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ONTOLOGY REPORT - ANNOTATIONS


Term:calcium-ion regulated exocytosis
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Accession:GO:0017156 term browser browse the term
Definition:The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
Comment:Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway.
Synonyms:exact_synonym: calcium ion-dependent exocytosis



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calcium-ion regulated exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap17 Rho GTPase activating protein 17 acts_upstream_of_or_within IDA PMID:10967100 MGI PMID:10967100 RGD:633422 NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:2181384 (MGI:2180460|PMID:12065603) RGD PMID:12065603 MGI:2180460 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C acts_upstream_of_or_within ISO MGI:2176227|MGI:2674119 (MGI:2670808|PMID:12881419) RGD PMID:12881419 MGI:2670808 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cltrn collectrin, amino acid transport regulator acts_upstream_of_positive_effect ISO (PMID:16330323) RGD PMID:16330323 NCBI chr  X:30,361,967...30,395,264
Ensembl chr  X:30,361,967...30,395,349
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5306323|PMID:11978799)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11978799 GO_REF:0000024 GO_REF:0000107 MGI:5306323 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (MGI:4830800|PMID:20338242) RGD PMID:20338242 MGI:4830800 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2151174|PMID:11056535)
Ensembl
RGD
PMID:11056535 GO_REF:0000107 MGI:2151174 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:2151174|PMID:11056535)
ParkinsonsUK-UCL
RGD
PMID:11056535 GO_REF:0000024 MGI:2151174 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Rims3 regulating synaptic membrane exocytosis 3 IDA RGD PMID:10748113 RGD:633421 NCBI chr 5:134,429,092...134,468,935
Ensembl chr 5:134,435,829...134,640,489
JBrowse link
G Sdf4 stromal cell derived factor 4 involved_in IBA
IMP
PMID:21873635
PMID:17442889
GO_Central
BHF-UCL
PMID:21873635 PMID:17442889 RGD:13792537, RGD:2312426 NCBI chr 5:166,586,581...166,606,661
Ensembl chr 5:166,586,390...166,604,521
JBrowse link
G Stx1a syntaxin 1A acts_upstream_of_or_within ISO (MGI:3703420|PMID:10468580) RGD PMID:10468580 MGI:3703420 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Syn2 synapsin II involved_in IEA
ISO
GO_REF:0000107
(MGI:4830800|PMID:20338242)
Ensembl
RGD
PMID:20338242 GO_REF:0000107 MGI:4830800 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
JBrowse link
G Syt1 synaptotagmin 1 involved_in TAS
IBA
PMID:21873635 RGD
GO_Central
PMID:2333096 PMID:21873635 RGD:729959, RGD:13792537 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Syt10 synaptotagmin 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:120,863,014...120,920,730
Ensembl chr 7:120,862,972...120,920,863
JBrowse link
G Syt11 synaptotagmin 11 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Syt12 synaptotagmin 12 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:201,729,307...201,760,192
Ensembl chr 1:201,730,371...201,759,609
JBrowse link
G Syt13 synaptotagmin 13 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:78,877,200...78,915,375
Ensembl chr 3:78,877,114...78,917,392
JBrowse link
G Syt15 synaptotagmin 15 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:9,532,478...9,543,288
Ensembl chr16:9,532,478...9,543,281
JBrowse link
G Syt17 synaptotagmin 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:172,695,275...172,761,906
Ensembl chr 1:172,696,120...172,761,960
JBrowse link
G Syt2 synaptotagmin 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859
JBrowse link
G Syt3 synaptotagmin 3 involved_in TAS
IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro
RGD
PMID:7791877 PMID:21873635 GO_REF:0000002, RGD:61762, RGD:13792537 NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246
JBrowse link
G Syt4 synaptotagmin 4 involved_in NAS
IBA
PMID:21873635 RGD
GO_Central
PMID:7892240 PMID:21873635 RGD:730180, RGD:13792537 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
G Syt5 synaptotagmin 5 involved_in NAS
IBA
PMID:21873635 RGD
GO_Central
PMID:12006594 PMID:21873635 RGD:730140, RGD:13792537 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Syt6 synaptotagmin 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
JBrowse link
G Syt7 synaptotagmin 7 involved_in IBA
IDA
PMID:21873635
PMID:11395007
GO_Central
UniProt
PMID:21873635 PMID:11395007 RGD:13792537, RGD:634203 NCBI chr 1:207,031,369...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
G Syt7_v1 synaptotagmin 7, variant 1 TAS RGD PMID:12071850 RGD:619692
G Syt7_v2 synaptotagmin 7, variant 2 TAS RGD PMID:12071850 RGD:619692
G Syt7_v3 synaptotagmin 7, variant 3 TAS RGD PMID:12071850 RGD:619692
G Syt8 synaptotagmin 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:197,588,126...197,593,598
Ensembl chr 1:197,590,149...197,593,504
JBrowse link
G Syt9 synaptotagmin 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 acts_upstream_of_or_within ISO MGI:2179745 (MGI:2384381|PMID:12145198), (MGI:3589987|PMID:15920476) RGD PMID:12145198 PMID:15920476 MGI:2384381 MGI:3589987 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link
G Vamp3 vesicle-associated membrane protein 3 acts_upstream_of_or_within ISO MGI:2385941 (MGI:3589987|PMID:15920476) RGD PMID:15920476 MGI:3589987 NCBI chr 5:161,498,109...161,508,704
Ensembl chr 5:161,498,109...161,508,751
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in IDA PMID:14993220 UniProt PMID:14993220 RGD:8553828 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097
JBrowse link
acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eqtn equatorin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5293452|PMID:19285662)
RGD PMID:19285662 PMID:21873635 MGI:5293452, RGD:13792537 NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840
JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:22248876) RGD PMID:22248876 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO
IEA
(PMID:22248876)
GO_REF:0000107
RGD
Ensembl
PMID:22248876 GO_REF:0000107 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (PMID:11437455) RGD PMID:11437455 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
JBrowse link
G Unc13b unc-13 homolog B involved_in ISO (PMID:22248876) RGD PMID:22248876 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO
IEA
(PMID:19004505)
GO_REF:0000107
RGD
Ensembl
PMID:19004505 GO_REF:0000107 NCBI chr17:59,005,649...59,012,202
Ensembl chr17:59,005,649...59,012,202
JBrowse link
calcium ion regulated lysosome exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ADP-ribosylation factor like GTPase 8B involved_in ISS
ISO
GO_REF:0000024
(PMID:29592961)
UniProt
RGD
PMID:29592961 GO_REF:0000024 NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596
JBrowse link
G Syt11 synaptotagmin 11 involved_in ISO (MGI:5788615|PMID:26450452) RGD PMID:26450452 MGI:5788615 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Syt7 synaptotagmin 7 involved_in IDA
ISO
PMID:10725327
(MGI:3690533|PMID:16982801), (MGI:3798323|PMID:18539119)
PMID:11511344
RGD PMID:16982801 PMID:18539119 PMID:10725327 PMID:11511344 MGI:3690533 MGI:3798323, RGD:2311145, RGD:11041027 NCBI chr 1:207,031,369...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
calcium ion-regulated exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209 (MGI:1353373|PMID:10670432) RGD PMID:10670432 MGI:1353373 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Doc2b double C2 domain beta involved_in IDA
ISO
IEA
PMID:20150444
(MGI:4439222|PMID:20150444)
GO_REF:0000107
RGD
Ensembl
PMID:20150444 PMID:20150444 GO_REF:0000107 MGI:4439222, RGD:8554647 NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2152972 (MGI:3703478|PMID:17124501)
RGD PMID:17124501 PMID:21873635 MGI:3703478, RGD:13792537 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in
acts_upstream_of_or_within
ISS
ISO
IBA
GO_REF:0000024
MGI:2152971 (MGI:3703478|PMID:17124501)
PMID:21873635
ParkinsonsUK-UCL
RGD
PMID:17124501 PMID:21873635 GO_REF:0000024 MGI:3703478, RGD:13792537 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Rims3 regulating synaptic membrane exocytosis 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:134,429,092...134,468,935
Ensembl chr 5:134,435,829...134,640,489
JBrowse link
G Snap25 synaptosome associated protein 25 IDA RGD PMID:14980208 RGD:1581082 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Stx1b syntaxin 1B involved_in ISO (MGI:3803800|PMID:18703708) RGD PMID:18703708 MGI:3803800 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
JBrowse link
G Syt1 synaptotagmin 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857252 (MGI:5141208|PMID:21521611)
RGD PMID:21521611 PMID:21873635 MGI:5141208, RGD:13792537 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Syt2 synaptotagmin 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859
JBrowse link
G Syt5 synaptotagmin 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Syt7 synaptotagmin 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5707519|PMID:26738595)
UniProt
RGD
PMID:26738595 GO_REF:0000024 MGI:5707519 NCBI chr 1:207,031,369...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
G Syt8 synaptotagmin 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:197,588,126...197,593,598
Ensembl chr 1:197,590,149...197,593,504
JBrowse link
cortical granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myh9 myosin, heavy chain 9 involved_in ISO
IEA
ISS
(MGI:6323780|PMID:31118423)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31118423 GO_REF:0000024 GO_REF:0000107 MGI:6323780 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
JBrowse link
G Nlrp5 NLR family, pyrin domain containing 5 involved_in ISO (MGI:6323780|PMID:31118423) RGD PMID:31118423 MGI:6323780 NCBI chr 1:67,778,037...67,810,946
Ensembl chr 1:67,777,948...68,023,736
JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in ISO UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293) RGD PMID:26575293 MGI:5819330 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link
G Unc13b unc-13 homolog B NOT|involved_in ISO UniProtKB:Q4KUS2 (MGI:5819330|PMID:26575293) RGD PMID:26575293 MGI:5819330 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps2 calcium dependent secretion activator 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829
JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in IBA
IGI
PMID:21873635
PMID:26575293
GO_Central
SynGO-UCL
PMID:21873635 PMID:26575293 RGD:13792537, RGD:12050107 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link
G Unc13b unc-13 homolog B involved_in IBA
IGI
PMID:21873635
PMID:26575293
GO_Central
SynGO-UCL
PMID:21873635 PMID:26575293 RGD:13792537, RGD:12050107 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
G Unc13c unc-13 homolog C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
JBrowse link
G Unc13d unc-13 homolog D involved_in IGI PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687
JBrowse link
fast, calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3040539|PMID:12526776), (MGI:3653150|PMID:9194562), (MGI:69538|PMID:7954835)
ParkinsonsUK-UCL
RGD
PMID:7954835 PMID:9194562 PMID:12526776 GO_REF:0000024 MGI:3040539 MGI:3653150 MGI:69538 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
negative regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A involved_in IMP PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Cbarp CACN subunit beta associated regulatory protein involved_in IBA
ISO
PMID:21873635
(MGI:5607190|PMID:24751537)
RGD PMID:24751537 PMID:21873635 MGI:5607190, RGD:13792537 NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:11533141 RGD:13508598 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO MGI:2684314 (MGI:3841508|PMID:19251639) RGD PMID:19251639 MGI:3841508 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (MGI:59016|PMID:2357966) RGD PMID:2357966 MGI:59016 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in IC PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family acts_upstream_of_or_within ISO MGI:97852 (MGI:5490391|PMID:23616533) RGD PMID:23616533 MGI:5490391 NCBI chr 7:53,423,039...53,456,388
Ensembl chr 7:53,423,130...53,456,370
JBrowse link
G Rest RE1-silencing transcription factor involved_in IMP PMID:21536750 UniProt PMID:21536750 RGD:8554180 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354
JBrowse link
G Stxbp3 syntaxin binding protein 3 involved_in ISO (PMID:12649283) RGD PMID:12649283 NCBI chr 2:196,442,738...196,485,733
Ensembl chr 2:196,442,634...196,485,671
JBrowse link
G Syt4 synaptotagmin 4 IDA RGD PMID:21551071 RGD:7205660 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
G Trim9 tripartite motif-containing 9 IMP RGD PMID:11524423 RGD:631246 NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:88,757,303...88,856,542
JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in IMP PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISS
ISO
GO_REF:0000024
(MGI:5476894|PMID:23229896)
UniProt
RGD
PMID:23229896 GO_REF:0000024 MGI:5476894 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link
G Unc13b unc-13 homolog B involved_in ISS
ISO
GO_REF:0000024
(MGI:5476894|PMID:23229896)
UniProt
RGD
PMID:23229896 GO_REF:0000024 MGI:5476894 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:4834982|PMID:20586096)
UniProt
Ensembl
RGD
PMID:20586096 GO_REF:0000024 GO_REF:0000107 MGI:4834982 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO
ISS
(PMID:19004505), (PMID:19246320)
GO_REF:0000024
RGD
UniProt
PMID:19004505 PMID:19246320 GO_REF:0000024 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
JBrowse link
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 IDA RGD PMID:10657240 RGD:9684853 NCBI chr10:43,997,983...44,014,543
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:17172292 PMID:21873635 RGD:2316206, RGD:13792537 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Cadps calcium dependent secretion activator IMP RGD PMID:9289490 RGD:1299539 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Cdk5 cyclin-dependent kinase 5 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) RGD PMID:15123626 MGI:3709145 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) RGD PMID:15123626 MGI:3709145 NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344
JBrowse link
G Doc2b double C2 domain beta involved_in IDA PMID:18596155 UniProt PMID:18596155 RGD:8554556 NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in IDA PMID:18167541
PMID:17301173
PMID:20484665
UniProt PMID:18167541 PMID:17301173 PMID:20484665 RGD:10047360, RGD:10047384, RGD:10047179 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
JBrowse link
G Scamp5 secretory carrier membrane protein 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19234194)
UniProt
Ensembl
RGD
PMID:19234194 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:57,845,831...57,884,516
Ensembl chr 8:57,846,659...57,872,027
JBrowse link
G Stx1a syntaxin 1A involved_in IDA PMID:17301173
PMID:20484665
PMID:18167541
UniProt PMID:17301173 PMID:20484665 PMID:18167541 RGD:10047384, RGD:10047179, RGD:10047360 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) RGD PMID:15123626 MGI:3709145 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Syt1 synaptotagmin 1 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Syt10 synaptotagmin 10 involved_in ISS
ISO
GO_REF:0000024
(MGI:5751674|PMID:21496647)
UniProt
RGD
PMID:21496647 GO_REF:0000024 MGI:5751674 NCBI chr 7:120,863,014...120,920,730
Ensembl chr 7:120,862,972...120,920,863
JBrowse link
G Syt7 synaptotagmin 7 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 1:207,031,369...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
G Syt9 synaptotagmin 9 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:2179533|PMID:11242035)
UniProt
RGD
PMID:11242035 GO_REF:0000024 MGI:2179533 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) RGD PMID:18468511 MGI:3795609 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA
ISO
GO_REF:0000107
UniProtKB:Q8BYR5 (MGI:5634021|PMID:25719439)
Ensembl
RGD
PMID:25719439 GO_REF:0000107 MGI:5634021 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) RGD PMID:11545717 MGI:3621672 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Syt6 synaptotagmin 6 involved_in IMP
IDA
PMID:26216953 SynGO PMID:26216953 PMID:26216953 RGD:13702162, RGD:13702162 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
JBrowse link
G Unc13a unc-13 homolog A involved_in IBA
ISO
PMID:21873635
UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293)
RGD PMID:26575293 PMID:21873635 MGI:5819330, RGD:13792537 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link
G Unc13b unc-13 homolog B involved_in IBA
ISO
PMID:21873635
(MGI:5819330|PMID:26575293)
RGD PMID:26575293 PMID:21873635 MGI:5819330, RGD:13792537 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
G Unc13c unc-13 homolog C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
JBrowse link
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stxbp1 syntaxin binding protein 1 involved_in ISO (PMID:23091057) RGD PMID:23091057 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (MGI:79428|PMID:8632762) RGD PMID:8632762 MGI:79428 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Doc2a double C2 domain alpha involved_in ISO (PMID:18354201)
(MGI:3778349|PMID:18354201)
RGD PMID:18354201 MGI:3778349 NCBI chr 1:181,457,415...181,462,528
Ensembl chr 1:181,458,390...181,462,030
JBrowse link
G Rph3al rabphilin 3A-like (without C2 domains) acts_upstream_of_or_within ISO MGI:3051976 (MGI:3044444|PMID:15159548) RGD PMID:15159548 MGI:3044444 NCBI chr10:60,689,943...60,833,354
Ensembl chr10:60,690,031...60,801,883
JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 involved_in TAS PMID:9704016 UniProt PMID:9704016 RGD:70020 NCBI chr 1:202,002,970...202,045,343
Ensembl chr 1:202,002,970...202,044,283
JBrowse link
G Sycn syncollin TAS RGD PMID:9244306 RGD:634177 NCBI chr 1:83,823,836...83,833,542
Ensembl chr 1:83,832,102...83,833,538
JBrowse link
G Syt1 synaptotagmin 1 involved_in IMP
ISO
IBA
(MGI:3761204|PMID:11562488)
PMID:21873635
PMID:12860971
RGD PMID:11562488 PMID:11751925 PMID:21873635 PMID:12860971 PMID:17686463 MGI:3761204, RGD:2311146, RGD:13792537, RGD:11079189, RGD:7205657 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Syt10 synaptotagmin 10 involved_in IBA
ISO
PMID:21873635
(MGI:5780544|PMID:12860971)
RGD PMID:12860971 PMID:21873635 MGI:5780544, RGD:13792537 NCBI chr 7:120,863,014...120,920,730
Ensembl chr 7:120,862,972...120,920,863
JBrowse link
G Syt11 synaptotagmin 11 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Syt12 synaptotagmin 12 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:201,729,307...201,760,192
Ensembl chr 1:201,730,371...201,759,609
JBrowse link
G Syt13 synaptotagmin 13 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:78,877,200...78,915,375
Ensembl chr 3:78,877,114...78,917,392
JBrowse link
G Syt15 synaptotagmin 15 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:9,532,478...9,543,288
Ensembl chr16:9,532,478...9,543,281
JBrowse link
G Syt17 synaptotagmin 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:172,695,275...172,761,906
Ensembl chr 1:172,696,120...172,761,960
JBrowse link
G Syt2 synaptotagmin 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859
JBrowse link
G Syt3 synaptotagmin 3 involved_in IMP
IBA
PMID:12860971
PMID:21873635
ParkinsonsUK-UCL
GO_Central
PMID:12860971 PMID:21873635 RGD:11079189, RGD:13792537 NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246
JBrowse link
G Syt4 synaptotagmin 4 involved_in IBA
ISO
PMID:21873635
(MGI:3836866|PMID:19136969), (MGI:4421257|PMID:20010821)
RGD PMID:19136969 PMID:20010821 PMID:21873635 MGI:3836866 MGI:4421257, RGD:13792537 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
G Syt5 synaptotagmin 5 involved_in IBA
ISO
PMID:21873635
(MGI:5780544|PMID:12860971)
RGD PMID:12860971 PMID:21873635 MGI:5780544, RGD:13792537 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Syt6 synaptotagmin 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
JBrowse link
G Syt7 synaptotagmin 7 involved_in IMP
ISO
IBA
(MGI:5780544|PMID:12860971)
PMID:21873635
RGD PMID:12860971 PMID:10725327 PMID:21873635 PMID:20016973 MGI:5780544, RGD:2311145, RGD:13792537, RGD:7241272 NCBI chr 1:207,031,369...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
G Syt8 synaptotagmin 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:197,588,126...197,593,598
Ensembl chr 1:197,590,149...197,593,504
JBrowse link
G Syt9 synaptotagmin 9 involved_in IMP
ISO
IBA
(MGI:5780544|PMID:12860971)
PMID:21873635
RGD PMID:12860971 PMID:11751925 PMID:21873635 PMID:15015935 PMID:17686463 MGI:5780544, RGD:2311146, RGD:13792537, RGD:7241274, RGD:7205657 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO (MGI:4866942|PMID:21106823) RGD PMID:21106823 MGI:4866942 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3652690|PMID:16782817)
ParkinsonsUK-UCL
RGD
PMID:16782817 GO_REF:0000024 MGI:3652690 NCBI chr13:39,355,698...39,429,154
Ensembl chr13:39,352,247...39,429,169
JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1-associated protein 3 involved_in ISO (PMID:28626000) RGD PMID:28626000 NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019
JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in EXP
IDA
PMID:24037803 SynGO PMID:24037803 PMID:24037803 RGD:13702177, RGD:13702177 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Syt4 synaptotagmin 4 involved_in ISO (MGI:4457852|PMID:19448629) RGD PMID:19448629 MGI:4457852 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
zymogen granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sdf4 stromal cell derived factor 4 involved_in IMP PMID:17442889 BHF-UCL PMID:17442889 RGD:2312426 NCBI chr 5:166,586,581...166,606,661
Ensembl chr 5:166,586,390...166,604,521
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 acts_upstream_of_or_within ISO MGI:3056083 (MGI:3801544|PMID:18535671) RGD PMID:18535671 MGI:3801544 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      vesicle-mediated transport 1677
        exocytosis 426
          regulated exocytosis 295
            calcium-ion regulated exocytosis 78
              acrosomal vesicle exocytosis + 9
              calcium ion regulated lysosome exocytosis 3
              calcium ion-regulated exocytosis of neurotransmitter + 22
              cortical granule exocytosis + 2
              dense core granule exocytosis + 11
              negative regulation of calcium ion-dependent exocytosis + 11
              positive regulation of calcium ion-dependent exocytosis + 19
              regulation of calcium ion-dependent exocytosis + 48
              zymogen granule exocytosis 2
Path 2
Term Annotations click to browse term
  biological_process 19497
    localization 6488
      establishment of localization 4887
        transport 4725
          secretion 1163
            secretion by cell 966
              exocytosis 426
                regulated exocytosis 295
                  calcium-ion regulated exocytosis 78
                    acrosomal vesicle exocytosis + 9
                    calcium ion regulated lysosome exocytosis 3
                    calcium ion-regulated exocytosis of neurotransmitter + 22
                    cortical granule exocytosis + 2
                    dense core granule exocytosis + 11
                    negative regulation of calcium ion-dependent exocytosis + 11
                    positive regulation of calcium ion-dependent exocytosis + 19
                    regulation of calcium ion-dependent exocytosis + 48
                    zymogen granule exocytosis 2
paths to the root