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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of ERBB signaling pathway
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Accession:GO:1901184 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: regulation of EGF receptor family signaling pathway;   regulation of ERBB signalling pathway;   regulation of ErbB signaling
 related_synonym: regulation of EGFR family signaling pathway

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regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SH3TC2 SH3 domain and tetratricopeptide repeats 2 acts_upstream_of_or_within ISO (PMID:23553667) MGI PMID:23553667 NCBI chr23:51,615,754...51,677,650 JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB7A RAB7A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:52,231,481...52,309,276
Ensembl chr22:52,230,835...52,309,306 		JBrowse link
G SNX5 sorting nexin 5 ISO RGD PMID:16487940 RGD:13508623 NCBI chr 2:47,001,684...47,028,510
Ensembl chr 2:47,002,443...47,028,293 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBL Cbl proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,581,049...110,679,284
Ensembl chr 1:110,581,143...110,674,481 		JBrowse link
G CBLC Cbl proto-oncogene C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,257,418...38,285,534
Ensembl chr 6:38,257,672...38,280,051 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in ISO PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr12:17,802,030...18,017,648
Ensembl chr12:17,801,831...17,830,890 		JBrowse link
G DUSP3 dual specificity phosphatase 3 involved_in ISO (PMID:28759036) BHF-UCL PMID:28759036 NCBI chr16:62,622,667...62,637,129
Ensembl chr16:62,622,663...62,637,127 		JBrowse link
G EGFR epidermal growth factor receptor involved_in ISO (PMID:11823423)
(PMID:23457600)		 MGI PMID:11823423 PMID:23457600 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO
IEA		 RGD
Ensembl
TreeGrafter		 PMID:19204184 GO_REF:0000107 GO_REF:0000118 RGD:9685562 NCBI chr20:123,738,971...123,753,575
Ensembl chr20:123,738,973...123,755,809 		JBrowse link
G ITGA1 integrin subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:49,081,687...49,248,321
Ensembl chr 4:49,082,787...49,246,186 		JBrowse link
G MVP major vault protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:26,805,070...26,833,043
Ensembl chr 5:26,801,753...26,833,199 		JBrowse link
G NPPA natriuretic peptide A involved_in ISO (PMID:20353436) UniProt PMID:20353436 NCBI chr20:119,942,412...119,946,211
Ensembl chr20:119,944,532...119,945,917 		JBrowse link
G NUP62 nucleoporin 62 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,063,483...43,086,264
Ensembl chr 6:43,064,875...43,066,440 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:71,302,082...71,400,201
Ensembl chr18:71,310,577...71,345,960 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO RGD PMID:8557682 RGD:1642757 NCBI chr20:89,192,426...89,284,989
Ensembl chr20:89,191,660...89,284,970 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,137,896...17,328,836
Ensembl chr 1:17,135,907...17,328,590 		JBrowse link
G RNF115 ring finger protein 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:12,919,988...13,001,736
Ensembl chr20:12,920,232...13,001,135 		JBrowse link
G RNF126 ring finger protein 126 involved_in ISO (PMID:23418353) UniProt PMID:23418353 NCBI chr 6:392,717...409,139 JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO (PMID:24854121) ARUK-UCL PMID:24854121 NCBI chr12:61,862,997...62,085,254
Ensembl chr12:61,862,943...61,917,315 		JBrowse link
G TFAP2A transcription factor AP-2 alpha acts_upstream_of_or_within ISO (PMID:16449191) MGI PMID:16449191 NCBI chr17:61,750,757...61,769,041 JBrowse link
G TNK2 tyrosine kinase non receptor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:91,187,702...91,232,391
Ensembl chr15:91,201,008...91,232,399 		JBrowse link
G TSG101 tumor susceptibility 101 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:46,401,889...46,451,122
Ensembl chr 1:46,402,024...46,450,916 		JBrowse link
G ZFYVE28 zinc finger FYVE-type containing 28 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:46,340,014...46,495,299
Ensembl chr27:46,340,244...46,495,651 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHMP6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr16:72,943,048...72,951,121
Ensembl chr16:72,943,122...72,950,694 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO PMID:17599051
(PMID:16648858)
(PMID:18046415)		 UniProt PMID:16648858 PMID:17599051 PMID:18046415 RGD:8553726 NCBI chr20:123,738,971...123,753,575
Ensembl chr20:123,738,973...123,755,809 		JBrowse link
G GPRC5A G protein-coupled receptor class C group 5 member A involved_in ISO (PMID:25744720) UniProt PMID:25744720 NCBI chr11:12,800,517...12,820,861
Ensembl chr11:12,816,729...12,820,805 		JBrowse link
G PSEN1 presenilin 1 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr24:50,394,310...50,476,521
Ensembl chr24:50,405,590...50,472,132 		JBrowse link
G PSEN2 presenilin 2 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr25:2,862,354...2,888,735
Ensembl chr25:2,862,251...2,877,386 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chr24:32,198,438...32,227,240
Ensembl chr24:32,220,800...32,222,122 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chr14:60,330,192...60,335,477
Ensembl chr14:60,431,401...60,433,011
Ensembl chr14:60,431,401...60,433,011 		JBrowse link
G TSG101 tumor susceptibility 101 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr 1:46,401,889...46,451,122
Ensembl chr 1:46,402,024...46,450,916 		JBrowse link
G VPS25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr16:63,512,161...63,520,923
Ensembl chr16:63,511,674...63,521,093 		JBrowse link
G ZFYVE28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) UniProt PMID:19460345 NCBI chr27:46,340,014...46,495,299
Ensembl chr27:46,340,244...46,495,651 		JBrowse link
G ZGPAT zinc finger CCCH-type and G-patch domain containing involved_in ISO (PMID:19644445) UniProt PMID:19644445 NCBI chr 2:494,547...520,081
Ensembl chr 2:494,771...519,519 		JBrowse link
negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LGMN legumain involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:70,456,463...70,500,345
Ensembl chr24:70,456,095...70,486,087 		JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP4 acid phosphatase 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:43,838,103...43,843,715
Ensembl chr 6:43,838,321...43,843,654 		JBrowse link
G CADM1 cell adhesion molecule 1 ISO RGD PMID:23769722 RGD:152975632 NCBI chr 1:106,539,262...106,876,397
Ensembl chr 1:106,539,136...106,606,637 		JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18625725) Ensembl
BHF-UCL		 PMID:18625725 GO_REF:0000107 NCBI chr14:98,092,093...98,157,657
Ensembl chr14:98,092,044...98,157,217 		JBrowse link
G ADRA2A adrenoceptor alpha 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:104,015,577...104,019,364
Ensembl chr 9:104,016,580...104,017,932 		JBrowse link
G AFAP1L2 actin filament associated protein 1 like 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:107,164,687...107,274,433
Ensembl chr 9:107,162,963...107,273,307 		JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:41,311,250...41,324,806
Ensembl chr21:41,312,415...41,326,663 		JBrowse link
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chr20:7,884,220...7,927,738
Ensembl chr20:7,905,662...7,930,657 		JBrowse link
G CCDC88A coiled-coil domain containing 88A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:51,484,886...51,615,066
Ensembl chr14:51,484,906...51,610,654 		JBrowse link
G CNOT9 CCR4-NOT transcription complex subunit 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,473,215...104,502,321
Ensembl chr10:104,473,216...104,503,007 		JBrowse link
G DGKD diacylglycerol kinase delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:119,390,217...119,509,148
Ensembl chr10:119,390,330...119,511,134 		JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:17928626 RGD:5128669 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:17928626 RGD:5128669 NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486 		JBrowse link
G FAM83B family with sequence similarity 83 member B involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:16,582,769...16,681,943
Ensembl chr17:16,582,782...16,601,534 		JBrowse link
G FASLG Fas ligand ISO RGD PMID:18471522 RGD:2315731 NCBI chr25:56,488,572...56,496,469
Ensembl chr25:56,489,417...56,496,251 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:20445128 GO_REF:0000107 RGD:4892084 NCBI chr28:20,491,874...20,497,966
Ensembl chr28:20,492,188...20,493,315 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr16:64,515,013...64,524,270 JBrowse link
G HIP1 huntingtin interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:9,805,985...10,007,931
Ensembl chr28:9,807,672...9,914,047 		JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,173,302...118,202,840
Ensembl chr11:118,173,544...118,202,985 		JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G NEU3 neuraminidase 3 involved_in ISO (PMID:17334392) UniProt PMID:17334392 NCBI chr 1:66,220,472...66,243,163 JBrowse link
G NEU3 neuraminidase 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 1:66,221,012...66,243,919 JBrowse link
G PDE6G phosphodiesterase 6G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11502744) MGI
TreeGrafter
Ensembl		 PMID:11502744 GO_REF:0000107 GO_REF:0000118 NCBI chr16:73,582,249...73,594,139
Ensembl chr16:73,583,362...73,585,414 		JBrowse link
G PDE6H phosphodiesterase 6H involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11502744) Ensembl
TreeGrafter
MGI		 PMID:11502744 GO_REF:0000107 GO_REF:0000118 NCBI chr11:14,869,864...14,880,307
Ensembl chr11:14,870,498...14,880,324 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chr 6:37,161,957...37,191,867 JBrowse link
G PLAUR plasminogen activator, urokinase receptor involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:37,173,177...37,191,754 JBrowse link
G RALA RAS like proto-oncogene A involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:18,826,569...18,911,379
Ensembl chr21:18,826,582...18,911,357 		JBrowse link
G RALB RAS like proto-oncogene B involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:9,999,828...10,041,158
Ensembl chr10:9,999,904...10,016,473 		JBrowse link
G SHKBP1 SH3KBP1 binding protein 1 involved_in ISO (PMID:21830225) UniProt PMID:21830225 NCBI chr 6:35,036,834...35,050,953 JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:8577724 RGD:1581110 NCBI chr14:68,259,509...68,404,167
Ensembl chr14:68,259,360...68,399,895 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:59,357,611...59,362,705
Ensembl chr 3:59,358,394...59,359,341 		JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:18625725) BHF-UCL
Ensembl		 PMID:18625725 GO_REF:0000107 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
positive regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:17336907) BHF-UCL PMID:17336907 NCBI chr27:23,911,084...24,023,856 JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 Ensembl chr27:23,910,533...23,921,725 JBrowse link
positive regulation of ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RTN4 reticulon 4 involved_in ISO (PMID:27353365) CAFA PMID:27353365 NCBI chr14:51,876,697...51,955,788 JBrowse link
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH13 cadherin 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:68,048,655...69,213,102
Ensembl chr 5:68,451,894...69,211,534 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO PMID:15467833
(PMID:15467833)		 UniProt PMID:15467833 RGD:11059592 NCBI chr 6:36,708,368...36,731,729
Ensembl chr 6:36,708,311...36,730,189 		JBrowse link
G FER FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:12,252,135...12,629,584
Ensembl chr23:12,192,800...12,620,443 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:105,118,969...105,125,037
Ensembl chr20:105,118,645...105,125,151 		JBrowse link
G MVB12A multivesicular body subunit 12A involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:15,917,568...15,923,168
Ensembl chr 6:15,917,539...15,923,361 		JBrowse link
G MVB12B multivesicular body subunit 12B involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:11,639,784...11,816,005
Ensembl chr12:11,636,244...11,809,074 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:71,285,917...71,389,645
Ensembl chr21:71,285,736...71,389,926 		JBrowse link
G RHBDF1 rhomboid 5 homolog 1 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:14,935...34,991
Ensembl chr 5:13,071...21,883 		JBrowse link
G RHBDF2 rhomboid 5 homolog 2 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr16:45,176,152...45,205,464
Ensembl chr16:45,194,852...45,204,761 		JBrowse link
G WDR54 WD repeat domain 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:32,851,904...32,855,918
Ensembl chr14:32,851,959...32,855,912 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17021
    regulation of biological process 11440
      regulation of response to stimulus 4185
        regulation of signal transduction 3205
          regulation of ERBB signaling pathway 77
            negative regulation of ERBB signaling pathway + 33
            positive regulation of ERBB signaling pathway + 33
            regulation of ERBB3 signaling pathway + 1
            regulation of epidermal growth factor receptor signaling pathway + 70
Path 2
Term Annotations click to browse term
  biological_process 17021
    biological regulation 11835
      regulation of biological process 11440
        signaling 6144
          signal transduction 5634
            cell surface receptor signaling pathway 2762
              enzyme-linked receptor protein signaling pathway 985
                cell surface receptor protein tyrosine kinase signaling pathway 635
                  ERBB signaling pathway 174
                    regulation of ERBB signaling pathway 77
                      negative regulation of ERBB signaling pathway + 33
                      positive regulation of ERBB signaling pathway + 33
                      regulation of ERBB3 signaling pathway + 1
                      regulation of epidermal growth factor receptor signaling pathway + 70
paths to the root