acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO
IEA 		(PMID:17371050)
GO_REF:0000107 		RGD
Ensembl		 PMID:17371050 GO_REF:0000107 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042 		JBrowse link
G Acly ATP citrate lyase involved_in IEA
IBA
ISO 		GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:1371749), (PMID:39881208) 		InterPro
Ensembl
GO_Central
RGD		 PMID:1371749 PMID:39881208 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:16788062)
(PMID:11150295)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:11150295 PMID:16788062 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:11150295) 		GO_Central
RGD		 PMID:11150295 GO_REF:0000033 NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830 		JBrowse link
G Dip2a disco-interacting protein 2 homolog A involved_in ISO (PMID:30672040) RGD PMID:30672040 NCBI chr20:12,284,037...12,373,519
Ensembl chr20:12,284,038...12,370,532 		JBrowse link
G Mlycd malonyl-CoA decarboxylase involved_in IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
GO_REF:0000041
(PMID:10417274), (PMID:10455107), (PMID:9869665) 		Ensembl
GO_Central
UniProt
RGD		 PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:1600790 NCBI chr19:64,356,582...64,372,447
Ensembl chr19:64,356,223...64,372,446 		JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase involved_in ISO
IEA 		(PMID:29754768)
GO_REF:0000107 		RGD
Ensembl		 PMID:29754768 GO_REF:0000107 NCBI chr 5:138,308,394...138,312,047
Ensembl chr 5:138,308,397...138,312,012 		JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748 		JBrowse link
negative regulation of pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pgk1 phosphoglycerate kinase 1 involved_in ISO
IEA 		(PMID:26942675)
GO_REF:0000107 		RGD
Ensembl		 PMID:26942675 GO_REF:0000107 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:75,336,687...75,352,959 		JBrowse link
G Pgk1l1 phosphoglycerate kinase 1 like 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:44,487,980...44,489,330
Ensembl chr 2:44,488,018...44,489,235 		JBrowse link
G Sirt4 sirtuin 4 involved_in ISO
IEA 		(PMID:25525879)
GO_REF:0000107 		RGD
Ensembl		 PMID:25525879 GO_REF:0000107 NCBI chr12:46,785,852...46,800,179
Ensembl chr12:46,791,898...46,800,173 		JBrowse link
positive regulation of pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 involved_in ISO (PMID:15855260) RGD PMID:15855260 NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960 		JBrowse link
G Pdpr pyruvate dehydrogenase phosphatase regulatory subunit involved_in ISO (PMID:38062777) RGD PMID:38062777 NCBI chr19:55,974,611...56,019,045
Ensembl chr19:55,974,550...56,019,044 		JBrowse link
pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase involved_in IDA
ISO
IEA
IBA 		(PMID:27621431)
(PMID:20160912), (PMID:24534072)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
GO_REF:0000033 		RGD
Ensembl
InterPro
UniProt
GO_Central		 PMID:20160912 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1599112 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in IDA
ISO
IEA 		MGI:2182403 (PMID:9405644)
(PMID:16442803), (PMID:24534072)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:9405644 PMID:16442803 PMID:24534072 PMID:7487891 GO_REF:0000107 GO_REF:0000117, RGD:1599112 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 acts_upstream_of_or_within
involved_in 		ISO (PMID:22628558) RGD PMID:22628558 NCBI chr 1:54,985,305...54,996,979
Ensembl chr 1:54,985,301...54,997,064 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 acts_upstream_of_or_within
involved_in 		IEA
ISO 		GO_REF:0000107
(PMID:22628558)
MGI:5635078 (PMID:22628558), (PMID:24910426) 		Ensembl
RGD		 PMID:22628558 PMID:24910426 GO_REF:0000107 NCBI chr13:80,261,143...80,280,668
Ensembl chr13:80,259,727...80,280,668 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 involved_in
acts_upstream_of_or_within 		IDA
ISO
IEA
IBA 		MGI:2386703 (PMID:17314311), (PMID:27621431)
MGI:2182095|MGI:2386703 (PMID:18586888)
GO_REF:0000002
GO_REF:0000117
GO_REF:0000033
GO_REF:0000114
(PMID:19081061), (PMID:24534072) 		RGD
InterPro
UniProt
GO_Central
ComplexPortal		 PMID:17314311 PMID:18586888 PMID:19081061 PMID:24534072 PMID:27621431 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:1599112 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:38,509,084...38,522,536 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 involved_in IDA
ISO
IEA
IBA 		(PMID:16436377)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033 		RGD
Ensembl
InterPro
GO_Central		 PMID:16436377 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1599112 NCBI chr 2:232,545,550...232,547,098
Ensembl chr 2:232,415,088...232,549,624 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta involved_in IDA
ISO
IBA
IEA 		MGI:2386703 (PMID:17314311), (PMID:27621431)
GO_REF:0000033
GO_REF:0000114
GO_REF:0000002
(PMID:19081061), (PMID:24534072)
GO_REF:0000107 		RGD
GO_Central
ComplexPortal
InterPro
Ensembl		 PMID:17314311 PMID:19081061 PMID:24534072 PMID:27621431 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1599112 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:19,181,208...19,188,976 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X involved_in ISO
IEA 		(PMID:24534072)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117 		RGD
Ensembl
InterPro
UniProt		 PMID:24534072 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:109,827,209...109,886,905 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
regulation of pyruvate decarboxylation to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdk branched chain ketoacid dehydrogenase kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
(PMID:22195962) 		Ensembl
GO_Central
RGD		 PMID:22195962 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:22360721) 		UniProt
GO_Central
RGD		 PMID:22360721 GO_REF:0000024 GO_REF:0000033 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:62,480,535...62,547,371
Ensembl chr  X:62,480,535...62,547,371 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
ISS
IEA
IBA 		(PMID:21852536)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:16606348) 		RGD
UniProt
Ensembl
GO_Central		 PMID:16606348 PMID:21852536 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960 		JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 involved_in ISO
IEA 		(PMID:38547260)
GO_REF:0000107 		RGD
Ensembl		 PMID:38547260 GO_REF:0000107 NCBI chr 4:73,170,125...73,557,683
Ensembl chr 4:73,170,125...73,557,783 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        purine-containing compound metabolic process 591
          purine-containing compound biosynthetic process 231
            acyl-CoA biosynthetic process 43
              acetyl-CoA biosynthetic process 26
                acetyl-CoA biosynthetic process from acetate 1
                acetyl-CoA biosynthetic process from ethanol 0
                acetyl-CoA biosynthetic process from pantothenate 0
                carbon fixation by acetyl-CoA pathway 0
                pyruvate decarboxylation to acetyl-CoA + 19
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        primary metabolic process 10162
          nucleobase-containing compound metabolic process 5642
            nucleobase-containing small molecule metabolic process 693
              nucleoside phosphate metabolic process 660
                acyl-CoA metabolic process 104
                  acyl-CoA biosynthetic process 43
                    acetyl-CoA biosynthetic process 26
                      acetyl-CoA biosynthetic process from acetate 1
                      acetyl-CoA biosynthetic process from ethanol 0
                      acetyl-CoA biosynthetic process from pantothenate 0
                      carbon fixation by acetyl-CoA pathway 0
                      pyruvate decarboxylation to acetyl-CoA + 19
paths to the root