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ONTOLOGY REPORT - ANNOTATIONS

Term:presynaptic dense core vesicle exocytosis
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Accession:GO:0099525 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.


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presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in ISO
IEA		 UniProtKB:Q8BYR5 (MGI:5634021|PMID:25719439), (PMID:25719439)
GO_REF:0000107		 RGD
Ensembl		 PMID:25719439 GO_REF:0000107 MGI:5634021 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) RGD PMID:31679900 NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28404788)		 Ensembl
RGD		 PMID:28404788 GO_REF:0000107 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) RGD PMID:11545717 MGI:3621672 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (PMID:28683263) RGD PMID:28683263 NCBI chr 7:120,857,698...120,920,863
Ensembl chr 7:120,862,972...120,920,863 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO
IEA
IBA		 UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293)
GO_REF:0000118
GO_REF:0000033		 RGD
TreeGrafter
GO_Central		 PMID:26575293 GO_REF:0000033 GO_REF:0000118 MGI:5819330 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO
IEA
IBA		 (MGI:5819330|PMID:26575293)
GO_REF:0000118
GO_REF:0000033		 RGD
TreeGrafter
GO_Central		 PMID:26575293 GO_REF:0000033 GO_REF:0000118 MGI:5819330 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
G Unc13c unc-13 homolog C involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in EXP
IDA		 PMID:24037803 SynGO PMID:24037803 PMID:24037803 RGD:13702177, RGD:13702177 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in IDA
IMP		 PMID:14627637 SynGO PMID:14627637 PMID:14627637 RGD:8554199, RGD:8554199 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IEA
ISO		 GO_REF:0000107
(PMID:31679900)		 Ensembl
RGD		 PMID:31679900 GO_REF:0000107 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Unc13b unc-13 homolog B involved_in IMP
IEP
IDA		 PMID:31679900 SynGO PMID:31679900 PMID:31679900 PMID:31679900 RGD:155230690, RGD:155230690, RGD:155230690 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cellular localization 3776
        establishment of localization in cell 2203
          synaptic vesicle exocytosis 139
            calcium ion-regulated exocytosis of neurotransmitter 29
              presynaptic dense core vesicle exocytosis 11
                neuropeptide secretion from presynapse 0
                regulation of presynaptic dense core granule exocytosis 4
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        signaling 7775
          cell-cell signaling 1480
            synaptic signaling 1008
              trans-synaptic signaling 969
                anterograde trans-synaptic signaling 961
                  chemical synaptic transmission 961
                    neurotransmitter secretion 205
                      synaptic vesicle exocytosis 139
                        calcium ion-regulated exocytosis of neurotransmitter 29
                          presynaptic dense core vesicle exocytosis 11
                            neuropeptide secretion from presynapse 0
                            regulation of presynaptic dense core granule exocytosis 4
paths to the root