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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:14,719,078...15,173,218
Ensembl chr15:14,720,726...15,173,211 		JBrowse link
G Cadps2 calcium dependent secretion activator 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:52,746,065...53,275,004 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in ISO UniProtKB:Q9Z1N9 (PMID:26575293) RGD PMID:26575293 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899 		JBrowse link
G Unc13b unc-13 homolog B NOT|involved_in ISO UniProtKB:Q4KUS2 (PMID:26575293) RGD PMID:26575293 NCBI chr 5:62,084,809...62,299,884
Ensembl chr 5:62,084,819...62,299,884 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in IGI
IEA
IBA 		PMID:26575293
GO_REF:0000117
GO_REF:0000033 		UniProt
GO_Central		 PMID:26575293 GO_REF:0000033 GO_REF:0000117, RGD:12050107 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899 		JBrowse link
G Unc13b unc-13 homolog B involved_in IGI
IEA
IBA 		PMID:26575293
GO_REF:0000117
GO_REF:0000033 		UniProt
GO_Central		 PMID:26575293 GO_REF:0000033 GO_REF:0000117, RGD:12050107 NCBI chr 5:62,084,809...62,299,884
Ensembl chr 5:62,084,819...62,299,884 		JBrowse link
G Unc13c unc-13 homolog C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:83,127,650...83,553,822
Ensembl chr 8:83,128,523...83,553,822 		JBrowse link
G Unc13d unc-13 homolog D involved_in IGI PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr10:101,795,652...101,810,409
Ensembl chr10:101,795,652...101,810,409 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in IMP PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815 		JBrowse link
G Trim9 tripartite motif-containing 9 IDA RGD PMID:11524423 RGD:631246 NCBI chr 6:94,492,789...94,592,597
Ensembl chr 6:94,493,268...94,592,551 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISS
IDA
ISO 		GO_REF:0000024
(PMID:23229896) 		UniProt
RGD		 PMID:23229896 PMID:31467284 GO_REF:0000024, RGD:616473717 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISS
ISO 		GO_REF:0000024
(PMID:23229896) 		UniProt
RGD		 PMID:23229896 GO_REF:0000024 NCBI chr 5:62,084,809...62,299,884
Ensembl chr 5:62,084,819...62,299,884 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator IMP RGD PMID:30893606 RGD:616473719 NCBI chr15:14,719,078...15,173,218
Ensembl chr15:14,720,726...15,173,211 		JBrowse link
G Syt4 synaptotagmin 4 involved_in ISO
IEA 		(PMID:18468511)
GO_REF:0000107 		RGD
Ensembl		 PMID:18468511 GO_REF:0000107 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin 6 involved_in IDA
IMP 		PMID:26216953 SynGO PMID:26216953 PMID:26216953 RGD:13702162, RGD:13702162 NCBI chr 2:193,781,051...193,840,741
Ensembl chr 2:193,781,476...193,840,741 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA
ISO 		GO_REF:0000107
(PMID:25719439) 		Ensembl
RGD		 PMID:25719439 GO_REF:0000107 NCBI chr15:14,719,078...15,173,218
Ensembl chr15:14,720,726...15,173,211 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) RGD PMID:31679900 NCBI chr 9:32,193,352...32,692,998
Ensembl chr 9:32,193,352...32,692,772 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in ISO (PMID:28404788) RGD PMID:28404788 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058 		JBrowse link
G Stxbp2 syntaxin binding protein 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:6,487,265...6,498,351
Ensembl chr12:6,487,297...6,504,212 		JBrowse link
G Stxbp3 syntaxin binding protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:199,130,725...199,173,823 		JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (PMID:28683263) RGD PMID:28683263 NCBI chr 7:122,737,301...122,800,462
Ensembl chr 7:122,648,419...122,800,462 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1-associated protein 3 involved_in ISO
IBA 		(PMID:28626000)
GO_REF:0000033 		RGD
GO_Central		 PMID:28626000 GO_REF:0000033 NCBI chr10:14,764,768...14,777,516
Ensembl chr10:14,756,693...14,777,516 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO
IEA 		(PMID:19448629)
GO_REF:0000107 		RGD
Ensembl		 PMID:19448629 GO_REF:0000107 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in EXP
IDA 		PMID:24037803 SynGO PMID:24037803 PMID:24037803 RGD:13702177, RGD:13702177 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in IDA
IMP 		PMID:14627637 SynGO PMID:14627637 PMID:14627637 RGD:8554199, RGD:8554199 NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IEA
ISO 		GO_REF:0000107
(PMID:31679900) 		Ensembl
RGD		 PMID:31679900 GO_REF:0000107 NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842 		JBrowse link
G Unc13b unc-13 homolog B involved_in IMP
IEP
IDA 		PMID:31679900 SynGO PMID:31679900 PMID:31679900 PMID:31679900 RGD:155230690, RGD:155230690, RGD:155230690 NCBI chr 5:62,084,809...62,299,884
Ensembl chr 5:62,084,819...62,299,884 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    localization 5832
      organelle localization 629
        vesicle localization 217
          establishment of vesicle localization 194
            dense core granule exocytosis 19
              dense core granule docking 2
              dense core granule priming 4
              negative regulation of dense core granule exocytosis 2
              neuronal dense core vesicle exocytosis + 14
              positive regulation of dense core granule exocytosis 2
              regulation of dense core granule exocytosis + 8
Path 2
Term Annotations click to browse term
  biological_process 20668
    localization 5832
      establishment of localization 5111
        transport 4854
          secretion 1249
            secretion by cell 1051
              exocytosis 415
                regulated exocytosis 281
                  calcium-ion regulated exocytosis 83
                    dense core granule exocytosis 19
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 2
                      neuronal dense core vesicle exocytosis + 14
                      positive regulation of dense core granule exocytosis 2
                      regulation of dense core granule exocytosis + 8
paths to the root