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Gene: TAF1 (TATA-box binding protein associated factor 1) Homo sapiens
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Symbol: TAF1
Name: TATA-box binding protein associated factor 1
Description: Exhibits several functions, including RNA polymerase II general transcription initiation factor activity; lysine-acetylated histone binding activity; and transcription factor binding activity. Contributes to H3K27me3 modified histone binding activity. Involved in several processes, including cellular protein metabolic process; regulation of cellular protein metabolic process; and regulation of transcription, DNA-templated. Localizes to the MLL1 complex; nuclear chromatin; and transcription factor TFIID complex. Colocalizes with the nucleolus. Implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BA2R; CCG1; CCGS; cell cycle gene 1 protein; cell cycle, G1 phase defect; complementation of cell cycle block, G1-to-S; dystonia 3 (with Parkinsonism); DYT3; DYT3/TAF1; KAT4; MRXS33; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; TAF2A; TAFII-250; TAFII250; TATA box binding protein associated factor 1; TBP-associated factor 250 kDa; Torsion dystonia-parkinsonism, Filipino type; transcription factor TFIID p250 polypeptide; transcription initiation factor TFIID 250 kDa subunit; transcription initiation factor TFIID subunit 1; XDP
Orthologs:
Mus musculus (house mouse) : Taf1 (TATA-box binding protein associated factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Taf1 (TATA-box binding protein associated factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Taf1 (TATA-box binding protein associated factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TAF1 (TATA-box binding protein associated factor 1)
Canis lupus familiaris (dog) : TAF1 (TATA-box binding protein associated factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Taf1 (TATA-box binding protein associated factor 1)
Sus scrofa (pig) : TAF1 (TATA-box binding protein associated factor 1)
Chlorocebus sabaeus (African green monkey) : TAF1 (TATA-box binding protein associated factor 1)
Heterocephalus glaber (naked mole-rat) : Taf1 (TATA-box binding protein associated factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX71,366,239 - 71,532,374 (+)Ensembl
GRCh38X71,366,220 - 71,530,525 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,586,094 - 70,685,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,502,839 - 70,601,025 (+)NCBINCBI36hg18NCBI36
Build 34X70,369,134 - 70,467,321NCBI
CeleraX70,939,992 - 71,039,729 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,401,859 - 64,501,671 (+)NCBIHuRef
CHM1_1X70,479,113 - 70,642,732 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TAF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349671
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.