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ONTOLOGY REPORT - ANNOTATIONS

Term:neuronal dense core vesicle exocytosis
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Accession:GO:0099011 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels.


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neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISS
ISO		 GO_REF:0000024
(MGI:5476894|PMID:23229896)		 UniProt
RGD		 PMID:23229896 GO_REF:0000024 MGI:5476894 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5476894|PMID:23229896)		 UniProt
RGD		 PMID:23229896 GO_REF:0000024 MGI:5476894 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin 6 involved_in IDA
IMP		 PMID:26216953 SynGO PMID:26216953 PMID:26216953 RGD:13702162, RGD:13702162 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in ISO
IEA		 UniProtKB:Q8BYR5 (MGI:5634021|PMID:25719439), (PMID:25719439)
GO_REF:0000107		 RGD
Ensembl		 PMID:25719439 GO_REF:0000107 MGI:5634021 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) RGD PMID:31679900 NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28404788)		 Ensembl
RGD		 PMID:28404788 GO_REF:0000107 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) RGD PMID:11545717 MGI:3621672 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (PMID:28683263) RGD PMID:28683263 NCBI chr 7:120,857,698...120,920,863
Ensembl chr 7:120,862,972...120,920,863 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO
IBA		 UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293)
GO_REF:0000033		 RGD
GO_Central		 PMID:26575293 GO_REF:0000033 MGI:5819330 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO
IBA		 (MGI:5819330|PMID:26575293)
GO_REF:0000033		 RGD
GO_Central		 PMID:26575293 GO_REF:0000033 MGI:5819330 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
G Unc13c unc-13 homolog C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (PMID:19448629) RGD PMID:19448629 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in EXP
IDA		 PMID:24037803 SynGO PMID:24037803 PMID:24037803 RGD:13702177, RGD:13702177 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in IDA
IMP		 PMID:14627637 SynGO PMID:14627637 PMID:14627637 RGD:8554199, RGD:8554199 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IEA
ISO		 GO_REF:0000107
(PMID:31679900)		 Ensembl
RGD		 PMID:31679900 GO_REF:0000107 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Unc13b unc-13 homolog B involved_in IMP
IEP
IDA		 PMID:31679900 SynGO PMID:31679900 PMID:31679900 PMID:31679900 RGD:155230690, RGD:155230690, RGD:155230690 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    localization 5683
      organelle localization 626
        vesicle localization 204
          establishment of vesicle localization 182
            dense core granule exocytosis 16
              neuronal dense core vesicle exocytosis 13
                postsynaptic dense core vesicle exocytosis + 2
                presynaptic dense core vesicle exocytosis + 11
Path 2
Term Annotations click to browse term
  biological_process 20115
    localization 5683
      establishment of localization 4990
        transport 4683
          secretion 1208
            secretion by cell 1013
              exocytosis 407
                regulated exocytosis 280
                  calcium-ion regulated exocytosis 83
                    dense core granule exocytosis 16
                      neuronal dense core vesicle exocytosis 13
                        postsynaptic dense core vesicle exocytosis + 2
                        presynaptic dense core vesicle exocytosis + 11
paths to the root