HSPA1A (heat shock protein family A (Hsp70) member 1A) - Rat Genome Database

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Gene: HSPA1A (heat shock protein family A (Hsp70) member 1A) Homo sapiens
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
RGD ID: 1349475
Description: Exhibits several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including regulation of RNA metabolic process; regulation of microtubule cytoskeleton organization; and regulation of signal transduction. Localizes to several cellular components, including aggresome; microtubule organizing center; and nuclear speck. Colocalizes with COP9 signalosome. Implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and vascular dementia. Biomarker of atherosclerosis; cardiovascular system disease; status epilepticus; systolic heart failure; and visual epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock-induced protein; HEL-S-103; HSP70; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70.2; HSP70I; HSP72; HSPA1; HSPA1B
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl631,815,543 - 31,817,946 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,783,320 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBINCBI36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-amphetamine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (EXP)
2-hydroxyethyl methacrylate  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (EXP)
ammonia  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (EXP)
apigenin  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
Aurin  (EXP)
azadiradione  (EXP)
azetidinecarboxylic acid  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (EXP)
bromobenzene  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
cannabidiol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carbonyl sulfide  (ISO)
carboplatin  (ISO)
carrageenan  (ISO)
cefaloridine  (ISO)
celastrol  (EXP,ISO)
cerium trichloride  (EXP)
chelerythrine  (ISO)
chloroform  (ISO)
chlorohydrocarbon  (ISO)
chloromethylisothiazolinone  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cyfluthrin  (EXP)
D-penicillamine  (EXP)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (EXP)
Dimethyl adipate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disulfiram  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
edaravone  (ISO)
elemental selenium  (EXP)
elesclomol  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
famotidine  (ISO)
fenbuconazole  (EXP)
ferric ammonium citrate  (EXP)
ferric oxide  (ISO)
flavone  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formetanate  (EXP)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gedunin  (EXP)
gefitinib  (EXP)
geldanamycin  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
GYKI 52466  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (EXP)
ibuprofen  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
LY294002  (EXP)
melatonin  (EXP)
menadione  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
methamphetamine  (ISO)
methomyl  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
morphine  (ISO)
motexafin gadolinium  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nitrobenzenes  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (EXP,ISO)
omeprazole  (ISO)
organoselenium compound  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirimicarb  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
polaprezinc  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
Protolichesterinic acid  (EXP)
pyrene  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
radicicol  (EXP)
raloxifene  (EXP,ISO)
ranitidine  (ISO)
reactive oxygen species  (EXP)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (EXP)
SCH772984  (ISO)
selenium atom  (EXP)
selenomethionine  (EXP)
sertraline  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
styrene  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP)
temozolomide  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thimerosal  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
triazines  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
tungsten  (ISO)
Tungsten carbide  (EXP)
urethane  (EXP)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)
wortmannin  (EXP)
zearalenone  (EXP)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (EXP,ISO)
zinc oxide  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (IDA)
cellular heat acclimation  (IMP)
cellular response to heat  (IDA)
cellular response to oxidative stress  (TAS)
cellular response to unfolded protein  (IBA,IMP)
chaperone cofactor-dependent protein refolding  (IBA)
chaperone-mediated protein complex assembly  (IDA)
DNA repair  (ISO)
lysosomal transport  (ISS)
mRNA catabolic process  (IDA)
negative regulation of apoptotic process  (IMP,TAS)
negative regulation of cell death  (IDA,IMP,ISO)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IDA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
negative regulation of inclusion body assembly  (IDA)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IDA)
negative regulation of protein ubiquitination  (IDA)
negative regulation of transcription from RNA polymerase II promoter in response to stress  (IDA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IMP)
neuron differentiation  (ISO)
positive regulation of endoribonuclease activity  (IDA)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of interleukin-8 production  (IMP)
positive regulation of microtubule nucleation  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IDA)
positive regulation of RNA splicing  (IDA)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IMP)
protein folding  (ISO)
protein refolding  (IBA,IDA,IMP)
protein stabilization  (IDA,IMP,TAS)
regulation of cell death  (IMP)
regulation of mitotic spindle assembly  (IBA,IMP)
regulation of protein ubiquitination  (IDA)
response to ethanol  (ISO)
response to heat  (ISO)
response to ischemia  (ISO)
response to mechanical stimulus  (ISO)
response to radiation  (ISO)
response to unfolded protein  (IDA,ISO)
telomere maintenance  (ISO)
vesicle-mediated transport  (IBA)
viral entry into host cell  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

References - curated
1. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
2. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
3. Corvol H, etal., J Cyst Fibros. 2012 Jan;11(1):63-7. Epub 2011 Oct 10.
4. Dong Z, etal., Mol Ther. 2005 Jan;11(1):80-8.
5. Dulin E, etal., Cell Stress Chaperones. 2010 Nov;15(6):929-37. Epub 2010 May 20.
6. Dulin E, etal., Cell Stress Chaperones. 2012 Jul;17(4):507-16. doi: 10.1007/s12192-012-0328-4. Epub 2012 Feb 11.
7. Fung HC, etal., Dement Geriatr Cogn Disord. 2005;20(1):1-7. Epub 2005 Apr 12.
8. Furnrohr BG, etal., Ann Rheum Dis. 2010 Nov;69(11):1983-9. Epub 2010 May 24.
9. Garg M, etal., Eur J Cancer. 2010 Jan;46(1):207-15. doi: 10.1016/j.ejca.2009.10.020. Epub .
10. GOA_HUMAN data from the GO Consortium
11. Grossin L, etal., FASEB J. 2006 Jan;20(1):65-75.
12. He M, etal., PLoS One. 2009;4(3):e4851. doi: 10.1371/journal.pone.0004851. Epub 2009 Mar 31.
13. Hua F, etal., J Neuroinflammation. 2011 May 8;8:42.
14. Jenei ZM, etal., Cell Stress Chaperones. 2013 Apr 7.
15. Jenei ZM, etal., Cell Stress Chaperones. 2013 Jul;18(4):447-54. doi: 10.1007/s12192-012-0399-2. Epub 2013 Jan 16.
16. Kawaguchi S, etal., Acta Otolaryngol. 2008 Nov;128(11):1173-7. doi: 10.1080/00016480801901675.
17. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
18. Kowalczyk M, etal., Cell Stress Chaperones. 2013 Jul 28.
19. Lonati C, etal., Anesthesiology. 2012 Mar;116(3):692-700. doi: 10.1097/ALN.0b013e318246ea68.
20. Maggioli E, etal., Int J Immunogenet. 2014 Feb;41(1):44-53. doi: 10.1111/iji.12077. Epub 2013 Jul 22.
21. Mosenson JA, etal., Sci Transl Med. 2013 Feb 27;5(174):174ra28. doi: 10.1126/scitranslmed.3005127.
22. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
23. Pae CU, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. Epub 2007 Feb 27.
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Rejdak K, etal., Epilepsia. 2012 May;53(5):922-7. doi: 10.1111/j.1528-1167.2012.03459.x. Epub 2012 Apr 17.
26. RGD automated import pipeline for gene-chemical interactions
27. Wilhide ME, etal., J Mol Cell Cardiol. 2011 Jul;51(1):82-9. doi: 10.1016/j.yjmcc.2011.03.011. Epub 2011 Mar 23.
28. Yang M, etal., Cell Stress Chaperones. 2006 Autumn;11(3):233-9.
29. Zhang HN, etal., Neurol Sci. 2013 Apr;34(4):471-7. doi: 10.1007/s10072-012-1063-4. Epub 2012 Apr 18.
30. Zhang X, etal., Cardiology. 2011;119(1):57-64. doi: 10.1159/000329917. Epub 2011 Aug 17.
Additional References at PubMed
PMID:1478667   PMID:1540595   PMID:1628823   PMID:1700760   PMID:2538825   PMID:2858050   PMID:2880793   PMID:3019832   PMID:3470951   PMID:3786141   PMID:3931075   PMID:7529764  
PMID:7811761   PMID:7906708   PMID:7954368   PMID:8125298   PMID:8729618   PMID:8887650   PMID:9148915   PMID:9222587   PMID:9250404   PMID:9252351   PMID:9261129   PMID:9305631  
PMID:9499401   PMID:9553041   PMID:9649501   PMID:9699716   PMID:9830037   PMID:9873016   PMID:9920933   PMID:10092532   PMID:10205060   PMID:10216320   PMID:10330192   PMID:10354271  
PMID:10376524   PMID:10593983   PMID:10617616   PMID:10629618   PMID:10651811   PMID:10786835   PMID:10811660   PMID:10862698   PMID:10934467   PMID:10964507   PMID:10980614   PMID:11101523  
PMID:11133992   PMID:11215307   PMID:11230127   PMID:11310559   PMID:11356186   PMID:11413142   PMID:11415446   PMID:11500375   PMID:11527400   PMID:11533664   PMID:11584023   PMID:11595173  
PMID:11679576   PMID:11696222   PMID:11741305   PMID:11779758   PMID:11785981   PMID:11790298   PMID:11798084   PMID:11809754   PMID:11821413   PMID:11864979   PMID:11877453   PMID:11888936  
PMID:11909948   PMID:11912194   PMID:11932435   PMID:11971973   PMID:12008944   PMID:12077419   PMID:12080070   PMID:12082088   PMID:12082592   PMID:12093808   PMID:12149123   PMID:12150907  
PMID:12161444   PMID:12167617   PMID:12167701   PMID:12207910   PMID:12391142   PMID:12397061   PMID:12411538   PMID:12477932   PMID:12481031   PMID:12490434   PMID:12526792   PMID:12670868  
PMID:12677068   PMID:12682040   PMID:12687213   PMID:12724406   PMID:12832005   PMID:12840151   PMID:12853476   PMID:12865437   PMID:12930708   PMID:12935469   PMID:12941774   PMID:12963728  
PMID:14499622   PMID:14501185   PMID:14503850   PMID:14517289   PMID:14527417   PMID:14574404   PMID:14605873   PMID:14636579   PMID:14656967   PMID:14676191   PMID:14702039   PMID:14718530  
PMID:14981913   PMID:14993262   PMID:15079808   PMID:15142379   PMID:15165109   PMID:15166037   PMID:15189447   PMID:15190186   PMID:15207703   PMID:15232679   PMID:15280693   PMID:15292002  
PMID:15324660   PMID:15331702   PMID:15456888   PMID:15489334   PMID:15544165   PMID:15569319   PMID:15603737   PMID:15632129   PMID:15638722   PMID:15662014   PMID:15671022   PMID:15735003  
PMID:15735699   PMID:15748471   PMID:15780175   PMID:15817944   PMID:15832179   PMID:15870294   PMID:15877962   PMID:15885686   PMID:15952740   PMID:15963462   PMID:15963589   PMID:15967112  
PMID:16009940   PMID:16012946   PMID:16130169   PMID:16133872   PMID:16140033   PMID:16159877   PMID:16172114   PMID:16201310   PMID:16202503   PMID:16263121   PMID:16306228   PMID:16333988  
PMID:16344560   PMID:16400691   PMID:16441767   PMID:16492383   PMID:16538175   PMID:16538176   PMID:16543726   PMID:16624816   PMID:16647242   PMID:16679378   PMID:16713569   PMID:16804002  
PMID:16806014   PMID:16809764   PMID:16896546   PMID:16948906   PMID:16964243   PMID:17081983   PMID:17110338   PMID:17158748   PMID:17167422   PMID:17182002   PMID:17206383   PMID:17235439  
PMID:17267499   PMID:17278879   PMID:17289661   PMID:17332370   PMID:17341665   PMID:17342744   PMID:17357109   PMID:17364813   PMID:17471537   PMID:17555092   PMID:17582394   PMID:17591867  
PMID:17601350   PMID:17616579   PMID:17645866   PMID:17668636   PMID:17707232   PMID:17873279   PMID:17891901   PMID:17908427   PMID:17915554   PMID:17915559   PMID:17977914   PMID:17979178  
PMID:18155754   PMID:18158591   PMID:18166694   PMID:18274635   PMID:18323737   PMID:18350254   PMID:18372927   PMID:18387829   PMID:18407958   PMID:18425350   PMID:18508912   PMID:18579131  
PMID:18704483   PMID:18712940   PMID:18772114   PMID:18813331   PMID:18818748   PMID:18819021   PMID:18839337   PMID:18845908   PMID:18850631   PMID:18850735   PMID:18975920   PMID:18977241  
PMID:18986301   PMID:18987644   PMID:19001088   PMID:19018093   PMID:19019335   PMID:19041431   PMID:19085089   PMID:19089598   PMID:19158413   PMID:19165527   PMID:19167051   PMID:19190083  
PMID:19199708   PMID:19221897   PMID:19275585   PMID:19275587   PMID:19287380   PMID:19299420   PMID:19336004   PMID:19339340   PMID:19351493   PMID:19351530   PMID:19357992   PMID:19367718  
PMID:19394292   PMID:19405961   PMID:19439993   PMID:19486887   PMID:19527514   PMID:19546256   PMID:19549684   PMID:19582769   PMID:19626584   PMID:19666596   PMID:19738201   PMID:19771447  
PMID:19815544   PMID:19817876   PMID:19840767   PMID:19851445   PMID:19875381   PMID:19875982   PMID:19913121   PMID:19921986   PMID:19933325   PMID:20000738   PMID:20007907   PMID:20012387  
PMID:20029029   PMID:20048054   PMID:20062073   PMID:20093746   PMID:20195357   PMID:20199785   PMID:20223214   PMID:20300187   PMID:20368414   PMID:20388090   PMID:20391533   PMID:20415540  
PMID:20430459   PMID:20458337   PMID:20471030   PMID:20531386   PMID:20542028   PMID:20552383   PMID:20558613   PMID:20568452   PMID:20585345   PMID:20587610   PMID:20601427   PMID:20625543  
PMID:20628086   PMID:20633729   PMID:20682791   PMID:20692469   PMID:20694452   PMID:20704535   PMID:20805357   PMID:20806039   PMID:20807285   PMID:20808282   PMID:20850016   PMID:20864555  
PMID:20876613   PMID:20930503   PMID:20936779   PMID:20946988   PMID:20959453   PMID:21044950   PMID:21059845   PMID:21081503   PMID:21081504   PMID:21081666   PMID:21094186   PMID:21132545  
PMID:21132546   PMID:21145461   PMID:21146485   PMID:21150319   PMID:21187371   PMID:21231916   PMID:21266579   PMID:21318276   PMID:21333981   PMID:21373891   PMID:21390211   PMID:21423176  
PMID:21443787   PMID:21446356   PMID:21532586   PMID:21738476   PMID:21745403   PMID:21751214   PMID:21763498   PMID:21784850   PMID:21873635   PMID:21909508   PMID:21915333   PMID:21966512  
PMID:21970979   PMID:21988832   PMID:22070286   PMID:22077956   PMID:22123078   PMID:22198139   PMID:22219199   PMID:22236337   PMID:22268729   PMID:22337587   PMID:22360420   PMID:22414085  
PMID:22477150   PMID:22497815   PMID:22515481   PMID:22516433   PMID:22528486   PMID:22542718   PMID:22623428   PMID:22645313   PMID:22658674   PMID:22681889   PMID:22863883   PMID:22933322  
PMID:22939629   PMID:22948392   PMID:22963397   PMID:23042605   PMID:23065523   PMID:23084401   PMID:23090292   PMID:23125841   PMID:23154057   PMID:23171464   PMID:23184937   PMID:23212905  
PMID:23246001   PMID:23266770   PMID:23271055   PMID:23272037   PMID:23272104   PMID:23341456   PMID:23349634   PMID:23383273   PMID:23395854   PMID:23398456   PMID:23416714   PMID:23443559  
PMID:23482560   PMID:23533145   PMID:23554879   PMID:23569248   PMID:23581516   PMID:23620494   PMID:23629654   PMID:23666708   PMID:23698466   PMID:23704948   PMID:23729439   PMID:23737532  
PMID:23798571   PMID:23812373   PMID:23824909   PMID:23885119   PMID:23892143   PMID:23901248   PMID:23904609   PMID:23921388   PMID:23973223   PMID:23979991   PMID:24041570   PMID:24061851  
PMID:24070736   PMID:24085588   PMID:24113772   PMID:24126416   PMID:24133061   PMID:24175631   PMID:24189400   PMID:24196953   PMID:24244333   PMID:24252804   PMID:24318877   PMID:24325467  
PMID:24328534   PMID:24337577   PMID:24338975   PMID:24379352   PMID:24399297   PMID:24428437   PMID:24457600   PMID:24524071   PMID:24550385   PMID:24552808   PMID:24567332   PMID:24613385  
PMID:24658140   PMID:24718257   PMID:24736948   PMID:24740910   PMID:24790089   PMID:24833463   PMID:24919558   PMID:24949977   PMID:25027693   PMID:25058147   PMID:25144556   PMID:25156257  
PMID:25202009   PMID:25243181   PMID:25281747   PMID:25319762   PMID:25324306   PMID:25394481   PMID:25402006   PMID:25437307   PMID:25458010   PMID:25468996   PMID:25473902   PMID:25496916  
PMID:25552722   PMID:25620081   PMID:25678563   PMID:25694550   PMID:25722377   PMID:25739548   PMID:25756610   PMID:25814554   PMID:25864199   PMID:25874231   PMID:25893192   PMID:25921289  
PMID:25940345   PMID:25943677   PMID:25959826   PMID:25963833   PMID:26010904   PMID:26186194   PMID:26193369   PMID:26205540   PMID:26209609   PMID:26214432   PMID:26264872   PMID:26344197  
PMID:26361762   PMID:26381412   PMID:26446488   PMID:26448330   PMID:26450908   PMID:26460568   PMID:26494212   PMID:26496610   PMID:26496868   PMID:26547206   PMID:26550577   PMID:26608509  
PMID:26618866   PMID:26637413   PMID:26641092   PMID:26643874   PMID:26657847   PMID:26693507   PMID:26725010   PMID:26735018   PMID:26752685   PMID:26851345   PMID:26868087   PMID:26902796  
PMID:26960140   PMID:26979993   PMID:27020764   PMID:27094592   PMID:27129302   PMID:27133716   PMID:27137183   PMID:27206651   PMID:27248496   PMID:27375898   PMID:27437069   PMID:27477512  
PMID:27483141   PMID:27489107   PMID:27512140   PMID:27545878   PMID:27570075   PMID:27609421   PMID:27637333   PMID:27644267   PMID:27684187   PMID:27708256   PMID:27751915   PMID:27787517  
PMID:27976729   PMID:27998983   PMID:28025138   PMID:28038712   PMID:28042827   PMID:28099440   PMID:28182740   PMID:28302793   PMID:28317868   PMID:28416769   PMID:28450725   PMID:28460195  
PMID:28514442   PMID:28515276   PMID:28533407   PMID:28581483   PMID:28631886   PMID:28679534   PMID:28685749   PMID:28720575   PMID:28757353   PMID:28821611   PMID:28842558   PMID:28848044  
PMID:28927264   PMID:28977666   PMID:29090408   PMID:29104064   PMID:29111377   PMID:29117863   PMID:29188629   PMID:29228324   PMID:29229926   PMID:29255093   PMID:29298432   PMID:29323151  
PMID:29331340   PMID:29395577   PMID:29474905   PMID:29507755   PMID:29519959   PMID:29563501   PMID:29564676   PMID:29568061   PMID:29572464   PMID:29615496   PMID:29631603   PMID:29656893  
PMID:29735542   PMID:29764935   PMID:29773831   PMID:29844126   PMID:29884807   PMID:29911972   PMID:30135474   PMID:30209976   PMID:30238325   PMID:30258100   PMID:30342847   PMID:30349055  
PMID:30384997   PMID:30390173   PMID:30397336   PMID:30404004   PMID:30442662   PMID:30463901   PMID:30502916   PMID:30559338   PMID:30559450   PMID:30569142   PMID:30641209   PMID:30711629  
PMID:30719818   PMID:30745168   PMID:30792309   PMID:30864724   PMID:30890647   PMID:30940648   PMID:30948266   PMID:30999671   PMID:31005254   PMID:31010829   PMID:31048545   PMID:31091453  
PMID:31152661   PMID:31180492   PMID:31239290   PMID:31300519   PMID:31353912   PMID:31395886   PMID:31501420   PMID:31504778   PMID:31620119   PMID:31659016   PMID:31669268   PMID:31676290  
PMID:31792442   PMID:31793711   PMID:31862882   PMID:31899237   PMID:31980649   PMID:32041737   PMID:32127624   PMID:32162334   PMID:32176628   PMID:32200342   PMID:32296183   PMID:32298923  
PMID:32322062   PMID:32382008   PMID:32453286   PMID:32478477   PMID:32529326   PMID:32786267   PMID:32814053   PMID:32873777   PMID:32887360   PMID:33845483   PMID:33957083  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl631,815,543 - 31,817,946 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,783,320 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBINCBI36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,188,335 - 35,191,132 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,188,166 - 35,191,132 (-)Ensembl
GRCm381734,969,359 - 34,972,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,106,304 - 35,109,101 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,577,246 - 34,580,180 (-)NCBImm8
Celera1738,065,583 - 38,068,380 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,875,834 - 4,881,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1632,363,499 - 32,366,005 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBIMhudiblu_PPA_v0panPan3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494635,825,952 - 35,828,975 (+)NCBI
SpeTri2.0NW_0049367271,732,323 - 1,735,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11740,203,647 - 40,206,028 (-)NCBI
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)Ensembl
Vero_WHO_p1.0NW_0236679469,302 - 10,259 (-)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,855 - 31,797,984UniSTSGRCh37
Build 36631,905,834 - 31,905,963RGDNCBI36
Celera633,396,106 - 33,396,234RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,584,380 - 31,584,508UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,738 - 31,797,920UniSTSGRCh37
Build 36631,905,717 - 31,905,899RGDNCBI36
Celera633,395,989 - 33,396,171RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,584,258 - 31,584,445UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,796,074 - 31,796,553UniSTSGRCh37
GRCh37631,783,880 - 31,784,359UniSTSGRCh37
Build 36631,891,859 - 31,892,338RGDNCBI36
Celera633,382,129 - 33,382,608RGD
Celera633,394,325 - 33,394,804UniSTS
HuRef631,570,287 - 31,570,766UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,105 - 31,783,386UniSTSGRCh37
Build 36631,891,084 - 31,891,365RGDNCBI36
Celera633,381,354 - 33,381,635RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,512 - 31,569,793UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,469 - 31,783,740UniSTSGRCh37
Build 36631,891,448 - 31,891,719RGDNCBI36
Celera633,381,718 - 33,381,989RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,876 - 31,570,147UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,111 - 31,783,372UniSTSGRCh37
Build 36631,891,090 - 31,891,351RGDNCBI36
Celera633,381,360 - 33,381,621RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,518 - 31,569,779UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,785,265 - 31,785,504UniSTSGRCh37
Build 36631,893,244 - 31,893,483RGDNCBI36
Celera633,383,514 - 33,383,753RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,571,755 - 31,571,994UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,201 - 31,783,391UniSTSGRCh37
Build 36631,891,180 - 31,891,370RGDNCBI36
Celera633,381,450 - 33,381,640RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,608 - 31,569,798UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,469 - 31,783,801UniSTSGRCh37
Build 36631,891,448 - 31,891,780RGDNCBI36
Celera633,381,718 - 33,382,050RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,876 - 31,570,208UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,796,096 - 31,796,584UniSTSGRCh37
GRCh37631,783,902 - 31,784,390UniSTSGRCh37
Build 36631,891,881 - 31,892,369RGDNCBI36
Celera633,382,151 - 33,382,639RGD
Celera633,394,347 - 33,394,835UniSTS
HuRef631,570,309 - 31,570,797UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,785,459 - 31,785,686UniSTSGRCh37
Build 36631,893,438 - 31,893,665RGDNCBI36
Celera633,383,708 - 33,383,935RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,571,949 - 31,572,176UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,784,996 - 31,785,751UniSTSGRCh37
Build 36631,892,975 - 31,893,730RGDNCBI36
Celera633,383,245 - 33,384,000RGD
HuRef631,571,486 - 31,572,241UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,904 - 31,797,982UniSTSGRCh37
Build 36631,905,883 - 31,905,961RGDNCBI36
Celera633,396,155 - 33,396,232RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,584,429 - 31,584,506UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,785,441 - 31,785,617UniSTSGRCh37
Build 36631,893,420 - 31,893,596RGDNCBI36
Celera633,383,690 - 33,383,866RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,571,931 - 31,572,107UniSTS
GeneMap99-GB4 RH Map6119.38UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,376 - 31,783,530UniSTSGRCh37
Build 36631,891,355 - 31,891,509RGDNCBI36
Celera633,381,625 - 33,381,779RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,783 - 31,569,937UniSTS
GeneMap99-GB4 RH Map6120.03UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,785,448 - 31,785,611UniSTSGRCh37
Build 36631,893,427 - 31,893,590RGDNCBI36
Celera633,383,697 - 33,383,860RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,571,938 - 31,572,101UniSTS
GeneMap99-GB4 RH Map6119.71UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:283
Count of miRNA genes:139
Interacting mature miRNAs:142
Transcripts:ENST00000375651, ENST00000458062, ENST00000608703
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system appendage entire extraembryonic component pharyngeal arch
High 2 14 12 1 12 2 6 17 2
Medium 375 55 575 449 652 456 591 125 317 579 639 719 22 1 4 7 2
Low 65 16 19 9 766 9 11 11 33 24 27 31 3
Below cutoff 2 1 41 2 9 4 1


Nucleotide Sequences
RefSeq Transcripts NG_011855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB018045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF134726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR388202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA256622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA486842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ388429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ451402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S52686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000375651   ⟹   ENSP00000364802
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,815,543 - 31,817,942 (+)Ensembl
RefSeq Acc Id: ENST00000608703   ⟹   ENSP00000477378
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,815,543 - 31,817,946 (+)Ensembl
RefSeq Acc Id: NM_005345   ⟹   NP_005336
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38631,815,543 - 31,817,942 (+)NCBI
GRCh37631,782,952 - 31,785,719 (+)NCBI
Build 36631,891,316 - 31,893,698 (+)NCBI Archive
HuRef631,569,698 - 31,572,209 (+)ENTREZGENE
CHM1_1631,785,425 - 31,787,853 (+)NCBI
Protein Sequences
Protein RefSeqs NP_005336 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52697 (Get FASTA)   NCBI Sequence Viewer  
  AAA59844 (Get FASTA)   NCBI Sequence Viewer  
  AAA63226 (Get FASTA)   NCBI Sequence Viewer  
  AAD21816 (Get FASTA)   NCBI Sequence Viewer  
  AAH02453 (Get FASTA)   NCBI Sequence Viewer  
  AAH18740 (Get FASTA)   NCBI Sequence Viewer  
  ABD48956 (Get FASTA)   NCBI Sequence Viewer  
  ABD96830 (Get FASTA)   NCBI Sequence Viewer  
  ACI45984 (Get FASTA)   NCBI Sequence Viewer  
  ADO22332 (Get FASTA)   NCBI Sequence Viewer  
  AQY76864 (Get FASTA)   NCBI Sequence Viewer  
  AQY76865 (Get FASTA)   NCBI Sequence Viewer  
  AQY76866 (Get FASTA)   NCBI Sequence Viewer  
  AQY76867 (Get FASTA)   NCBI Sequence Viewer  
  AQY76868 (Get FASTA)   NCBI Sequence Viewer  
  AQY76869 (Get FASTA)   NCBI Sequence Viewer  
  AQY76870 (Get FASTA)   NCBI Sequence Viewer  
  AQY76871 (Get FASTA)   NCBI Sequence Viewer  
  AQY76872 (Get FASTA)   NCBI Sequence Viewer  
  AQY76873 (Get FASTA)   NCBI Sequence Viewer  
  BAA77235 (Get FASTA)   NCBI Sequence Viewer  
  BAB63300 (Get FASTA)   NCBI Sequence Viewer  
  BAD93055 (Get FASTA)   NCBI Sequence Viewer  
  BAF83984 (Get FASTA)   NCBI Sequence Viewer  
  BAG53197 (Get FASTA)   NCBI Sequence Viewer  
  BAG57500 (Get FASTA)   NCBI Sequence Viewer  
  BAG60350 (Get FASTA)   NCBI Sequence Viewer  
  BAG60366 (Get FASTA)   NCBI Sequence Viewer  
  BAG60383 (Get FASTA)   NCBI Sequence Viewer  
  BAG62811 (Get FASTA)   NCBI Sequence Viewer  
  BAG63067 (Get FASTA)   NCBI Sequence Viewer  
  BAG64898 (Get FASTA)   NCBI Sequence Viewer  
  BAG65400 (Get FASTA)   NCBI Sequence Viewer  
  BAG65428 (Get FASTA)   NCBI Sequence Viewer  
  CAA28381 (Get FASTA)   NCBI Sequence Viewer  
  CAA28382 (Get FASTA)   NCBI Sequence Viewer  
  EAX03528 (Get FASTA)   NCBI Sequence Viewer  
  P0DMV8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_005336   ⟸   NM_005345
- UniProtKB: P0DMV9 (UniProtKB/Swiss-Prot),   P0DMV8 (UniProtKB/Swiss-Prot),   A8K5I0 (UniProtKB/TrEMBL),   B3KTT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000364802   ⟸   ENST00000375651
RefSeq Acc Id: ENSP00000477378   ⟸   ENST00000608703

RGD ID:6872654
Promoter ID:EPDNEW_H9492
Type:multiple initiation site
Description:heat shock protein family A member 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38631,815,543 - 31,815,603EPDNEW
RGD ID:6804149
Promoter ID:HG_KWN:53002
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000375652,   OTTHUMT00000076401,   OTTHUMT00000076416
Human AssemblyChrPosition (strand)Source
Build 36631,890,496 - 31,893,612 (+)MPROMDB
RGD ID:6850312
Promoter ID:EP17088
Type:single initiation site
Description:Heatshock protein 70K
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Nuclease protection; Primer extension
Regulation:(induced by or strongly expressed in) heatshock
Human AssemblyChrPosition (strand)Source
Build 36631,891,299 - 31,891,359EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
GRCh37/hg19 6p21.33(chr6:31777500-31831302)x1 copy number loss See cases [RCV000449096] Chr6:31777500..31831302 [GRCh37]
likely benign
GRCh37/hg19 6p21.33(chr6:31785228-31797422)x1 copy number loss See cases [RCV000449485] Chr6:31785228..31797422 [GRCh37]
GRCh37/hg19 6p21.33(chr6:31782789-31797422)x1 copy number loss See cases [RCV000448141] Chr6:31782789..31797422 [GRCh37]
GRCh37/hg19 6p21.33(chr6:31384577-31902308)x3 copy number gain See cases [RCV000448679] Chr6:31384577..31902308 [GRCh37]
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
uncertain significance
NM_005345.6(HSPA1A):c.330G>C (p.Glu110Asp) single nucleotide variant Chronic obstructive pulmonary disease [RCV000856574] Chr6:31816086 [GRCh38]
Chr6:31783863 [GRCh37]
NC_000006.12:g.31815431A>C single nucleotide variant Chronic obstructive pulmonary disease [RCV000856575] Chr6:31815431 [GRCh38]
Chr6:31783208 [GRCh37]
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
NM_005345.6(HSPA1A):c.-27G>C single nucleotide variant Chronic obstructive pulmonary disease [RCV000856576] Chr6:31815730 [GRCh38]
Chr6:31783507 [GRCh37]
NM_005345.6(HSPA1A):c.1053G>A (p.Gln351=) single nucleotide variant Chronic obstructive pulmonary disease [RCV000856577] Chr6:31816809 [GRCh38]
Chr6:31784586 [GRCh37]
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5232 AgrOrtholog
Ensembl Genes ENSG00000204388 UniProtKB/Swiss-Prot
  ENSG00000204389 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000212866 UniProtKB/Swiss-Prot
  ENSG00000215328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000224501 UniProtKB/Swiss-Prot
  ENSG00000231555 UniProtKB/Swiss-Prot
  ENSG00000232804 UniProtKB/Swiss-Prot
  ENSG00000234475 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000235941 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000237724 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000364801 UniProtKB/Swiss-Prot
  ENSP00000364802 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000372880 UniProtKB/TrEMBL
  ENSP00000375391 UniProtKB/Swiss-Prot
  ENSP00000375399 UniProtKB/Swiss-Prot
  ENSP00000382915 UniProtKB/Swiss-Prot
  ENSP00000393087 UniProtKB/Swiss-Prot
  ENSP00000393259 UniProtKB/TrEMBL
  ENSP00000403530 UniProtKB/Swiss-Prot
  ENSP00000404524 UniProtKB/Swiss-Prot
  ENSP00000406359 UniProtKB/Swiss-Prot
  ENSP00000408907 UniProtKB/Swiss-Prot
  ENSP00000410693 UniProtKB/TrEMBL
  ENSP00000415927 UniProtKB/TrEMBL
  ENSP00000477378 UniProtKB/TrEMBL
Ensembl Transcript ENST00000375650 UniProtKB/Swiss-Prot
  ENST00000375651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000383389 UniProtKB/TrEMBL
  ENST00000391548 UniProtKB/Swiss-Prot
  ENST00000391555 UniProtKB/Swiss-Prot
  ENST00000400040 UniProtKB/Swiss-Prot
  ENST00000422919 UniProtKB/TrEMBL
  ENST00000430065 UniProtKB/Swiss-Prot
  ENST00000433487 UniProtKB/Swiss-Prot
  ENST00000441618 UniProtKB/Swiss-Prot
  ENST00000445736 UniProtKB/Swiss-Prot
  ENST00000449876 UniProtKB/TrEMBL
  ENST00000450744 UniProtKB/Swiss-Prot
  ENST00000452298 UniProtKB/TrEMBL
  ENST00000608703 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204388 GTEx
  ENSG00000204389 GTEx
  ENSG00000212866 GTEx
  ENSG00000215328 GTEx
  ENSG00000224501 GTEx
  ENSG00000231555 GTEx
  ENSG00000232804 GTEx
  ENSG00000234475 GTEx
  ENSG00000235941 GTEx
  ENSG00000237724 GTEx
Human Proteome Map HSPA1A Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3303 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hsa:3304 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
OMIM 140550 OMIM
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29498 PharmGKB
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HS71A_HUMAN UniProtKB/Swiss-Prot
  HS71B_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B4E3B6 UniProtKB/Swiss-Prot
  P08107 UniProtKB/Swiss-Prot
  P19790 UniProtKB/Swiss-Prot
  Q5JQI4 UniProtKB/Swiss-Prot
  Q5SP17 UniProtKB/Swiss-Prot
  Q9UQL9 UniProtKB/Swiss-Prot
  Q9UQM0 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA1A  heat shock protein family A (Hsp70) member 1A  HSPA1A  heat shock 70kDa protein 1A  Symbol and/or name change 5135510 APPROVED