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ONTOLOGY REPORT - ANNOTATIONS

Term:transcription regulator inhibitor activity
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Accession:GO:0140416 term browser browse the term
Definition:A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.
Comment:Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA.
Synonyms:narrow_synonym: DNA-binding transcription factor inhibitor activity


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transcription regulator inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAXX death domain associated protein enables IDA (PMID:10698492), (PMID:15572661) GO_Central PMID:10698492 PMID:15572661 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 enables ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 enables IDA (PMID:9499401) GO_Central PMID:9499401 NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,513,789...14,560,391 		JBrowse link
G ELK1 ETS transcription factor ELK1 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,520...47,650,604 		JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 enables IDA (PMID:14580347) HGNC-UCL PMID:14580347 NCBI chr17:45,148,475...45,152,099
Ensembl chr17:45,148,475...45,152,099 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A enables IDA (PMID:9499401) GO_Central PMID:9499401 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B enables IDA (PMID:9499401) GO_Central PMID:9499401 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G ID1 inhibitor of DNA binding 1 enables IDA (PMID:7665172) ARUK-UCL PMID:7665172 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,573,014...31,606,515 		JBrowse link
G ID2 inhibitor of DNA binding 2 enables TAS
ISS		 (PMID:25248477) ARUK-UCL PMID:25248477 GO_REF:0000024 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G ID3 inhibitor of DNA binding 3 enables IEA
TAS		 (PMID:25248477) Ensembl
ARUK-UCL		 PMID:25248477 GO_REF:0000107 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501 		JBrowse link
G ID4 inhibitor of DNA binding 4 enables IDA (PMID:7665172) ARUK-UCL PMID:7665172 NCBI chr 6:19,837,370...19,842,197
Ensembl chr 6:19,837,370...19,842,197 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 enables IDA (PMID:17015834) ParkinsonsUK-UCL PMID:17015834 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 enables IDA (PMID:18794125) GO_Central PMID:18794125 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956 		JBrowse link
G LYAR Ly1 antibody reactive enables IDA (PMID:31413131) ARUK-UCL PMID:31413131 NCBI chr 4:4,267,701...4,290,154
Ensembl chr 4:4,267,701...4,290,154 		JBrowse link
G MDFI MyoD family inhibitor enables TAS (PMID:8797820) GO_Central PMID:8797820 NCBI chr 6:41,637,018...41,654,244
Ensembl chr 6:41,636,882...41,654,244 		JBrowse link
G NFIB nuclear factor I B enables IDA (PMID:9099724) GO_Central PMID:9099724 NCBI chr 9:14,081,843...14,532,077
Ensembl chr 9:14,081,843...14,398,983 		JBrowse link
G NFKBIA NFKB inhibitor alpha enables IEA Ensembl GO_REF:0000107 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:31,546,851...31,558,829
Ensembl chr 6:31,546,870...31,558,829 		JBrowse link
G NKX3-1 NK3 homeobox 1 enables IDA (PMID:18794125) GO_Central PMID:18794125 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 enables IDA (PMID:27471003) MGI PMID:27471003 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G PASD1 PAS domain containing repressor 1 enables IDA (PMID:25936801) GO_Central PMID:25936801 NCBI chr  X:151,563,675...151,676,739
Ensembl chr  X:151,563,675...151,676,739 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting enables ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:2,088,708...2,135,898
Ensembl chr16:2,088,708...2,135,898 		JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel enables IPI (PMID:16311606) BHF-UCL PMID:16311606 NCBI chr 4:88,007,635...88,077,777
Ensembl chr 4:88,007,635...88,077,777 		JBrowse link
G PURA purine rich element binding protein A enables IEA Ensembl GO_REF:0000107 NCBI chr 5:140,114,109...140,125,619
Ensembl chr 5:140,107,777...140,125,619 		JBrowse link
G SIN3A SIN3 transcription regulator family member A enables IDA (PMID:22783022) BHF-UCL PMID:22783022 NCBI chr15:75,369,379...75,455,815
Ensembl chr15:75,369,379...75,455,842 		JBrowse link
G SMAD6 SMAD family member 6 enables TAS
IBA
IDA		 (PMID:19018011)
(PMID:9256479)		 BHF-UCL
GO_Central		 PMID:9256479 PMID:19018011 GO_REF:0000033 NCBI chr15:66,702,236...66,782,849
Ensembl chr15:66,702,236...66,782,849 		JBrowse link
G SMAD7 SMAD family member 7 enables IDA
IBA		 (PMID:9256479) BHF-UCL
GO_Central		 PMID:9256479 GO_REF:0000033 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SNIP1 Smad nuclear interacting protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:37,534,449...37,554,293
Ensembl chr 1:37,534,449...37,554,293 		JBrowse link
G TAF1 TATA-box binding protein associated factor 1 enables IDA (PMID:24289924) ParkinsonsUK-UCL PMID:24289924 NCBI chr  X:71,366,357...71,530,525
Ensembl chr  X:71,366,136...71,532,374 		JBrowse link
G TAF3 TATA-box binding protein associated factor 3 enables IEA Ensembl GO_REF:0000107 NCBI chr10:7,818,505...8,016,631
Ensembl chr10:7,818,497...8,016,631 		JBrowse link
G TCF23 transcription factor 23 enables IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:27,149,004...27,156,974
Ensembl chr 2:27,149,004...27,156,974 		JBrowse link
G TFDP3 transcription factor Dp family member 3 enables IDA (PMID:17062573) ARUK-UCL PMID:17062573 NCBI chr  X:133,216,662...133,218,354
Ensembl chr  X:133,216,662...133,218,354 		JBrowse link
G TRAPPC2 trafficking protein particle complex subunit 2 enables IDA (PMID:11134351) UniProt PMID:11134351 NCBI chr  X:13,712,245...13,734,620
Ensembl chr  X:13,712,244...13,734,635 		JBrowse link
G TRAPPC2B trafficking protein particle complex subunit 2B enables IDA (PMID:11134351) UniProt PMID:11134351 NCBI chr19:57,363,551...57,365,405
Ensembl chr19:57,363,551...57,365,405 		JBrowse link
G UACA uveal autoantigen with coiled-coil domains and ankyrin repeats enables ISO (PMID:14961764) MGI PMID:14961764 NCBI chr15:70,654,554...70,778,903
Ensembl chr15:70,654,554...70,763,558 		JBrowse link
G ZNF451 zinc finger protein 451 enables IDA (PMID:24324267) GO_Central PMID:24324267 NCBI chr 6:57,090,188...57,170,305
Ensembl chr 6:57,086,844...57,170,305 		JBrowse link
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  molecular_function 19551
    molecular function regulator activity 2411
      molecular function inhibitor activity 613
        transcription regulator inhibitor activity 36
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